{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:42:12Z","timestamp":1786992132996,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.jemermed.2007.11.083","type":"journal-article","created":{"date-parts":[[2008,7,27]],"date-time":"2008-07-27T04:10:26Z","timestamp":1217131826000},"page":"21-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fever, Abdominal Pain, and Leukopenia in a 13-Year-Old: A Case-Based Review of Meningococcemia"],"prefix":"10.1016","volume":"37","author":[{"given":"Renee Yuen-Jan","family":"Hsia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy T.","family":"Thanassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2007.11.083_bib1","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1086\/315158","article-title":"The changing epidemiology of meningococcal disease in the United States, 1992\u20131996","volume":"180","author":"Rosenstein","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jemermed.2007.11.083_bib2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0196-0644(05)80991-6","article-title":"Practice guideline for the management of infants and children 0 to 36 months of age with fever without source","volume":"22","author":"Baraff","year":"1993","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0022-3476(86)80564-9","article-title":"Risk factors for development of bacterial meningitis among children with occult bacteremia","volume":"109","author":"Shapiro","year":"1986","journal-title":"J Pediatr"},{"key":"10.1016\/j.jemermed.2007.11.083_bib4","series-title":"Infectious diseases","first-page":"1452","article-title":"Neisseria meningitidis","author":"Boslego","year":"1992"},{"key":"10.1016\/j.jemermed.2007.11.083_bib5","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1097\/01.PCC.0000161947.57506.D6","article-title":"Diagnosing meningococcemia as a cause of sepsis","volume":"6","author":"Hazelzet","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0891-5520(05)70323-8","article-title":"Meningococcemia","volume":"10","author":"Salzman","year":"1996","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.jemermed.2007.11.083_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/00365549609027149","article-title":"Clinical manifestations and course of meningococcal disease in 562 patients","volume":"28","author":"Schildkamp","year":"1996","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.jemermed.2007.11.083_bib8","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1001\/jama.1990.03450100061026","article-title":"Respiratory virus and mycoplasma as cofactors for epidemic group A meningococcal meningitis","volume":"264","author":"Moore","year":"1990","journal-title":"JAMA"},{"key":"10.1016\/j.jemermed.2007.11.083_bib9","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/infdis\/166.3.542","article-title":"Meningococcal disease and influenza-like syndrome: a new approach to an old question","volume":"166","author":"Hubert","year":"1992","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jemermed.2007.11.083_bib10","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0140-6736(91)91112-8","article-title":"Influenza A and meningococcal disease","volume":"338","author":"Cartwright","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.jemermed.2007.11.083_bib11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1128\/jcm.32.2.323-330.1994","article-title":"Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population","volume":"32","author":"Cauguant","year":"1994","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jemermed.2007.11.083_bib12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1056\/NEJM199707173370317","article-title":"Predispositions to meningococcemia","volume":"337","author":"Bansal","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib13","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.129.6.1307","article-title":"Human immunity to the meningococcus","volume":"129","author":"Goldschneider","year":"1969","journal-title":"J Exp Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib14","series-title":"Emergency medicine: concepts and clinical practice","first-page":"1801","article-title":"Meningococcemia","author":"Fern\u00e1ndez-Frackelton","year":"2002"},{"key":"10.1016\/j.jemermed.2007.11.083_bib15","first-page":"2001","article-title":"Primary immunodeficiencies","volume":"68","author":"Cooper","year":"2003","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jemermed.2007.11.083_bib16","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00006454-199611000-00009","article-title":"Pathophysiology, treatment, and outcome of meningococcemia: a review and recent experience","volume":"15","author":"Kirsch","year":"1996","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jemermed.2007.11.083_bib17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1128\/CMR.4.3.359","article-title":"Infectious diseases associated with complement deficiencies","volume":"4","author":"Figueroa","year":"1991","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jemermed.2007.11.083_bib18","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJM198304213081601","article-title":"Prevalence of congenital or acquired complement deficiency in patients with sporadic meningocococcal disease","volume":"308","author":"Ellison","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib19","doi-asserted-by":"crossref","first-page":"E20","DOI":"10.1542\/peds.103.2.e20","article-title":"Clinical and hematologic features do not reliably identify children with unsuspected meningococcal disease","volume":"103","author":"Kuppermann","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.jemermed.2007.11.083_bib20","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1651-2227.1995.tb13513.x","article-title":"Factors associated with fatal outcome in childhood meningococcal disease","volume":"84","author":"Flaegstad","year":"1995","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jemermed.2007.11.083_bib21","series-title":"Red book: 2003 report of the Committee on Infectious Diseases","first-page":"430","article-title":"Meningococcal infections","year":"2003"},{"key":"10.1016\/j.jemermed.2007.11.083_bib22","series-title":"Harrison's principles of internal medicine","first-page":"910","article-title":"Meningococcal infections","author":"Solberg","year":"1998"},{"key":"10.1016\/j.jemermed.2007.11.083_bib23","series-title":"Harrison's principles of internal medicine","first-page":"850","article-title":"Meningococcal infections","author":"Stephens","year":"2004"},{"key":"10.1016\/j.jemermed.2007.11.083_bib24","first-page":"1","article-title":"Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practice (ACIP)","volume":"49","year":"2000","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.jemermed.2007.11.083_bib25","series-title":"Nelson textbook of pediatrics","first-page":"897","article-title":"Gram-negative bacterial infections: neisseria meningitidis (Meningococcus)","author":"Woods","year":"2004"},{"key":"10.1016\/j.jemermed.2007.11.083_bib26","series-title":"Principles and practice of infectious disease","first-page":"2228","article-title":"Gram-negative cocci: neisseria meningitidis","author":"Apicella","year":"2000"},{"key":"10.1016\/j.jemermed.2007.11.083_bib27","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1086\/517786","article-title":"Abdominal pain and fever\u2014an unusual presentation of meningococcemia","volume":"28","author":"Demeter","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jemermed.2007.11.083_bib28","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1001\/jama.1981.03320180052031","article-title":"Neisseria meningitidis serogroup W135 disease in adults","volume":"246","author":"Brandstetter","year":"1981","journal-title":"JAMA"},{"key":"10.1016\/j.jemermed.2007.11.083_bib29","first-page":"436","article-title":"Primary meningococcal peritonitis","volume":"117","author":"Bannatyne","year":"1977","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.jemermed.2007.11.083_bib30","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s004310050958","article-title":"Pathophysiology of meningococcal sepsis in children","volume":"157","author":"de Kleijn","year":"1998","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jemermed.2007.11.083_bib31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/milmed\/133.12.951","article-title":"Fatal meningococcal infections: the changing pathologic picture of the '60s","volume":"133","author":"Hardman","year":"1968","journal-title":"Mil Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib32","series-title":"Infectious disease","first-page":"2173","article-title":"Neisseria","author":"Dankert","year":"2003"},{"key":"10.1016\/j.jemermed.2007.11.083_bib33","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1097\/00003246-200106000-00033","article-title":"Can generic scores (Pediatric Risk of Mortality and Pediatric Index of Mortality) replace specific scores in predicting the outcome of presumed meningococcal septic shock in children?","volume":"29","author":"Leteurtre","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib34","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1097\/00003246-200008000-00047","article-title":"Comparison of the performance of two general and three specific scoring systems for meningococcal septic shock in children","volume":"28","author":"Castellanos-Ortega","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib35","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/BF01709565","article-title":"Meningococcal disease: a comparison of eight severity scores in 125 children","volume":"22","author":"Derkx","year":"1996","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib36","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00431-002-1024-7","article-title":"Prospective validation of the Glasgow Meningococcal Septicaemia Prognostic Score","volume":"161","author":"Riordan","year":"2002","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jemermed.2007.11.083_bib37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0140-6736(87)93067-4","article-title":"Prognosis of meningococcal septicaemia","volume":"330","author":"Sinclair","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.jemermed.2007.11.083_bib38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/00003246-200009001-00014","article-title":"Meningococcal diseases as a model to evaluate novel anti-sepsis strategies","volume":"28","author":"Cohen","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib39","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1086\/425368","article-title":"Practice guidelines for the management of bacterial meningitis","volume":"39","author":"Tunkel","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jemermed.2007.11.083_bib40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1017\/S0950268800048433","article-title":"Endotoxin liberation by strains of N. meningitides isolated from patients and healthy carriers","volume":"106","author":"Mellado","year":"1991","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jemermed.2007.11.083_bib41","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/00006454-199209000-00014","article-title":"Sepsis and septic shock: a review for clinicians","volume":"11","author":"Jafari","year":"1992","journal-title":"Pediatr Infect Dis J"},{"issue":"20","key":"10.1016\/j.jemermed.2007.11.083_bib42","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1056\/NEJMoa021334","article-title":"Dexamethasone in adults with bacterial meningitis","volume":"347","author":"de Gans","year":"2002","journal-title":"N Engl J Med"},{"issue":"24","key":"10.1016\/j.jemermed.2007.11.083_bib43","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa070852","article-title":"Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis","volume":"357","author":"Nguyen","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib44","series-title":"Red Book: 2006 Report of the Committee on Infectious Diseases","first-page":"525","article-title":"Pneumococcal infections","year":"2006"},{"key":"10.1016\/j.jemermed.2007.11.083_bib45","series-title":"Red Book: 2006 Report of the Committee on Infectious Diseases","first-page":"310","article-title":"Haemophilus influenzae infections","year":"2006"},{"key":"10.1016\/j.jemermed.2007.11.083_bib46","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1056\/NEJM197010082831502","article-title":"Heparin therapy in septicemia with disseminated intravascular coagulation","volume":"283","author":"Corrigan","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib47","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0022-3476(95)70369-1","article-title":"Treatment of purpura fulminans in meningococcemia with protein C concentrate","volume":"126","author":"Rivard","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.jemermed.2007.11.083_bib48","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/infdis\/165.4.695","article-title":"Treatment of severe infectious purpura in children with human plasma with donors immunized with Escherichia coli J5: a prospective double-blind study","volume":"165","author":"Group","year":"1992","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jemermed.2007.11.083_bib49","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1086\/515184","article-title":"Randomized, placebo-controlled trial of HA-1A, a human monoclonal antibody to endotoxin, in children with meningococcal septic shock","volume":"28","author":"Derkx","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jemermed.2007.11.083_bib50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00003246-200009001-00013","article-title":"Do new strategies in meningococcemia produce better outcomes?","volume":"28","author":"Leclerc","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib51","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/00003246-199706000-00028","article-title":"Recombinant tissue plasminogen activator restores perfusion in meningococcal purpura fulminans","volume":"25","author":"Aiuto","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jemermed.2007.11.083_bib52","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1542\/peds.96.1.144","article-title":"Recombinant tissue plasminogen activator in two infants with fulminant meningococcemia","volume":"96","author":"Zenz","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.jemermed.2007.11.083_bib53","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1525-1470.1998.1998015169.x","article-title":"Acute infectious purpura fulminans: pathogenesis and medical management","volume":"15","author":"Darmstadt","year":"1998","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jemermed.2007.11.083_bib54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s004310051032","article-title":"Are there specific haemostatic abnormalities in children surviving septic shock with purpura and having skin necrosis or limb ischaemia that need skin grafts or limb amputations?","volume":"158","author":"Cremer","year":"1999","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jemermed.2007.11.083_bib55","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0022-3476(99)70253-2","article-title":"Topical nitroglycerin and pain in purpura fulminans","volume":"134","author":"Meyer","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.jemermed.2007.11.083_bib56","first-page":"1","article-title":"Prevention and control of meningococcal disease","volume":"54","author":"Bilukha","year":"2005","journal-title":"MMWR Recomm Rep"}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467908001984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467908001984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:19:27Z","timestamp":1760026767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467908001984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0736467908001984"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2007.11.083","relation":{},"ISSN":["0736-4679"],"issn-type":[{"value":"0736-4679","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fever, Abdominal Pain, and Leukopenia in a 13-Year-Old: A Case-Based Review of Meningococcemia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2007.11.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}