{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:54:46Z","timestamp":1787068486956,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ethics, Medicine and Public Health"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.jemep.2016.07.006","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T03:17:46Z","timestamp":1475205466000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["\u201cI think we\u2019ve got too many tests!\u201d: Prenatal providers\u2019 reflections on ethical and clinical challenges in the practice integration of cell-free DNA screening"],"prefix":"10.1016","volume":"2","author":[{"given":"B.L.","family":"Gammon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Michie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Allyse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemep.2016.07.006_bib0270","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10897-013-9673-4","article-title":"Genetic counsellors\u2019 experience with cell-free fetal DNA testing as a prenatal screening option for aneuploidy","volume":"23","author":"Horsting","year":"2014","journal-title":"J Genet Couns"},{"issue":"9076","key":"10.1016\/j.jemep.2016.07.006_bib0275","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"issue":"51","key":"10.1016\/j.jemep.2016.07.006_bib0280","doi-asserted-by":"crossref","first-page":"20458","DOI":"10.1073\/pnas.0810641105","article-title":"Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma","volume":"105","author":"Chiu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.jemep.2016.07.006_bib0285","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/pd.2680","article-title":"Incremental cost of non-invasive prenatal diagnosis versus invasive prenatal diagnosis of fetal sex in england","volume":"31","author":"Hill","year":"2011","journal-title":"Prenat Diagn"},{"issue":"3","key":"10.1016\/j.jemep.2016.07.006_bib0290","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/gim.2011.73","article-title":"DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as down syndrome: an international collaborative study","volume":"13","author":"Palomaki","year":"2012","journal-title":"Genet Med"},{"key":"10.1016\/j.jemep.2016.07.006_bib0295","doi-asserted-by":"crossref","first-page":"c7401","DOI":"10.1136\/bmj.c7401","article-title":"Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large-scale validity study","volume":"342","author":"Chiu","year":"2011","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.jemep.2016.07.006_bib0300","doi-asserted-by":"crossref","first-page":"205.e1","DOI":"10.1016\/j.ajog.2010.12.060","article-title":"Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting","volume":"204","author":"Ehrich","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.jemep.2016.07.006_bib0305","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1373\/clinchem.2011.165910","article-title":"Optimal detection of fetal chromosomal abnormalities by massively parallel DNA sequencing of cell-free fetal DNA from maternal blood","volume":"57","author":"Sehnert","year":"2011","journal-title":"Clin Chem"},{"issue":"13","key":"10.1016\/j.jemep.2016.07.006_bib0310","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/pd.3993","article-title":"Noninvasive prenatal aneuploidy testing of chromosomes 13, 18, 21, X, and Y, using targeted sequencing of polymorphic loci","volume":"32","author":"Zimmermann","year":"2012","journal-title":"Prenat Diagn"},{"issue":"2","key":"10.1016\/j.jemep.2016.07.006_bib0315","doi-asserted-by":"crossref","first-page":"137.e1","DOI":"10.1016\/j.ajog.2012.05.021","article-title":"Non-invasive chromosomal evaluation (NICE) study: results of a multicenter prospective cohort study for detection of fetal trisomy 21 and trisomy 18","volume":"207","author":"Norton","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.jemep.2016.07.006_bib0535","doi-asserted-by":"crossref","first-page":"651-e1","DOI":"10.1016\/j.ajog.2014.06.038","article-title":"Uptake of noninvasive prenatal testing at a large academic referral center","volume":"211","author":"Larion","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"10.1016\/j.jemep.2016.07.006_bib0540","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/gim.2014.197","article-title":"Maternal cell-free DNA-based screening for fetal microdeletion and the importance of careful diagnostic follow-up","volume":"17","author":"Yatsenko","year":"2015","journal-title":"Genet Med"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.jemep.2016.07.006_bib0330","first-page":"1","article-title":"NIPT 2.0: identification of 22q microdeletions by non-invasive prenatal testing","volume":"34","author":"Dharajiya","year":"2014","journal-title":"Prenatal Diagn"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.jemep.2016.07.006_bib0335","first-page":"167S","article-title":"Noninvasive cell-free DNA-based prenatal detection of microdeletions using single nucleotide polymorphism-targeted sequencing","volume":"123","author":"Rabinowitz","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.jemep.2016.07.006_bib0545","doi-asserted-by":"crossref","first-page":"332-e1","DOI":"10.1016\/j.ajog.2014.11.041","article-title":"Expanding the scope of noninvasive prenatal testing: detection of fetal microdeletion syndromes","volume":"212","author":"Wapner","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jemep.2016.07.006_bib0345","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/gim.2013.29","article-title":"ACMG statement on noninvasive prenatal screening for fetal aneuploidy","volume":"15","author":"Gregg","year":"2013","journal-title":"Genet Med"},{"issue":"11","key":"10.1016\/j.jemep.2016.07.006_bib0550","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/ejhg.2015.57","article-title":"Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening","volume":"23","author":"Dondorp","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"10.1016\/j.jemep.2016.07.006_bib0555","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/uog.14699","article-title":"Clinical implementation of cell-free DNA-based aneuploidy screening: perspectives from a national audit","volume":"45","author":"Hui","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.jemep.2016.07.006_bib0360","doi-asserted-by":"crossref","first-page":"368-e1","DOI":"10.1016\/j.ajog.2014.03.065","article-title":"Impact of noninvasive prenatal testing in regionally dispersed medical centers in the United States","volume":"211","author":"Platt","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.jemep.2016.07.006_bib0365","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/1471-0528.12579","article-title":"Non-invasive prenatal testing for trisomy 21: a cross-sectional survey of service users\u2019 views and likely uptake","volume":"121","author":"Lewis","year":"2014","journal-title":"BJOG"},{"issue":"5","key":"10.1016\/j.jemep.2016.07.006_bib0370","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/pd.4091","article-title":"Non-invasive prenatal testing with cell-free DNA: US physician attitudes toward implementation in clinical practice","volume":"33","author":"Musci","year":"2013","journal-title":"Prenat Diagn"},{"issue":"6","key":"10.1016\/j.jemep.2016.07.006_bib0375","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/pd.4812","article-title":"The use of noninvasive prenatal testing in obstetric care: educational resources, practice patterns, and barriers reported by a national sample of clinicians","volume":"36","author":"Farrell","year":"2016","journal-title":"Prenat Diagn"},{"issue":"1","key":"10.1016\/j.jemep.2016.07.006_bib0380","first-page":"7","article-title":"The first 3000 non-invasive prenatal tests (NIPT) with the harmony test in belgium and the netherlands","volume":"6","author":"Willems","year":"2014","journal-title":"Facts Views Vis Obgyn"},{"issue":"1","key":"10.1016\/j.jemep.2016.07.006_bib0385","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1373\/clinchem.2013.202663","article-title":"Integration of noninvasive DNA testing for aneuploidy into prenatal care: what has happened since the rubber met the road?","volume":"60","author":"Bianchi","year":"2014","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.jemep.2016.07.006_bib0390","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/23294515.2014.993096","article-title":"Ethical concerns in the implementation of DNA sequencing-based noninvasive prenatal testing for fetal aneuploidy among obstetric professionals in hong kong","volume":"6","author":"Yi","year":"2015","journal-title":"AJOB Empirical Bioethics"},{"issue":"3","key":"10.1016\/j.jemep.2016.07.006_bib0560","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/birt.12113","article-title":"What women want: lead considerations for current and future applications of noninvasive prenatal testing in prenatal care","volume":"41","author":"Farrell","year":"2014","journal-title":"Birth"},{"key":"10.1016\/j.jemep.2016.07.006_bib0565","doi-asserted-by":"crossref","DOI":"10.1136\/medethics-2011-100180","article-title":"Ethical considerations for choosing between possible models for using NIPD for aneuploidy detection","author":"Deans","year":"2012","journal-title":"J Med Ethics"},{"issue":"4","key":"10.1016\/j.jemep.2016.07.006_bib0405","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000279626","article-title":"Non-invasive prenatal diagnosis using cell-free fetal DNA technology: applications and implications","volume":"13","author":"Hall","year":"2010","journal-title":"Public Health Genomics"},{"issue":"3","key":"10.1016\/j.jemep.2016.07.006_bib0410","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/ejhg.2009.203","article-title":"Non-invasive prenatal testing: ethical issues explored","volume":"18","author":"de Jong","year":"2010","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"10.1016\/j.jemep.2016.07.006_bib0415","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/bioe.12122","article-title":"Prenatal screening: an ethical agenda for the near future","volume":"29","author":"de Jong","year":"2015","journal-title":"Bioethics"},{"issue":"6","key":"10.1016\/j.jemep.2016.07.006_bib0420","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1701-2163(15)30568-5","article-title":"Non-invasive prenatal testing: ethics and policy considerations","volume":"36","author":"Vanstone","year":"2014","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.jemep.2016.07.006_bib0425","first-page":"1","article-title":"Prenatal screening for fetal aneuploidies with cell-free DNA in the general pregnancy population: a cost-effectiveness analysis","author":"Fairbrother","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jemep.2016.07.006_bib0570","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-genom-090314-050000","article-title":"Noninvasive prenatal genetic testing: current and emerging ethical, legal, and social issues","volume":"16","author":"Minear","year":"2015","journal-title":"Ann Rev Genet Genomics"},{"issue":"7","key":"10.1016\/j.jemep.2016.07.006_bib0435","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/pd.4144","article-title":"Best ethical practices for clinicians and laboratories in the provision of non-invasive prenatal testing","volume":"33","author":"Allyse","year":"2013","journal-title":"Prenat Diagn"},{"issue":"2","key":"10.1016\/j.jemep.2016.07.006_bib0440","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/pd.4272","article-title":"Obstetricians\u2019 and gynecologists\u2019 practice and opinions of expanded carrier testing and non-invasive prenatal testing","volume":"34","author":"Benn","year":"2014","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jemep.2016.07.006_bib0445","doi-asserted-by":"crossref","first-page":"b2451","DOI":"10.1136\/bmj.b2451","article-title":"Cell-free fetal DNA and RNA in maternal blood: implications for safer antenatal testing","volume":"339","author":"Wright","year":"2009","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.jemep.2016.07.006_bib0450","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/pd.2835","article-title":"Cell-free fetal DNA testing: a pilot study of obstetric healthcare provider attitudes toward clinical implementation","volume":"31","author":"Sayres","year":"2011","journal-title":"Prenat Diagn"},{"issue":"2","key":"10.1016\/j.jemep.2016.07.006_bib0455","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3390\/jcm3020614","article-title":"It's more than a blood test: patients\u2019 perspectives on noninvasive prenatal testing","volume":"3","author":"Farrell","year":"2014","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.jemep.2016.07.006_bib0460","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/23294515.2014.993100","article-title":"The imbalance of information and funding with noninvasive prenatal screening","volume":"6","author":"Leach","year":"2015","journal-title":"AJOB Empirical Bioethics"},{"key":"10.1016\/j.jemep.2016.07.006_bib0465","series-title":"Poster presented at: ACMG Annual Clinical Genetics Meeting.","article-title":"Decisional regret in women receiving high-risk or inconclusive results from non-invasive prenatal genetic screening","author":"Gammon","year":"2016"},{"issue":"4","key":"10.1016\/j.jemep.2016.07.006_bib0470","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/AOG.0000000000001029","article-title":"Prenatal testing in the genomic age: clinical outcomes, quality of life, and costs","volume":"126","author":"Kaimal","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.jemep.2016.07.006_bib0475","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/pd.4511","article-title":"A cost-effectiveness analysis of cell free DNA as a replacement for serum screening for Down syndrome","volume":"35","author":"Walker","year":"2015","journal-title":"Prenat Diagn"},{"issue":"7","key":"10.1016\/j.jemep.2016.07.006_bib0480","doi-asserted-by":"crossref","first-page":"e0132313","DOI":"10.1371\/journal.pone.0132313","article-title":"An economic analysis of cell-free DNA non-invasive prenatal testing in the US general pregnancy population","volume":"10","author":"Benn","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jemep.2016.07.006_bib0485","doi-asserted-by":"crossref","first-page":"e93559","DOI":"10.1371\/journal.pone.0093559","article-title":"Model-based analysis of costs and outcomes of non-invasive prenatal testing for Down's syndrome using cell free fetal DNA in the UK national health service","volume":"9","author":"Morris","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jemep.2016.07.006_bib0490","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ajmg.1320350214","article-title":"Legal and ethical implications of fetal diagnosis and gene therapy","volume":"35","author":"Annas","year":"1990","journal-title":"Am J Med Genet"},{"issue":"2","key":"10.1016\/j.jemep.2016.07.006_bib0495","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ajog.2005.02.134","article-title":"Evidence-based obstetric ethics and informed decision-making by pregnant women about invasive diagnosis after first-trimester assessment of risk for trisomy 21","volume":"193","author":"Nicolaides","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.jemep.2016.07.006_bib0500","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.siny.2007.12.004","article-title":"Ethical aspects arising from non-invasive fetal diagnosis","volume":"13","author":"Newson","year":"2008","journal-title":"Semin Fetal Neonatal Med"},{"issue":"4","key":"10.1016\/j.jemep.2016.07.006_bib0505","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1097\/01.AOG.0000263889.07297.d1","article-title":"Patient testing: ethical issues in selection and counseling","volume":"109","author":"American College of Obstetricians and Gynecologists","year":"2007","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.jemep.2016.07.006_bib0510","doi-asserted-by":"crossref","first-page":"e693","DOI":"10.1542\/peds.2007-0820","article-title":"Ethical, legal, and social concerns about expanded newborn screening: fragile X syndrome as a prototype for emerging issues","volume":"121","author":"Bailey","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jemep.2016.07.006_bib0515","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrg2631","article-title":"An offer you can\u2019t refuse? Ethical implications of non-invasive prenatal diagnosis","volume":"10","author":"Schmitz","year":"2009","journal-title":"Nat Rev Genet"},{"issue":"7","key":"10.1016\/j.jemep.2016.07.006_bib0520","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/pd.4594","article-title":"A first look at women's perspectives on noninvasive prenatal testing to detect sex chromosome aneuploidies and microdeletion syndromes","volume":"35","author":"Agatisa","year":"2015","journal-title":"Prenat Diagn"},{"issue":"2","key":"10.1016\/j.jemep.2016.07.006_bib0525","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijgo.2013.11.001","article-title":"Ethical and legal aspects of noninvasive prenatal genetic diagnosis","volume":"124","author":"Dickens","year":"2014","journal-title":"Int J Gynaecol Obstet"},{"issue":"4","key":"10.1016\/j.jemep.2016.07.006_bib0530","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/0163278707307899","article-title":"Methodologies for improving response rates in surveys of physicians: a systematic review","volume":"30","author":"VanGeest","year":"2007","journal-title":"Eval Health Prof"}],"container-title":["Ethics, Medicine and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352552516300597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352552516300597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T21:59:59Z","timestamp":1536357599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352552516300597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S2352552516300597"],"URL":"https:\/\/doi.org\/10.1016\/j.jemep.2016.07.006","relation":{},"ISSN":["2352-5525"],"issn-type":[{"value":"2352-5525","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u201cI think we\u2019ve got too many tests!\u201d: Prenatal providers\u2019 reflections on ethical and clinical challenges in the practice integration of cell-free DNA screening","name":"articletitle","label":"Article Title"},{"value":"Ethics, Medicine and Public Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemep.2016.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}