{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:38:27Z","timestamp":1788305907114,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.jemermed.2004.12.015","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T07:43:59Z","timestamp":1118821439000},"page":"77-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Are one or two dangerous? Opioid exposure in toddlers"],"prefix":"10.1016","volume":"29","author":[{"given":"Deepak K.","family":"Sachdeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Stadnyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2004.12.015_bib1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0196-0644(83)80343-6","article-title":"Naloxone","volume":"12","author":"Handal","year":"1983","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib2","series-title":"Goldfrank\u2019s toxicologic emergencies","first-page":"975","article-title":"Opioids","author":"Nelson","year":"1998"},{"key":"10.1016\/j.jemermed.2004.12.015_bib3","first-page":"483","article-title":"The effects of narcotics and antagonists upon respiration and circulation in man","volume":"1","author":"Eckenhoff","year":"1960","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jemermed.2004.12.015_bib4","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1378\/chest.120.5.1628","article-title":"Heroin-related noncardiogenic pulmonary edema","volume":"120","author":"Sporer","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.jemermed.2004.12.015_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/00952999309002676","article-title":"Dextropropoxyphene addiction","volume":"19","author":"Ng","year":"1983","journal-title":"Am J Drug Alcohol Abuse"},{"key":"10.1016\/j.jemermed.2004.12.015_bib6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/00007611-199705000-00022","article-title":"Meperidine-induced generalized seizures with normal renal function","volume":"90","author":"Marinella","year":"1997","journal-title":"South Med J"},{"key":"10.1016\/j.jemermed.2004.12.015_bib7","series-title":"Goodman & Gilman\u2019s the pharmacological basis of therapeutics","first-page":"569","article-title":"Opioid analgesics","author":"Gutstein","year":"2001"},{"key":"10.1016\/j.jemermed.2004.12.015_bib8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/heart.83.6.627","article-title":"Recreational drug misuse","volume":"83","author":"Ghuran","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.jemermed.2004.12.015_bib9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0022-3565(25)11227-5","article-title":"Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an \u2018atypical\u2019 opioid analgesic","volume":"260","author":"Raffa","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jemermed.2004.12.015_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0735-6757(97)90116-9","article-title":"Tramadol overdose requiring prolonged opioid antagonism","volume":"15","author":"Sachdeva","year":"1997","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0735-6757(84)90046-9","article-title":"1983 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"2","author":"Veltri","year":"1984","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib12","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0735-6757(85)90203-7","article-title":"1984 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"3","author":"Litovitz","year":"1985","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0735-6757(86)90220-2","article-title":"1985 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"4","author":"Litovitz","year":"1986","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0735-6757(87)90393-7","article-title":"1986 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"5","author":"Litovitz","year":"1987","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0735-6757(88)90252-5","article-title":"1987 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"6","author":"Litovitz","year":"1988","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0735-6757(89)90252-0","article-title":"1988 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"5","author":"Litovitz","year":"1989","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0735-6757(90)90234-Q","article-title":"1989 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"8","author":"Litovitz","year":"1990","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0735-6757(91)90216-7","article-title":"1990 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"9","author":"Litovitz","year":"1991","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0735-6757(92)90075-9","article-title":"1991 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"10","author":"Litovitz","year":"1992","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib20","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0735-6757(93)90093-Q","article-title":"1992 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"11","author":"Litovitz","year":"1993","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/0735-6757(94)90276-3","article-title":"1993 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"12","author":"Litovitz","year":"1994","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0735-6757(95)90171-X","article-title":"1994 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"13","author":"Litovitz","year":"1995","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0735-6757(96)90160-6","article-title":"1995 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"14","author":"Litovitz","year":"1996","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0735-6757(97)90193-5","article-title":"1996 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"15","author":"Litovitz","year":"1997","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0735-6757(98)90000-6","article-title":"1997 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"16","author":"Litovitz","year":"1998","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0735-6757(99)90254-1","article-title":"1998 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"17","author":"Litovitz","year":"1999","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1053\/ajem.2000.9261","article-title":"1999 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"18","author":"Litovitz","year":"2000","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/ajem.2001.25272","article-title":"2000 Annual Report of the American Association of Poison Control Centers National Data Collection System","volume":"19","author":"Litovitz","year":"2001","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1053\/ajem.2002.34955","article-title":"2001 Annual report of the American Association of Poison Control Centers Toxic Surveillance System","volume":"20","author":"Litovitz","year":"2002","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0735-6757(03)00088-3","article-title":"2002 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System","volume":"21","author":"Watson","year":"2003","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2004.12.015_bib31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0140-6736(76)90749-2","article-title":"Codeine intoxication in childhood","volume":"7","author":"Von Muhlendahl","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.jemermed.2004.12.015_bib32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1046\/j.1442-200X.2001.01427.x","article-title":"Codeine ingestion and apparent life-threatening event n a neonate","volume":"43","author":"Tong","year":"2001","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jemermed.2004.12.015_bib33","first-page":"944","article-title":"Continuous naloxone infusion in pediatric narcotic overdose","volume":"10","author":"Lewis","year":"1984","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jemermed.2004.12.015_bib34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.1972.03190290017005","article-title":"Childhood poisoning. An unfortunate consequence of Methadone Availability","volume":"219","author":"Aronow","year":"1972","journal-title":"JAMA"},{"key":"10.1016\/j.jemermed.2004.12.015_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/000992287401300110","article-title":"Childhood methadone intoxication","volume":"13","author":"Lee","year":"1974","journal-title":"Clin Pediatr"},{"key":"10.1016\/j.jemermed.2004.12.015_bib36","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1136\/bmj.308.6940.1335","article-title":"Accidental ingestion of methadone by children in merseyside","volume":"308","author":"Binchy","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.jemermed.2004.12.015_bib37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1520\/JFS10021J","article-title":"Fatal methadone poisoning in children","volume":"18","author":"DiMaio","year":"1973","journal-title":"J Forensic Sci"},{"key":"10.1016\/j.jemermed.2004.12.015_bib38","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0022-3476(71)80325-6","article-title":"The hazard of narcotics in the home","volume":"79","author":"Robinson","year":"1971","journal-title":"J Pediatr"},{"key":"10.1016\/j.jemermed.2004.12.015_bib39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1542\/peds.48.2.294","article-title":"Accidental methadone intoxication in a child","volume":"48","author":"Sey","year":"1971","journal-title":"Pediatrics"},{"key":"10.1016\/j.jemermed.2004.12.015_bib40","first-page":"388","article-title":"Clinical nuances of pediatric methadone intoxication","volume":"41","author":"Brooks","year":"1999","journal-title":"Vet Hum Toxicol"},{"key":"10.1016\/j.jemermed.2004.12.015_bib41","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1177\/000992287501400411","article-title":"Naloxone therapy in a 7 month old with methadone poisoning","volume":"14","author":"Sesso","year":"1975","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.jemermed.2004.12.015_bib42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1542\/peds.43.1.90","article-title":"Methadone toxicity in a child","volume":"43","author":"McCurley","year":"1969","journal-title":"Pediatrics"},{"key":"10.1016\/j.jemermed.2004.12.015_bib43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/000992280104000212","article-title":"Pediatric methadone poisoning revisited","volume":"40","author":"Schwab","year":"2001","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.jemermed.2004.12.015_bib44","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3109\/15563659709043367","article-title":"Prospective multicenter evaluation of tramadol exposure","volume":"35","author":"Spiller","year":"1997","journal-title":"J Toxicol Clin Toxicol"},{"key":"10.1016\/j.jemermed.2004.12.015_bib45","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00000433-198703000-00014","article-title":"Death associated with inadvertent hydrocodone overdose in a child with a respiratory tract infection","volume":"8","author":"Morrow","year":"1987","journal-title":"Am J Forensic Med Pathol"},{"key":"10.1016\/j.jemermed.2004.12.015_bib46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0379-0738(95)01797-6","article-title":"Fatal morphine poisoning in a child due to accidental oral ingestion","volume":"76","author":"Poklis","year":"1995","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.jemermed.2004.12.015_bib47","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0022-3476(99)70457-9","article-title":"Transdermal fentanyl in children with cancer pain","volume":"134","author":"Collins","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.jemermed.2004.12.015_bib48","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/00007611-199709000-00023","article-title":"Respiratory depression in a child unintentionally exposed to transdermal fentanyl patch","volume":"90","author":"Hardwick","year":"1997","journal-title":"South Med J"},{"key":"10.1016\/j.jemermed.2004.12.015_bib49","series-title":"Drug facts and comparisons","first-page":"860","article-title":"Narcotic agonist analgesics","year":"2003"},{"key":"10.1016\/j.jemermed.2004.12.015_bib50","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1553-2712.1999.tb01235.x","article-title":"Emergency department observation of poisoned patients","volume":"6","author":"Hollander","year":"1999","journal-title":"Acad Emerg Med"}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467905000788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467905000788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:14:58Z","timestamp":1760026498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467905000788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0736467905000788"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2004.12.015","relation":{},"ISSN":["0736-4679"],"issn-type":[{"value":"0736-4679","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are one or two dangerous? Opioid exposure in toddlers","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2004.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}