{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:13:51Z","timestamp":1784556831870,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"publisher","award":["B13F660137"],"award-info":[{"award-number":["B13F660137"]}],"id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Evidence-Based Dental Practice"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jebdp.2025.102142","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:37:56Z","timestamp":1744288676000},"page":"102142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["EFFICACY OF HYALURONIC NANOGEL SPRAY FOR TREATING DRY MOUTH: A RANDOMIZED CROSSOVER STUDY"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1483-9611","authenticated-orcid":false,"given":"NONGNAPAT","family":"EAKPUNYAKUL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PEERAWAS","family":"KOPONGPANICH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1149-3405","authenticated-orcid":false,"given":"KANOKPORN","family":"BHALANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JITTIMA AMIE","family":"LUCKANAGUL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jebdp.2025.102142_bib0001","first-page":"306","article-title":"Xerostomia in the geriatric patient: causes, oral manifestations, and treatment","volume":"37","author":"Ouanounou","year":"2016","journal-title":"Compend Contin Educ Dent"},{"issue":"S57","key":"10.1016\/j.jebdp.2025.102142_bib0002","first-page":"e1","article-title":"Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations","volume":"103","author":"von B\u00fcltzingsl\u00f6wen","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jebdp.2025.102142_bib0003","series-title":"Oral and Maxillofacial Pathology","author":"Neville","year":"2015"},{"issue":"9","key":"10.1016\/j.jebdp.2025.102142_bib0004","first-page":"685","article-title":"Oral health in America: a report of the Surgeon General","volume":"28","year":"2000","journal-title":"J Calif Dent Assoc"},{"issue":"5","key":"10.1016\/j.jebdp.2025.102142_bib0005","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1159\/000448292","article-title":"Influence of intrinsic factors on erosive tooth wear in a large-scale epidemiological study","volume":"50","author":"Alaraudanjoki","year":"2016","journal-title":"Caries Res"},{"issue":"1","key":"10.1016\/j.jebdp.2025.102142_bib0006","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/hed.20456","article-title":"Radiation-induced xerostomia","volume":"29","author":"Chambers","year":"2007","journal-title":"Head Neck"},{"issue":"8","key":"10.1016\/j.jebdp.2025.102142_bib0007","doi-asserted-by":"crossref","first-page":"397","DOI":"10.17221\/1930-VETMED","article-title":"Hyaluronic acid (hyaluronan): a review","volume":"53","author":"Necas","year":"2008","journal-title":"Vet Med (Praha)"},{"issue":"1","key":"10.1016\/j.jebdp.2025.102142_bib0008","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF03219073","article-title":"Preparation of thermo-responsive and injectable hydrogels based on hyaluronic acid and poly(N-isopropylacrylamide) and their drug release behaviors","volume":"14","author":"Ha","year":"2006","journal-title":"Macromol Res"},{"issue":"7","key":"10.1016\/j.jebdp.2025.102142_bib0009","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/gels8070454","article-title":"Poly(N-isopropylacrylamide)-based hydrogels for biomedical applications: a review of the state-of-the-art","volume":"8","author":"Ansari","year":"2022","journal-title":"Gels"},{"issue":"23","key":"10.1016\/j.jebdp.2025.102142_bib0010","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.3390\/polym13234071","article-title":"In vivo biocompatible self-assembled nanogel based on hyaluronic acid for aqueous solubility and stability enhancement of Asiatic acid","volume":"13","author":"Win","year":"2021","journal-title":"Polymers (Basel)"},{"issue":"2","key":"10.1016\/j.jebdp.2025.102142_bib0011","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/polym13020194","article-title":"Self-assembled thermoresponsive nanogel from grafted hyaluronic acid as a biocompatible delivery platform for curcumin with enhanced drug loading and biological activities","volume":"13","author":"Luckanagul","year":"2021","journal-title":"Polymers"},{"issue":"3","key":"10.1016\/j.jebdp.2025.102142_bib0012","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0091-7435(92)90030-L","article-title":"Characteristics of heavy smokers","volume":"21","author":"Wilson","year":"1992","journal-title":"Prev Med"},{"issue":"10","key":"10.1016\/j.jebdp.2025.102142_bib0013","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrcardio.2015.91","article-title":"Cardiovascular risks and benefits of moderate and heavy alcohol consumption","volume":"12","author":"Fern\u00e1ndez-Sol\u00e0","year":"2015","journal-title":"Nat Rev Cardiol"},{"issue":"8","key":"10.1016\/j.jebdp.2025.102142_bib0014","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1600-0714.1992.tb01369.x","article-title":"Comparison between new saliva stimulants in patients with dry mouth: a placebo-controlled double-blind crossover study","volume":"21","author":"Aagaard","year":"1992","journal-title":"J Oral Pathol Med"},{"issue":"10","key":"10.1016\/j.jebdp.2025.102142_bib0015","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1177\/00220345820610100901","article-title":"A comparison of whole mouth resting and stimulated salivary measurement procedures","volume":"61","author":"Navazesh","year":"1982","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.jebdp.2025.102142_bib0016","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for primary Sj\u00f6gren's Syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"10.1016\/j.jebdp.2025.102142_bib0017","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0360-3016(01)01512-7","article-title":"Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer","volume":"50","author":"Eisbruch","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jebdp.2025.102142_bib0018","doi-asserted-by":"crossref","DOI":"10.1111\/odi.14891","article-title":"Cross-cultural adaptation of the Thai Xerostomia Inventory and Summated Xerostomia Inventory","author":"Lapnimitanun","year":"2024","journal-title":"Oral Dis"},{"issue":"3","key":"10.1016\/j.jebdp.2025.102142_bib0019","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1532-5415.2002.50123.x","article-title":"Xerostomia and the geriatric patient","volume":"50","author":"Ship","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jebdp.2025.102142_bib0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijnurstu.2016.08.009","article-title":"Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: A randomized controlled study","volume":"63","author":"Yu","year":"2016","journal-title":"Int J Nurs Stud"},{"issue":"12","key":"10.1016\/j.jebdp.2025.102142_bib0021","first-page":"644","article-title":"Sodium-hyaluronate mouthwash on radiotherapy-induced xerostomia: a randomised clinical trial","volume":"31","author":"Rupe","year":"2023","journal-title":"Support Care Cancer"},{"issue":"1","key":"10.1016\/j.jebdp.2025.102142_bib0022","first-page":"58","article-title":"A randomized clinical trial in subjects with dry mouth evaluating subjective perceptions of an experimental oral gel, an oral rinse and a mouth spray compared to water","volume":"29","author":"Jose","year":"2016","journal-title":"Am J Dent"},{"issue":"4","key":"10.1016\/j.jebdp.2025.102142_bib0023","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.oooo.2020.12.002","article-title":"Duration of effect of Biot\u00e8ne spray in patients with symptomatic dry mouth: A pilot study","volume":"131","author":"Lung","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"4","key":"10.1016\/j.jebdp.2025.102142_bib0024","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0300-9785(86)80027-8","article-title":"A double-blind crossover trial of CMC- and mucin-containing saliva substitutes","volume":"15","author":"Visch","year":"1986","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.jebdp.2025.102142_bib0025","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s10266-008-0099-7","article-title":"Diagnosis and treatment of xerostomia (dry mouth)","volume":"97","author":"Nape\u00f1as","year":"2009","journal-title":"Odontology"}],"container-title":["Journal of Evidence-Based Dental Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532338225000570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532338225000570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:08:23Z","timestamp":1777964903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532338225000570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1532338225000570"],"URL":"https:\/\/doi.org\/10.1016\/j.jebdp.2025.102142","relation":{},"ISSN":["1532-3382"],"issn-type":[{"value":"1532-3382","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EFFICACY OF HYALURONIC NANOGEL SPRAY FOR TREATING DRY MOUTH: A RANDOMIZED CROSSOVER STUDY","name":"articletitle","label":"Article Title"},{"value":"Journal of Evidence-Based Dental Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jebdp.2025.102142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102142"}}