{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:52:17Z","timestamp":1791057137280,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Japanese Dental Science Review"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jdsr.2026.09.002","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:36:15Z","timestamp":1791041775000},"page":"308-318","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Root canal microbiota in diabetic versus non-diabetic patients with apical periodontitis: A systematic review"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-2480","authenticated-orcid":false,"given":"Sevin\u00e7","family":"Aktemur T\u00fcrker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Uzuno\u011flu-\u00d6zy\u00fcrek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdsr.2026.09.002_bib1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1177\/0022034509346549","article-title":"Diversity of endodontic microbiota revisited","volume":"88","author":"Siqueira","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.jdsr.2026.09.002_bib2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.joen.2016.07.007","article-title":"Association between systemic diseases and apical periodontitis","volume":"42","author":"Khalighinejad","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.jdsr.2026.09.002_bib3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.joen.2016.11.008","article-title":"Association between systemic diseases and endodontic outcome: a systematic review","volume":"43","author":"Aminoshariae","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.jdsr.2026.09.002_bib4","first-page":"931","article-title":"Association between endodontic infection, its treatment and systemic health: a narrative review","volume":"58","author":"Niazi","year":"2022","journal-title":"Med (Kaunas)"},{"key":"10.1016\/j.jdsr.2026.09.002_bib5","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.joen.2023.07.016","article-title":"Diabetes mellitus increases the risk of apical periodontitis in endodontically treated teeth: a meta-analysis from 15 studies","volume":"49","author":"Liu","year":"2023","journal-title":"J Endod"},{"key":"10.1016\/j.jdsr.2026.09.002_bib6","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/iej.13366","article-title":"Diabetes mellitus and the healing of periapical lesions in root filled teeth: a systematic review and meta-analysis","volume":"53","author":"Gupta","year":"2020","journal-title":"Int Endod J"},{"key":"10.1016\/j.jdsr.2026.09.002_bib7","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00784-016-1805-4","article-title":"Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis","volume":"20","author":"Segura-Egea","year":"2016","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.jdsr.2026.09.002_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/j.0022-0337.2003.67.4.tb03647.x","article-title":"Diabetes mellitus as a modulating factor of endodontic infections","volume":"67","author":"Fouad","year":"2003","journal-title":"J Dent Educ"},{"key":"10.1016\/j.jdsr.2026.09.002_bib9","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1128\/JCM.40.9.3223-3231.2002","article-title":"PCR-based identification of bacteria associated with endodontic infections","volume":"40","author":"Fouad","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jdsr.2026.09.002_bib10","first-page":"241","article-title":"PCR-based identification of Eubacteirum species in endodontic infection","volume":"28","author":"Kum","year":"2003","journal-title":"Restor Dent Endod"},{"key":"10.1016\/j.jdsr.2026.09.002_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1034\/j.1399-302X.2003.00077.x","article-title":"Molecular characterization of the presence of Eubacterium spp and Streptococcus spp in endodontic infections","volume":"18","author":"Fouad","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2026.09.002_bib12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tripleo.2004.06.064","article-title":"Molecular detection of Enterococcus species in root canals of therapy-resistant endodontic infections","volume":"99","author":"Fouad","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jdsr.2026.09.002_bib13","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/01.don.0000164133.04548.26","article-title":"Enterococcus spp. in endodontically treated teeth with and without periradicular lesions","volume":"31","author":"Kaufman","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.jdsr.2026.09.002_bib14","first-page":"4001","article-title":"Impact of Peptostreptococcus on type 2 diabetes mellitus related secondary root canal infections","volume":"4","author":"Nayak","year":"2013","journal-title":"Int J Pharm Sci Res"},{"key":"10.1016\/j.jdsr.2026.09.002_bib15","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1590\/1678-7757-2016-0432","article-title":"Investigations of the prevalence and virulence of Candida albicans in periodontal and endodontic lesions in diabetic and normoglycemic patients","volume":"25","author":"Gomes","year":"2017","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.jdsr.2026.09.002_bib16","first-page":"13","article-title":"A comparative study of isolation of obligate anaerobes and facultative anaerobes in microbial flora of non-vital teeth in diabetic (Type II) and non-diabetic patients","volume":"10","author":"Shetty","year":"2018","journal-title":"Int J Cur Res Rev"},{"issue":"5","key":"10.1016\/j.jdsr.2026.09.002_bib17","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4103\/JCD.JCD_326_19","article-title":"PCR-based detection of three anaerobic bacteria associated with endodontic-periodontic lesions in type-2 diabetic and nondiabetic subjects","volume":"22","author":"Nair","year":"2019","journal-title":"J Conserv Dent"},{"key":"10.1016\/j.jdsr.2026.09.002_bib18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10096-019-03702-z","article-title":"Prevalence of Candida albicans in primary endodontic infections associated with a higher frequency of apical periodontitis in type two diabetes mellitus patients","volume":"39","author":"De la Torre-Luna","year":"2020","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jdsr.2026.09.002_bib19","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/aej.12797","article-title":"Presence of methanogenic archaea in necrotic root canals of patients with or without type 2 diabetes mellitus","volume":"49","author":"Soza-Bola\u00f1os","year":"2023","journal-title":"Aust Endod J"},{"key":"10.1016\/j.jdsr.2026.09.002_bib20","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/iej.13927","article-title":"Bacterial quantity and interleukin-17 expression in necrotic teeth with apical periodontitis from type II diabetic patients","volume":"56","author":"Aldoss","year":"2023","journal-title":"Int Endod J"},{"key":"10.1016\/j.jdsr.2026.09.002_bib21","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.joen.2025.05.003","article-title":"Impact of type 2 diabetes mellitus on apical periodontitis size, endotoxin levels, and bacterial load in root canals with necrotic pulp","volume":"51","author":"Barros","year":"2025","journal-title":"J Endod"},{"key":"10.1016\/j.jdsr.2026.09.002_bib22","article-title":"Analysis of the diversity and function of the microbiota in infected root canals of type 2 diabetes mellitus with apical periodontitis","volume":"15","author":"Li","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jdsr.2026.09.002_bib23","doi-asserted-by":"crossref","first-page":"6643","DOI":"10.3390\/jcm14186643","article-title":"Comparative analysis of root canal microbiota in patients with diabetes and systemically healthy individuals: a pilot next-generation sequencing study","volume":"14","author":"Day\u0131can","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.jdsr.2026.09.002_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00784-026-06763-5","article-title":"A clinical next-generation sequencing study on the microbial profiles of asymptomatic apical periodontitis in type 2 diabetic and systemically healthy individuals following adjuvant antimicrobial photodynamic therapy","volume":"30","author":"U\u011fur Aydin","year":"2026","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.jdsr.2026.09.002_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.15644\/asc51\/3\/5","article-title":"Frequency of bacterial content finding in persistant periapical lesions","volume":"51","author":"Grgurevi\u0107","year":"2017","journal-title":"Acta Stomatol Croat"},{"key":"10.1016\/j.jdsr.2026.09.002_bib26","first-page":"49","article-title":"Antibacterial effect of longan extract and diode laser combination on Peptostreptococcus species in type 2 diabetic patients with apical periodontitis - a pilot study","volume":"11","author":"Nayak","year":"2021","journal-title":"Int J Pharma Bio Sci"},{"key":"10.1016\/j.jdsr.2026.09.002_bib27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5530\/jyp.2017.9.42","article-title":"Effect of Garcinia imberti Bourd against Candida isolates in root canal infection","volume":"9","author":"Ramkumar","year":"2017","journal-title":"J Young-- Pharm"},{"key":"10.1016\/j.jdsr.2026.09.002_bib28","article-title":"Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients","volume":"30","author":"V\u00e1zquez-Ramos","year":"2023","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.jdsr.2026.09.002_bib29","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3889\/oamjms.2016.124","article-title":"The use of different irrigation techniques to decrease bacterial loads in healthy and diabetic patients with asymptomatic apical periodontitis","volume":"4","author":"Ghoneim","year":"2016","journal-title":"Open Access Maced J Med Sci"},{"key":"10.1016\/j.jdsr.2026.09.002_bib30","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.jdsr.2026.09.002_bib31","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.2337\/dc24-S002","article-title":"2. Diagnosis and classification of diabetes: standards of care in diabetes-2024","volume":"47","author":"American Diabetes Association Professional Practice Committee","year":"2024","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdsr.2026.09.002_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-9657.1986.tb00119.x","article-title":"The periapical index: a scoring system for radiographic assessment of apical periodontitis","volume":"2","author":"Orstavik","year":"1986","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.jdsr.2026.09.002_bib33","doi-asserted-by":"crossref","unstructured":"Moola S., Munn Z., Tufanaru C., et al. Chapter 7: Systematic reviews of etiology and risk. In: Aromataris E, Munn Z, eds. JBI Manual for Evidence Synthesis. JBI; 2020.","DOI":"10.46658\/JBIRM-17-06"},{"key":"10.1016\/j.jdsr.2026.09.002_bib34","unstructured":"Joanna Briggs Institute. Checklist for Analytical Cross-Sectional Studies. Adelaide: JBI; 2020."},{"key":"10.1016\/j.jdsr.2026.09.002_bib35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/iej.13253","article-title":"Association between diabetes and the outcome of root canal treatment in adults: an umbrella review","volume":"53","author":"Nagendrababu","year":"2020","journal-title":"Int Endod J"},{"key":"10.1016\/j.jdsr.2026.09.002_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00784-025-06151-5","article-title":"Effect of diabetes and hyperglycaemia on the physical and mechanical properties of dentine: a systematic review","volume":"29","author":"Hwang","year":"2025","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.jdsr.2026.09.002_bib37","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1399-302X.2007.00378.x","article-title":"Bacterial examination of endodontic infections by clonal analysis in concert with denaturing high-performance liquid chromatography","volume":"22","author":"Jacinto","year":"2007","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jdsr.2026.09.002_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5152\/eurasianjmed.2023.21164","article-title":"A positive or negative connection of diabetes mellitus to the oral microbiota","volume":"55","author":"Al-Janabi","year":"2023","journal-title":"Eurasia J Med"},{"key":"10.1016\/j.jdsr.2026.09.002_bib39","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.joen.2015.03.010","article-title":"Comparison of bacterial community composition of primary and persistent endodontic infections using pyrosequencing","volume":"41","author":"Tzanetakis","year":"2015","journal-title":"J Endod"}],"container-title":["Japanese Dental Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1882761626000232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1882761626000232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:57:47Z","timestamp":1791053867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1882761626000232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":39,"alternative-id":["S1882761626000232"],"URL":"https:\/\/doi.org\/10.1016\/j.jdsr.2026.09.002","relation":{},"ISSN":["1882-7616"],"issn-type":[{"value":"1882-7616","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Root canal microbiota in diabetic versus non-diabetic patients with apical periodontitis: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Japanese Dental Science Review","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdsr.2026.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Japanese Association for Dental Science. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}