{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:27:07Z","timestamp":1787149627034,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","jenonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Emergency Nursing"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jen.2026.03.003","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:15:10Z","timestamp":1787145310000},"page":"1125-1131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Navigating Colchicine Toxicity: Essential Management for a Timeless Therapy"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-3450","authenticated-orcid":false,"given":"Nancy J.","family":"Denke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jen.2026.03.003_bib1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/bjd.15896","article-title":"Colchicine: an ancient drug with novel applications","volume":"178","author":"Dasgeb","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jen.2026.03.003_bib2","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.eclinm.2024.102835","article-title":"Colchicine for secondary prevention of ischaemic stroke and atherosclerotic events: a meta-analysis of randomised trials","volume":"76","author":"Fiolet","year":"2024","journal-title":"EClinicalMedicine"},{"issue":"13","key":"10.1016\/j.jen.2026.03.003_bib3","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/jama.2024.12935","article-title":"Diagnosis, risk stratification, and treatment of pericarditis: a review","volume":"332","author":"Cremer","year":"2024","journal-title":"JAMA"},{"issue":"20","key":"10.1016\/j.jen.2026.03.003_bib4","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMcp2203385","article-title":"Gout","volume":"387","author":"Mikuls","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jen.2026.03.003_bib5","series-title":"Goldfrank\u2019s Toxicologic Emergencies","article-title":"Chapter 34. Colchicine, podophyllin, and the vinca alkaloids","author":"Santos","year":"2022"},{"issue":"4","key":"10.1016\/j.jen.2026.03.003_bib6","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/rheumatology\/kead625","article-title":"Colchicine: the good, the bad, the ugly and how to minimize the risks","volume":"63","author":"Stamp","year":"2024","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.jen.2026.03.003_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11845-022-02938-7","article-title":"Colchicine-regeneration of an old drug","volume":"192","author":"Casey","year":"2023","journal-title":"Ir J Med Sci"},{"key":"10.1016\/j.jen.2026.03.003_bib8","series-title":"Treasure Island (FL): StatPearls Publishing; Updated 2025","article-title":"Colchicine","author":"Sadiq","year":"2025"},{"issue":"5","key":"10.1016\/j.jen.2026.03.003_bib9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/ATVBAHA.124.319851","article-title":"Colchicine\u2019s role in cardiovascular disease management","volume":"44","author":"Buckley","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jen.2026.03.003_bib10","article-title":"Colchicine (Colcrys): uses & side effects","year":"2025","journal-title":"Cleveland Clinic"},{"issue":"7","key":"10.1016\/j.jen.2026.03.003_bib11","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1007\/s11739-022-03079-6","article-title":"Progress in the management of acute colchicine poisoning in adults","volume":"17","author":"Wu","year":"2022","journal-title":"Intern Emerg Med"},{"issue":"9","key":"10.1016\/j.jen.2026.03.003_bib12","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1038\/s41401-021-00835-w","article-title":"Therapeutic potential of colchicine in cardiovascular medicine: A pharmacological review","volume":"43","author":"Zhang","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jen.2026.03.003_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.658347","article-title":"Case report: colchicine toxicokinetic analysis in a poisoned child requiring extracorporeal life support","volume":"9","author":"P\u00e9rez Mar\u00edn","year":"2021","journal-title":"Front Pediatr"},{"issue":"11","key":"10.1016\/j.jen.2026.03.003_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32407","article-title":"Colchicine poisoning: case report of three homicides in a family","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"issue":"30","key":"10.1016\/j.jen.2026.03.003_bib15","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000016580","article-title":"Clinical outcomes after colchicine overdose: A case report","volume":"98","author":"Fu","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jen.2026.03.003_bib16","series-title":"Poisoning & Drug Overdose","year":"2022"},{"issue":"6","key":"10.1016\/j.jen.2026.03.003_bib17","article-title":"A case of colchicine overdose and toxicity","volume":"17","author":"Parekh","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.jen.2026.03.003_bib18","article-title":"Clinical, laboratory, and electrocardiographic findings in colchicine toxicity: 10 years of experience","volume":"9","author":"Sheibani","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jen.2026.03.003_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2022.152150","article-title":"Systematic review of colchicine neuromyopathy: risk factors, duration and resolution","volume":"58","author":"McEwan","year":"2023","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jen.2026.03.003_bib20","series-title":"Cardiac Intensive Care","first-page":"394","article-title":"CWS Chapter 37. Inotropic and vasotropic agents","author":"Biolo","year":"2019"},{"key":"10.1016\/j.jen.2026.03.003_bib21","series-title":"Tintinalli\u2019s Emergency Medicine: A Comprehensive Study Guide","article-title":"Chapter 50. Cardiogenic shock","author":"Petrilli","year":"2020"},{"key":"10.1016\/j.jen.2026.03.003_bib22","unstructured":"Rose DB, Kollef MH. Chapter 4. Critical care- pharmacologic therapies. In: Ancha S, Auberle C, Cash D, Harsh M, Hickman J, Kounga, C, eds. The Washington Manual of Medical Therapeutics. (37th ed.) Philadelphia: Wolter Kluwer."},{"issue":"5","key":"10.1016\/j.jen.2026.03.003_bib23","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.3390\/pharmaceutics15051396","article-title":"Lipid emulsion to treat acute poisonings: mechanisms of action, indications, and controversies","volume":"15","author":"Jaffal","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.jen.2026.03.003_bib24","first-page":"9","article-title":"N-acetylcysteine in non-acetaminophen-induced acute liver failure: a systematic review and meta-analysis of prospective studies","volume":"17","author":"Amjad","year":"2022","journal-title":"Prz Gastroenterol"},{"key":"10.1016\/j.jen.2026.03.003_bib25","series-title":"Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases","year":"2012"},{"issue":"3","key":"10.1016\/j.jen.2026.03.003_bib26","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3390\/biomedicines12030676","article-title":"The use and potential benefits of N-acetylcysteine in non-acetaminophen acute liver failure: an etiology-based review","volume":"12","author":"Popescu","year":"2024","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.jen.2026.03.003_bib27","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.14309\/ajg.0000000000002340","article-title":"Acute liver failure guidelines","volume":"118","author":"Shingina","year":"2023","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.jen.2026.03.003_bib28","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jceh.2022.01.002","article-title":"Dosage of N-Acetyl cysteine in acute liver failure not related to acetaminophen","volume":"12","author":"Praharaj","year":"2022","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.jen.2026.03.003_bib29","series-title":"Does NAC interfere with blood tests? A detailed look at N-acetylcysteine\u2019s effects on lab results","year":"2025"},{"issue":"2","key":"10.1016\/j.jen.2026.03.003_bib30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s13181-018-0653-9","article-title":"Anaphylactoid reactions to intravenous N-acetylcysteine during treatment for acetaminophen poisoning","volume":"14","author":"Yarema","year":"2018","journal-title":"J Med Toxicol"},{"key":"10.1016\/j.jen.2026.03.003_bib31","series-title":"StatPearls Publishing","article-title":"N-acetylcysteine","author":"Ershad","year":"2025"},{"key":"10.1016\/j.jen.2026.03.003_bib32","series-title":"Goldfrank\u2019s Toxicologic Emergencies","article-title":"Chapter A3. N-acetylcysteine","author":"Hendrickson","year":"2019"},{"issue":"4","key":"10.1016\/j.jen.2026.03.003_bib33","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jaccas.2020.02.014","article-title":"Colchicine toxicity: the fatal masquerader","volume":"2","author":"Mulkareddy","year":"2020","journal-title":"JACC Case Rep"},{"issue":"19","key":"10.1016\/j.jen.2026.03.003_bib34","article-title":"Colchicine overdose: challenges with venoarterial extracorporeal membrane oxygenation and microaxial flow pump support","volume":"29","author":"Golob","year":"2024","journal-title":"JACC Case Rep"},{"key":"10.1016\/j.jen.2026.03.003_bib35","series-title":"Critical Care Toxicology","first-page":"1","article-title":"Extracorporeal membrane oxygenation and cardiopulmonary bypass in the poisoned patient","author":"Kerns","year":"2016"},{"issue":"3","key":"10.1016\/j.jen.2026.03.003_bib36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s40264-022-01265-1","article-title":"Colchicine drug interaction errors and misunderstandings: recommendations for improved evidence-based management","volume":"46","author":"Hansten","year":"2023","journal-title":"Drug Saf"},{"key":"10.1016\/j.jen.2026.03.003_bib37","article-title":"The ugly side of colchicine","volume":"9","author":"Cozza","year":"2021","journal-title":"J Investig Med High Impact Case Rep"},{"issue":"7\/8","key":"10.1016\/j.jen.2026.03.003_bib38","first-page":"41","article-title":"Colchicine and drug-drug interactions in ASCVD","volume":"50","author":"Canield","year":"2025","journal-title":"US Pharm"}],"container-title":["Journal of Emergency Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099176726000759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099176726000759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:48:28Z","timestamp":1787147308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099176726000759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0099176726000759"],"URL":"https:\/\/doi.org\/10.1016\/j.jen.2026.03.003","relation":{},"ISSN":["0099-1767"],"issn-type":[{"value":"0099-1767","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Navigating Colchicine Toxicity: Essential Management for a Timeless Therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Emergency Nursing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jen.2026.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Emergency Nurses Association. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}