{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:52:27Z","timestamp":1793926347352,"version":"4.8.0"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K09931"],"award-info":[{"award-number":["20K09931"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Japanese Dental Science Review"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jdsr.2021.09.003","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:32:11Z","timestamp":1633653131000},"page":"190-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"special_numbering":"C","title":["Porphyromonas gingivalis FimA and Mfa1 fimbriae: Current insights on localization, function, biogenesis, and genotype"],"prefix":"10.1016","volume":"57","author":[{"given":"Yoshiaki","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdsr.2021.09.003_bib0005","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0010","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.chom.2011.10.006","article-title":"Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement","volume":"10","author":"Hajishengallis","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0020","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0025","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1177\/0022034510375281","article-title":"\"Gum bug, leave my heart alone!\"\u2014epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis","volume":"89","author":"Kebschull","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003627","article-title":"Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)","volume":"9","author":"Maresz","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0035","first-page":"S170","article-title":"Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms","volume":"84","author":"Madianos","year":"2013","journal-title":"J Periodontol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0040","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer\u2019s disease brains: evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0045","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/MMBR.62.4.1244-1263.1998","article-title":"Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis","volume":"62","author":"Lamont","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0765.2008.01135.x","article-title":"Surface components of Porphyromonas gingivalis","volume":"44","author":"Yoshimura","year":"2009","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0055","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v5i0.20265","article-title":"Porphyromonas gingivalis fimbriae","volume":"5","author":"Enersen","year":"2013","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1399-302X.1998.tb00724.x","article-title":"The importance of fimbriae in the virulence and ecology of some oral bacteria","volume":"13","author":"Hamada","year":"1998","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1034\/j.1600-0757.2002.03006.x","article-title":"In or out: the invasiveness of oral bacteria","volume":"30","author":"Lamont","year":"2002","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0070","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1177\/0022034516655083","article-title":"Role of Mfa5 in Expression of Mfa1 Fimbriae in Porphyromonas gingivalis","volume":"95","author":"Hasegawa","year":"2016","journal-title":"J Dent Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0075","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1099\/mic.0.028928-0","article-title":"Anchoring and length regulation of Porphyromonas gingivalis Mfa1 fimbriae by the downstream gene product Mfa2","volume":"155","author":"Hasegawa","year":"2009","journal-title":"Microbiology (Reading, Engl)"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0080","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/omi.12040","article-title":"Localization and function of the accessory protein Mfa3 in Porphyromonas gingivalis Mfa1 fimbriae","volume":"28","author":"Hasegawa","year":"2013","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139454","article-title":"Mfa4, an accessory protein of Mfa1 fimbriae, modulates fimbrial biogenesis, cell auto-aggregation, and biofilm formation in Porphyromonas gingivalis","volume":"10","author":"Ikai","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0090","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1099\/mic.0.2006\/005561-0","article-title":"Involvement of minor components associated with the FimA fimbriae of Porphyromonas gingivalis in adhesive functions","volume":"153","author":"Nishiyama","year":"2007","journal-title":"Microbiology (Reading, Engl)"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0095","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1177\/0022034510370089","article-title":"FimB regulates FimA fimbriation in Porphyromonas gingivalis","volume":"89","author":"Nagano","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0100","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/dnares\/dsn013","article-title":"Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis","volume":"15","author":"Naito","year":"2008","journal-title":"DNA Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0105","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1128\/JB.185.18.5591-5601.2003","article-title":"Complete genome sequence of the oral pathogenic Bacterium Porphyromonas gingivalis strain W83","volume":"185","author":"Nelson","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0110","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1128\/JB.05269-11","article-title":"Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease","volume":"193","author":"Watanabe","year":"2011","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0115","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.cell.2016.03.016","article-title":"A distinct type of pilus from the human microbiome","volume":"165","author":"Xu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0120","doi-asserted-by":"crossref","first-page":"22945","DOI":"10.1038\/srep22945","article-title":"Structure of the fimbrial protein Mfa4 from Porphyromonas gingivalis in its precursor form: implications for a donor-strand complementation mechanism","volume":"6","author":"Kloppsteck","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0125","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1038\/s41598-018-20067-z","article-title":"Structural and functional characterization of shaft, anchor, and tip proteins of the Mfa1 fimbria from the periodontal pathogen Porphyromonas gingivalis","volume":"8","author":"Hall","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0130","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/1348-0421.12838","article-title":"Biogenesis of type V pili","volume":"64","author":"Shoji","year":"2020","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0135","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41564-020-0705-1","article-title":"Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange","volume":"5","author":"Shibata","year":"2020","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0140","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrmicro.2017.40","article-title":"A comprehensive guide to pilus biogenesis in Gram-negative bacteria","volume":"15","author":"Hospenthal","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0145","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s42003-020-01621-w","article-title":"Porphyromonas gingivalis fimbrial protein Mfa5 contains a von Willebrand factor domain and an intramolecular isopeptide","volume":"4","author":"Heidler","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jre.12255","article-title":"Porphyromonas gingivalis and related bacteria: from colonial pigmentation to the type IX secretion system and gliding motility","volume":"50","author":"Nakayama","year":"2015","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0155","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/mmi.13752","article-title":"Type IX secretion: the generation of bacterial cell surface coatings involved in virulence, gliding motility and the degradation of complex biopolymers","volume":"106","author":"Veith","year":"2017","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0160","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fcimb.2017.00215","article-title":"The type IX secretion system (T9SS): highlights and recent insights into its structure and function","volume":"7","author":"Lasica","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.job.2014.04.002","article-title":"Porphyromonas gingivalis fimbriae: recent developments describing the function and localization of mfa1 gene cluster proteins","volume":"56","author":"Hasegawa","year":"2014","journal-title":"J Oral Biosci"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0170","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-0765.2004.00719.x","article-title":"Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis","volume":"39","author":"Amano","year":"2004","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0175","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2020.1775333","article-title":"Phylogenetic diversity in fim and mfa gene clusters between Porphyromonas gingivalis and Porphyromonas gulae, as a potential cause of host specificity","volume":"12","author":"Fujiwara-Takahashi","year":"2020","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0180","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1177\/0022034515588275","article-title":"A major fimbrilin variant of Mfa1 fimbriae in Porphyromonas gingivalis","volume":"94","author":"Nagano","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0185","doi-asserted-by":"crossref","first-page":"e0255111","DOI":"10.1371\/journal.pone.0255111","article-title":"Diversity analysis of genes encoding Mfa1-fimbrial components in Porphyromonas gingivalis strains","volume":"16","author":"Sakae","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0190","doi-asserted-by":"crossref","first-page":"e5581","DOI":"10.7717\/peerj.5581","article-title":"Distribution of Porphyromonas gingivalis fimA and mfa1 fimbrial genotypes in subgingival plaques","volume":"6","author":"Nagano","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0195","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1128\/jb.160.3.949-957.1984","article-title":"Purification and characterization of a novel type of fimbriae from the oral anaerobe Bacteroides gingivalis","volume":"160","author":"Yoshimura","year":"1984","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0200","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1128\/jb.170.4.1658-1665.1988","article-title":"Molecular cloning and sequencing of the gene encoding the fimbrial subunit protein of Bacteroides gingivalis","volume":"170","author":"Dickinson","year":"1988","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0205","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1128\/iai.57.11.3646-3652.1989","article-title":"Purification and properties of a 75-kilodalton major protein, an immunodominant surface antigen, from the oral anaerobe Bacteroides gingivalis","volume":"57","author":"Yoshimura","year":"1989","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0210","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.1128\/iai.64.11.4788-4794.1996","article-title":"Isolation and characterization of a minor fimbria from Porphyromonas gingivalis","volume":"64","author":"Hamada","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1574-6968.1994.tb07002.x","article-title":"Molecular cloning and characterization of the genes encoding the immunoreactive major cell-surface proteins of Porphyromonas gingivalis","volume":"120","author":"Ogawa","year":"1994","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0220","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1574-695X.1995.tb00122.x","article-title":"Immunochemical characterisation and epitope mapping of a novel fimbrial protein (Pg-II fimbria) of Porphyromonas gingivalis","volume":"11","author":"Ogawa","year":"1995","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0225","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1034\/j.1399-302X.2002.170311.x","article-title":"Cytokine production induced by a 67-kDa fimbrial protein from Porphyromonas gingivalis","volume":"17","author":"Hamada","year":"2002","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0230","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1574-6968.1992.tb05233.x","article-title":"Molecular cloning and expression of a major surface protein (the 75-kDa protein) of Porphyromonas (Bacteroides) gingivalis in Escherichia coli","volume":"71","author":"Watanabe","year":"1992","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0235","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1128\/IAI.73.7.3983-3989.2005","article-title":"Short fimbriae of Porphyromonas gingivalis and their role in coadhesion with Streptococcus gordonii","volume":"73","author":"Park","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0240","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1111\/j.1365-2958.2004.04105.x","article-title":"The major structural components of two cell surface filaments of Porphyromonas gingivalis are matured through lipoprotein precursors","volume":"52","author":"Shoji","year":"2004","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0245","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1139\/W10-084","article-title":"Recombinant Porphyromonas gingivalis FimA preproprotein expressed in Escherichia coli is lipidated and the mature or processed recombinant FimA protein forms a short filament in vitro","volume":"56","author":"Shoji","year":"2010","journal-title":"Can J Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0250","doi-asserted-by":"crossref","first-page":"29072","DOI":"10.1074\/jbc.273.44.29072","article-title":"Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis","volume":"273","author":"Kadowaki","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0255","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0882-4010(96)80006-4","article-title":"Identification of Porphyromonas gingivalis prefimbrilin possessing a long leader peptide: possible involvement of trypsin-like protease in fimbrilin maturation","volume":"19","author":"Onoe","year":"1995","journal-title":"Microb Pathog"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0260","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.job.2012.07.002","article-title":"Porphyromonas gingivalis FimA fimbriae: roles of the fim gene cluster in the fimbrial assembly and antigenic heterogeneity among fimA genotypes","volume":"54","author":"Nagano","year":"2012","journal-title":"J Oral Biosci"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0265","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fcimb.2018.00137","article-title":"Maturation of the Mfa1 fimbriae in the oral pathogen Porphyromonas gingivalis","volume":"8","author":"Lee","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0270","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00750-18","article-title":"Peptide-based inhibitors of fimbrial biogenesis in Porphyromonas gingivalis","volume":"87","author":"Alaei","year":"2019","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0275","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1128\/IAI.68.12.6758-6762.2000","article-title":"Identification of a Porphyromonas gingivalis receptor for the Streptococcus gordonii SspB protein","volume":"68","author":"Chung","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0280","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1348-0421.1996.tb01133.x","article-title":"Sequence and product analyses of the four genes downstream from the fimbrilin gene (fimA) of the oral anaerobe Porphyromonas gingivalis","volume":"40","author":"Watanabe","year":"1996","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0285","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1091\/mbc.e02-05-0259","article-title":"Distribution and evolution of von Willebrand\/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere","volume":"13","author":"Whittaker","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0290","doi-asserted-by":"crossref","first-page":"24605","DOI":"10.1074\/jbc.M112.369223","article-title":"PG0026 is the C-terminal signal peptidase of a novel secretion system of Porphyromonas gingivalis","volume":"287","author":"Glew","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0295","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1248\/yakushi.13-00177","article-title":"FimA fimbriae of the periodontal disease-associated bacterium Porphyromonas gingivalis","volume":"133","author":"Nagano","year":"2013","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0300","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1128\/iai.64.5.1631-1637.1996","article-title":"Structural domains of Porphyromonas gingivalis recombinant fimbrillin that mediate binding to salivary proline-rich protein and statherin","volume":"64","author":"Amano","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0305","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1128\/iai.65.8.3159-3164.1997","article-title":"Active sites of salivary proline-rich protein for binding to Porphyromonas gingivalis fimbriae","volume":"65","author":"Kataoka","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0310","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1128\/iai.65.2.422-427.1997","article-title":"Role of the carboxyl-terminal region of Porphyromonas gingivalis fimbrillin in binding to salivary proteins","volume":"65","author":"Nagata","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0315","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1128\/IAI.67.5.2399-2405.1999","article-title":"Molecular interactions of Porphyromonas gingivalis fimbriae with host proteins: kinetic analyses based on surface plasmon resonance","volume":"67","author":"Amano","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0320","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1128\/IAI.67.8.3780-3785.1999","article-title":"Secretion of functional salivary peptide by Streptococcus gordonii which inhibits fimbria-mediated adhesion of Porphyromonas gingivalis","volume":"67","author":"Kataoka","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0325","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1128\/IAI.66.5.2072-2077.1998","article-title":"Binding of Porphyromonas gingivalis fimbriae to proline-rich glycoproteins in parotid saliva via a domain shared by major salivary components","volume":"66","author":"Amano","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0330","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1128\/iai.62.8.3372-3380.1994","article-title":"Salivary receptors for recombinant fimbrillin of Porphyromonas gingivalis","volume":"62","author":"Amano","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0335","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1128\/iai.64.10.4249-4254.1996","article-title":"Binding sites of salivary statherin for Porphyromonas gingivalis recombinant fimbrillin","volume":"64","author":"Amano","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0340","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2180-13-5","article-title":"Integrin alpha5beta1-fimbriae binding and actin rearrangement are essential for Porphyromonas gingivalis invasion of osteoblasts and subsequent activation of the JNK pathway","volume":"13","author":"Zhang","year":"2013","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0345","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.2741\/2363","article-title":"Disruption of epithelial barrier and impairment of cellular function by Porphyromonas gingivalis","volume":"12","author":"Amano","year":"2007","journal-title":"Front Biosci"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0350","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.micinf.2004.10.007","article-title":"Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins","volume":"7","author":"Nakagawa","year":"2005","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0355","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1462-5822.2002.00192.x","article-title":"Involvement of integrins in fimbriae-mediated binding and invasion by Porphyromonas gingivalis","volume":"4","author":"Yilmaz","year":"2002","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0360","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.1128\/IAI.73.10.6290-6298.2005","article-title":"Requirement for intercellular adhesion molecule 1 and caveolae in invasion of human oral epithelial cells by Porphyromonas gingivalis","volume":"73","author":"Tamai","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0365","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.femsim.2005.01.006","article-title":"Identification of glyceraldehyde-3-phosphate dehydrogenase of epithelial cells as a second molecule that binds to Porphyromonas gingivalis fimbriae","volume":"45","author":"Sojar","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0370","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1128\/IAI.70.1.96-101.2002","article-title":"Porphyromonas gingivalis fimbriae bind to cytokeratin of epithelial cells","volume":"70","author":"Sojar","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0375","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1574-6968.1999.tb13630.x","article-title":"Specific interactions between Porphyromonas gingivalis fimbriae and human extracellular matrix proteins","volume":"175","author":"Nakamura","year":"1999","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0380","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1128\/iai.64.3.756-762.1996","article-title":"Cysteine protease of Porphyromonas gingivalis 381 enhances binding of fimbriae to cultured human fibroblasts and matrix proteins","volume":"64","author":"Kontani","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0385","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1399-302X.1993.tb00559.x","article-title":"Adherence and hydrophobicity of invasive and noninvasive strains of Porphyromonas gingivalis","volume":"8","author":"Naito","year":"1993","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0390","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1128\/IAI.67.9.4917-4920.1999","article-title":"Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis","volume":"67","author":"Kontani","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0395","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1574-695X.1998.tb01214.x","article-title":"Fibronectin in saliva inhibits Porphyromonas gingivalis fimbria-induced expression of inflammatory cytokine gene in mouse macrophages","volume":"22","author":"Murakami","year":"1998","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0400","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1046\/j.1365-2958.1997.4321788.x","article-title":"Adherence of Porphyromonas gingivalis to matrix proteins via a fimbrial cryptic receptor exposed by its own arginine-specific protease","volume":"24","author":"Kontani","year":"1997","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0405","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1128\/iai.64.7.2571-2576.1996","article-title":"Porphyromonas gingivalis fimbrillin is one of the fibronectin-binding proteins","volume":"64","author":"Murakami","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0410","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1006\/bbrc.1995.2690","article-title":"Fibronectin binding domain of P. gingivalis fimbriae","volume":"216","author":"Sojar","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0415","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1128\/IAI.72.9.5475-5477.2004","article-title":"Characterization of binding of Streptococcus oralis glyceraldehyde-3-phosphate dehydrogenase to Porphyromonas gingivalis major fimbriae","volume":"72","author":"Maeda","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0420","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/IAI.00875-12","article-title":"Identification and characterization of Porphyromonas gingivalis client proteins that bind to Streptococcus oralis glyceraldehyde-3-phosphate dehydrogenase","volume":"81","author":"Maeda","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0425","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.micinf.2004.06.005","article-title":"Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae","volume":"6","author":"Maeda","year":"2004","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0430","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1128\/IAI.72.3.1341-1348.2004","article-title":"Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus oralis functions as a coadhesin for Porphyromonas gingivalis major fimbriae","volume":"72","author":"Maeda","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0435","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1128\/IAI.00439-09","article-title":"Identification of the binding domain of Streptococcus oralis glyceraldehyde-3-phosphate dehydrogenase for Porphyromonas gingivalis major fimbriae","volume":"77","author":"Nagata","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0440","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1399-302X.1992.tb00025.x","article-title":"Inhibition of Actinomyces viscosus\u2013Porphyromonas gingivalis coadhesion by trypsin and other proteins","volume":"7","author":"Ellen","year":"1992","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0445","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1128\/jb.173.17.5266-5274.1991","article-title":"Evidence that Porphyromonas (Bacteroides) gingivalis fimbriae function in adhesion to Actinomyces viscosus","volume":"173","author":"Goulbourne","year":"1991","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0450","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.femsle.2005.07.019","article-title":"Synergistic biofilm formation by Treponema denticola and Porphyromonas gingivalis","volume":"250","author":"Yamada","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0455","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0378-1097(03)00615-3","article-title":"Binding of Porphyromonas gingivalis fimbriae to Treponema denticola dentilisin","volume":"226","author":"Hashimoto","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0460","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1348-0421.1999.tb01218.x","article-title":"Fimbria-mediated coaggregation between human oral anaerobes Treponema medium and Porphyromonas gingivalis","volume":"43","author":"Umemoto","year":"1999","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0465","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1128\/IAI.00784-06","article-title":"Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages","volume":"74","author":"Hajishengallis","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0470","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.4049\/jimmunol.176.12.7645","article-title":"TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae","volume":"176","author":"Harokopakis","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0475","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/eji.200425883","article-title":"Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase","volume":"35","author":"Harokopakis","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0480","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1600-0765.2008.01149.x","article-title":"Porphyromonas gingivalis fimbriae induce unique dendritic cell subsets via Toll-like receptor 2","volume":"44","author":"Kanaya","year":"2009","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0485","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.4049\/jimmunol.0900524","article-title":"Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae","volume":"182","author":"Hajishengallis","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0490","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.4049\/jimmunol.180.4.2187","article-title":"Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs","volume":"180","author":"Davey","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0495","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.4049\/jimmunol.179.11.7777","article-title":"Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components","volume":"179","author":"Zhou","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0500","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.2741\/2409","article-title":"Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?","volume":"12","author":"Hajishengallis","year":"2007","journal-title":"Front Biosci"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0505","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1128\/IAI.01604-06","article-title":"Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae","volume":"75","author":"Eskan","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0510","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/j.1462-5822.2006.00730.x","article-title":"Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus","volume":"8","author":"Hajishengallis","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0515","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00319-19","article-title":"The distinct immune-stimulatory capacities of Porphyromonas gingivalis strains 381 and ATCC 33277 are determined by the fimB allele and gingipain activity","volume":"87","author":"Coats","year":"2019","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0520","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.4049\/jimmunol.179.4.2359","article-title":"Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo","volume":"179","author":"Hajishengallis","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0525","first-page":"203","article-title":"Subversion of innate immunity by periodontopathic bacteria via exploitation of complement receptor-3","volume":"632","author":"Hajishengallis","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0530","doi-asserted-by":"crossref","first-page":"38902","DOI":"10.1074\/jbc.M507326200","article-title":"Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors","volume":"280","author":"Hajishengallis","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0535","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1128\/IAI.66.9.4056-4060.1998","article-title":"Porphyromonas gingivalis fimbriae use beta2 integrin (CD11\/CD18) on mouse peritoneal macrophages as a cellular receptor, and the CD18 beta chain plays a functional role in fimbrial signaling","volume":"66","author":"Takeshita","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0540","doi-asserted-by":"crossref","first-page":"13532","DOI":"10.1073\/pnas.0803852105","article-title":"Pathogen induction of CXCR4\/TLR2 cross-talk impairs host defense function","volume":"105","author":"Hajishengallis","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0545","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/omi.12021","article-title":"Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis","volume":"28","author":"Hajishengallis","year":"2013","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0550","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1128\/IAI.00797-06","article-title":"Porphyromonas gingivalis minor fimbriae are required for cell-cell interactions","volume":"74","author":"Lin","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0555","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1471-2180-9-105","article-title":"Distinct roles of long\/short fimbriae and gingipains in homotypic biofilm development by Porphyromonas gingivalis","volume":"9","author":"Kuboniwa","year":"2009","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0560","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1128\/JB.00275-10","article-title":"The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs","volume":"192","author":"Zeituni","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0565","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.4049\/jimmunol.0901030","article-title":"Targeting of DC-SIGN on human dendritic cells by minor fimbriated Porphyromonas gingivalis strains elicits a distinct effector T cell response","volume":"183","author":"Zeituni","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0570","article-title":"Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk","volume":"10","author":"El-Awady","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0575","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1128\/IAI.00361-10","article-title":"Structural dissection and in vivo effectiveness of a peptide inhibitor of Porphyromonas gingivalis adherence to Streptococcus gordonii","volume":"79","author":"Daep","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0580","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1128\/IAI.00366-08","article-title":"Interaction of Porphyromonas gingivalis with oral streptococci requires a motif that resembles the eukaryotic nuclear receptor box protein-protein interaction domain","volume":"76","author":"Daep","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0585","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1128\/IAI.00813-06","article-title":"Structural characterization of peptide-mediated inhibition of Porphyromonas gingivalis biofilm formation","volume":"74","author":"Daep","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0590","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/omi.12280","article-title":"Identification of functional domains of the minor fimbrial antigen involved in the interaction of Porphyromonas gingivalis with oral streptococci","volume":"35","author":"Roky","year":"2020","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0595","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.3389\/fimmu.2019.02286","article-title":"Disruption of immune homeostasis in human dendritic cells via regulation of autophagy and apoptosis by Porphyromonas gingivalis","volume":"10","author":"Meghil","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0600","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41522-019-0084-7","article-title":"Polymicrobial synergy within oral biofilm promotes invasion of dendritic cells and survival of consortia members","volume":"5","author":"El-Awady","year":"2019","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0605","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-1097(03)00788-2","article-title":"Porphyromonas gingivalis 67-kDa fimbriae induced cytokine production and osteoclast differentiation utilizing TLR2","volume":"229","author":"Hiramine","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0610","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9124004","article-title":"Porphyromonas gingivalis Mfa1 induces chemokine and cell adhesion molecules in mouse gingival fibroblasts via toll-like receptors","volume":"9","author":"Takayanagi","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0615","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1073\/pnas.92.6.2081","article-title":"FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae","volume":"92","author":"Jones","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0620","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/356252a0","article-title":"P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips","volume":"356","author":"Kuehn","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0625","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173541","article-title":"Novel fimbrilin PGN_1808 in Porphyromonas gingivalis","volume":"12","author":"Nagano","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0630","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0757.2009.00311.x","article-title":"Subgingival biofilm formation","volume":"52","author":"Kuboniwa","year":"2010","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0635","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1128\/JCM.37.5.1426-1430.1999","article-title":"Distribution of Porphyromonas gingivalis strains with fimA genotypes in periodontitis patients","volume":"37","author":"Amano","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0640","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1600-0765.2007.00975.x","article-title":"Prevalence of fimA genotypes of Porphyromonas gingivalis and periodontal health status in Chinese adults","volume":"42","author":"Zhao","year":"2007","journal-title":"J Periodontal Res Suppl"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0645","article-title":"The prevalence of fimA genotypes of Porphyromonas gingivalis in patients with chronic periodontitis: a meta-analysis","volume":"15","author":"Wang","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0650","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1034\/j.1600-0722.2003.00065.x","article-title":"Prevalence of Porphyromonas gingivalis fimA genotypes in Caucasians","volume":"111","author":"Beikler","year":"2003","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0655","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/omi.12032","article-title":"Genetic and antigenic analyses of Porphyromonas gingivalis FimA fimbriae","volume":"28","author":"Nagano","year":"2013","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0660","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1600-0765.1999.tb02273.x","article-title":"The rag locus of Porphyromonas gingivalis: a novel pathogenicity island","volume":"34","author":"Curtis","year":"1999","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jdsr.2021.09.003_bib0665","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-1-0716-0939-2_8","article-title":"Purification of native Mfa1 fimbriae from Porphyromonas gingivalis","volume":"2210","author":"Hasegawa","year":"2021","journal-title":"Methods Mol Biol"}],"container-title":["Japanese Dental Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1882761621000259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1882761621000259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:44:59Z","timestamp":1761821099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1882761621000259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":133,"alternative-id":["S1882761621000259"],"URL":"https:\/\/doi.org\/10.1016\/j.jdsr.2021.09.003","relation":{},"ISSN":["1882-7616"],"issn-type":[{"value":"1882-7616","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porphyromonas gingivalis FimA and Mfa1 fimbriae: Current insights on localization, function, biogenesis, and genotype","name":"articletitle","label":"Article Title"},{"value":"Japanese Dental Science Review","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdsr.2021.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}]}}