{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:19:24Z","timestamp":1771395564727,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005637","name":"Technology Promotion Foundation","doi-asserted-by":"publisher","award":["10146"],"award-info":[{"award-number":["10146"]}],"id":[{"id":"10.13039\/501100005637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005431","name":"Pirkanmaan Rahasto","doi-asserted-by":"publisher","award":["50231659"],"award-info":[{"award-number":["50231659"]}],"id":[{"id":"10.13039\/501100005431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Finnish Cultural Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009450","name":"Kaute Fundation","doi-asserted-by":"publisher","award":["20240420"],"award-info":[{"award-number":["20240420"]}],"id":[{"id":"10.13039\/100009450","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["338678"],"award-info":[{"award-number":["338678"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007634","name":"Ida Montinin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Electrocardiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jelectrocard.2025.154098","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T21:48:33Z","timestamp":1756072113000},"page":"154098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["QT and RR interval analysis in genetic cardiac diseases using the AccuQT and advanced heart rate variability methods"],"prefix":"10.1016","volume":"93","author":[{"given":"Aliisa","family":"L\u00f6nnrot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matias","family":"Kanniainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teemu","family":"Pukkila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Vaarpu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katriina","family":"Aalto-Set\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esa","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jelectrocard.2025.154098_bb0005","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.hrthm.2009.02.044","article-title":"The QT interval: too long, too short or just right","volume":"6","author":"Viskin","year":"2009","journal-title":"Heart Rhythm"},{"issue":"2","key":"10.1016\/j.jelectrocard.2025.154098_bb0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.hrthm.2015.11.008","article-title":"Optimal QT interval correction formula in sinus tachycardia for identifying cardiovascular and mortality risk: findings from the Penn atrial fibrillation free study","volume":"13","author":"Patel","year":"2016","journal-title":"Heart Rhythm"},{"issue":"1149","key":"10.1016\/j.jelectrocard.2025.154098_bb0015","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/postgradmedj-2020-138661","article-title":"Managing drug-induced QT prolongation in clinical practice","volume":"97","author":"Khatib","year":"2021","journal-title":"Postgrad Med J"},{"issue":"3","key":"10.1016\/j.jelectrocard.2025.154098_bb0020","first-page":"353","article-title":"An analysis of the time relations of electrocardiograms","volume":"7","author":"Bazett","year":"1920","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.jelectrocard.2025.154098_bb0025","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.0954-6820.1920.tb18266.x","article-title":"Die Systolendauer im Elektrokardiogramm bei normalen Menschen und bei Herzkranken","volume":"53","author":"Fridericia","year":"1920","journal-title":"Acta Med Scand"},{"issue":"7","key":"10.1016\/j.jelectrocard.2025.154098_bb0030","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0002-9149(92)90562-D","article-title":"An improved method for adjusting the QT interval for heart rate (the Framingham heart study)","volume":"70","author":"Sagie","year":"1992","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.jelectrocard.2025.154098_bb0035","first-page":"694","article-title":"Bazett\u2019s QT correction reviewed - evidence that a linear QT correction for heart is better","volume":"1","author":"Hodges","year":"1983","journal-title":"J Am Coll Cardiol"},{"issue":"SUPPL","key":"10.1016\/j.jelectrocard.2025.154098_bb0040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jelectrocard.2004.08.030","article-title":"A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGs","volume":"37","author":"Luo","year":"2004","journal-title":"J Electrocardiol"},{"issue":"1","key":"10.1016\/j.jelectrocard.2025.154098_bb0045","doi-asserted-by":"crossref","first-page":"14269","DOI":"10.1038\/s41598-021-93774-9","article-title":"Influence of heart rate correction formulas on QTc interval stability","volume":"11","author":"Andr\u0161ov\u00e1","year":"2021","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jelectrocard.2025.154098_bb0050","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jelectrocard.2014.01.002","article-title":"QT\/RR hysteresis","volume":"47","author":"Malik","year":"2014","journal-title":"J Electrocardiol"},{"issue":"7","key":"10.1016\/j.jelectrocard.2025.154098_bb0055","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/bjp.2008.123","article-title":"The impact of varying autonomic states on the dynamic beat-to-beat QT-RR and QT-TQ interval relationships","volume":"154","author":"Fossa","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.jelectrocard.2025.154098_bb0060","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5152\/akd.2015.5875","article-title":"QT interval variations and mortality risk: is there any relationship?","volume":"15","author":"Rezu\u015f","year":"2015","journal-title":"Anadolu Kardiyol Derg"},{"issue":"1","key":"10.1016\/j.jelectrocard.2025.154098_bb0065","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tcm.2017.07.012","article-title":"Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome","volume":"28","author":"Vink","year":"2018","journal-title":"Trends Cardiovasc Med"},{"issue":"S1","key":"10.1016\/j.jelectrocard.2025.154098_bb0070","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1017\/S1047951116002195","article-title":"Hypertrophic cardiomyopathy","volume":"27","author":"Shah","year":"2017","journal-title":"Cardiol Young"},{"issue":"9","key":"10.1016\/j.jelectrocard.2025.154098_bb0075","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/eurheartj\/ehr021","article-title":"Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy","volume":"32","author":"Johnson","year":"2011","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.jelectrocard.2025.154098_bb0080","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/01.CIR.88.2.782","article-title":"Diagnostic criteria for the long QT syndrome an update","volume":"88","author":"Schwartz","year":"1993","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.jelectrocard.2025.154098_bb0085","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jacep.2022.02.017","article-title":"Congenital long QT syndrome","volume":"8","author":"Krahn","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"issue":"4","key":"10.1016\/j.jelectrocard.2025.154098_bb0090","first-page":"739","article-title":"Congenital long QT syndrome: a systematic review","volume":"60","author":"Gali\u0107","year":"2021","journal-title":"Acta Clin Croat"},{"issue":"6","key":"10.1016\/j.jelectrocard.2025.154098_bb0095","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0002-9149(01)02339-6","article-title":"Differentiation between LQT1 and LQT2 patients and unaffected subjects using 24-hour electrocardiographic recordings","volume":"89","author":"Viitasalo","year":"2002","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.jelectrocard.2025.154098_bb0100","first-page":"1","article-title":"Accurate QT correction method from transfer entropy","volume":"4","author":"R\u00e4s\u00e4nen","year":"2022","journal-title":"Cardiovasc Digit Health J"},{"issue":"2","key":"10.1016\/j.jelectrocard.2025.154098_bb0105","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1103\/PhysRevLett.85.461","article-title":"Measuring information transfer","volume":"85","author":"Schreiber","year":"2000","journal-title":"Phys Rev Lett"},{"issue":"1","key":"10.1016\/j.jelectrocard.2025.154098_bb0110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41598-018-33359-1","article-title":"Information transfer in QT-RR dynamics: application to QT-correction","volume":"8","author":"Potapov","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jelectrocard.2025.154098_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jelectrocard.2024.153790","article-title":"Relevance of accurate QT correction in the assessment of long QT syndrome","volume":"87","author":"Kanniainen","year":"2024","journal-title":"J Electrocardiol"},{"issue":"2","key":"10.1016\/j.jelectrocard.2025.154098_bb0120","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1103\/PhysRevE.49.1685","article-title":"Mosaic organization of DNA nucleotides","volume":"49","author":"Peng","year":"1994","journal-title":"Phys Rev E"},{"issue":"1","key":"10.1016\/j.jelectrocard.2025.154098_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-70358-7","article-title":"Dynamical heart beat correlations during running","volume":"10","author":"Molkkari","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jelectrocard.2025.154098_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2017.00258","article-title":"An overview of heart rate variability metrics and norms","volume":"5","author":"Shaffer","year":"2017","journal-title":"Front Public Health"},{"key":"10.1016\/j.jelectrocard.2025.154098_bb0135","series-title":"Computing in cardiology","article-title":"Reduced RR interval correlations of long QT syndrome patients","author":"Pukkila","year":"2022"},{"issue":"9","key":"10.1016\/j.jelectrocard.2025.154098_bb0140","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.jacep.2024.04.018","article-title":"Prediction of sudden cardiac death with ultra-short-term heart rate fluctuations","volume":"10","author":"Hernesniemi","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"issue":"4","key":"10.1016\/j.jelectrocard.2025.154098_bb0145","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.hroo.2025.01.014","article-title":"Detection of congestive heart failure from RR intervals during long-term electrocardiographic recordings","volume":"6","author":"Pukkila","year":"2025","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.jelectrocard.2025.154098_bb0150","series-title":"Congestive heart failure detection based on long-term RR interval dynamics","author":"Pukkila","year":"2025"},{"issue":"6","key":"10.1016\/j.jelectrocard.2025.154098_bb0155","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jelectrocard.2010.07.015","article-title":"A unique digital electrocardiographic repository for the development of quantitative electrocardiography and cardiac safety: the telemetric and Holter ECG warehouse (THEW)","volume":"43","author":"Couderc","year":"2010","journal-title":"J Electrocardiol"},{"issue":"6","key":"10.1016\/j.jelectrocard.2025.154098_bb0160","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jelectrocard.2012.08.001","article-title":"The telemetric and Holter ECG warehouse (THEW): the first three years of development and research","volume":"45","author":"Couderc","year":"2012","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.jelectrocard.2025.154098_bb0165","series-title":"Computational optimization of wave detection algorithms for the electrocardiogram","author":"Niemi","year":"2024"},{"issue":"64","key":"10.1016\/j.jelectrocard.2025.154098_bb0170","first-page":"654","article-title":"Overdiagnosis: causes and consequences in primary health care","volume":"9","author":"Singh","year":"2018","journal-title":"Can Fam Physician"},{"issue":"10","key":"10.1016\/j.jelectrocard.2025.154098_bb0175","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1177\/0141076817722050","article-title":"An epidemic of overdiagnosis and overtreatment: getting to the heart of the problem","volume":"110","author":"Warriner","year":"2017","journal-title":"J R Soc Med"},{"key":"10.1016\/j.jelectrocard.2025.154098_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1112759","article-title":"Long QTc in hypertrophic cardiomyopathy: a consequence of structural myocardial damage or a distinct genetic disease?","volume":"10","author":"Cava","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"16","key":"10.1016\/j.jelectrocard.2025.154098_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168933","article-title":"Pathogenic mechanisms of hypertrophic cardiomyopathy beyond sarcomere dysfunction","volume":"22","author":"Chou","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jelectrocard.2025.154098_bb0190","doi-asserted-by":"crossref","first-page":"1299104","DOI":"10.3389\/fphys.2023.1299104","article-title":"Estimation of physiological exercise thresholds based on dynamical correlation properties of heart rate variability","volume":"14","author":"Kanniainen","year":"2023","journal-title":"Front Physiol"},{"issue":"12","key":"10.1016\/j.jelectrocard.2025.154098_bb0195","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1056\/NEJM199209173271204","article-title":"The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome","volume":"327","author":"Vincent","year":"1992","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.jelectrocard.2025.154098_bb0200","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.rec.2017.01.006","article-title":"Value of the \u2018standing test\u2019 in the diagnosis and evaluation of beta-blocker therapy response in long QT syndrome","volume":"70","author":"Mu\u00f1oz-Esparza","year":"2017","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"},{"issue":"2","key":"10.1016\/j.jelectrocard.2025.154098_bb0205","first-page":"78","article-title":"New era: Mavacamten for obstructive hypertrophic cardiomyopathy","volume":"21","author":"Woodland","year":"2022","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"10.1016\/j.jelectrocard.2025.154098_bb0210","series-title":"Computing in cardiology, CinC","first-page":"1","article-title":"Effects of beta blocker therapy on RR interval correlations during exercise","author":"Pukkila","year":"2023"}],"container-title":["Journal of Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022073625002262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022073625002262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:35:25Z","timestamp":1771392925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022073625002262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":42,"alternative-id":["S0022073625002262"],"URL":"https:\/\/doi.org\/10.1016\/j.jelectrocard.2025.154098","relation":{},"ISSN":["0022-0736"],"issn-type":[{"value":"0022-0736","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"QT and RR interval analysis in genetic cardiac diseases using the AccuQT and advanced heart rate variability methods","name":"articletitle","label":"Article Title"},{"value":"Journal of Electrocardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jelectrocard.2025.154098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154098"}}