{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:49:33Z","timestamp":1785325773998,"version":"3.55.0"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Management"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jenvman.2025.124865","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T10:39:47Z","timestamp":1742553587000},"page":"124865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A comprehensive review on the treatment of pharmaceutically active compounds using moving bed biofilm reactor: A systematic meta-analysis coupled with meta-neural approach"],"prefix":"10.1016","volume":"380","author":[{"given":"Saswata","family":"Sahu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranjal","family":"Ghosal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshit","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha Sarathi","family":"Ghosal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jenvman.2025.124865_bib1","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.scitotenv.2018.06.303","article-title":"Micropollutants removal in tertiary moving bed biofilm reactors (MBBRs): contribution of the biofilm and suspended biomass","volume":"643","author":"Abtahi","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib2","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jclepro.2017.10.100","article-title":"A review of moving-bed biofilm reactor technology for palm oil mill effluent treatment","volume":"171","author":"Abu Bakar","year":"2018","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.jenvman.2025.124865_bib3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jhazmat.2018.11.068","article-title":"Optimizing of pharmaceutical active compounds biodegradability in secondary effluents by \u0392-lactamase from Bacillus subtilis using central composite design","volume":"365","author":"Al-Gheethi","year":"2019","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2025.124865_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2023.110226","article-title":"A review on the application of biofilm-based bioreactors in the removal of pharmaceutically active compounds (PhACs) from wastewater","volume":"11","author":"Alkarim","year":"2023","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jenvman.2025.124865_bib5","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ecoenv.2017.09.060","article-title":"Bacterial community dynamics within an aerobic granular sludge reactor treating wastewater loaded with pharmaceuticals","volume":"147","author":"Amorim","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jenvman.2025.124865_bib6","first-page":"1","article-title":"A systematic review and meta-analysis of stature growth complications in \u03b2-thalassemia major patients","volume":"87","author":"Arab-Zozani","year":"2021","journal-title":"Ann. Glob. Heal."},{"key":"10.1016\/j.jenvman.2025.124865_bib7","article-title":"Recent developments in moving bed biofilm reactor (MBBR) for the treatment of phenolic wastewater -A review","author":"Aslam","year":"2024","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"10.1016\/j.jenvman.2025.124865_bib8","series-title":"Handbook of Environmental Chemistry","first-page":"171","article-title":"Hospital wastewater treatments adopted in Asia, Africa, and Australia","author":"Aukidy","year":"2018"},{"key":"10.1016\/j.jenvman.2025.124865_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2022.113462","article-title":"Evaluation of conventional wastewater treatment plants efficiency to remove microplastics in terms of abundance, size, shape, and type: a systematic review and Meta-analysis","volume":"177","author":"Azizi","year":"2022","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.jenvman.2025.124865_bib10","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jclepro.2018.08.113","article-title":"Treatment of a pesticide industry wastewater mixture in a moving bed biofilm reactor followed by conventional and membrane processes for water reuse","volume":"201","author":"Bachmann Pinto","year":"2018","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.jenvman.2025.124865_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127271","article-title":"Temporal distribution of microbial community in an industrial wastewater treatment system following crash and during recovery periods","volume":"258","author":"Barak","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2025.124865_bib12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jwpe.2015.10.008","article-title":"Impact of carrier filling ratio on oxygen uptake & transfer rate, volumetric oxygen transfer coefficient and energy saving potential in a lab-scale MBBR","volume":"8","author":"Barwal","year":"2015","journal-title":"J. Water Process Eng."},{"key":"10.1016\/j.jenvman.2025.124865_bib13","series-title":"Moving Bed Biofilm Reactor","author":"Bassin","year":"2018"},{"key":"10.1016\/j.jenvman.2025.124865_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.arres.2021.100017","article-title":"Role of malonaldehyde as a surrogate biomarker for iron overload in the \u03b2-thalassemia patient: a systematic meta-analysis","author":"Basu","year":"2021","journal-title":"Adv. Redox Res."},{"key":"10.1016\/j.jenvman.2025.124865_bib15","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.techfore.2005.09.001","article-title":"Forecasting emerging technologies with the aid of science and technology databases","volume":"73","author":"Bengisu","year":"2006","journal-title":"Technol. Forecast. Soc. Change"},{"key":"10.1016\/j.jenvman.2025.124865_bib16","article-title":"Neural network and random forest-based analyses of the performance of community Drinking water arsenic treatment plants","volume":"13","author":"Bhattacharya","year":"2021","journal-title":"Water 2021"},{"key":"10.1016\/j.jenvman.2025.124865_bib17","article-title":"Moving bed biofilm reactor technology in municipal wastewater treatment: a review","author":"Biase","year":"2019","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.jenvman.2025.124865_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2023.137810","article-title":"Towards sustainable physiochemical and biological techniques for the remediation of phenol from wastewater: a review on current applications and removal mechanisms","volume":"417","author":"Bibi","year":"2023","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.jenvman.2025.124865_bib19","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/AEM.06570-11","article-title":"Microbial community composition and dynamics of moving bed biofilm reactor systems treating municipal sewage","volume":"78","author":"Biswas","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jenvman.2025.124865_bib20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.scitotenv.2015.05.099","article-title":"Biodegradation of pharmaceuticals in hospital wastewater by a hybrid biofilm and activated sludge system (Hybas)","volume":"530\u2013531","author":"Casas","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.watres.2015.06.042","article-title":"Biodegradation of pharmaceuticals in hospital wastewater by staged moving bed biofilm reactors (MBBR)","volume":"83","author":"Casas","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.jenvman.2025.124865_bib22","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1007\/s11356-016-7119-x","article-title":"Treatment of a simulated textile wastewater containing the Reactive Orange 16 azo dye by a combination of ozonation and moving-bed biofilm reactor: evaluating the performance, toxicity, and oxidation by-products","volume":"24","author":"Castro","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jenvman.2025.124865_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.125339","article-title":"Response of wastewater treatment performance, microbial composition and functional genes to different C\/N ratios and carrier types in MBBR inoculated with heterotrophic nitrification-aerobic denitrification bacteria","volume":"336","author":"Chen","year":"2021","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142615","article-title":"Quantitative microbial risk assessment and sensitivity analysis for workers exposed to pathogenic bacterial bioaerosols under various aeration modes in two wastewater treatment plants","volume":"755","author":"Chen","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.scitotenv.2019.04.261","article-title":"PAC dosing to an MBBR \u2013 effects on adsorption of micropollutants, nitrification and microbial community","volume":"677","author":"Cimbritz","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib26","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1039\/D0RA10821A","article-title":"Moving-bed biofilm reactor combined with three-dimensional electrochemical pretreatment (MBBR-3DE) for 2,4-D herbicide treatment: application for real wastewater, improvement of biodegradability","volume":"11","author":"Dargahi","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.jenvman.2025.124865_bib27","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.biortech.2014.06.003","article-title":"Co-metabolic oxidation of pharmaceutical compounds by a nitrifying bacterial enrichment","volume":"167","author":"Dawas-Massalha","year":"2014","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2024.141526","article-title":"Olive mill wastewater co-treatment: effect of (electro)Fenton processes and dilution ratio on moving bed biofilm reactor performance","volume":"447","author":"De Carluccio","year":"2024","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.jenvman.2025.124865_bib29","author":"Dezotti"},{"key":"10.1016\/j.jenvman.2025.124865_bib30","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jenvman.2019.06.053","article-title":"Moving bed biofilm reactor technology in municipal wastewater treatment: a review","volume":"247","author":"di Biase","year":"2019","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.jenvman.2025.124865_bib98","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.biortech.2013.08.147","article-title":"The characteristics of extracellular polymeric substances and soluble microbial products in moving bed biofilm reactor-membrane bioreactor","volume":"148","author":"Duan","year":"2013","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib31","first-page":"1","article-title":"Enhanced degradation of naproxen by","volume":"25","author":"Dzionek","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jenvman.2025.124865_bib32","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"Eck","year":"2010","journal-title":"Scientometrics"},{"key":"10.1016\/j.jenvman.2025.124865_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125535","article-title":"Promoting the degradation of organic micropollutants in tertiary moving bed biofilm reactors by controlling growth and redox conditions","volume":"414","author":"Edefell","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2025.124865_bib34","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1016\/j.jece.2018.08.029","article-title":"Application of moving bed biofilm reactor in the removal of pharmaceutical compounds (diclofenac and ibuprofen)","volume":"6","author":"Fatehifar","year":"2018","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jenvman.2025.124865_bib35","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1016\/j.jece.2018.08.029","article-title":"Application of moving bed biofilm reactor in the removal of pharmaceutical compounds (diclofenac and ibuprofen)","volume":"6","author":"Fatehifar","year":"2018","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jenvman.2025.124865_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2020.103881","article-title":"Potential of bacterial consortia obtained from different environments for bioremediation of paroxetine and bezafibrate","volume":"8","author":"Fernandes","year":"2020","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jenvman.2025.124865_bib37","first-page":"781","article-title":"Analysis of microbial population in treatment of wastewater with isooctanol by biopreparation","volume":"9","author":"Fu","year":"2005","journal-title":"J. Shanghai Univ."},{"key":"10.1016\/j.jenvman.2025.124865_bib38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2166\/washdev.2016.134","article-title":"Sewage treatment efficacy and heavy metal removal in moving bed biofilm based treatment plants of northern India","volume":"6","author":"Gani","year":"2016","journal-title":"J. Water, Sanit. Hyg. Dev."},{"key":"10.1016\/j.jenvman.2025.124865_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.saa.2015.01.086","article-title":"Isotherm and kinetics study of malachite green adsorption onto copper nanowires loaded on activated carbon: artificial neural network modeling and genetic algorithm optimization","volume":"142","author":"Ghaedi","year":"2015","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jenvman.2025.124865_bib40","first-page":"1","volume":"vol. 144","author":"Ghosal","year":"2018"},{"key":"10.1016\/j.jenvman.2025.124865_bib41","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5004\/dwt.2021.27617","article-title":"Investigate the simultaneous effect of ph, temperature, and hydraulic retention time in moving bed biofilm reactor: optimization and modelinusing response surface methodology","volume":"235","author":"Golestani","year":"2021","journal-title":"Desalination Water Treat."},{"key":"10.1016\/j.jenvman.2025.124865_bib42","series-title":"Amino Acid Based Bioanalogous Polymers. Synthesis and Study of New Poly (Ester Amide) S Composed of Hydrophobic \u03b1-amino Acids and Dianhydrohexitoles","author":"Gomurashvili","year":"2000"},{"key":"10.1016\/j.jenvman.2025.124865_bib43","article-title":"Biological removal and fate assessment of diclofenac using Bacillus subtilis and brevibacillus laterosporus strains and ecotoxicological effects of diclofenac and 4\u2032-Hydroxy-diclofenac","author":"Grandcl\u00e9ment","year":"2020","journal-title":"J. Chem. 2020"},{"key":"10.1016\/j.jenvman.2025.124865_bib44","article-title":"Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions-a review","author":"Han","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.jenvman.2025.124865_bib46","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.dsx.2020.04.018","article-title":"Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia \u2013 a systematic review, meta-analysis, and meta-regression: diabetes and COVID-19","volume":"14","author":"Huang","year":"2020","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"10.1016\/j.jenvman.2025.124865_bib47","first-page":"8","article-title":"Effect of dose and duration of reduction in dietary sodium on blood pressure levels: systematic review and meta-analysis of randomised trials","volume":"368","author":"Huang","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.jenvman.2025.124865_bib48","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.sleep.2016.08.006","article-title":"Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression","volume":"32","author":"Itani","year":"2017","journal-title":"Sleep Med."},{"key":"10.1016\/j.jenvman.2025.124865_bib49","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.biortech.2017.09.114","article-title":"Effect of hydraulic retention time on the performance of a hybrid moving bed biofilm reactor-membrane bioreactor system for micropollutants removal from municipal wastewater","volume":"247","author":"Jiang","year":"2017","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib50","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/03067319.2020.1855333","article-title":"Pharmaceuticals of emerging concern in hospital wastewater: removal of Ibuprofen and Ofloxacin drugs using MBBR method","volume":"103","author":"Khan","year":"2023","journal-title":"Int. J. Environ. Anal. Chem."},{"key":"10.1016\/j.jenvman.2025.124865_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134243","article-title":"Efficient removal of ibuprofen and ofloxacin pharmaceuticals using biofilm reactors for hospital wastewater treatment","volume":"298","author":"Khan","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2025.124865_bib52","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.scitotenv.2018.08.130","article-title":"Performance of secondary wastewater treatment methods for the removal of contaminants of emerging concern implicated in crop uptake and antibiotic resistance spread: a review","volume":"648","author":"Krzeminski","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib53","article-title":"Occurrence and removal of antibiotics , hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea","author":"Kumar","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111333","article-title":"Modulating the physicochemical and biological properties of carbon dots synthesised from plastic waste for effective sensing of E. coli","volume":"196","author":"Kumari","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jenvman.2025.124865_bib55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cep.2015.03.017","article-title":"Kinetic study of the combined processes of a membrane bioreactor and a hybrid moving bed biofilm reactor-membrane bioreactor with advanced oxidation processes as a post-treatment stage for wastewater treatment","volume":"91","author":"Leyva-D\u00edaz","year":"2015","journal-title":"Chem. Eng. Process. Process Intensif."},{"key":"10.1016\/j.jenvman.2025.124865_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2019.122631","article-title":"Moving bed biofilm reactor as an alternative wastewater treatment process for nutrient removal and recovery in the circular economy model","volume":"299","author":"Leyva-D\u00edaz","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2019.122631","article-title":"Moving bed biofilm reactor as an alternative wastewater treatment process for nutrient removal and recovery in the circular economy model","author":"Leyva-D\u00edaz","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib58","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.3390\/w13233365","article-title":"Glucose addition enhanced the advanced treatment of coking wastewater","volume":"13","author":"Li","year":"2021","journal-title":"Water"},{"key":"10.1016\/j.jenvman.2025.124865_bib59","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jes.2020.11.013","article-title":"Toxic effects of nano-TiO 2 in bivalves \u2014 a synthesis of meta-analysis and bibliometric analysis","volume":"104","author":"Li","year":"2021","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.jenvman.2025.124865_bib60","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.scitotenv.2013.12.065","article-title":"A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment","volume":"473\u2013474","author":"Luo","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib104","doi-asserted-by":"crossref","first-page":"128963","DOI":"10.1016\/j.cej.2021.128963","article-title":"Biodegradation kinetics of organic micropollutants and microbial community dynamics in a moving bed biofilm reactor","volume":"415","author":"Liang","year":"2021","journal-title":"Chem. Eng. j."},{"key":"10.1016\/j.jenvman.2025.124865_bib102","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.watres.2019.04.026","article-title":"Dose-dependent effects of acetate on the biodegradation of pharmaceuticals in moving bed biofilm reactors","volume":"159","author":"Liang","year":"2019","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.jenvman.2025.124865_bib100","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bej.2010.06.005","article-title":"Laccase-catalyzed degradation of anti-inflammatories and estrogens","volume":"51","author":"Lloret","year":"2010","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.jenvman.2025.124865_bib61","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biortech.2014.02.107","article-title":"Removal and fate of micropollutants in a sponge-based moving bed bioreactor","volume":"159","author":"Luo","year":"2014","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13201-022-01662-y","article-title":"Advancement in biological wastewater treatment using hybrid moving bed biofilm reactor (MBBR): a review","volume":"12","author":"Madan","year":"2022","journal-title":"Appl. Water Sci."},{"key":"10.1016\/j.jenvman.2025.124865_bib63","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.psep.2019.12.004","article-title":"Advanced oxidation processes for the removal of organophosphorus pesticides in aqueous matrices: a systematic review and meta-analysis","volume":"134","author":"Malakootian","year":"2020","journal-title":"Process Saf. Environ. Prot."},{"key":"10.1016\/j.jenvman.2025.124865_bib64","article-title":"A bibliometric analysis of industrial wastewater treatments from 1998 to 2019","author":"Mao","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jenvman.2025.124865_bib65","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1515\/aep-2017-0020","article-title":"Dynamics of ibuprofen biodegradation by Bacillus sp. B1(2015b)","volume":"43","author":"Marchlewicz","year":"2017","journal-title":"Arch. Environ. Protect."},{"key":"10.1016\/j.jenvman.2025.124865_bib66","series-title":"R2019a - Updates to the MATLAB and Simulink Product Families - MATLAB & Simulink","year":"2019"},{"key":"10.1016\/j.jenvman.2025.124865_bib67","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jhazmat.2016.06.035","article-title":"Hybrid moving bed biofilm reactor for the biodegradation of benzotriazoles and hydroxy-benzothiazole in wastewater","volume":"323","author":"Mazioti","year":"2017","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2025.124865_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2021.126761","article-title":"Comparative analysis of biorefinery designs based on acetone-butanol-ethanol fermentation under exergetic, techno-economic, and sensitivity analyses towards a sustainability perspective","volume":"298","author":"Meramo-Hurtado","year":"2021","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.jenvman.2025.124865_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.115732","article-title":"Biofilms remember: osmotic stress priming as a microbial management strategy for improving salinity acclimation in nitrifying biofilms","volume":"176","author":"Navada","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.jenvman.2025.124865_bib70","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.biortech.2018.07.077","article-title":"Biological removal of pharmaceuticals from hospital wastewater in a pilot-scale staged moving bed biofilm reactor (MBBR) utilising nitrifying and denitrifying processes","volume":"267","author":"Ooi","year":"2018","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib71","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1529-8817.2010.00934.x","article-title":"Organic carbon supplementation of sterilized municipal wastewater is essential for heterotrophic growth and removing ammonium by the microalga Chlorella Vulgaris 1","volume":"47","author":"Perez\u2010Garcia","year":"2011","journal-title":"J. Phycol."},{"key":"10.1016\/j.jenvman.2025.124865_bib72","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1001\/jama.295.6.676","article-title":"Comparison of two methods to detect publication bias in meta-analysis","volume":"295","author":"Peters","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jenvman.2025.124865_bib73","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1590\/S1413-41522010000100006","article-title":"Biological removal of phenol by use of continuous reactor with Aspergillus Niger inoculum","volume":"15","author":"Pinheiro","year":"2010","journal-title":"Eng. Sanit\u00e1ria Ambient."},{"key":"10.1016\/j.jenvman.2025.124865_bib74","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biortech.2013.04.077","article-title":"Characterization of bacterial communities in hybrid upflow anaerobic sludge blanket (UASB)-membrane bioreactor (MBR) process for berberine antibiotic wastewater treatment","volume":"142","author":"Qiu","year":"2013","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib75","series-title":"A Language and Environment for Statistical Computing","year":"2020"},{"key":"10.1016\/j.jenvman.2025.124865_bib76","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1177\/0962280216688033","article-title":"Deriving percentage study weights in multi-parameter meta-analysis models: with application to meta-regression, network meta-analysis and one-stage individual participant data models","volume":"27","author":"Riley","year":"2017","journal-title":"Stat. Methods Med. Res."},{"key":"10.1016\/j.jenvman.2025.124865_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.128641","article-title":"Elucidating the performance of integrated anoxic\/oxic moving bed biofilm reactor: assessment of organics and nutrients removal and optimization using feed forward back propagation neural network","volume":"371","author":"Saidulu","year":"2023","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2021.128469","article-title":"A review of 3D printing techniques for bio-carrier fabrication","volume":"318","author":"Sfetsas","year":"2021","journal-title":"J. Clean. Prod."},{"issue":"6","key":"10.1016\/j.jenvman.2025.124865_bib101","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.biotechadv.2010.08.001","article-title":"Extracellular polymeric substances (EPS) of microbial aggregates in biological wastewater treatment systems: a review","volume":"28","author":"Sheng","year":"2010","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jenvman.2025.124865_bib79","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s13762-017-1255-9","article-title":"Modelling of moving bed biofilm reactor (MBBR) efficiency on hospital wastewater (HW) treatment: a comprehensive analysis on BOD and COD removal","volume":"14","author":"Shokoohi","year":"2017","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.eti.2023.103108","article-title":"Engineered nanomaterials for water desalination: trends and challenges","volume":"30","author":"Sirohi","year":"2023","journal-title":"Environ. Technol. Innov."},{"key":"10.1016\/j.jenvman.2025.124865_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2022.133930","article-title":"Biosurfactant-driven synergic roles to accelerate biofilm formation in an anaerobic moving bed biofilm reactor (MBBR): a comprehensive analysis on meso and micro scale","volume":"373","author":"Song","year":"2022","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.jenvman.2025.124865_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140660","article-title":"Specific microbial diversity and functional gene (AOB amoA) analysis of a sponge-based aerobic nitrifying moving bed biofilm reactor exposed to typical pharmaceuticals","volume":"742","author":"Song","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.desal.2022.116316","article-title":"Three chambered fuel cell for desalination coupled urea oxidation and hexavalent chromium remediation","volume":"549","author":"Sriram","year":"2023","journal-title":"Desalination"},{"key":"10.1016\/j.jenvman.2025.124865_bib84","first-page":"2004","article-title":"Identification of microbial communities and their removal efficiency of multiple pharmaceutical micropollutants combined in Membrane-Bioreactors","author":"Suleiman","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.jenvman.2025.124865_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.126921","article-title":"Effect of mixing intensity on biodegradation of phenol in a moving bed biofilm reactor: process optimization and external mass transfer study","volume":"351","author":"Swain","year":"2022","journal-title":"Bioresour. Technol."},{"issue":"12","key":"10.1016\/j.jenvman.2025.124865_bib99","doi-asserted-by":"crossref","first-page":"8081","DOI":"10.1007\/s13762-019-02360-0","article-title":"Role of bacterial extracellular polymeric substances (EPS) in uptake and accumulation of co-contaminants","volume":"16","author":"Tahir","year":"2019","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib86","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biortech.2017.03.159","article-title":"Removal of pharmaceuticals in conventionally treated wastewater by a polishing moving bed biofilm reactor (MBBR) with intermittent feeding","volume":"236","author":"Tang","year":"2017","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib87","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biortech.2017.03.159","article-title":"Removal of pharmaceuticals in conventionally treated wastewater by a polishing moving bed biofilm reactor (MBBR) with intermittent feeding","volume":"236","author":"Tang","year":"2017","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib103","doi-asserted-by":"crossref","first-page":"127397","DOI":"10.1016\/j.chemosphere.2020.127397","article-title":"Municipal wastewater treatment targeting pharmaceuticals by a pilot-scale hybrid attached biofilm and activated sludge system (Hybas\u2122)","volume":"259","author":"Tang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2025.124865_bib88","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.watres.2018.03.014","article-title":"Reactor staging influences microbial community composition and diversity of denitrifying MBBRs- Implications on pharmaceutical removal","volume":"138","author":"Torresi","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.jenvman.2025.124865_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.129190","article-title":"Marine associated microbial consortium applied to RBBR textile dye detoxification and decolorization: combined approach and metatranscriptomic analysis","volume":"267","author":"Vieira","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2025.124865_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.124978","article-title":"Co-digestion of sewage sludge and food waste in a wastewater treatment plant based on mainstream anaerobic membrane bioreactor technology: a techno-economic evaluation","volume":"330","author":"Vinardell","year":"2021","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127889","article-title":"Polishing micropollutants in municipal wastewater, using biogenic manganese oxides in a moving bed biofilm reactor (BioMn-MBBR)","volume":"427","author":"Wang","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jenvman.2025.124865_bib92","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/es072026x","article-title":"Effects of pharmaceutically active compounds on a mixed microbial community originating from a municipal wastewater treatment plant","volume":"42","author":"Wang","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jenvman.2025.124865_bib93","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/app.28103","article-title":"Synthesis and characterization of novel biodegradable aromatic\u2013aliphatic poly (ester amide) s containing ethylene oxide moieties","volume":"109","author":"Wang","year":"2008","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.jenvman.2025.124865_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2023.136321","article-title":"Insights into biodegradation of antibiotics during the biofilm-based wastewater treatment processes","volume":"393","author":"Wang","year":"2023","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.jenvman.2025.124865_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142917","article-title":"Microbial diversity reveals the partial denitrification-anammox process serves as a new pathway in the first mainstream anammox plant","volume":"764","author":"Wang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2025.124865_bib96","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/17453670710014284","article-title":"How to interpret a meta-analysis and judge its value as a guide for clinical practice","volume":"78","author":"Zlowodzki","year":"2007","journal-title":"Acta Orthop."},{"key":"10.1016\/j.jenvman.2025.124865_bib97","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.ultsonch.2012.12.003","article-title":"Removal of pharmaceuticals from wastewater by biological processes, hydrodynamic cavitation and UV treatment","volume":"20","author":"Zupanc","year":"2013","journal-title":"Ultrason. Sonochem."}],"container-title":["Journal of Environmental Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301479725008412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301479725008412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T20:23:03Z","timestamp":1750278183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301479725008412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":103,"alternative-id":["S0301479725008412"],"URL":"https:\/\/doi.org\/10.1016\/j.jenvman.2025.124865","relation":{},"ISSN":["0301-4797"],"issn-type":[{"value":"0301-4797","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive review on the treatment of pharmaceutically active compounds using moving bed biofilm reactor: A systematic meta-analysis coupled with meta-neural approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Management","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jenvman.2025.124865","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"124865"}}