{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:58:30Z","timestamp":1760057910907,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jem-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Emergency Medicine"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jemermed.2020.06.009","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T01:39:57Z","timestamp":1594863597000},"page":"e113-e117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Naphthalene Toxicity in a Three-Year-Old Child Complicated by Severe Hemolytic Anemia and Mild Methemoglobinemia: A Case Report"],"prefix":"10.1016","volume":"59","author":[{"given":"Rawan M.","family":"Eskandarani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-7560","authenticated-orcid":false,"given":"Faisal S.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jemermed.2020.06.009_bib1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1080\/15563650.2019.1677022","article-title":"2018 Annual Report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 36th annual report","volume":"57","author":"Gummin","year":"2019","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.jemermed.2020.06.009_bib2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1186\/s13054-014-0460-x","article-title":"Vitamin C revisited","volume":"18","author":"Oudemans-van Straaten","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jemermed.2020.06.009_bib3","doi-asserted-by":"crossref","first-page":"684.e1","DOI":"10.1016\/j.ajem.2013.11.036","article-title":"High-dose vitamin C management in dapsone-induced methemoglobinemia","volume":"32","author":"Park","year":"2014","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jemermed.2020.06.009_bib4","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0196-0644(86)80434-6","article-title":"Mothball composition: three simple tests for distinguishing paradichlorobenzene from naphthalene","volume":"15","author":"Ambre","year":"1986","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2020.06.009_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13256-018-1963-x","article-title":"Acute intravascular hemolysis due to naphthalene toxicity: a case report","volume":"13","author":"Uthuman","year":"2019","journal-title":"J Med Case Rep"},{"key":"10.1016\/j.jemermed.2020.06.009_bib6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0300-483X(02)00384-0","article-title":"Naphthalene toxicity and antioxidant nutrients","volume":"180","author":"Stohs","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.jemermed.2020.06.009_bib8","first-page":"740","article-title":"Severe haemolytic anaemia due to ingestion of naphthalene (mothball) containing coconut oil","volume":"22","author":"Rahman","year":"2012","journal-title":"J Coll Physicians Surg Pak"},{"key":"10.1016\/j.jemermed.2020.06.009_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0891-5849(98)00063-X","article-title":"Naphthalene-induced oxidative stress and DNA damage in cultured macrophage J774A.1 cells","volume":"25","author":"Bagchi","year":"1998","journal-title":"Free Radic Biol Med"},{"year":"2019","series-title":"Goldfrank\u2019s toxicologic emergencies, Chapter 127 Methemoglobin Inducers","author":"Hoffman","key":"10.1016\/j.jemermed.2020.06.009_bib10"},{"key":"10.1016\/j.jemermed.2020.06.009_bib11","first-page":"e3147","article-title":"Naphthalene toxicity: methemoglobinemia and acute intravascular hemolysis","volume":"10","author":"Volney","year":"2018","journal-title":"Cureus"},{"key":"10.1016\/j.jemermed.2020.06.009_bib12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/ajh.20738","article-title":"Methemoglobin--it\u2019s not just blue: a concise review","volume":"82","author":"Umbreit","year":"2007","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jemermed.2020.06.009_bib13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.pedn.2012.07.003","article-title":"Benzocaine-induced methemoglobinemia in the pediatric population","volume":"27","author":"Lehr","year":"2012","journal-title":"J Pediatr Nurs"},{"key":"10.1016\/j.jemermed.2020.06.009_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jemermed.2008.06.025","article-title":"Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report","volume":"38","author":"Chung","year":"2010","journal-title":"J Emerg Med"},{"key":"10.1016\/j.jemermed.2020.06.009_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.md.0000141096.00377.3f","article-title":"Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals","volume":"83","author":"Ash-Bernal","year":"2004","journal-title":"Medicine"},{"key":"10.1016\/j.jemermed.2020.06.009_bib16","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1542\/peds.2005-1497","article-title":"American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Committee on Environmental Health. Infant methemoglobinemia: the role of dietary nitrate in food and water","volume":"116","author":"Greer","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jemermed.2020.06.009_bib17","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1440-1681.2007.04639.x","article-title":"Sickle cell disease: role of reactive oxygen and nitrogen metabolites","volume":"34","author":"Wood","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jemermed.2020.06.009_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.7326\/0003-4819-75-1-83","article-title":"Failure of methylene blue treatment in toxic methemoglobinemia. Association with glucose-6-phosphate dehydrogenase deficiency","volume":"75","author":"Rosen","year":"1971","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jemermed.2020.06.009_bib19","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1182\/blood.V13.12.1113.1113","article-title":"Acute hemolytic anemia in the newborn infant due to naphthalene poisoning: report of two cases, with investigations into the mechanism of the disease","volume":"13","author":"Dawson","year":"1958","journal-title":"Blood"},{"key":"10.1016\/j.jemermed.2020.06.009_bib20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1542\/peds.70.3.364","article-title":"Severe hemolytic anemia in black children with glucose-6-phosphate dehydrogenase deficiency","volume":"70","author":"Shannon","year":"1982","journal-title":"Pediatrics"},{"key":"10.1016\/j.jemermed.2020.06.009_bib21","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0196-0644(99)70167-8","article-title":"Methemoglobinemia: etiology, pharmacology, and clinical management","volume":"34","author":"Wright","year":"1999","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2020.06.009_bib22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000351048","article-title":"Rasburicase causing severe oxidative hemolysis and methemoglobinemia in a patient with previously unrecognized glucose-6-phosphate dehydrogenase deficiency","volume":"130","author":"Cheah","year":"2013","journal-title":"Acta Haematol"},{"key":"10.1016\/j.jemermed.2020.06.009_bib23","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.2146\/ajhp150591","article-title":"ascorbic acid for treatment of apparent rasburicase-induced methemoglobinemia in a patient with acute kidney injury and assumed glucose-6-phosphate dehydrogenase deficiency","volume":"73","author":"Reeves","year":"2016","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.jemermed.2020.06.009_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.15406\/mojt.2016.02.00035","article-title":"Naphthalene induced acute hemolysis in a G6PD deficient Bangladeshi boy \u2013 a case report","volume":"2","author":"Tahura","year":"2016","journal-title":"MOJ Toxicol"},{"key":"10.1016\/j.jemermed.2020.06.009_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ienj.2008.12.005","article-title":"Severe toxic methemoglobinemia mimicking septic shock in an infant","volume":"17","author":"Khemiri","year":"2009","journal-title":"Int Emerg Nurs"},{"key":"10.1016\/j.jemermed.2020.06.009_bib26","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ajh.23182","article-title":"Methemoglobinemia and hemolysis in a patient with G6PD deficiency treated with rasburicase","volume":"88","author":"Sonbol","year":"2013","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jemermed.2020.06.009_bib27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/MJT.0000000000000028","article-title":"Ascorbic acid for the treatment of methemoglobinemia: the experience of a large tertiary care pediatric hospital","volume":"21","author":"Rino","year":"2014","journal-title":"Am J Ther"},{"key":"10.1016\/j.jemermed.2020.06.009_bib28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3945\/an.113.005157","article-title":"Vitamin C","volume":"5","author":"Lykkesfeldt","year":"2014","journal-title":"Adv Nutr"},{"key":"10.1016\/j.jemermed.2020.06.009_bib29","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1136\/bmj.2.6198.1097","article-title":"Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning","volume":"2","author":"Prescott","year":"1979","journal-title":"Br Med J"},{"key":"10.1016\/j.jemermed.2020.06.009_bib30","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1053\/j.gastro.2009.06.006","article-title":"Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure","volume":"137","author":"Lee","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jemermed.2020.06.009_bib31","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/bcp.12880","article-title":"N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review","volume":"81","author":"Chughlay","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jemermed.2020.06.009_bib32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2013.09.006","article-title":"Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant bnefits","volume":"141","author":"Rushworth","year":"2014","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jemermed.2020.06.009_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1553-2712.1998.tb02617.x","article-title":"N-acetylcysteine reduces methemoglobin in an in-vitro model of glucose-6-phosphate dehydrogenase deficiency","volume":"5","author":"Wright","year":"1998","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jemermed.2020.06.009_bib34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0196-0644(00)70056-4","article-title":"Failure of intravenous N-acetylcysteine to reduce methemoglobin produced by sodium nitrite in human volunteers: a randomized controlled trial","volume":"35","author":"Tanen","year":"2000","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jemermed.2020.06.009_bib35","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.lfs.2016.03.003","article-title":"A minireview on N-acetylcysteine: an old drug with new approaches","volume":"151","author":"Elbini Dhouib","year":"2016","journal-title":"Life Sci"},{"key":"10.1016\/j.jemermed.2020.06.009_bib36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1553-2712.2000.tb01889.x","article-title":"Association of naphthalene with acute hemolytic anemia","volume":"7","author":"Santucci","year":"2000","journal-title":"Acad Emerg Med"}],"container-title":["The Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467920305588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736467920305588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:45:24Z","timestamp":1760028324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0736467920305588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0736467920305588"],"URL":"https:\/\/doi.org\/10.1016\/j.jemermed.2020.06.009","relation":{},"ISSN":["0736-4679"],"issn-type":[{"type":"print","value":"0736-4679"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naphthalene Toxicity in a Three-Year-Old Child Complicated by Severe Hemolytic Anemia and Mild Methemoglobinemia: A Case Report","name":"articletitle","label":"Article Title"},{"value":"The Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jemermed.2020.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}