{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:54:56Z","timestamp":1778774096314,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Evidence Based Dental Practice"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jebdp.2021.101547","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T19:58:14Z","timestamp":1616788694000},"page":"101547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["CLINICAL EFFICACY OF PROBIOTICS AS AN ADJUNCTIVE THERAPY TO SCALING AND ROOT PLANNING IN THE MANAGEMENT OF PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRAILS"],"prefix":"10.1016","volume":"21","author":[{"given":"Daoyong","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jebdp.2021.101547_bib0001","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0757.2012.00449.x","article-title":"Periodontal disease epidemiology - learned and unlearned?","volume":"62","author":"Baelum","year":"2013","journal-title":"Periodontol 2000"},{"issue":"7","key":"10.1016\/j.jebdp.2021.101547_bib0002","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/jcpe.12259","article-title":"Surgical periodontal therapy with and without initial scaling and root planing in the management of chronic periodontitis: a randomized clinical trial","volume":"41","author":"Aljateeli","year":"2014","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101547_bib0003","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/prd.12147","article-title":"Microbial colonization of the periodontal pocket and its significance for periodontal therapy","volume":"76","author":"Mombelli","year":"2018","journal-title":"Periodontol 2000"},{"issue":"8","key":"10.1016\/j.jebdp.2021.101547_bib0004","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1902\/jop.2005.76.8.1227","article-title":"Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review","volume":"76","author":"Bonito","year":"2005","journal-title":"J Periodontol"},{"issue":"6","key":"10.1016\/j.jebdp.2021.101547_bib0005","doi-asserted-by":"crossref","first-page":"837","DOI":"10.11607\/prd.4252","article-title":"Effectiveness of adjunctive use of low-level laser therapy and photodynamic therapy after scaling and root planing in patients with chronic periodontitis","volume":"39","author":"Gandhi","year":"2019","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.jebdp.2021.101547_bib0006","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jdent.2016.03.002","article-title":"Probiotics for managing caries and periodontitis: systematic review and meta-analysis","volume":"48","author":"Gruner","year":"2016","journal-title":"J Dent"},{"issue":"2","key":"10.1016\/j.jebdp.2021.101547_bib0007","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.copbio.2005.02.003","article-title":"Probiotic and other functional microbes: from markets to mechanisms","volume":"16","author":"Saxelin","year":"2005","journal-title":"Curr Opin Biotechnol"},{"issue":"7","key":"10.1016\/j.jebdp.2021.101547_bib0008","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/14787210.2016.1194198","article-title":"The role of probiotic bacteria in managing periodontal disease: a systematic review","volume":"14","author":"Matsubara","year":"2016","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"6","key":"10.1016\/j.jebdp.2021.101547_bib0009","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1902\/jop.2015.140612","article-title":"Clinical and biochemical evaluation of lozenges containing lactobacillus reuteri as an adjunct to non-surgical periodontal therapy in chronic periodontitis","volume":"86","author":"Ince","year":"2015","journal-title":"J Periodontol"},{"issue":"10","key":"10.1016\/j.jebdp.2021.101547_bib0010","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/jcpe.12995","article-title":"Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial","volume":"45","author":"Invernici","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"4","key":"10.1016\/j.jebdp.2021.101547_bib0011","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/jcpe.12387","article-title":"Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1-year follow-up study","volume":"42","author":"Tekce","year":"2015","journal-title":"J Clin Periodontol"},{"issue":"11","key":"10.1016\/j.jebdp.2021.101547_bib0012","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/jcpe.12155","article-title":"Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study","volume":"40","author":"Teughels","year":"2013","journal-title":"J Clin Periodontol"},{"issue":"6","key":"10.1016\/j.jebdp.2021.101547_bib0013","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/jcpe.12545","article-title":"Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: a systematic review and meta-analysis","volume":"43","author":"Martin-Cabezas","year":"2016","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jebdp.2021.101547_bib0014","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.jebdp.2021.101547_bib0015","first-page":"4495","article-title":"Role of probiotics containing Lactobacillus reuteri in adjunct to scaling and root planing for management of patients with chronic periodontitis: a meta-analysis","volume":"24","author":"Song","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.jebdp.2021.101547_bib0016","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-0040-1709924","article-title":"Effectiveness of Probiotic Lozenges in Periodontal Management of Chronic Periodontitis Patients: clinical and Immunological Study","volume":"14","author":"Alshareef","year":"2020","journal-title":"Eur J Dent"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101547_bib0017","first-page":"67","article-title":"Effect of a locally delivered probiotic-prebiotic mixture as an adjunct to scaling and root planing in the management of chronic periodontitis","volume":"18","author":"Chandra","year":"2016","journal-title":"J Int Acad Periodontol"},{"issue":"4","key":"10.1016\/j.jebdp.2021.101547_bib0018","first-page":"191","article-title":"Clinical effects of lactobacillus reuteri probiotic in treatment of chronic periodontitis. A randomized, controlled trial","volume":"11","author":"Costacurta","year":"2018","journal-title":"Oral Implantol"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101547_bib0019","first-page":"101","article-title":"Clinical and microbiological investigation of the effects of probiotics combined with scaling and root planing in the management of chronic periodontitis: a randomized, controlled study","volume":"19","author":"Dhaliwal","year":"2017","journal-title":"J Int Acad Periodontol"},{"key":"10.1016\/j.jebdp.2021.101547_bib0020","first-page":"31","article-title":"Clinical effcacy of probiotics as an adjunct to scaling and root planing in the treatment of chronic periodontitis","volume":"24","author":"Ikram","year":"2019","journal-title":"Annals ASH KMDC"},{"issue":"9","key":"10.1016\/j.jebdp.2021.101547_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238425","article-title":"Bifidobacterium animalis subsp lactis HN019 presents antimicrobial potential against periodontopathogens and modulates the immunological response of oral mucosa in periodontitis patients","volume":"15","author":"Invernici","year":"2020","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101547_bib0022","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/jcpe.13198","article-title":"A dual-strain Lactobacilli reuteri probiotic improves the treatment of residual pockets: a randomized controlled clinical trial","volume":"47","author":"Laleman","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"11","key":"10.1016\/j.jebdp.2021.101547_bib0023","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/jcpe.12464","article-title":"The effect of a streptococci containing probiotic in periodontal therapy: a randomized controlled trial","volume":"42","author":"Laleman","year":"2015","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101547_bib0024","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5005\/jp-journals-10029-1145","article-title":"Efficacy of oral probiotics as an adjunct to scaling and root planing in nonsurgical treatment outcome of generalized chronic periodontitis patients: a clinico-microbiological study","volume":"6","author":"Mani","year":"2017","journal-title":"Int J Exp Dent Sci"},{"issue":"8","key":"10.1016\/j.jebdp.2021.101547_bib0025","first-page":"1381","article-title":"Adjunctive effect of probiotic (Lactobacillus casei Shirota) to scaling and root planing in the management of chronic periodontitis","volume":"10","author":"Meenakshi","year":"2018","journal-title":"Drug Invention Today"},{"issue":"8","key":"10.1016\/j.jebdp.2021.101547_bib0026","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1902\/jop.2016.150665","article-title":"clinical effects of lactobacillus rhamnosus in non-surgical treatment of chronic periodontitis: a randomized placebo-controlled trial with 1-year follow-up","volume":"87","author":"Morales","year":"2016","journal-title":"J Periodontol"},{"key":"10.1016\/j.jebdp.2021.101547_bib0027","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2017-0075","article-title":"Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up","volume":"26","author":"Morales","year":"2018","journal-title":"J Appl Oral Sci"},{"issue":"12","key":"10.1016\/j.jebdp.2021.101547_bib0028","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/jcpe.13191","article-title":"A double-blind, paralleled-arm, placebo-controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care","volume":"46","author":"Pelekos","year":"2019","journal-title":"J Clin Periodontol"},{"issue":"2","key":"10.1016\/j.jebdp.2021.101547_bib0029","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/2279-042X.179568","article-title":"Efficacy of local use of probiotics as an adjunct to scaling and root planing in chronic periodontitis and halitosis: a randomized controlled trial","volume":"5","author":"Penala","year":"2016","journal-title":"J Res Pharm Pract"},{"key":"10.1016\/j.jebdp.2021.101547_bib0030","article-title":"Probiotic strains of Lactobacillus brevis and Lactobacillus plantarum as adjunct to non-surgical periodontal therapy: 3-month results of a randomized controlled clinical trial","author":"Pudgar","year":"2020","journal-title":"Clin Oral Investig"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101547_bib0031","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12602-017-9296-4","article-title":"Lactobacillus salivarius NK02: a potent probiotic for clinical application in mouthwash","volume":"10","author":"Sajedinejad","year":"2018","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101547_bib0032","first-page":"9","article-title":"Clinical effect of Lactobacillus on the treatment of severe periodontitis and halitosis: a double-blinded, placebo-controlled, randomized clinical trial","volume":"32","author":"Soares","year":"2019","journal-title":"Am J Dent"},{"issue":"4","key":"10.1016\/j.jebdp.2021.101547_bib0033","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3920\/BM2018.0150","article-title":"Effects of Lactobacillus reuteri as an adjunct to the treatment of periodontitis in smokers: randomised clinical trial","volume":"10","author":"Theodoro","year":"2019","journal-title":"Benef Microbes"},{"issue":"3\u20134","key":"10.1016\/j.jebdp.2021.101547_bib0034","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3109\/00016357.2012.734404","article-title":"Clinical changes in periodontal subjects with the probiotic Lactobacillus reuteri Prodentis: a preliminary randomized clinical trial","volume":"71","author":"Vicario","year":"2013","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.jebdp.2021.101547_bib0035","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v2i0.5344","article-title":"Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial","volume":"2","author":"Vivekananda","year":"2010","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.jebdp.2021.101547_bib0036","doi-asserted-by":"crossref","DOI":"10.1002\/JPER.19-0464","article-title":"Effectiveness of scaling and root planing with and without adjunct probiotic therapy in the treatment of chronic periodontitis among shamma users and non-users: a randomized controlled trial","author":"Vohra","year":"2020","journal-title":"J Periodontol"},{"issue":"Suppl 20","key":"10.1016\/j.jebdp.2021.101547_bib0037","first-page":"S17","article-title":"Dental plaque-induced gingival conditions","volume":"45","author":"Murakami","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101547_bib0038","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-0722.2005.00191.x","article-title":"Probiotics: do they have a role in oral medicine and dentistry?","volume":"113","author":"Meurman","year":"2005","journal-title":"Eur J Oral Sci"},{"issue":"2","key":"10.1016\/j.jebdp.2021.101547_bib0039","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/jre.12608","article-title":"Probiotics alter the immune response of gingival epithelial cells challenged by Porphyromonas gingivalis","volume":"54","author":"Albuquerque-Souza","year":"2019","journal-title":"J Periodontal Res"},{"issue":"6","key":"10.1016\/j.jebdp.2021.101547_bib0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00005-014-0277-y","article-title":"Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis","volume":"62","author":"Szkaradkiewicz","year":"2014","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"12","key":"10.1016\/j.jebdp.2021.101547_bib0041","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/iej.13192","article-title":"Systemic administration of probiotics reduces the severity of apical periodontitis","volume":"52","author":"Cosme-Silva","year":"2019","journal-title":"Int Endod J"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101547_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12602-014-9178-y","article-title":"Antimicrobial Effect of Lactobacillus reuteri on Cariogenic Bacteria Streptococcus gordonii, Streptococcus mutans, and Periodontal Diseases Actinomyces naeslundii and Tannerella forsythia","volume":"7","author":"Baca-Castanon","year":"2015","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"5","key":"10.1016\/j.jebdp.2021.101547_bib0043","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1399-302X.2006.00299.x","article-title":"Oral adhesion and survival of probiotic and other lactobacilli and bifidobacteria in vitro","volume":"21","author":"Haukioja","year":"2006","journal-title":"Oral Microbiol Immunol"},{"issue":"8","key":"10.1016\/j.jebdp.2021.101547_bib0044","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1600-051X.2012.01914.x","article-title":"Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial","volume":"39","author":"Iniesta","year":"2012","journal-title":"J Clin Periodontol"},{"issue":"10","key":"10.1016\/j.jebdp.2021.101547_bib0045","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1600-051X.2008.01306.x","article-title":"Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study","volume":"35","author":"Shimauchi","year":"2008","journal-title":"J Clin Periodontol"}],"container-title":["Journal of Evidence Based Dental Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532338221000221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532338221000221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:53:28Z","timestamp":1761519208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532338221000221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S1532338221000221"],"URL":"https:\/\/doi.org\/10.1016\/j.jebdp.2021.101547","relation":{},"ISSN":["1532-3382"],"issn-type":[{"value":"1532-3382","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CLINICAL EFFICACY OF PROBIOTICS AS AN ADJUNCTIVE THERAPY TO SCALING AND ROOT PLANNING IN THE MANAGEMENT OF PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRAILS","name":"articletitle","label":"Article Title"},{"value":"Journal of Evidence Based Dental Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jebdp.2021.101547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101547"}}