{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:19:14Z","timestamp":1776449954174,"version":"3.51.2"},"reference-count":7,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jemermed.2015.09.017","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T13:40:04Z","timestamp":1445780404000},"page":"104-107.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Commentary on Reconstituting Fibrinogen Concentrate to Maintain Blinding in a Double-blind, Randomized Trial in an Emergency Setting"],"prefix":"10.1016","volume":"50","author":[{"given":"Daniel","family":"Bruynseels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Hallam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.","family":"Collis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Hamlyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith E.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2015.09.017_bib1","unstructured":"Copenhagen University Hospital, Denmark. Pilot randomized trial of fibrinogen in trauma haemorrhage. Bethesda, MD: National Library of Medicine (US). Available at: https:\/\/clinicaltrials.gov\/show\/NCT02344069 NLM Identifier: NCT00004451. Accessed June 7,\u00a02015."},{"key":"10.1016\/j.jemermed.2015.09.017_bib2","unstructured":"Sunnybrook Health Sciences Centre, Toronto, Canada. Fibrinogen in\u00a0the initial Resuscitation of Severe Trauma (FiiRST). Bethesda, MD: National Library of Medicine (US). Available at: https:\/\/clinicaltrials.gov\/show\/NCT02203968 NLM Identifier: NCT02203968. Accessed June 7,\u00a02015."},{"key":"10.1016\/j.jemermed.2015.09.017_bib3","unstructured":"Laboratoire fran\u00e7ais de Fractionnement et de Biotechnologies, France. Fibrinogen in Haemorrhage of Delivery (FIDEL). Bethesda, MD: National Library of Medicine (US). Available at: https:\/\/clinicaltrials.gov\/show\/NCT02155725 NLM Identifier: NCT02155725. Accessed June 7,\u00a02015."},{"key":"10.1016\/j.jemermed.2015.09.017_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13063-015-0670-9","article-title":"Fibrinogen concentrate versus placebo for treatment of postpartum haemorrhage: study protocol for a randomised controlled trial","volume":"16","author":"Aawar","year":"2015","journal-title":"Trials"},{"key":"10.1016\/j.jemermed.2015.09.017_bib5","unstructured":"CSL Behring, Marburg, Germany. RiaSTAP\u00ae summary of product characteristics. Available at: http:\/\/www.mhra.gov.uk\/Safetyinformation\/Medicinesinformation\/SPCandPILs\/?prodName=RIASTAP%201G%20POWDER%20FOR%20SOLUTION%20FOR%20INJECTION%20OR%20INFUSION&subsName=HUMAN%20FIBRINOGEN&pageID=SecondLevel. Accessed April 30,\u00a02014."},{"key":"10.1016\/j.jemermed.2015.09.017_bib6","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jss.2013.11.534","article-title":"In\u00a0vitro efficacy of RiaSTAP\u00ae after rapid reconstitution","volume":"186","author":"Karri","year":"2014","journal-title":"J Surg Res"},{"key":"10.1016\/j.jemermed.2015.09.017_bib7","unstructured":"The University of Queensland, Australia. Trial of meropenem versus\u00a0piperacillin-tazobactam on mortality and clinical response (MERINO II). Bethesda, MD: National Library of Medicine (US). Available at: https:\/\/clinicaltrials.gov\/show\/NCT02437045 NLM Identifier: NCT02437045. Accessed June 7,\u00a02015."}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467915009476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467915009476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:33:27Z","timestamp":1760027607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467915009476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0736467915009476"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2015.09.017","relation":{},"ISSN":["0736-4679"],"issn-type":[{"value":"0736-4679","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Commentary on Reconstituting Fibrinogen Concentrate to Maintain Blinding in a Double-blind, Randomized Trial in an Emergency Setting","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2015.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}