{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:01:54Z","timestamp":1790262114559,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Japanese Dental Science Review"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jdsr.2022.03.001","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T04:55:40Z","timestamp":1651294540000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Management of bisphosphonate preparation-treated children in the field of pediatric dentistry"],"prefix":"10.1016","volume":"58","author":[{"given":"Chieko","family":"Mitsuhata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Kozai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdsr.2022.03.001_bib1","unstructured":"Jawbone necrosis review committee: Pathophysiology and management of bone resorption inhibitor-related osteonecrosis of the jaw: Jawbone Necrosis Review Committee Position Paper 2016. (Japanese) (\u3008https:\/\/www.jsoms.or.jp\/medical\/wp-content\/uploads\/2015\/08\/position_paper2016.pdf\u3009)."},{"key":"10.1016\/j.jdsr.2022.03.001_bib2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and Zoledronate(Zometa) incuced avascular necrosis of the jaws: growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jdsr.2022.03.001_bib3","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1016\/j.joms.2011.03.051","article-title":"Nationwide survey for bisphosphonate-related osteonecrosis of the jaws in Japan","volume":"11","author":"Urade","year":"2011","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jdsr.2022.03.001_bib4","unstructured":"Fact-finding survey on BRONJ treatment. JSOMS 2015. (Japanese) \u3008https:\/\/www.jsoms.or.jp\/medical\/work\/study\/bronj\/\u3009."},{"key":"10.1016\/j.jdsr.2022.03.001_bib5","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.joms.2018.04.009","article-title":"National survey on bisphosphonate-related osteonecrosis of the jaws in Japan","volume":"76","author":"Shibahara","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jdsr.2022.03.001_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00774-010-0162-7","volume":"28","author":"Yoneda","year":"2010","journal-title":"J Bone Min Metab"},{"key":"10.1016\/j.jdsr.2022.03.001_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bone.2010.11.020","article-title":"Denosumab and bisphosphonates: different mechanisms of action and effects","volume":"48","author":"Baron","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jdsr.2022.03.001_bib8","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/annonc\/mdr435","article-title":"Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases","volume":"23","author":"Saad","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jdsr.2022.03.001_bib9","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw--2014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jdsr.2022.03.001_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/452737","article-title":"Is bisphosphonate-related osteonecrosis of the jaw an infection? a histological and microbiological ten-year summary","volume":"2014","author":"Hinson","year":"2014","journal-title":"Int J Dent"},{"key":"10.1016\/j.jdsr.2022.03.001_bib11","first-page":"307","article-title":"Dental treatment experience for juvenile idiopathic arthritis patients receiving oral bisphosphonates","volume":"47","author":"Funayama","year":"2009","journal-title":"Jpn j Ped Dent"},{"key":"10.1016\/j.jdsr.2022.03.001_bib12","first-page":"348","article-title":"Dental implications of Osteogenesis imperfect: treatment with \u2163 bisphosphonate: report of a case","volume":"33","author":"Milano","year":"2011","journal-title":"Pedia Dent"},{"key":"10.1016\/j.jdsr.2022.03.001_bib13","first-page":"144","article-title":"Analysis of children with osteogenesis imperfecta who had their deciduous teeth extracted during the permanent tooth replacement period","volume":"53","author":"Saga","year":"2015","journal-title":"Jpn j Ped Dent"},{"key":"10.1016\/j.jdsr.2022.03.001_bib14","first-page":"537","article-title":"Bisphosphonates, osteonecrosis, osteogenesis imperfecta and dental extractions: a case series","volume":"74","author":"Schwartz","year":"2008","journal-title":"J Can Dent Assoc"},{"key":"10.1016\/j.jdsr.2022.03.001_bib15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1600-0714.2007.00607.x","article-title":"No osteonecrosis in jaws of young patients with osteogenesis imperfecta treated with bisphosphonates","volume":"37","author":"Malmgren Malmgren","year":"2008","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jdsr.2022.03.001_bib16","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00774-011-0331-3","article-title":"Children and adolescents treated with neridronate for osteogenesis imperfecta show no evidence of any osteonecrosis of the jaw","volume":"30","author":"Maines","year":"2012","journal-title":"J Bone Min Metab"},{"key":"10.1016\/j.jdsr.2022.03.001_bib17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1365-2265.2008.03189.x","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: does it occur in children?","volume":"68","author":"Brown","year":"2008","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jdsr.2022.03.001_bib18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jpeds.2008.05.003","article-title":"Tooth extraction socket healing in pediatric patients treated with intravenous pamidronate","volume":"153","author":"Chahine","year":"2008","journal-title":"J Pedia"},{"key":"10.1016\/j.jdsr.2022.03.001_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/ipd.12047","article-title":"Bisphosphonate-related osteonecrosis of the jaws and its relevance to children--a review","volume":"23","author":"Christou","year":"2013","journal-title":"Int J Paediatr Dent"},{"key":"10.1016\/j.jdsr.2022.03.001_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/adj.12140","article-title":"The use of bisphosphonates in children: review of the literature and guidelines for dental management","volume":"59","author":"Bhatt","year":"2014","journal-title":"Aust Dent J"},{"key":"10.1016\/j.jdsr.2022.03.001_bib21","first-page":"1","volume":"17","author":"Consens","year":"2000","journal-title":"Statement: Osteoporos Diagn Ther"},{"key":"10.1016\/j.jdsr.2022.03.001_bib22","first-page":"113","article-title":"A case of long-term steroid and bisphosphonate patients who underwent dentate cystectomy","volume":"51","author":"Tsuboi","year":"2013","journal-title":"Jpn J Ped Dent"},{"key":"10.1016\/j.jdsr.2022.03.001_bib23","first-page":"161","article-title":"Mechanisms of glucocorticoid-induced osteoporosis and bisphosphonate therapy in the growing mandible","volume":"50","author":"Fujita","year":"2012","journal-title":"Jpn J Ped Dent"},{"key":"10.1016\/j.jdsr.2022.03.001_bib24","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/en.2003-0990","article-title":"Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength","volume":"145","author":"O\u2019Brien","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jdsr.2022.03.001_bib25","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bone.2009.05.008","article-title":"Histologic and histomorphometric features of bisphosphonate-related osteonecrosis of the jaws: an analysis of 31 cases with confocal laser scanning microscopy","volume":"45","author":"Favia","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.jdsr.2022.03.001_bib26","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joms.2008.01.026","article-title":"Inhibition of oral mucosal cell wound healing by bisphosphonates","volume":"66","author":"Landesberg","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jdsr.2022.03.001_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00223-008-9146-1","article-title":"Effects of vitamin K (2) and risedronate on bone formation and resorption, osteocyte lacunar system, and porosity in the cortical bone of glucocorticoid-treated rats","volume":"83","author":"Iwamoto","year":"2008","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jdsr.2022.03.001_bib28","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.joms.2008.01.038","article-title":"Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment","volume":"66","author":"Allen","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jdsr.2022.03.001_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00774-009-0128-9","article-title":"Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice","volume":"28","author":"Kobayashi","year":"2010","journal-title":"J Bone Min Metab"},{"key":"10.1016\/j.jdsr.2022.03.001_bib30","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.bone.2008.01.003","article-title":"Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis","volume":"42","author":"Rizzoli","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.jdsr.2022.03.001_bib31","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1177\/0022034511420430","article-title":"A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw","volume":"90","author":"Mawardi","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.jdsr.2022.03.001_bib32","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jbmr.37","article-title":"Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice","volume":"25","author":"Kikuiri","year":"2010","journal-title":"J Bone Min Res"},{"key":"10.1016\/j.jdsr.2022.03.001_bib33","first-page":"1","article-title":"Role of immune cells in development of bisphosphonate-related osteonecrosis of the jaw","volume":"53","author":"Kikuiri","year":"2015","journal-title":"Jpn J Ped Dent"},{"key":"10.1016\/j.jdsr.2022.03.001_bib34","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/jbmr.2097","article-title":"RANKL inhibitors induce osteonecrosis of the jaw in mice with periapical disease","volume":"29","author":"Aghaloo","year":"2014","journal-title":"J Bone Min Res"},{"key":"10.1016\/j.jdsr.2022.03.001_bib35","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/jbmr.2490","article-title":"OPG-Fc but not zoledronic acid discontinuation reverses osteonecrosis of the jaws (ONJ) in mice","volume":"30","author":"de Molon","year":"2015","journal-title":"J Bone Min Res"},{"key":"10.1016\/j.jdsr.2022.03.001_bib36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijom.2019.08.004","article-title":"Can children be affected by bisphosphonate-related osteonecrosis of the jaw? A systematic review","volume":"49","author":"Duarte","year":"2020","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jdsr.2022.03.001_bib37","unstructured":"Kado N., Mitsuhta C., Kozai K..The oral microbiome analysis of children with Down syndrome. Jpn j Ped Dent 2020: 58(abstracs of 58th annual conference of JAPD):103."},{"key":"10.1016\/j.jdsr.2022.03.001_bib38","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory disease","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun Rev"}],"container-title":["Japanese Dental Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1882761622000060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1882761622000060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:43:43Z","timestamp":1761821023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1882761622000060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":38,"alternative-id":["S1882761622000060"],"URL":"https:\/\/doi.org\/10.1016\/j.jdsr.2022.03.001","relation":{},"ISSN":["1882-7616"],"issn-type":[{"value":"1882-7616","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of bisphosphonate preparation-treated children in the field of pediatric dentistry","name":"articletitle","label":"Article Title"},{"value":"Japanese Dental Science Review","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdsr.2022.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/","name":"copyright","label":"Copyright"}]}}