{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:08:29Z","timestamp":1778634509185,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jemermed.2019.10.031","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T18:26:58Z","timestamp":1576261618000},"page":"e121-e127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["C1 Esterase Inhibitor for Ace-Inhibitor Angioedema: A Case Series and Literature Review"],"prefix":"10.1016","volume":"58","author":[{"given":"Michael","family":"Perza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Koczirka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason T.","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2019.10.031_bib1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2340\/00015555-1760","article-title":"Angiotensin-converting enzyme inhibitor-induced angioedema\u2014a dangerous new epidemic","volume":"94","author":"Rasmussen","year":"2014","journal-title":"Acta Derm Venereol"},{"issue":"9117","key":"10.1016\/j.jemermed.2019.10.031_bib2","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(97)09137-X","article-title":"Plasma bradykinin in angio-oedema","volume":"351","author":"Nussberger","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jemermed.2019.10.031_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1865-1380-5-39","article-title":"Emerging concepts in the diagnosis and treatment of patients with undifferentiated angioedema","volume":"5","author":"Bernstein","year":"2012","journal-title":"Int J Emerg Med"},{"key":"10.1016\/j.jemermed.2019.10.031_bib4","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1398-9995.2007.01427.x","article-title":"Nonallergic angioedema: role of bradykinin","volume":"62","author":"Bas","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jemermed.2019.10.031_bib5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0022-3565(24)39065-2","article-title":"Metabolism of bradykinin in\u00a0vivo in humans: identification of bk1-5 as a stable plasma peptide metabolite","volume":"294","author":"Murphey","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jemermed.2019.10.031_bib6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1081-1206(10)60594-7","article-title":"Multicenter study of patients with angiotensin converting enzyme inhibitor\u2013induced angioedema who present to the emergency department","volume":"100","author":"Banerji","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jemermed.2019.10.031_bib7","first-page":"1476402","article-title":"Assessment of 105 patients with angiotensin converting enzyme-inhibitor induced angioedema","author":"Rasmussen","year":"2017","journal-title":"Int J Otolaryngol"},{"key":"10.1016\/j.jemermed.2019.10.031_bib8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMcp0803977","article-title":"Hereditary angioedema","volume":"359","author":"Zurow","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jemermed.2019.10.031_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.anai.2014.12.007","article-title":"Effectiveness of ecallantide in treating angiotensin-converting enzyme inhibitor\u2013induced angioedema in the emergency department","volume":"114","author":"Bernstein","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jemermed.2019.10.031_bib10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.annemergmed.2014.07.014","article-title":"Ecallantide for the acute treatment of angiotensin-converting enzyme inhibitor\u2013induced angioedema: a multicenter, randomized, controlled trial","volume":"65","author":"Lewis","year":"2015","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2019.10.031_bib11","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1056\/NEJMoa1312524","article-title":"A randomized trial of icatibant in ACE-inhibitor\u2013induced angioedema","volume":"372","author":"Bas","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jemermed.2019.10.031_bib12","first-page":"S119","article-title":"Managed care implications of hereditary angioedema","volume":"19","author":"Cardarelli","year":"2013","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.jemermed.2019.10.031_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0194-5998(99)70182-8","article-title":"Predicting airway risk in angioedema: staging system based on presentation","volume":"121","author":"Ishoo","year":"1999","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jemermed.2019.10.031_bib15","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1177\/000348940111000906","article-title":"Angiotensin-converting enzyme inhibitor-induced angioedema: a multicenter review and an algorithm for airway management","volume":"110","author":"Chiu","year":"2001","journal-title":"Ann Otol Rhinol Larvngol"},{"key":"10.1016\/j.jemermed.2019.10.031_bib16","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/0194599815588909","article-title":"Predictors of airway intervention in angiotensin-converting enzyme inhibitor\u2013induced angioedema","volume":"153","author":"Kieu","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jemermed.2019.10.031_bib17","first-page":"133","article-title":"C1-esterase inhibitor in ACE inhibitor-induced severe angioedema of the tongue","volume":"26","author":"Steinbach","year":"2001","journal-title":"Anaesthesiol Reanim"},{"key":"10.1016\/j.jemermed.2019.10.031_bib18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1399-6576.2005.00819.x","article-title":"Angioedema from angiotensin-converting enzyme (ACE) inhibitor treated with complement 1 (C1) inhibitor concentrate","volume":"50","author":"Nielsen","year":"2006","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jemermed.2019.10.031_bib19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.revmed.2007.09.038","article-title":"Angiotensin-converting enzyme inhibitor-related angioedema: emergency treatment with complement C1 inhibitor concentrate","volume":"29","author":"Gel\u00e9e","year":"2008","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.jemermed.2019.10.031_bib20","first-page":"2013","article-title":"ACE-inhibitor induced angio-oedema treated with complement C1-inhibitor concentrate","author":"Rasmussen","year":"2013","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.jemermed.2019.10.031_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/ccr3.171","article-title":"Angiotensin-converting enzyme inhibitors-induced angioedema treated by C1 esterase inhibitor concentrate (Berinert): about one case and review of the therapeutic arsenal","volume":"3","author":"Lipski","year":"2015","journal-title":"Clin Case Rep"},{"key":"10.1016\/j.jemermed.2019.10.031_bib22","doi-asserted-by":"crossref","first-page":"E198","DOI":"10.1002\/lary.25113","article-title":"Effect of C1-esterase-inhibitor in angiotensin-converting enzyme inhibitor-induced angioedema","volume":"125","author":"Greve","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jemermed.2019.10.031_bib23","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1016\/j.jemermed.2015.06.076","article-title":"Use of C1 inhibitor for angiotensin-converting enzyme (ACE) inhibitor\u2013induced angioedema decreases mechanical ventilation time","volume":"49","author":"Urnoski","year":"2015","journal-title":"J Emerg Med"},{"key":"10.1016\/j.jemermed.2019.10.031_bib24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1177\/0897190016677427","article-title":"C1 Esterase inhibitor (Berinert) for ACE inhibitor-induced angioedema: two case reports","volume":"30","author":"Leibfried","year":"2017","journal-title":"J Pharm Pract"},{"key":"10.1016\/j.jemermed.2019.10.031_bib25","first-page":"3930923","article-title":"The use of plasma-derived complement C1-esterase inhibitor concentrate (Berinert\u00ae) in the treatment of angiotensin converting enzyme-inhibitor related angioedema","author":"Hermanrud","year":"2016","journal-title":"Case Rep Emerg Med"}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467919309357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467919309357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:45:38Z","timestamp":1760028338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467919309357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0736467919309357"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2019.10.031","relation":{},"ISSN":["0736-4679"],"issn-type":[{"value":"0736-4679","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C1 Esterase Inhibitor for Ace-Inhibitor Angioedema: A Case Series and Literature Review","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2019.10.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}