{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:58:07Z","timestamp":1761519487028,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Evidence Based Dental Practice"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jebdp.2021.101635","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T11:33:29Z","timestamp":1630323209000},"page":"101635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Connective Tissue Graft with or without Enamel Matrix Derivative for Treating Gingival Recession Defects: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"21","author":[{"given":"Prerana","family":"Dubey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manasa","family":"Narasimhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navneet Kaur","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Yanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Wan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne L.","family":"Kapila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-9994","authenticated-orcid":false,"given":"Guo-Hao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jebdp.2021.101635_bib0001","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/jre.12199","article-title":"Root coverage by coronally advanced flap with connective tissue graft and\/or enamel matrix derivative: a meta-analysis","volume":"50","author":"Cheng","year":"2015","journal-title":"J Periodontal Res"},{"issue":"12","key":"10.1016\/j.jebdp.2021.101635_bib0002","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1902\/jop.1985.56.12.715","article-title":"Subepithelial connective tissue graft technique for root coverage","volume":"56","author":"Langer","year":"1985","journal-title":"J Periodontol"},{"issue":"10","key":"10.1016\/j.jebdp.2021.101635_bib0003","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1902\/jop.1994.65.10.929","article-title":"Subepithelial connective tissue grafts in the treatment of gingival recessions. A comparative study of 2 procedures","volume":"65","author":"Bouchard","year":"1994","journal-title":"J Periodontol"},{"issue":"suppl 2","key":"10.1016\/j.jebdp.2021.101635_bib0004","first-page":"S8","article-title":"Periodontal soft tissue root coverage procedures: a systematic review from the AAP Regeneration Workshop","volume":"86","author":"Chambrone","year":"2015","journal-title":"J Periodontol"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101635_bib0005","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/JPER.19-0310","article-title":"The significance of surgically modifying soft tissue phenotype around fixed dental prostheses: an American Academy of Periodontology best evidence review","volume":"91","author":"Lin","year":"2020","journal-title":"J Periodontol"},{"key":"10.1016\/j.jebdp.2021.101635_bib0006","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1034\/j.1600-0757.2000.2220107.x","article-title":"The treatment of intrabony defects with bone grafts","volume":"22","author":"Rosen","year":"2000","journal-title":"Periodontol 2000"},{"issue":"4","key":"10.1016\/j.jebdp.2021.101635_bib0007","first-page":"152","article-title":"Free autogenous gingival grafts. 3. Utilization of grafts in the treatment of gingival recession","volume":"6","author":"Sullivan","year":"1968","journal-title":"Periodontics"},{"issue":"9","key":"10.1016\/j.jebdp.2021.101635_bib0008","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1902\/jop.1997.68.9.890","article-title":"Creeping attachment associated with the connective tissue with partial-thickness double pedicle graft","volume":"68","author":"Harris","year":"1997","journal-title":"J Periodontol"},{"issue":"12","key":"10.1016\/j.jebdp.2021.101635_bib0009","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1902\/jop.1980.51.12.681","article-title":"Creeping attachment of free gingival grafts. A five-year follow-up study","volume":"51","author":"Matter","year":"1980","journal-title":"J Periodontol"},{"issue":"6","key":"10.1016\/j.jebdp.2021.101635_bib0010","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1902\/jop.2011.110266","article-title":"Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: a systematic review","volume":"83","author":"Koop","year":"2012","journal-title":"J Periodontol"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101635_bib0011","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1601-6343.2009.01459.x","article-title":"Enamel matrix proteins; old molecules for new applications","volume":"12","author":"Lyngstadaas","year":"2009","journal-title":"Orthod Craniofac Res"},{"issue":"9 Pt 2","key":"10.1016\/j.jebdp.2021.101635_bib0012","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1600-051X.1997.tb00247.x","article-title":"Enamel matrix, cementum development and regeneration","volume":"24","author":"Hammarstrom","year":"1997","journal-title":"J Clin Periodontol"},{"issue":"suppl 8","key":"10.1016\/j.jebdp.2021.101635_bib0013","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-051X.2008.01264.x","article-title":"Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels","volume":"35","author":"Bosshardt","year":"2008","journal-title":"J Clin Periodontol"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101635_bib0014","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/ten.teb.2011.0365","article-title":"Enamel matrix derivative: a review of cellular effects in vitro and a model of molecular arrangement and functioning","volume":"18","author":"Grandin","year":"2012","journal-title":"Tissue Eng Part B Rev"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101635_bib0015","first-page":"269","article-title":"Clinical and histologic evaluation of human gingival recession treated with a subepithelial connective tissue graft and enamel matrix derivative (Emdogain): a case report","volume":"20","author":"Rasperini","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"41 Suppl","key":"10.1016\/j.jebdp.2021.101635_bib0016","first-page":"S36","article-title":"Clinical efficacy of periodontal plastic surgery procedures: consensus report of Group 2 of the 10th European Workshop on Periodontology","volume":"15","author":"Tonetti","year":"2014","journal-title":"J Clin Periodontol"},{"issue":"7","key":"10.1016\/j.jebdp.2021.101635_bib0017","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.jebdp.2021.101635_bib0018","unstructured":"Higgins JPT, Thomas J, Chandler J, et al. (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Accessed 17 December 2020."},{"issue":"7","key":"10.1016\/j.jebdp.2021.101635_bib0019","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/jcpe.12923","article-title":"Treatment of class III multiple gingival recessions: prognostic factors for achieving a complete root coverage","volume":"45","author":"Aroca","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101635_bib0020","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/jcpe.13229","article-title":"Coronally advanced flap and composite restoration of the enamel with or without connective tissue graft for the treatment of single maxillary gingival recession with non-carious cervical lesion. A randomized controlled clinical trial","volume":"47","author":"Cairo","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101635_bib0021","first-page":"38","article-title":"Connective tissue graft vs. emdogain: a new approach to compare the outcomes","volume":"10","author":"Sayar","year":"2013","journal-title":"Dent Res J (Isfahan)"},{"issue":"10","key":"10.1016\/j.jebdp.2021.101635_bib0022","first-page":"829","article-title":"The modified coronally advanced tunnel combined with an enamel matrix derivative and subepithelial connective tissue graft for the treatment of isolated mandibular Miller Class I and II gingival recessions: a report of 16 cases","volume":"45","author":"Sculean","year":"2014","journal-title":"Quintessence Int"},{"issue":"8","key":"10.1016\/j.jebdp.2021.101635_bib0023","first-page":"653","article-title":"Treatment of multiple adjacent maxillary Miller Class I, II, and III gingival recessions with the modified coronally advanced tunnel, enamel matrix derivative, and subepithelial connective tissue graft: a report of 12 cases","volume":"47","author":"Sculean","year":"2016","journal-title":"Quintessence Int"},{"issue":"9","key":"10.1016\/j.jebdp.2021.101635_bib0024","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/jcpe.13328","article-title":"Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivate for root coverage: 2-year results of an RCT using 3D digital measuring for volumetric comparison of gingival dimensions","volume":"47","author":"Zuhr","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"5","key":"10.1016\/j.jebdp.2021.101635_bib0025","first-page":"497","article-title":"Harvesting technique using a mucotome and modified surgical procedure for root coverage with enamel matrix derivatives with and without a connective tissue graft","volume":"28","author":"Gunay","year":"2008","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101635_bib0026","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-051X.2009.01492.x","article-title":"Treatment of class III multiple gingival recessions: a randomized-clinical trial","volume":"37","author":"Aroca","year":"2010","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jebdp.2021.101635_bib0027","doi-asserted-by":"crossref","first-page":"e006","DOI":"10.1590\/1807-3107bor-2019.vol33.0006","article-title":"The effect of enamel matrix derivatives on root coverage: a 12-month follow-up of a randomized clinical trial","volume":"33","author":"Aydinyurt","year":"2019","journal-title":"Braz Oral Res"},{"issue":"12","key":"10.1016\/j.jebdp.2021.101635_bib0028","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1007\/s00784-020-03312-6","article-title":"Tunnel technique with enamel matrix derivative in addition to subepithelial connective tissue graft compared with connective tissue graft alone for the treatment of multiple gingival recessions: a randomized clinical trial","volume":"24","author":"Gorski","year":"2020","journal-title":"Clin Oral Investig"},{"issue":"3","key":"10.1016\/j.jebdp.2021.101635_bib0029","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2334\/josnusd.52.463","article-title":"Application of subepithelial connective tissue graft with or without enamel matrix derivative for root coverage: a split-mouth randomized study","volume":"52","author":"Henriques","year":"2010","journal-title":"J Oral Sci"},{"issue":"4","key":"10.1016\/j.jebdp.2021.101635_bib0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/JPER.19-0058","article-title":"Subepithelial connective tissue graft with or without enamel matrix derivative for the treatment of multiple Class III-IV recessions in lower anterior teeth: a 3-year randomized clinical trial","volume":"91","author":"Mercado","year":"2020","journal-title":"J Periodontol"},{"issue":"2","key":"10.1016\/j.jebdp.2021.101635_bib0031","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/jre.12715","article-title":"3-year prospective clinical and patient-centered trial on subepithelial connective tissue graft with or without enamel matrix derivative in Class I-II Miller recessions","volume":"55","author":"Mercado","year":"2020","journal-title":"J Periodontal Res"},{"issue":"2","key":"10.1016\/j.jebdp.2021.101635_bib0032","first-page":"133","article-title":"Subepithelial connective tissue graft for treatment of gingival recessions with and without enamel matrix derivative: a multicenter, randomized controlled clinical trial","volume":"31","author":"Rasperini","year":"2011","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"5","key":"10.1016\/j.jebdp.2021.101635_bib0033","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/jre.12039","article-title":"Subepithelial connective tissue graft with or without enamel matrix derivative for the treatment of Miller class I and II gingival recessions: a controlled randomized clinical trial","volume":"48","author":"Roman","year":"2013","journal-title":"J Periodontal Res"},{"issue":"2","key":"10.1016\/j.jebdp.2021.101635_bib0034","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00784-019-03008-6","article-title":"Effect of enamel matrix derivative on wound healing following gingival recession coverage using the modified coronally advanced tunnel and subepithelial connective tissue graft: a randomised, controlled, clinical study","volume":"24","author":"Stahli","year":"2020","journal-title":"Clin Oral Investig"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101635_bib0035","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"issue":"5","key":"10.1016\/j.jebdp.2021.101635_bib0036","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/jre.12245","article-title":"Enamel matrix derivative, inflammation and soft tissue wound healing","volume":"50","author":"Miron","year":"2015","journal-title":"J Periodontal Res"},{"issue":"5","key":"10.1016\/j.jebdp.2021.101635_bib0037","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1902\/jop.2006.050244","article-title":"Effects of enamel matrix derivative on bone-related mRNA expression in human periodontal ligament cells in vitro","volume":"77","author":"Takayanagi","year":"2006","journal-title":"J Periodontol"},{"issue":"12","key":"10.1016\/j.jebdp.2021.101635_bib0038","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1902\/jop.2011.100678","article-title":"Interactions of enamel matrix derivative and biomechanical loading in periodontal regenerative healing","volume":"82","author":"Nokhbehsaim","year":"2011","journal-title":"J Periodontol"},{"issue":"5","key":"10.1016\/j.jebdp.2021.101635_bib0039","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0002-8177(89)95015-0","article-title":"The incidence of mucogingival defects: report of case","volume":"119","author":"Gliksberg","year":"1989","journal-title":"J Am Dent Assoc"},{"issue":"2","key":"10.1016\/j.jebdp.2021.101635_bib0040","first-page":"8","article-title":"A classification of marginal tissue recession","volume":"5","author":"Miller","year":"1985","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"1","key":"10.1016\/j.jebdp.2021.101635_bib0041","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/10454411960070010601","article-title":"A critical evaluation of methods for root coverage","volume":"7","author":"Goldstein","year":"1996","journal-title":"Crit Rev Oral Biol Med"},{"issue":"6","key":"10.1016\/j.jebdp.2021.101635_bib0042","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1902\/jop.2016.150554","article-title":"Commentary: statistical significance versus clinical relevance in periodontal research: implications for clinical practice","volume":"87","author":"Chambrone","year":"2016","journal-title":"J Periodontol"}],"container-title":["Journal of Evidence Based Dental Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153233822100110X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153233822100110X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:54:02Z","timestamp":1761519242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153233822100110X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S153233822100110X"],"URL":"https:\/\/doi.org\/10.1016\/j.jebdp.2021.101635","relation":{},"ISSN":["1532-3382"],"issn-type":[{"type":"print","value":"1532-3382"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connective Tissue Graft with or without Enamel Matrix Derivative for Treating Gingival Recession Defects: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Evidence Based Dental Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jebdp.2021.101635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101635"}}