{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:56:29Z","timestamp":1760057789386,"version":"build-2065373602"},"reference-count":7,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jemermed.2018.06.043","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T17:03:10Z","timestamp":1539795790000},"page":"107-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Local Anesthetic Systemic Toxicity (LAST), Needs Treatment"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-8587","authenticated-orcid":false,"given":"Cornelis","family":"Slagt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3548-0417","authenticated-orcid":false,"given":"Rein","family":"Ketelaars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlou","family":"Swenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Jan van Geffen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2018.06.043_bib1","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.jemermed.2017.12.004","article-title":"Profound prolonged bradycardia and hypotension after interscalene brachial plexus block with bupivacaine","volume":"54","author":"Nelson","year":"2018","journal-title":"J Emerg Med"},{"key":"10.1016\/j.jemermed.2018.06.043_bib2","first-page":"564","article-title":"Maximum recommended doses of local anesthetics: a multifactorial concept","volume":"29","author":"Rosenberg","year":"2004","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.jemermed.2018.06.043_bib3","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/bja\/aes419","article-title":"Minimum effective volume of 0.5% bupivacaine with epinephrine in ultrasound-guided interscalene brachial plexus block","volume":"110","author":"Falc\u00e3o","year":"2013","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jemermed.2018.06.043_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/AAP.0000000000000720","article-title":"The third American Society of Regional Anesthesia and Pain Medicine practice advisory on local anesthetic systemic toxicity: executive summary 2017","volume":"43","author":"Neal","year":"2018","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.jemermed.2018.06.043_bib5","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1056\/NEJMra1502824","article-title":"Cardiac complications in patients undergoing major noncardiac surgery","volume":"373","author":"Devereaux","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jemermed.2018.06.043_bib6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/bja\/aew321","article-title":"Troponin elevations after non-cardiac, non-vascular surgery are predictive of major adverse cardiac events and mortality: a systematic review and meta-analysis","volume":"117","author":"Ekeloef","year":"2016","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jemermed.2018.06.043_bib7","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1001\/jama.2017.4360","article-title":"Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery","volume":"317","author":"Devereaux","year":"2017","journal-title":"JAMA"}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467918309521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467918309521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:41:31Z","timestamp":1760028091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467918309521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0736467918309521"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2018.06.043","relation":{},"ISSN":["0736-4679"],"issn-type":[{"type":"print","value":"0736-4679"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local Anesthetic Systemic Toxicity (LAST), Needs Treatment","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2018.06.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}