{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:20:12Z","timestamp":1773148812558,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.jemermed.2011.06.011","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T10:21:02Z","timestamp":1317032462000},"page":"413-416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Combined Vaginal Contraceptive Ring, NuvaRing, and Cerebral Venous Sinus Thrombosis: A Case Report and Review of the Literature"],"prefix":"10.1016","volume":"42","author":[{"given":"Christian","family":"Kolacki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2011.06.011_bib1","first-page":"1","article-title":"Cardiovascular disease and steroid hormone contraception: report of a WHO scientific group","volume":"877","year":"1998","journal-title":"World Health Organ Tech Rep Ser"},{"key":"10.1016\/j.jemermed.2011.06.011_bib2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0140-6736(70)91046-9","article-title":"Intracranial venous thrombosis as complication of oral contraception","volume":"1","author":"Atkinson","year":"1970","journal-title":"Lancet"},{"key":"10.1016\/j.jemermed.2011.06.011_bib3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1001\/archneur.1970.00480230058006","article-title":"Dural sinus thrombosis and cerebral venous thrombosis. Incidence in young women receiving oral contraceptives","volume":"22","author":"Buchanan","year":"1970","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jemermed.2011.06.011_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF03028806","article-title":"Risk of acute cerebrovascular events related to low oestrogen oral contraceptive treatment","volume":"19","author":"Scoditti","year":"1998","journal-title":"Ital J Neurol Sci"},{"key":"10.1016\/j.jemermed.2011.06.011_bib5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/bmj.316.7131.589","article-title":"Case-control\u00a0study of risk of cerebral sinus thrombosis in oral contraceptive users and of who are carriers of hereditary prothrombotic conditions. The cerebral venous sinus thrombosis study group","volume":"316","author":"De Bruijn","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.jemermed.2011.06.011_bib6","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1056\/NEJM199806183382502","article-title":"High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives","volume":"338","author":"Martinelli","year":"1998","journal-title":"N Engl J\u00a0Med"},{"key":"10.1016\/j.jemermed.2011.06.011_bib7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.contraception.2006.05.071","article-title":"Cerebral venous sinus thrombosis in users of four\u00a0hormonal contraceptives: levonorgestrel-containing oral contraceptives, norgestimate-containing oral contraceptives, desogestrel-containing oral contraceptives, and the contraceptive patch","volume":"74","author":"Jick","year":"2006","journal-title":"Contraception"},{"key":"10.1016\/j.jemermed.2011.06.011_bib8","first-page":"559","article-title":"Oral contraceptives and cerebral venous thrombosis: case report and a brief review of the literature","volume":"56","author":"Sheerani","year":"2006","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.jemermed.2011.06.011_bib9","first-page":"195","article-title":"Cerebral venous thrombosis as a complication of oral contraceptive use in a 15-year-old patient: a case report","volume":"159","author":"Hill","year":"2007","journal-title":"La State Med Soc"},{"key":"10.1016\/j.jemermed.2011.06.011_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s100720050036","article-title":"Low-oestrogen oral contraceptives as a major risk factor for cerebral venous and sinus thrombosis: evidence from a clinical series","volume":"20","author":"Buccino","year":"1999","journal-title":"Ital J Neurol Sci"},{"key":"10.1016\/j.jemermed.2011.06.011_bib11","unstructured":"Organon, USA Inc. Full product information, including boxed warning; 2008. Available at: http:\/\/www.nuvaring.com\/Consumer\/Global\/prescribingInformation.asp. Accessed January 1, 2010."},{"key":"10.1016\/j.jemermed.2011.06.011_bib12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.contraception.2004.09.001","article-title":"Efficacy and safety of a contraceptive vaginal ring (NuvaRing) compared with a combined oral contraceptive: a 1-year randomized trial","volume":"71","author":"Oddsson","year":"2005","journal-title":"Contraception"},{"key":"10.1016\/j.jemermed.2011.06.011_bib13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.contraception.2006.07.004","article-title":"Efficacy, acceptability and tolerability of the combined contraceptive ring, NuvaRing, compared with an oral contraceptive containing 30 \u03bcg of ethinyl\u00a0estradiol and 3 mg of drospirenone","volume":"74","author":"Ahrendt","year":"2006","journal-title":"Contraception"},{"key":"10.1016\/j.jemermed.2011.06.011_bib14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1067\/mob.2002.121103","article-title":"Comparison of cycle control with a combined contraceptive vaginal ring and oral levonorgestrel\/ethinyl estradiol","volume":"186","author":"Bjarnadottir","year":"2002","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.jemermed.2011.06.011_bib15","first-page":"CD003552","article-title":"Skin patch and vaginal ring versus combined oral contraceptives for contraception","author":"Lopez","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jemermed.2011.06.011_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/13625180500389547","article-title":"The combined contraceptive vaginal ring (NuvaRing): first experience in daily clinical practice in The Netherlands","volume":"11","author":"Roumen","year":"2006","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"10.1016\/j.jemermed.2011.06.011_bib17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0002-9378(16)33897-2","article-title":"Contraception by means of a silastic vaginal ring impregnated with medroxyprogesterone acetate","volume":"107","author":"Mishell","year":"1970","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jemermed.2011.06.011_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fertnstert.2004.01.025","article-title":"Why consider vaginal drug administration?","volume":"82","author":"Alexander","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jemermed.2011.06.011_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.contraception.2005.03.005","article-title":"Comparison of ethinylestradiol pharmacokinetics in three hormonal contraceptive formulations: the vaginal ring, the transdermal patch and an oral contraceptive","volume":"72","author":"Van den Heuvel","year":"2005","journal-title":"Contraception"},{"key":"10.1016\/j.jemermed.2011.06.011_bib20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2165\/00003088-200039030-00005","article-title":"Pharmacokinetics of etonogestrel and ethinylestradiol released from a combined contraceptive vaginal ring","volume":"39","author":"Timmer","year":"2000","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jemermed.2011.06.011_bib21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/01.AOG.0000136082.59644.13","article-title":"A comparison between the vaginal ring and oral contraceptives","volume":"104","author":"Veres","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jemermed.2011.06.011_bib22","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1210\/jc.2007-0026","article-title":"Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, crossover study","volume":"92","author":"Sitruk-Ware","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jemermed.2011.06.011_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ajog.2005.12.007","article-title":"Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables","volume":"195","author":"Rad","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jemermed.2011.06.011_bib24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.thromres.2008.04.022","article-title":"Effects of the contraceptive patch, the vaginal ring and an oral contraceptive on APC resistance and SHBG: a cross-over study","volume":"123","author":"Fleischer","year":"2009","journal-title":"Thromb Res"},{"key":"10.1016\/j.jemermed.2011.06.011_bib25","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1056\/NEJM200105173442007","article-title":"Oral contraceptives and the risk of venous thrombosis","volume":"344","author":"Vandenbrouke","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jemermed.2011.06.011_bib26","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(95)91926-0","article-title":"Venous thromboembolic disease and combined oral contraceptives: results of international multi-centre case-control study","volume":"346","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jemermed.2011.06.011_bib27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1136\/bmj.323.7305.131","article-title":"Third generation oral contraceptives and risk of venous thrombosis: meta-analysis","volume":"323","author":"Kemmeren","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.jemermed.2011.06.011_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bmj.312.7023.83","article-title":"Third generation oral contraceptives and risk of venous thromboembolic disorders: an international case-control study. Transitional research group on oral contraceptives and the health of young women","volume":"312","author":"Spitzer","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.jemermed.2011.06.011_bib29","first-page":"56","article-title":"Risk of nonfatal venous thromboembolism with oral contraceptives containing norgestimate or desogestrel compared with oral contraceptives containing levonorgestrel","volume":"3","author":"Jick","year":"2006","journal-title":"Contraception"},{"key":"10.1016\/j.jemermed.2011.06.011_bib30","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/S0140-6736(95)91928-7","article-title":"Risk\u00a0of\u00a0idiopathic cardiovascular death and nonfatal venous thromboembolism in women using oral contraceptives with differing progestagen components","volume":"346","author":"Jick","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jemermed.2011.06.011_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0010-7824(01)00234-7","article-title":"Risk of venous thromboembolism from oral contraceptives containing gestodene and desogestrel versus levonorgestrel: a meta-analysis and formal sensitivity analysis","volume":"64","author":"Hennessy","year":"2001","journal-title":"Contraception"},{"key":"10.1016\/j.jemermed.2011.06.011_bib32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/humrep\/deh612","article-title":"Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestins","volume":"20","author":"Van Vliet","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jemermed.2011.06.011_bib33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1055\/s-0037-1613958","article-title":"Effects on coagulation of levonorgestrel- and desogestrel-containing low dose oral contraceptives: a crossover study","volume":"84","author":"Middledorp","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jemermed.2011.06.011_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-996021","article-title":"Molecular biology and pathophysiology of APC resistance: current insights and clinical implications","volume":"24","author":"Rosing","year":"1998","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jemermed.2011.06.011_bib35","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0002-9378(03)00950-5","article-title":"Sex-hormone-binding globulin-a surrogate marker for the prothrombotic effects of combined oral contraceptives","volume":"190","author":"Van Rooijen","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jemermed.2011.06.011_bib36","first-page":"482","article-title":"Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills?","volume":"81","author":"Odlind","year":"2002","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.jemermed.2011.06.011_bib37","series-title":"Medical eligibility criteria for contraceptive use","year":"2009"}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467911006354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467911006354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:23:44Z","timestamp":1760027024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467911006354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0736467911006354"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2011.06.011","relation":{},"ISSN":["0736-4679"],"issn-type":[{"value":"0736-4679","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Combined Vaginal Contraceptive Ring, NuvaRing, and Cerebral Venous Sinus Thrombosis: A Case Report and Review of the Literature","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2011.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}