{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:11:18Z","timestamp":1773925878780,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.jemermed.2016.12.039","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T04:15:27Z","timestamp":1488860127000},"page":"601-608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Use of Ketamine for Acute Treatment of Pain: A Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.1016","volume":"52","author":[{"given":"Billy","family":"Sin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Tatunchak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Paryavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Olivo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Mian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josel","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bupendra","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-868X","authenticated-orcid":false,"given":"Sylvie","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2016.12.039_bib1","unstructured":"Centers for Disease Control and Prevention website. National Center for Health Statistics: emergency department visits. Available at: http:\/\/www.cdc.gov\/nchs\/fastats\/emergency-department.htm. Accessed March 8,\u00a02016."},{"key":"10.1016\/j.jemermed.2016.12.039_bib2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.annemergmed.2009.01.024","article-title":"Patient satisfaction as a function of emergency department previsit expectations","volume":"54","author":"Toma","year":"2009","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2016.12.039_bib3","first-page":"5","article-title":"Problems and barriers of pain management in the emergency department: are we ever going to get better?","volume":"2","author":"Motov","year":"2008","journal-title":"J Pain Res"},{"key":"10.1016\/j.jemermed.2016.12.039_bib4","doi-asserted-by":"crossref","first-page":"ES9","DOI":"10.36076\/ppj.2012\/15\/ES9","article-title":"Opioid epidemic in the United States","volume":"15","author":"Manchikanti","year":"2012","journal-title":"Pain Physician"},{"key":"10.1016\/j.jemermed.2016.12.039_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/acem.12328","article-title":"Rising opioid prescribing in adult U.S. emergency department visits: 2001-2010","volume":"21","author":"Mazer-Amirshahi","year":"2014","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jemermed.2016.12.039_bib6","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.15585\/mmwr.mm6450a3","article-title":"Increases in drug and opioid overdose deaths- United States, 2000-2014","volume":"64","author":"Rudd","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jemermed.2016.12.039_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.7748\/ns.25.9.35.s50","article-title":"Use of ketamine in uncontrolled acute and procedural pain","volume":"25","author":"Chumbley","year":"2010","journal-title":"Nurs Stand"},{"key":"10.1016\/j.jemermed.2016.12.039_bib8","first-page":"61","article-title":"Ketamine: a review of its pharmacologic properties and use in ambulatory anesthesia","volume":"39","author":"Haas","year":"1992","journal-title":"Anesth Prog"},{"key":"10.1016\/j.jemermed.2016.12.039_bib9","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0022-3565(25)11430-4","article-title":"Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors","volume":"260","author":"\u00d8ye","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jemermed.2016.12.039_bib10","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1213\/01.ANE.0000081061.12235.55","article-title":"The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review","volume":"97","author":"Petrenko","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jemermed.2016.12.039_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/acem.12604","article-title":"The use of sub-dissociative-dose ketamine for acute pain in the emergency department","volume":"22","author":"Sin","year":"2015","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jemermed.2016.12.039_bib12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/0976-500X.72352","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials","volume":"2","author":"Schulz","year":"2010","journal-title":"J Pharmacol Pharmcother"},{"key":"10.1016\/j.jemermed.2016.12.039_bib13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1530-7085.2003.03034.x","article-title":"The numeric rating scale for clinical pain measurement: a ratio measure?","volume":"3","author":"Hartrick","year":"2003","journal-title":"Pain Pract"},{"key":"10.1016\/j.jemermed.2016.12.039_bib14","first-page":"102","article-title":"Validation of a verbally administered numerical rating scale of acute pain for use in the ED","volume":"86","author":"Bijur","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jemermed.2016.12.039_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1442-2026.2003.00499.x","article-title":"Comparison of a verbal numeric rating scale with the visual analogue scale for the measurement of acute pain","volume":"15","author":"Holdgate","year":"2003","journal-title":"Emerg Med"},{"key":"10.1016\/j.jemermed.2016.12.039_bib16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/acem.12510","article-title":"Low-dose ketamine improves pain relief in patients receiving intravenous opioids for acute pain in the emergency department: results of a randomized, double-blind, clinical trial","volume":"21","author":"Beaudoin","year":"2014","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jemermed.2016.12.039_bib17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.annemergmed.2015.03.004","article-title":"Intravenous sub-dissociative-dose ketamine versus morphine for analgesia in the emergency department: a randomized controlled trial","volume":"66","author":"Motov","year":"2015","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2016.12.039_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ajem.2014.12.058","article-title":"Low-dose ketamine vs morphine for acute pain in the ED: a randomized controlled trial","volume":"33","author":"Miller","year":"2015","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2016.12.039_bib19","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1213\/01.ANE.0000118109.12855.07","article-title":"Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review","volume":"99","author":"Subramaniam","year":"2004","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jemermed.2016.12.039_bib20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/cns.12099","article-title":"Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings)","volume":"19","author":"Mion","year":"2013","journal-title":"CNS Neurosci Ther"}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467917301294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467917301294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:37:46Z","timestamp":1760027866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467917301294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0736467917301294"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2016.12.039","relation":{},"ISSN":["0736-4679"],"issn-type":[{"value":"0736-4679","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Use of Ketamine for Acute Treatment of Pain: A Randomized, Double-Blind, Placebo-Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2016.12.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}