{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:46:20Z","timestamp":1785743180437,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002948","name":"Hubei University of Technology","doi-asserted-by":"publisher","award":["HGKFYBP04"],"award-info":[{"award-number":["HGKFYBP04"]}],"id":[{"id":"10.13039\/501100002948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Management"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jenvman.2026.129476","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:19:58Z","timestamp":1774484398000},"page":"129476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effects of ibuprofen and its transformation products on algal-bacterial granular sludge system"],"prefix":"10.1016","volume":"404","author":[{"given":"Jingxin","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-8928","authenticated-orcid":false,"given":"Shulian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jenvman.2026.129476_bib1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.envpol.2017.06.085","article-title":"Histopathological effects, responses of oxidative stress, inflammation, apoptosis biomarkers and alteration of gene expressions related to apoptosis, oxidative stress, and reproductive system in chlorpyrifos-exposed common carp (Cyprinus carpio L.)","volume":"230","author":"Altun","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jenvman.2026.129476_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2025.127563","article-title":"Unraveling the effect of water and ethanol on ibuprofen nanoparticles formation","volume":"428","author":"Anagha","year":"2025","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.jenvman.2026.129476_bib3","series-title":"Standard Methods for the Examination of Water and Wastewater","year":"2012"},{"key":"10.1016\/j.jenvman.2026.129476_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.2276","article-title":"Quality-filtering vastly improves diversity estimates from illumina amplicon sequencing","volume":"10","author":"Bokulich","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jenvman.2026.129476_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138180","article-title":"Impact of ibuprofen on microalgal-bacterial granular sludge: Metabolic pathways, functional gene responses and biodegradation mechanisms","volume":"492","author":"Chen","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jenvman.2026.129476_bib6","article-title":"New insight into the combined effects of ibuprofen and Cu (II) on activated sludge system: system performance, community structure, microbial interaction network","volume":"11","author":"Chen","year":"2023","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jenvman.2026.129476_bib7","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3390\/w17111647","article-title":"Algal\u2013bacterial symbiotic granular sludge technology in wastewater treatment: a review on advances and future prospects","volume":"17","author":"Chen","year":"2025","journal-title":"Water"},{"key":"10.1016\/j.jenvman.2026.129476_bib8","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1021\/es034354c","article-title":"Fluorescence excitation\u2212 emission matrix regional integration to quantify spectra for dissolved organic matter","volume":"37","author":"Chen","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jenvman.2026.129476_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15344\/2456-351X\/2017\/132","article-title":"Application of subsurface bioreactor for wastewater treatment","volume":"2","author":"D\u00f6lle","year":"2017","journal-title":"Int. J. Earth Environ. Sci."},{"key":"10.1016\/j.jenvman.2026.129476_bib10","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jenvman.2026.129476_bib11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.scitotenv.2013.07.068","article-title":"Ibuprofen adsorption in four agricultural volcanic soils","volume":"468","author":"Estevez","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2026.129476_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136327","article-title":"Ibuprofen at environmentally relevant concentrations alters embryonic development, induces teratogenesis and oxidative stress in Cyprinus carpio","volume":"710","author":"Guti\u00e9rrez-Noya","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2026.129476_bib13","doi-asserted-by":"crossref","first-page":"22199","DOI":"10.1021\/acs.jafc.4c05967","article-title":"Identification of a novel ibuprofen biotransformation pathway in Streptomyces sp. D218 and detoxification as indicated by the green algae Scenedesmus obliquus","volume":"72","author":"Huang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jenvman.2026.129476_bib14","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1021\/acsestwater.1c00303","article-title":"Assessment of microalgal-bacterial granular sludge process for environmentally sustainable municipal wastewater treatment","volume":"1","author":"Ji","year":"2021","journal-title":"ACS ES&T Water"},{"key":"10.1016\/j.jenvman.2026.129476_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2020.123531","article-title":"Removal mechanisms of phosphorus in non-aerated microalgal-bacterial granular sludge process","volume":"312","author":"Ji","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2026.129476_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106265","article-title":"Influence of ibuprofen and its biotransformation products on different biological sludge systems and ecosystem","volume":"146","author":"Jia","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.jenvman.2026.129476_bib17","article-title":"Non-steroidal anti-inflammatory drugs and oxidative stress biomarkers in fish: a meta-analytic review","volume":"14","author":"Justi","year":"2025","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.jenvman.2026.129476_bib18","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1007\/s10661-023-11967-3","article-title":"Treatment of pharmaceutical wastewater through activated sludge process\u2014a critical review","volume":"195","author":"Katare","year":"2023","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.jenvman.2026.129476_bib19","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1021\/acs.est.4c13781","article-title":"Bioaccumulation of pharmaceutically active compounds from treated urban wastewaters in aquatic insect larvae and aerial adults","volume":"59","author":"Let","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jenvman.2026.129476_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133940","article-title":"From\" resistance genes expression\" to\" horizontal migration\" as well as over secretion of extracellular polymeric substances: sludge microorganism's response to the increasing of long-term disinfectant stress","volume":"469","author":"Li","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jenvman.2026.129476_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.127104","article-title":"Insight into aerobic phosphorus removal from wastewater in algal-bacterial aerobic granular sludge system","volume":"352","author":"Li","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2026.129476_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128960","article-title":"Marine bacteria-mediated abiotic-biotic coupling degradation mechanism of ibuprofen","volume":"435","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jenvman.2026.129476_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.122270","article-title":"Revisiting iodide species transformation in peracetic acid oxidation: unexpected role of radicals in micropollutants decontamination and iodate formation","volume":"265","author":"Liu","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.jenvman.2026.129476_bib24","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhazmat.2010.01.064","article-title":"Combined advanced oxidation processes for the synergistic degradation of ibuprofen in aqueous environments","volume":"178","author":"Madhavan","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jenvman.2026.129476_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2021.112852","article-title":"Effect of ibuprofen on extracellular polymeric substances (EPS) production and composition, and assessment of microbial structure by quantitative image analysis","volume":"293","author":"Melo","year":"2021","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.jenvman.2026.129476_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.141678","article-title":"Occurrence and fate of pharmaceutical pollutants in wastewater: insights on ecotoxicity, health risk, and state\u2013of\u2013the-art removal","author":"Nguyen","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2026.129476_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jwpe.2019.101061","article-title":"Degradation of widespread pharmaceuticals by activated sludge: kinetic study, toxicity assessment, and comparison with adsorption processes","volume":"33","author":"Quintelas","year":"2020","journal-title":"J. Water Process Eng."},{"key":"10.1016\/j.jenvman.2026.129476_bib28","doi-asserted-by":"crossref","first-page":"10974","DOI":"10.1021\/acs.jpcb.3c06273","article-title":"Computing the relative affinity of chlorophylls a and b to light-harvesting complex II","volume":"127","author":"Ranepura","year":"2023","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jenvman.2026.129476_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142354","article-title":"Ibuprofen degradation by mixed bacterial consortia: Metabolic pathway and microbial community analysis","volume":"359","author":"Rastogi","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.jenvman.2026.129476_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2021.113694","article-title":"A review on environmental occurrence, toxicity and microbial degradation of non-steroidal anti-inflammatory drugs (NSAIDs)","volume":"300","author":"Rastogi","year":"2021","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.jenvman.2026.129476_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.nexus.2022.100076","article-title":"Pharmaceutical wastewater as Emerging Contaminants (EC): treatment technologies, impact on environment and human health","volume":"6","author":"Samal","year":"2022","journal-title":"Energy Nexus"},{"key":"10.1016\/j.jenvman.2026.129476_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.147096","article-title":"Preparation of hydroxyapatite (HAP) from waste eggshells for enhancing the granulation and treatment performance of aerobic granular sludge: enhancement effects and mechanism insights","volume":"477","author":"Shi","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jenvman.2026.129476_bib33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s43247-024-01499-0","article-title":"Microalgal-bacterial granular sludge can remove complex organics from municipal wastewater with algae-bacteria interactions","volume":"5","author":"Shi","year":"2024","journal-title":"Commun. Earth Environ."},{"key":"10.1016\/j.jenvman.2026.129476_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2025.132516","article-title":"Metabolic responses of microalgal-bacterial granular sludge to enrofloxacin and sulfamethoxazole exposure","volume":"429","author":"Shi","year":"2025","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2026.129476_bib35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jenvman.2026.129476_bib36","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/ismej.2012.22","article-title":"Stochastic and deterministic assembly processes in subsurface microbial communities","volume":"6","author":"Stegen","year":"2012","journal-title":"ISME J."},{"key":"10.1016\/j.jenvman.2026.129476_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136176","article-title":"Photosynthetic toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) on green algae Scenedesmus obliquus","volume":"707","author":"Wang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2026.129476_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137192","article-title":"Impact of ibuprofen on nitrogen removal performance and its biotransformation in a coupled sulfur autotrophic denitrification and anammox system","volume":"487","author":"Wang","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jenvman.2026.129476_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.179670","article-title":"Algae-driven bacterial production of extracellular reactive oxygen species for emerging contaminants degradation","volume":"982","author":"Wang","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2026.129476_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148682","article-title":"Effect of EPS and its forms of aerobic granular sludge on sludge aggregation performance during granulation process based on XDLVO theory","volume":"795","author":"Wang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2026.129476_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164600","article-title":"Occurrence, removal and risk evaluation of ibuprofen and acetaminophen in municipal wastewater treatment plants: a critical review","volume":"891","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jenvman.2026.129476_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.116699","article-title":"New roles for Bacillus thuringiensis in the removal of environmental pollutants","volume":"236","author":"Wu","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.jenvman.2026.129476_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.129261","article-title":"Effect of ibuprofen on the sulfur autotrophic denitrification process and microbial toxic response mechanism","volume":"384","author":"Xu","year":"2023","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jenvman.2026.129476_bib44","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.3390\/w15213833","article-title":"Over-produced extracellular polymeric substances and activated antioxidant enzymes attribute to resistance of Pb (II) for algal\u2013bacterial granular sludge in municipal wastewater treatment","volume":"15","author":"Yang","year":"2023","journal-title":"Water"},{"key":"10.1016\/j.jenvman.2026.129476_bib45","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.desal.2011.03.078","article-title":"Degradation of the emerging contaminant ibuprofen in aqueous solution by gamma irradiation","volume":"276","author":"Zheng","year":"2011","journal-title":"Desalination"},{"key":"10.1016\/j.jenvman.2026.129476_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123635","article-title":"Deciphering the core bacterial community structure and function and their response to environmental factors in activated sludge from pharmaceutical wastewater treatment plants","volume":"346","author":"Zheng","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jenvman.2026.129476_bib47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jenvman.2019.05.044","article-title":"Chemical composition of extracellular polymeric substances and evolution of microbial community in activated sludge exposed to ibuprofen","volume":"246","author":"Zhou","year":"2019","journal-title":"J. Environ. Manag."}],"container-title":["Journal of Environmental Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301479726009369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301479726009369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:02:39Z","timestamp":1785740559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301479726009369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":47,"alternative-id":["S0301479726009369"],"URL":"https:\/\/doi.org\/10.1016\/j.jenvman.2026.129476","relation":{},"ISSN":["0301-4797"],"issn-type":[{"value":"0301-4797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of ibuprofen and its transformation products on algal-bacterial granular sludge system","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Management","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jenvman.2026.129476","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"129476"}}