{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:28:04Z","timestamp":1781090884272,"version":"3.54.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.jemermed.2016.08.006","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T13:07:41Z","timestamp":1475327261000},"page":"311-313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute Toxicity from Topical Cocaine for Epistaxis: Treatment with Labetalol"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-3877","authenticated-orcid":false,"given":"John R.","family":"Richards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik G.","family":"Laurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Tabish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2016.08.006_bib1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/coa.12563","article-title":"Assessing the safety and efficacy of drugs used in preparing the nose for diagnostic and therapeutic procedures: a systematic review","volume":"41","author":"Saif","year":"2016","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.jemermed.2016.08.006_bib2","unstructured":"National Institutes of Health. U.S. National Library of Medicine. Cocaine hydrochloride. Available at: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=24faa247-fe12-4574-881d-445b078b3e87. Accessed April 27,\u00a02016."},{"key":"10.1016\/j.jemermed.2016.08.006_bib3","unstructured":"Drug Enforcement Agency. Drug fact sheet: cocaine. Available at: http:\/\/www.dea.gov\/druginfo\/drug_data_sheets\/Cocaine.pdf. Accessed April 27,\u00a02016."},{"key":"10.1016\/j.jemermed.2016.08.006_bib4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0735-6757(92)90213-H","article-title":"Myocardial infarction associated with inappropriate use of topical cocaine as treatment for epistaxis","volume":"10","author":"Ross","year":"1992","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2016.08.006_bib5","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/BF03010938","article-title":"Intraoperative pulmonary oedema in a young cocaine smoker","volume":"41","author":"Singh","year":"1994","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.jemermed.2016.08.006_bib6","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/archotol.1995.01890060079016","article-title":"Cardiac complication from use of cocaine and phenylephrine in nasal septoplasty","volume":"121","author":"Ashchi","year":"1995","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jemermed.2016.08.006_bib7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0952-8180(99)00074-4","article-title":"Prolonged perioperative myocardial ischemia in a young male: due to topical intranasal cocaine?","volume":"11","author":"Laffey","year":"1999","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.jemermed.2016.08.006_bib8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/01.smj.0000223951.68627.32","article-title":"Acute myocardial infarction following the use of intranasal anesthetic cocaine","volume":"99","author":"Makaryus","year":"2006","journal-title":"South Med J"},{"key":"10.1016\/j.jemermed.2016.08.006_bib9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.12659\/AJCR.883837","article-title":"Coronary spasm after the topical use of cocaine in nasal surgery","volume":"14","author":"Lenders","year":"2013","journal-title":"Am J Case Rep"},{"key":"10.1016\/j.jemermed.2016.08.006_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-209698","article-title":"Chest pain in the recovery room, following topical intranasal cocaine solution use","volume":"2015","author":"Rhidian","year":"2015","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.jemermed.2016.08.006_bib11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/15563650.2016.1142090","article-title":"Treatment of cocaine cardiovascular toxicity: a systematic review","volume":"54","author":"Richards","year":"2016","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.jemermed.2016.08.006_bib12","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.annemergmed.2007.08.020","article-title":"Cocaine, myocardial infarction, and beta-blockers: time to rethink the equation?","volume":"51","author":"Freeman","year":"2008","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2016.08.006_bib13","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/phar.1486","article-title":"Controversial therapeutics: the \u03b2-adrenergic antagonist and cocaine-associated cardiovascular complications dilemma","volume":"34","author":"Schurr","year":"2014","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jemermed.2016.08.006_bib14","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0196-0644(82)80434-4","article-title":"Clinical management of acute and chronic cocaine poisoning","volume":"11","author":"Gay","year":"1982","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2016.08.006_bib15","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1136\/heart.83.6.688","article-title":"Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans","volume":"83","author":"Heesch","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.jemermed.2016.08.006_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0196-0644(87)80038-0","article-title":"Labetalol treatment of cocaine toxicity","volume":"16","author":"Dusenberry","year":"1987","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2016.08.006_bib17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0196-0644(88)80124-0","article-title":"The use of labetalol in the management of cocaine crisis","volume":"17","author":"Gay","year":"1988","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2016.08.006_bib18","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/0002-9343(93)90212-8","article-title":"Influence of labetalol on cocaine-induced coronary vasoconstriction in humans","volume":"94","author":"Boehrer","year":"1993","journal-title":"Am J Med"},{"key":"10.1016\/j.jemermed.2016.08.006_bib19","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1016\/j.jacc.2013.01.014","volume":"61","author":"Anderson","year":"2013","journal-title":"J Am Coll Cardiol"}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467916306369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467916306369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:36:33Z","timestamp":1760027793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467916306369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0736467916306369"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2016.08.006","relation":{},"ISSN":["0736-4679"],"issn-type":[{"value":"0736-4679","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Toxicity from Topical Cocaine for Epistaxis: Treatment with Labetalol","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2016.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}