{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:18:12Z","timestamp":1787908692205,"version":"build-2784847793"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP2024R98"],"award-info":[{"award-number":["RSP2024R98"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Management"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jenvman.2024.123337","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T06:26:04Z","timestamp":1731997564000},"page":"123337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Nitric oxide application alleviates fungicide and ampicillin co-exposure induced phytotoxicity by regulating antioxidant defense, detoxification system, and secondary metabolism in wheat seedlings"],"prefix":"10.1016","volume":"372","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-9990","authenticated-orcid":false,"given":"Nabil","family":"Touzout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-700X","authenticated-orcid":false,"given":"Adil","family":"Mihoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdia","family":"Boukheddimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir Oumaima","family":"Moualdia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftikhar","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-6207","authenticated-orcid":false,"given":"Subhan","family":"Danish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Alarfaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman Ali","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Javed Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jenvman.2024.123337_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"[13] catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"issue":"12","key":"10.1016\/j.jenvman.2024.123337_bib2","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/horticulturae8121142","article-title":"Melatonin-induced detoxification of organic pollutants and alleviation of phytotoxicity in selected horticultural crops","volume":"8","author":"Ahammed","year":"2022","journal-title":"horticultura"},{"key":"10.1016\/j.jenvman.2024.123337_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jxb\/ers323","article-title":"Role of brassinosteroids in alleviation of phenanthrene-cadmium co-contamination-induced photosynthetic inhibition and oxidative stress in tomato","volume":"64","author":"Ahammed","year":"2013","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124852","article-title":"Nitric oxide donor , sodium nitroprusside , mitigates mercury toxicity in different cultivars of soybean","volume":"408","author":"Ahmad","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2024.123337_bib5","article-title":"Main nitric oxide ( NO ) hallmarks to relieve arsenic stress in higher plants As-","volume":"406","author":"Akhter","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2024.123337_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10725-014-9917-9","article-title":"Improvement of element uptake and antioxidative defense in Brassica napus under lead stress by application of hydrogen sulfide","volume":"74","author":"Ali","year":"2014","journal-title":"Plant Growth Regul."},{"key":"10.1016\/j.jenvman.2024.123337_bib7","article-title":"Phytotoxicity and cytogenotoxicity of pesticide mixtures : analysis of the effects of environmentally relevant concentrations on the aquatic environment","author":"Alves","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jenvman.2024.123337_bib8","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","article-title":"[70] Determination of glutathione and glutathione disulfide in biological samples","author":"Anderson","year":"1985"},{"key":"10.1016\/j.jenvman.2024.123337_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143759","article-title":"Enantioselective effects of imazethapyr on the secondary metabolites and nutritional value of wheat seedlings","volume":"757","author":"Bao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib10","first-page":"2290","volume":"vol. 144","author":"B\u00e1rt\u00edkov\u00e1","year":"2016"},{"key":"10.1016\/j.jenvman.2024.123337_bib11","article-title":"Deciphering the alleviation potential of Nitric oxide, for low temperature and chromium stress via maintaining photosynthetic capacity, antioxidant defence, and redox homeostasis in rice (Oryza sativa)","volume":"108957","author":"Basit","year":"2024","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jenvman.2024.123337_bib12","doi-asserted-by":"crossref","DOI":"10.1071\/FP21268","article-title":"Seed priming with nitric oxide and\/or spermine mitigate the chromium toxicity in rice (Oryza sativa) seedlings by improving the carbon-assimilation and minimising the oxidative damages","author":"Basit","year":"2022","journal-title":"Funct. Plant Biol."},{"key":"10.1016\/j.jenvman.2024.123337_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00018060","article-title":"Rapid determination of free proline for water-stress studies","volume":"39","author":"Bates","year":"1973","journal-title":"Plant Soil"},{"key":"10.1016\/j.jenvman.2024.123337_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.envexpbot.2019.02.003","article-title":"Nitric oxide regulates plant responses to drought , salinity , and heavy metal","volume":"161","author":"Begum","year":"2019","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.envexpbot.2018.10.017","article-title":"Reactive oxygen species and heavy metal stress in plants: impact on the cell wall and secondary metabolism","volume":"161","author":"Berni","year":"2019","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jenvman.2024.123337_bib17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.scitotenv.2017.11.164","article-title":"Phytotoxicity of pyrethroid pesticides and its metabolite towards Cucumis sativus","volume":"619\u2013620","author":"Bragan\u00e7a","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib18","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1104\/pp.98.4.1222","article-title":"Magnesium deficiency and high light intensity enhance activities of superoxide dismutase, ascorbate peroxidase, and glutathione reductase in bean leaves","volume":"98","author":"Cakmak","year":"1992","journal-title":"Plant Physiol."},{"key":"10.1016\/j.jenvman.2024.123337_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pestbp.2009.12.003","article-title":"Nitric oxide reduces oxidative stress generated by lactofen in soybean plants","volume":"97","author":"Cesar","year":"2010","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jenvman.2024.123337_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130264","article-title":"Metabolomics and proteomics reveal the toxicological mechanisms of florfenicol stress on wheat (Triticum aestivum L.) seedlings","volume":"443","author":"Chen","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2024.123337_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envexpbot.2023.105615","article-title":"Morpho-physiological, biochemical, and molecular responses of lettuce (Lactuca sativa L.) seedlings to chlortetracycline stress","volume":"219","author":"Choe","year":"2024","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib22","article-title":"Veterinary antibiotics and plant physiology : an overview","volume":"767","author":"Cristina","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12298-022-01132-4","article-title":"Sodium nitroprusside mediates attenuation of paraquat-mediated oxidative stress in Eruca sativa in vitro","volume":"28","author":"C\u00fcce","year":"2022","journal-title":"Physiol. Mol. Biol. Plants"},{"key":"10.1016\/j.jenvman.2024.123337_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132568","article-title":"A novel mixture sampling strategy combining Latin hypercube sampling with optimized one factor at a time method : a case study on mixtures of antibiotics and pesticides","volume":"461","author":"Ding","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2024.123337_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162449","article-title":"Antibiotics induced changes in nitrogen metabolism and antioxidative enzymes in mung bean (Vigna radiata)","volume":"873","author":"Fiaz","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/abio.1993.1554","article-title":"New spectrophotometric assay for polyphenol oxidase activity","volume":"215","author":"Gauillard","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jenvman.2024.123337_bib27","author":"Geng"},{"key":"10.1016\/j.jenvman.2024.123337_bib28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.plaphy.2010.08.016","article-title":"Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants","volume":"48","author":"Gill","year":"2010","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jenvman.2024.123337_bib29","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0076-6879(81)77053-8","article-title":"Assays for differentiation of glutathione S-transferases","author":"Habig","year":"1981"},{"key":"10.1016\/j.jenvman.2024.123337_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-9861(68)90654-1","article-title":"Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation","volume":"125","author":"Heath","year":"1968","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jenvman.2024.123337_bib31","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1093\/jxb\/erv063","article-title":"Contribution of glutathione to the control of cellular redox homeostasis under toxic metal and metalloid stress","volume":"66","author":"Hern\u00e1ndez","year":"2015","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envexpbot.2021.104734","article-title":"Endogenous nitric oxide contributes to chloride and sulphate salinity tolerance by modulation of ion transporter expression and reestablishment of redox balance in Brassica napus cultivars","volume":"194","author":"Huang","year":"2022","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib33","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S0006-291X(71)80010-4","article-title":"Nitrate reductase assay in intact plant tissues","volume":"43","author":"Jaworski","year":"1971","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jenvman.2024.123337_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161544","article-title":"Oxidative response of rice (Oryza sativa L.) seedlings to quinolone antibiotics and its correlation with phyllosphere microbes and antibiotic resistance genes","volume":"867","author":"Jin","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.scienta.2019.05.029","article-title":"Alleviating effect of nitric oxide on oxidative stress and antioxidant defence system in pepper (Capsicum annuum L.) plants exposed to cadmium and lead toxicity applied separately or in combination","volume":"255","author":"Kaya","year":"2019","journal-title":"Sci. Hortic."},{"key":"10.1016\/j.jenvman.2024.123337_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160715","article-title":"Does pesticide use in agriculture present a risk to the terrestrial biota?","volume":"861","author":"Kenko","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11270-007-9441-x","article-title":"Phenylalanine ammonia-lyase and phenolic compounds in chamomile tolerance to cadmium and copper excess","volume":"185","author":"Kov\u00e1\u010dik","year":"2007","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.jenvman.2024.123337_bib38","author":"Kowalik"},{"key":"10.1016\/j.jenvman.2024.123337_bib40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/17429145.2021.2014579","article-title":"Effects of antibiotics on the photosynthetic apparatus of plants","volume":"17","author":"Krupka","year":"2022","journal-title":"J. Plant Interact."},{"key":"10.1016\/j.jenvman.2024.123337_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105688","article-title":"Integrative physiological , critical plant endogenous hormones , and transcriptomic analyses reveal the difenoconazole stress response mechanism in wheat (Triticum aestivum L)","volume":"197","author":"Li","year":"2023","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jenvman.2024.123337_bib42","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0076-6879(87)48036-1","article-title":"Chlorophylls and carotenoids: pigments of photosynthetic biomembranes","volume":"148","author":"Lichtenthaler","year":"1987","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jenvman.2024.123337_bib43","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/S1001-0742(10)60608-0","article-title":"Growth response and toxic e ff ects of three antibiotics on Selenastrum capricornutum evaluated by photosynthetic rate and chlorophyll biosynthesis","volume":"23","author":"Liu","year":"2011","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.jenvman.2024.123337_bib44","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fpls.2020.00697","article-title":"Ursolic acid limits salt-induced oxidative damage by interfering with nitric oxide production and oxidative defense machinery in rice","volume":"11","author":"Long","year":"2020","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jenvman.2024.123337_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envexpbot.2021.104533","article-title":"Mechanism of nitric oxide enhancing NaCl tolerance of barley seedlings based on physiol-biochemical analysis and LC-MS metabolomics","volume":"189","author":"Ma","year":"2021","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib46","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhazmat.2019.02.056","article-title":"Pesticide mediated oxidative stress induces genotoxicity and disrupts chromatin structure in fenugreek (Trigonella foenum - graecum L.) seedlings","volume":"369","author":"Mahapatra","year":"2019","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2024.123337_bib47","doi-asserted-by":"crossref","first-page":"43958","DOI":"10.1007\/s11356-020-10245-w","article-title":"Ecotoxicological evaluation of fungicides used in viticulture in non-target organisms","volume":"27","author":"Marinho","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jenvman.2024.123337_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.plantsci.2023.111835","article-title":"Review on nitric oxide at the forefront of rapid systemic signaling in mitigation of salinity stress in plants : crosstalk with calcium and hydrogen peroxide","volume":"336","author":"Mariyam","year":"2023","journal-title":"Plant Sci."},{"key":"10.1016\/j.jenvman.2024.123337_bib50","article-title":"Priming with sodium nitroprusside and hydrogen peroxide increases cotton seed tolerance to salinity and water deficit during seed germination and seedling development","volume":"209","author":"Mendes","year":"2023","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tplants.2016.08.002","article-title":"ROS are good","volume":"22","author":"Mittler","year":"2017","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.jenvman.2024.123337_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127353","article-title":"Phytotoxicity of different antibiotics to rice and stress alleviation upon application of organic amendments","volume":"258","author":"Mukhtar","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2024.123337_bib53","first-page":"867","article-title":"Hydrogen peroxide is scavenged by ascorbate-specific peroxidase in spinach chloroplasts","volume":"22","author":"Nakano","year":"1981","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.jenvman.2024.123337_bib54","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1365-3040.2011.02400.x","article-title":"Glutathione in plants: an integrated overview","volume":"35","author":"Noctor","year":"2012","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib55","article-title":"Emerging contaminants in water used for maize irrigation : economic and food safety losses associated with ciprofloxacin and glyphosate","volume":"196","author":"Pedrosa","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jenvman.2024.123337_bib56","first-page":"2671","volume":"vol. 651","author":"Pedrosa","year":"2019"},{"key":"10.1016\/j.jenvman.2024.123337_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130212","article-title":"Reactive oxygen species signaling is involved in melatonin-induced reduction of chlorothalonil residue in tomato leaves","volume":"443","author":"Peng","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2024.123337_bib58","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.niox.2022.08.005","article-title":"Nitric oxide mediated alleviation of abiotic challenges in plants","volume":"128","author":"Praveen","year":"2022","journal-title":"Nitric Oxide - Biol. Chem."},{"key":"10.1016\/j.jenvman.2024.123337_bib59","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.chemosphere.2017.08.164","article-title":"The phytoremediation potential of Plectranthus neochilus on 2,4-dichlorophenoxyacetic acid and the role of antioxidant capacity in herbicide tolerance","volume":"188","author":"Ramborger","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2024.123337_bib60","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.phytochem.2011.02.011","article-title":"Differential responses of five cherry tomato varieties to water stress: changes on phenolic metabolites and related enzymes","volume":"72","author":"S\u00e1nchez-Rodr\u00edguez","year":"2011","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jenvman.2024.123337_bib61","first-page":"24408","article-title":"Sodium nitroprusside ameliorates lead toxicity in rice (Oryza sativa L.) by modulating the antioxidant scavenging system , nitrogen metabolism , lead sequestration mechanism , and proline metabolism","author":"Sayyadi","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jenvman.2024.123337_bib62","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.envexpbot.2019.01.010","article-title":"Nitric oxide reverses glucose-mediated photosynthetic repression in wheat (Triticum aestivum L) under salt stress","volume":"161","author":"Sehar","year":"2019","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules24132452","article-title":"Response of phenylpropanoid pathway and the role of polyphenols in plants under abiotic stress","volume":"24","author":"Sharma","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jenvman.2024.123337_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117953","article-title":"Molybdenum and hydrogen sulfide synergistically mitigate arsenic toxicity by modulating defense system, nitrogen and cysteine assimilation in faba bean (Vicia faba L.) seedlings","volume":"290","author":"Siddiqui","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jenvman.2024.123337_bib65","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.plaphy.2018.09.001","article-title":"Impact of benzimidazole and dithiocarbamate fungicides on the photosynthetic machinery, sugar content and various antioxidative enzymes in chickpea","volume":"132","author":"Singh","year":"2018","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jenvman.2024.123337_bib66","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1134\/S1021443717040136","article-title":"Physiological and biochemical roles of nitric oxide against toxicity produced by glyphosate herbicide in Pisum sativum","volume":"64","author":"Singh","year":"2017","journal-title":"Russ. J. Plant Physiol."},{"key":"10.1016\/j.jenvman.2024.123337_bib67","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","article-title":"Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents","volume":"16","author":"Singleton","year":"1965","journal-title":"Am. J. Enol. Vitic."},{"key":"10.1016\/j.jenvman.2024.123337_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122871","article-title":"Glyphosate-dependent effects on photosynthesis of Solanum lycopersicum L.\u2014an ecophysiological, ultrastructural and molecular approach","volume":"398","author":"Soares","year":"2020","journal-title":"J. Hazard Mater."},{"issue":"9","key":"10.1016\/j.jenvman.2024.123337_bib69","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.3390\/plants10091862","article-title":"Foliar application of sodium nitroprusside boosts Solanum disorders and stimulating herbicide detoxification pathways","volume":"10","author":"Soares","year":"2021","journal-title":"Plants"},{"key":"10.1016\/j.jenvman.2024.123337_bib70","first-page":"263","article-title":"Specific glutathione-S-transferases ensure an efficient detoxification of diclofenac in Solanum lycopersicum L","volume":"168","author":"Sousa","year":"2021","journal-title":"Plants"},{"key":"10.1016\/j.jenvman.2024.123337_bib71","first-page":"900","article-title":"Can nano-SiO 2 reduce the phytotoxicity of acetaminophen ? e A physiological","volume":"241","author":"Sousa","year":"2018","journal-title":"biochemical and molecular approach"},{"key":"10.1016\/j.jenvman.2024.123337_bib72","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/antiox12030666","article-title":"Accumulation of proline in plants under contaminated soils\u2014are we on the same page?","volume":"12","author":"Spormann","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jenvman.2024.123337_bib73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.envpol.2017.11.041","article-title":"Pharmaceutical and personal care products-induced stress symptoms and detoxi fi cation mechanisms in cucumber plants","volume":"234","author":"Sun","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jenvman.2024.123337_bib74","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1021\/acs.estlett.9b00229","article-title":"Nitric oxide regulates triclosan-induced redox disequilibrium by enhancing glutathione metabolism in wheat seedlings","volume":"6","author":"Sun","year":"2019","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.jenvman.2024.123337_bib75","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/nph.12797","article-title":"Abiotic and biotic stress combinations","volume":"203","author":"Suzuki","year":"2014","journal-title":"New Phytol."},{"key":"10.1016\/j.jenvman.2024.123337_bib76","doi-asserted-by":"crossref","DOI":"10.1093\/jxb\/erz184","article-title":"Role of nitric oxide in plant responses to heavy metal stress: exogenous application versus endogenous production","author":"Terr\u00f3n-Camero","year":"2019","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib77","doi-asserted-by":"crossref","DOI":"10.1007\/s42729-023-01381-6","article-title":"Efficacy of silicon in mitigating the combined phytotoxic effects of salt and insecticide in Solanum lycopersicum L","author":"Touzout","year":"2023","journal-title":"J. Soil Sci. Plant Nutr."},{"key":"10.1016\/j.jenvman.2024.123337_bib78","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1007\/s10646-021-02421-6","article-title":"Phytotoxic evaluation of neonicotinoid imidacloprid and cadmium alone and in combination on tomato (Solanum lycopersicum L.)","volume":"30","author":"Touzout","year":"2021","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.jenvman.2024.123337_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11738-021-03261-x","article-title":"Co-contamination of deltamethrin and cadmium induce oxidative stress in tomato plants (Solanum lycopersicum L.)","volume":"43","author":"Touzout","year":"2021","journal-title":"Acta Physiol. Plant."},{"key":"10.1016\/j.jenvman.2024.123337_bib80","article-title":"Deciphering the role of nitric oxide in mitigation of systemic fungicide induced growth inhibition and oxidative damage in wheat","volume":"143046","author":"Touzout","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2024.123337_bib81","first-page":"1","article-title":"The multifaceted role of sodium nitroprusside in plants: crosstalk with phytohormones under normal and stressful conditions","author":"Ullah","year":"2024","journal-title":"Plant Growth Regul."},{"key":"10.1016\/j.jenvman.2024.123337_bib82","series-title":"The Multifaceted Role of Sodium Nitroprusside in Plants : Crosstalk with Phytohormones under Normal and Stressful Conditions","author":"Ullah","year":"2024"},{"key":"10.1016\/j.jenvman.2024.123337_bib83","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-9452(99)00197-1","article-title":"Oxidative stress and some antioxidant systems in acid rain-treated bean plants protective role of exogenous polyamines","volume":"151","author":"Velikova","year":"2000","journal-title":"Plant Sci."},{"key":"10.1016\/j.jenvman.2024.123337_bib84","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s10311-019-00905-w","article-title":"Combined toxicity of pyrethroid insecticides and heavy metals: a review","volume":"17","author":"Wang","year":"2019","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.jenvman.2024.123337_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2023.108096","article-title":"Phytotoxicity of nitrobenzene bioaccumulation in rice seedlings : nitrobenzene inhibits growth , induces oxidative stress , and reduces photosynthetic pigment synthesis","volume":"204","author":"Wang","year":"2023","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jenvman.2024.123337_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164413","article-title":"Mechanism of uptake , accumulation , transport , metabolism and phytotoxic effects of pharmaceuticals and personal care products within plants : a review","volume":"892","author":"Wei","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib87","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.scitotenv.2018.11.449","article-title":"Occurrence , distribution and ecological risks of antibiotics and pesticides in coastal waters around Liaodong Peninsula","volume":"656","author":"Xie","year":"2019","journal-title":"China. Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib88","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1111\/ppl.13576","article-title":"Endogenous indole\u20103\u2010acetic acid and nitric oxide are required for calcium\u2010mediated alleviation of copper oxide nanoparticles toxicity in wheat seedlings","volume":"173","author":"Yadav","year":"2021","journal-title":"Physiol. Plantarum"},{"key":"10.1016\/j.jenvman.2024.123337_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133639","article-title":"Distinct toxic effects , gene expression profiles , and phytohormone responses of Polygonatum cyrtonema exposed to two different antibiotics","volume":"466","author":"Yang","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2024.123337_bib90","article-title":"Phytotoxic effects on chloroplast and UHPLC-HRMS based untargeted metabolomic responses in Allium tuberosum Rottler ex Sprengel (Chinese leek) exposed to antibiotics","volume":"234","author":"Yasmin","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jenvman.2024.123337_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115732","article-title":"Glutathione-dependent redox homeostasis is critical for chlorothalonil detoxification in tomato leaves","volume":"268","author":"Yu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jenvman.2024.123337_bib92","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/nph.18087","article-title":"Plant responses to multifactorial stress combination","volume":"234","author":"Zandalinas","year":"2022","journal-title":"New Phytol."},{"key":"10.1016\/j.jenvman.2024.123337_bib93","article-title":"Assessing the impact ofChlorantraniliprole (CAP) pesticide stress on oilseed rape (Brassia campestris L.): residue dynamics, enzyme activities, and metabolite profiling","volume":"105785","author":"Zhang","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jenvman.2024.123337_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148034","article-title":"Metabolism and detoxification of pesticides in plants","volume":"790","author":"Zhang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib95","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.3390\/molecules28052158","article-title":"Recent advances of polyphenol oxidases in plants","volume":"28","author":"Zhang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jenvman.2024.123337_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115145","article-title":"Generalizing routes of plant exposure to pesticides by plant uptake models to assess pesticide application efficiency","volume":"262","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jenvman.2024.123337_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152056","article-title":"Veterinary antibiotics can reduce crop yields by modifying soil bacterial community and earthworm population in agro-ecosystems","volume":"808","author":"Zhao","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2024.123337_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.120159","article-title":"Research on phytotoxicity assessment and photosynthetic characteristics of nicosulfuron residues on Beta vulgaris L","volume":"353","author":"Zhao","year":"2024","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.jenvman.2024.123337_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/S0308-8146(98)00102-2","article-title":"The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals","author":"Zhishen","year":"1999","journal-title":"Food Chem."},{"key":"10.1016\/j.jenvman.2024.123337_bib100","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1093\/jxb\/eri319","article-title":"Nitric oxide is involved in abscisic acid-induced antioxidant activities in Stylosanthes guianensis","volume":"56","author":"Zhou","year":"2005","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jenvman.2024.123337_bib101","article-title":"Rhizosphere Protecting soybean yields from enrofloxacin toxicity : the role of Bradyrhizobium japonicum inoculation","volume":"28","author":"Zorman","year":"2023","journal-title":"Rhizosphere"}],"container-title":["Journal of Environmental Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301479724033231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301479724033231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T15:39:47Z","timestamp":1737646787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301479724033231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":99,"alternative-id":["S0301479724033231"],"URL":"https:\/\/doi.org\/10.1016\/j.jenvman.2024.123337","relation":{},"ISSN":["0301-4797"],"issn-type":[{"value":"0301-4797","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide application alleviates fungicide and ampicillin co-exposure induced phytotoxicity by regulating antioxidant defense, detoxification system, and secondary metabolism in wheat seedlings","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Management","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jenvman.2024.123337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123337"}}