{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:35:18Z","timestamp":1778132118754,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,17]],"date-time":"2017-09-17T00:00:00Z","timestamp":1505606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["japanesedentalsciencereview.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Japanese Dental Science Review"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jdsr.2017.08.001","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T13:56:09Z","timestamp":1507816569000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["A review on non-syndromic tooth agenesis associated with PAX9 mutations"],"prefix":"10.1016","volume":"54","author":[{"given":"Nurul Hasyiqin","family":"Fauzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunita Dewi","family":"Ardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarina","family":"Zainuddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Widya","family":"Lestari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jdsr.2017.08.001_bib0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejmg.2008.02.009","article-title":"The genetic basis of inherited anomalies of the teeth. Part 1: clinical and molecular aspects of non-syndromic dental disorders","volume":"51","author":"Bailleul-Forestier","year":"2008","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0010","article-title":"Hypodontia: genetics and future perspectives","author":"Pemberton","year":"2005","journal-title":"Braz J Oral Sci [Internet]"},{"issue":"1","key":"10.1016\/j.jdsr.2017.08.001_bib0015","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jdsr.2008.12.001","article-title":"Prevalence and genetic basis of tooth agenesis","volume":"45","author":"Shimizu","year":"2009","journal-title":"Jpn Dent Sci Rev [Internet]"},{"issue":"6","key":"10.1016\/j.jdsr.2017.08.001_bib0020","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0889-5406(00)70173-9","article-title":"The genetics of human tooth agenesis: new discoveries for understanding dental anomalies","volume":"117","author":"Vastardis","year":"2000","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"1","key":"10.1016\/j.jdsr.2017.08.001_bib0025","first-page":"165","article-title":"Anodontia of permanent teeth\u2014a case report","volume":"30","author":"Chaitra","year":"2010","journal-title":"Pak Oral Dent J"},{"issue":"4","key":"10.1016\/j.jdsr.2017.08.001_bib0030","first-page":"263","article-title":"Hypodontia\u2014a retrospective review of prevalence and etiology. Part I","volume":"36","author":"Larmour","year":"2005","journal-title":"Quintessence Int"},{"issue":"2","key":"10.1016\/j.jdsr.2017.08.001_bib0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.14219\/jada.archive.1980.0186","article-title":"Clinician\u2019s view of hypodontia","volume":"101","author":"Jorgenson","year":"1980","journal-title":"J Am Dent Assoc [Internet]"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/bdj.2007.732","article-title":"Familial human hypodontia\u2014is it all in the genes?","volume":"203","author":"Cobourne","year":"2007","journal-title":"Br Dent J"},{"issue":"4","key":"10.1016\/j.jdsr.2017.08.001_bib0045","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jez.b.21277","article-title":"Genetic basis of tooth agenesis","volume":"312","author":"Nieminen","year":"2009","journal-title":"J Exp Zool Part B Mol Dev Evol"},{"issue":"13","key":"10.1016\/j.jdsr.2017.08.001_bib0050","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1600-0722.2012.00986.x","article-title":"A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population","volume":"120","author":"Liu","year":"2012","journal-title":"Eur J Oral Sci"},{"issue":"June","key":"10.1016\/j.jdsr.2017.08.001_bib0055","first-page":"117","article-title":"A review of hypodontia: classification, prevalence, etiology, associated anomalies, clinical implications and treatment options","volume":"4","author":"Alshahrani","year":"2013","journal-title":"JP J"},{"issue":"5","key":"10.1016\/j.jdsr.2017.08.001_bib0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0003-9969(84)90163-8","article-title":"A unifying aetiological explanation for anomalies of human tooth number and size","volume":"29","author":"Brook","year":"1984","journal-title":"Arch Oral Biol"},{"issue":"4","key":"10.1016\/j.jdsr.2017.08.001_bib0065","doi-asserted-by":"crossref","first-page":"9997","DOI":"10.4238\/2014.November.28.4","article-title":"PAX-9 polymorphism may be a risk factor for hypodontia: a meta-analysis","volume":"13","author":"Zhang","year":"2014","journal-title":"Genet Mol Res"},{"issue":"2","key":"10.1016\/j.jdsr.2017.08.001_bib0070","first-page":"490","article-title":"Prevalence and patterns of tooth agenesis among Malay children","volume":"45","author":"Mani","year":"2014","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"93","key":"10.1016\/j.jdsr.2017.08.001_bib0075","first-page":"5","article-title":"Hypodontia in the permanent dentition: a study of its prevalence in Malaysian children","volume":"11","author":"Nik-Hussein","year":"1989","journal-title":"Aust Orthod J"},{"issue":"4","key":"10.1016\/j.jdsr.2017.08.001_bib0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1179\/1465313314Y.0000000116","article-title":"Prevalence of hypodontia and associated factors: a systematic review and meta-analysis","volume":"41","author":"Khalaf","year":"2014","journal-title":"J Orthod [Internet]"},{"issue":"3","key":"10.1016\/j.jdsr.2017.08.001_bib0085","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-0528.2004.00158.x","article-title":"A meta-analysis of the prevalence of dental agenesis of permanent teeth","volume":"32","author":"Polder","year":"2004","journal-title":"Community Dent Oral Epidemiol"},{"issue":"2 SPEC. ISS","key":"10.1016\/j.jdsr.2017.08.001_bib0090","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.archoralbio.2004.11.015","article-title":"The patterning of hypodontia in a group of young adults in Sheffield, UK","volume":"50","author":"Kirkham","year":"2005","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0095","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.ajodo.2006.12.019","article-title":"Hypodontia: an epidemiologic study of American black and white people","volume":"134","author":"Harris","year":"2008","journal-title":"Am J Orthod Dentofac Orthop [Internet]"},{"issue":"6","key":"10.1016\/j.jdsr.2017.08.001_bib0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF03320830","article-title":"Molecular factors resulting in tooth agenesis and contemporary approaches for regeneration: a review","volume":"13","author":"Cudney","year":"2012","journal-title":"Eur Arch Paediatr Dent [Internet]"},{"issue":"November(4)","key":"10.1016\/j.jdsr.2017.08.001_bib0105","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1601-6343.2007.00407.x","article-title":"Genes affecting tooth morphogenesis","volume":"10","author":"Kapadia","year":"2007","journal-title":"Orthod Craniofac Res [Internet]"},{"issue":"7","key":"10.1016\/j.jdsr.2017.08.001_bib0110","first-page":"339","article-title":"Genes and tooth development: reviewing the structure and function of some key players","volume":"2","author":"Scarel-Caminaga","year":"2003","journal-title":"Braz J Oral Sci"},{"issue":"5","key":"10.1016\/j.jdsr.2017.08.001_bib0115","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.gde.2009.09.002","article-title":"Molecular genetics of tooth development","volume":"19","author":"Bei","year":"2009","journal-title":"Curr Opin Genet Dev"},{"issue":"7","key":"10.1016\/j.jdsr.2017.08.001_bib0120","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.archoralbio.2012.01.005","article-title":"Genetic basis of non-syndromic anomalies of human tooth number","volume":"57","author":"Galluccio","year":"2012","journal-title":"Arch Oral Biol [Internet]"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0125","series-title":"Dental anatomy, histology and development","first-page":"215","article-title":"Development of teeth","author":"Bhalajhi","year":"2005"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0130","series-title":"Dental embryology, histology and anatomy","first-page":"61","article-title":"Tooth development and eruption","author":"Bath-Balogh","year":"2006"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0135","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0722.1998.tb02146.x","article-title":"A graphical WWW-database on gene expression in tooth","volume":"106","author":"Nieminen","year":"1998","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0140","series-title":"Dento\/oro\/craniofacial anomalies and genetics","first-page":"9","article-title":"Missinf teeth (hypodontia and oligodontia)","author":"Bloch-zupan","year":"2012"},{"issue":"2","key":"10.1016\/j.jdsr.2017.08.001_bib0145","first-page":"ZE09","article-title":"Role of homeobox genes in tooth morphogenesis: a review","volume":"9","author":"Suryadeva","year":"2015","journal-title":"J Clin Diagn Res"},{"issue":"2","key":"10.1016\/j.jdsr.2017.08.001_bib0150","doi-asserted-by":"crossref","first-page":"634","DOI":"10.4067\/S0717-95022012000200045","article-title":"Multiple tooth agenesis in non-syndromic patient: a rare case report","volume":"30","author":"Borie","year":"2012","journal-title":"Int J Morphol"},{"issue":"2","key":"10.1016\/j.jdsr.2017.08.001_bib0155","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2334\/josnusd.50.143","article-title":"An orthopantomographic study of hypodontia in permanent teeth of Japanese pediatric patients","volume":"50","author":"Goya","year":"2008","journal-title":"J Oral Sci [Internet]"},{"issue":"2","key":"10.1016\/j.jdsr.2017.08.001_bib0160","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF03194616","article-title":"A novel c.581C>T transition localized in a highly conserved homeobox sequence of MSX1: is it responsible for oligodontia?","volume":"47","author":"Mostowska","year":"2006","journal-title":"J Appl Genet"},{"issue":"20","key":"10.1016\/j.jdsr.2017.08.001_bib0165","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1034\/j.1600-0722.2003.00069.x","article-title":"Molecular basis of non-syndromic tooth agenesis: mutations of MSX1 and PAX9 reflect their role in patterning human dentition","volume":"111","author":"Mostowska","year":"2003","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0170","first-page":"1","article-title":"Clinical and functional data implicate the Arg (151) Ser variant of MSX1 in familial hypodontia","author":"Kamamoto","year":"2011","journal-title":"Eur J Hum Genet [Internet]"},{"issue":"6","key":"10.1016\/j.jdsr.2017.08.001_bib0175","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.archoralbio.2012.01.003","article-title":"Novel MSX1 mutation in a family with autosomal-dominant hypodontia of second premolars and third molars","volume":"57","author":"Mostowska","year":"2012","journal-title":"Arch Oral Biol [Internet]"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0180","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.archoralbio.2008.02.012","article-title":"Identification of a novel missense mutation of MSX1 gene in Chinese family with autosomal-dominant oligodontia","volume":"53","author":"Xuan","year":"2008","journal-title":"Arch Oral Biol"},{"issue":"7","key":"10.1016\/j.jdsr.2017.08.001_bib0185","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1177\/154405910808700715","article-title":"Tooth agenesis: from molecular genetics to molecular dentistry","volume":"87","author":"Matalova","year":"2008","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.jdsr.2017.08.001_bib0190","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/ajmg.a.34045","article-title":"Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes","volume":"155","author":"Bergendal","year":"2011","journal-title":"Am J Med Genet Part A"},{"issue":"October(10)","key":"10.1016\/j.jdsr.2017.08.001_bib0195","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.archoralbio.2011.03.023","article-title":"Sequence analysis of PAX9, MSX1 and AXIN2 genes in a Chinese oligodontia family","volume":"56","author":"Wang","year":"2011","journal-title":"Arch Oral Biol [Internet]"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0200","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1086\/386293","article-title":"Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer","volume":"74","author":"Lammi","year":"2004","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10.1016\/j.jdsr.2017.08.001_bib0205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/sj.ejhg.5201536","article-title":"A novel mutation in PAX9 causes familial form of molar oligodontia","volume":"14","author":"Mostowska","year":"2006","journal-title":"Eur J Hum Genet"},{"issue":"17","key":"10.1016\/j.jdsr.2017.08.001_bib0210","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1101\/gad.12.17.2735","article-title":"Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities","volume":"12","author":"Peters","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0215","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ajmg.a.10011","article-title":"Novel missense mutations and a 288-bp exonic insertion in pax9 in families with autosomal dominant hypodontia","author":"Das","year":"2003","journal-title":"Am J Med Genet [Internet]"},{"issue":"1","key":"10.1016\/j.jdsr.2017.08.001_bib0220","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/71634","article-title":"Mutation of PAX9 is associated with oligodontia","volume":"24","author":"Stockton","year":"2000","journal-title":"Nat Genet [Internet]"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0225","first-page":"1","article-title":"A novel nonsense mutation in PAX9 is associated with sporadic hypodontia","author":"Zhu","year":"2011","journal-title":"Mutagenesis"},{"issue":"February(2)","key":"10.1016\/j.jdsr.2017.08.001_bib0230","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/0810129","article-title":"A novel mutation in human PAX9 causes molar oligodontia","volume":"81","author":"Frazier-Bowers","year":"2002","journal-title":"J Dent Res [Internet]"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0235","first-page":"108","article-title":"PAX9 mutation of non-syndromic hypodontia in a Malysian family","volume":"1","author":"Nur Farahiyah","year":"2017","journal-title":"UI Proceeding on Health and Medicine"},{"issue":"4","key":"10.1016\/j.jdsr.2017.08.001_bib0240","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00439-002-0699-1","article-title":"Haploinsufficiency of PAX9 is associated with autosomal dominant hypodontia","volume":"110","author":"Das","year":"2002","journal-title":"Hum Genet"},{"issue":"January(1)","key":"10.1016\/j.jdsr.2017.08.001_bib0245","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/154405910508400107","article-title":"Novel mutation of the initiation codon of PAX9 causes oligodontia","volume":"84","author":"Klein","year":"2005","journal-title":"J Dent Res [Internet]"},{"key":"10.1016\/j.jdsr.2017.08.001_bib0250","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.archoralbio.2015.10.022","article-title":"A novel initiation codon mutation of PAX9 in a family with oligodontia","volume":"61","author":"Liang","year":"2016","journal-title":"Arch Oral Biol [Internet]"},{"issue":"10","key":"10.1016\/j.jdsr.2017.08.001_bib0255","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/sj.ejhg.5200715","article-title":"Identification of a nonsense mutation in the PAX9 gene in molar oligodontia","volume":"9","author":"Nieminen","year":"2001","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"10.1016\/j.jdsr.2017.08.001_bib0260","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00439-003-1066-6","article-title":"A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia","volume":"114","author":"Jumlongras","year":"2004","journal-title":"Hum Genet"},{"issue":"11","key":"10.1016\/j.jdsr.2017.08.001_bib0265","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/sj.ejhg.5201060","article-title":"A missense mutation in PAX9 in a family with distinct phenotype of oligodontia","volume":"11","author":"Lammi","year":"2003","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"10.1016\/j.jdsr.2017.08.001_bib0270","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/ejo\/cjp155","article-title":"Mutational analysis of MSX1 and PAX9 genes in Portuguese families with maxillary lateral incisor agenesis","volume":"32","author":"Pinho","year":"2010","journal-title":"Eur J Orthod [Internet]"}],"container-title":["Japanese Dental Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1882761616300679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1882761616300679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T22:02:38Z","timestamp":1535320958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1882761616300679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S1882761616300679"],"URL":"https:\/\/doi.org\/10.1016\/j.jdsr.2017.08.001","relation":{},"ISSN":["1882-7616"],"issn-type":[{"value":"1882-7616","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A review on non-syndromic tooth agenesis associated with PAX9 mutations","name":"articletitle","label":"Article Title"},{"value":"Japanese Dental Science Review","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdsr.2017.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}]}}