{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:21:09Z","timestamp":1771395669004,"version":"3.50.1"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Electrocardiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jelectrocard.2025.154139","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T01:32:49Z","timestamp":1759282369000},"page":"154139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Novel presentation of CACNA1C variant as neonatal complete atrioventricular block, heart failure and non-compaction cardiomyopathy with oligogenic influences"],"prefix":"10.1016","volume":"93","author":[{"given":"Sydney R.","family":"Rooney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brock","family":"Karolcik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Follansbee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mousumi","family":"Moulik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jelectrocard.2025.154139_bb0005","series-title":"Voltage-gated Ca2+ channels: pharmacology, modulation and their role in human disease","first-page":"159","article-title":"CACNA1C-related channelopathies","author":"Herold","year":"2023"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0010","series-title":"GeneReviews\u00ae [Internet]","author":"Napolitano","year":"2025"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0015","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000001206","article-title":"Pharmacological management of cardiac arrhythmias in the fetal and neonatal periods: a scientific statement from the American Heart Association","volume":"149","author":"Batra","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fphys.2019.00335","article-title":"Atomic mechanisms of Timothy syndrome-associated mutations in calcium channel Cav1.2","volume":"10","author":"Korkosh","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0025","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/CIRCULATIONAHA.106.668392","article-title":"Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death","volume":"115","author":"Antzelevitch","year":"2007","journal-title":"Circulation"},{"issue":"44","key":"10.1016\/j.jelectrocard.2025.154139_bb0030","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"ESC guidelines for the management of cardiomyopathies","volume":"2023","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0035","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1161\/CIRCRESAHA.121.318157","article-title":"The complex and diverse genetic architecture of dilated cardiomyopathy","volume":"128","author":"Hershberger","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0040","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1126\/science.aat5056","article-title":"Oligogenic inheritance of a human heart disease involving a genetic modifier","volume":"364","author":"Gifford","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0045","doi-asserted-by":"crossref","DOI":"10.31083\/RCM39044","article-title":"Left ventricular noncompaction cardiomyopathy in children: a focus on genetic and molecular mechanisms","volume":"26","author":"Lehman","year":"2025","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.yjmcc.2015.03.008","article-title":"TNNI3K in cardiovascular disease and prospects for therapy","volume":"82","author":"Milano","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.yjmcc.2012.10.004","article-title":"Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction","volume":"54","author":"Tang","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0060","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1093\/hmg\/ddu297","article-title":"TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy","volume":"23","author":"Theis","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jelectrocard.2025.154139_bb0065","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1520-6408(1998)22:3<263::AID-DVG8>3.0.CO;2-4","article-title":"Common role for each of the cGATA-4\/5\/6 genes in the regulation of cardiac morphogenesis","volume":"22","author":"Jiang","year":"1998","journal-title":"Dev Genet"}],"container-title":["Journal of Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022073625002675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022073625002675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:36:49Z","timestamp":1771393009000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022073625002675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":13,"alternative-id":["S0022073625002675"],"URL":"https:\/\/doi.org\/10.1016\/j.jelectrocard.2025.154139","relation":{},"ISSN":["0022-0736"],"issn-type":[{"value":"0022-0736","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel presentation of CACNA1C variant as neonatal complete atrioventricular block, heart failure and non-compaction cardiomyopathy with oligogenic influences","name":"articletitle","label":"Article Title"},{"value":"Journal of Electrocardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jelectrocard.2025.154139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"154139"}}