{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:54:43Z","timestamp":1790672083713,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.jep.2003.12.005","type":"journal-article","created":{"date-parts":[[2004,1,20]],"date-time":"2004-01-20T10:18:45Z","timestamp":1074593925000},"page":"159-165","source":"Crossref","is-referenced-by-count":16,"title":["In vitro effects of aqueous seeds extract of Acacia cyanophylla on the opsonized zymosan-induced superoxide anions production by rat polymorphonuclear leukocytes"],"prefix":"10.1016","volume":"91","author":[{"given":"Ahmed","family":"El Abbouyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Toumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"El Hachimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akino","family":"Jossang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2003.12.005_BIB1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/(SICI)1099-1573(199912)13:8<683::AID-PTR534>3.0.CO;2-X","article-title":"The pharmacological effects of an aqueous extract from Acacia nilotica seeds","volume":"13","author":"Amos","year":"1999","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2003.12.005_BIB2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-8741(00)00234-8","article-title":"Evaluation of the immunomodulatory effects of five herbal plants","volume":"72","author":"Amirghofran","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2003.12.005_BIB3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0047-6374(84)90121-0","article-title":"Non-specific immunity in aging. Deficiency of monocyte and polymorphonuclear cell-mediated functions","volume":"24","author":"Antonaci","year":"1984","journal-title":"Mechanisms of Ageing and Development"},{"key":"10.1016\/j.jep.2003.12.005_BIB4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-8741(00)00281-6","article-title":"Effect of Ocimum sanctum on noice induced changes in neutrophil functions","volume":"73","author":"Archana","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2003.12.005_BIB5","unstructured":"Bellakhdar, J., 1997. La Pharmacop\u00e9e Marocaine Traditionnelle. Ibis Press, France."},{"key":"10.1016\/j.jep.2003.12.005_BIB6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-8741(99)00010-0","article-title":"In vivo and in vitro immunomodulatory activities of Trichilia glabra aqueous leaf extracts","volume":"69","author":"Benencia","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2003.12.005_BIB7","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.2042-7158.1988.tb05178.x","article-title":"Effects of indomethacin and diclofenac on some functions of polymorphonuclear neutrophils","volume":"40","author":"Berradia","year":"1988","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.jep.2003.12.005_BIB8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(00)00334-2","article-title":"Shosaiko-to and other kampo (Japanese herbal) medicines: a review of their immunomodulatory activities","volume":"73","author":"Borchers","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2003.12.005_BIB9","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1021\/jf0100907","article-title":"Antioxidant activity of extracts from Acacia confusa bark and heartwood","volume":"49","author":"Chang","year":"2001","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2003.12.005_BIB10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1142\/S0192415X96000323","article-title":"Investigation of the anti-intlammatory activity of Acacia nilotica and Hibiscus sabdariffa","volume":"24","author":"Dafallah","year":"1996","journal-title":"American Journal of Chinese Medicine"},{"key":"10.1016\/j.jep.2003.12.005_BIB11","first-page":"807","article-title":"Etude du comportement des polynucl\u00e9aires sanguins au cours de la spondylarthrite ankylosante","volume":"54","author":"El Abbouyi","year":"1987","journal-title":"Revue de Rhumatisme"},{"key":"10.1016\/j.jep.2003.12.005_BIB12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0047-6374(88)90023-1","article-title":"In vitro and in vivo effects produced by the immunomodulating agent RU 41740 on human polymorphonuclear leukocytes in the elderly","volume":"44","author":"El Abbouyi","year":"1988","journal-title":"Mechanisms of Ageing and Development"},{"key":"10.1016\/j.jep.2003.12.005_BIB13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1440-1681.1990.tb01285.x","article-title":"Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin","volume":"17","author":"Gard","year":"1990","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"10.1016\/j.jep.2003.12.005_BIB14","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/BF01982869","article-title":"Stimulation of neutrophil oxidative metabolism by indomethacin","volume":"16","author":"Gay","year":"1985","journal-title":"Agents and Actions"},{"key":"10.1016\/j.jep.2003.12.005_BIB15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1189\/jlb.69.2.191","article-title":"Chronic granulomatous disease: more than the lack of superoxide?","volume":"69","author":"Geiszt","year":"2001","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.jep.2003.12.005_BIB16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1017\/S0007114500001252","article-title":"Effect of polyethylene glycol on in vitro degradability of nitrogen and microbial protein synthesis from tannin-rich browse and herbaceous legumes","volume":"84","author":"Getachew","year":"2000","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.jep.2003.12.005_BIB17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1017\/S0022149X00015340","article-title":"Cestocidal activity of Acacia auriculiformis","volume":"70","author":"Ghosh","year":"1996","journal-title":"Journal of Helminthology"},{"key":"10.1016\/j.jep.2003.12.005_BIB18","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/(SICI)1099-1573(199912)13:8<665::AID-PTR563>3.0.CO;2-T","article-title":"Studies on antihypertensive and antispasmodic activities of methanol extract of Acacia nilotica pods","volume":"13","author":"Gilani","year":"1999","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2003.12.005_BIB19","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/1099-1573(200011)14:7<510::AID-PTR646>3.0.CO;2-B","article-title":"Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease","volume":"14","author":"Hussein","year":"2000","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2003.12.005_BIB20","first-page":"995","article-title":"Anti-inflammatory properties of Go 6850: a selective inhibitor of protein kinase C","volume":"275","author":"Jacobson","year":"1995","journal-title":"Journal of Pharmacology and Experimental Therapy"},{"key":"10.1016\/j.jep.2003.12.005_BIB21","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1172\/JCI108055","article-title":"The role of superoxide anions generation in phagocytic bactericidal activity","volume":"55","author":"Johnston","year":"1975","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.jep.2003.12.005_BIB22","first-page":"841","article-title":"Stimulation of mouse peritoneal macrophages by lignin-related substances","volume":"11","author":"Kikuchi","year":"1991","journal-title":"Anticancer Research"},{"key":"10.1016\/j.jep.2003.12.005_BIB23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1179\/135100001101536003","article-title":"Evaluation of the process for superoxide production by NADPH oxidase in human neutrophils: evidence for cytoplasmic origin of superoxide","volume":"6","author":"Kobayashi","year":"2001","journal-title":"Redox Report"},{"key":"10.1016\/j.jep.2003.12.005_BIB24","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1248\/cpb.38.3031","article-title":"Lignified materials as potential medicinal resources. III. Diversity of biological activity and possible molecular species involved","volume":"38","author":"Oh Hara","year":"1990","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2003.12.005_BIB25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF02864559","article-title":"Tannins from Mimosoid legumes of Texas and Mexico","volume":"55","author":"Readel","year":"2001","journal-title":"Economic Botany"},{"key":"10.1016\/j.jep.2003.12.005_BIB26","first-page":"199","article-title":"Modulation by RU 41740 of oxidative metabolism and migration of rat polymorphonuclear leukocytes collected after induction of immune and non-immune inflammations","volume":"7","author":"Roch-Arveiller","year":"1987","journal-title":"Journal of Biological Response Modifiers"},{"key":"10.1016\/j.jep.2003.12.005_BIB27","first-page":"1523","article-title":"Stimulation of granulocytic cell iodination by tannins and related compounds","volume":"10","author":"Sakagami","year":"1990","journal-title":"Anticancer Research"},{"key":"10.1016\/j.jep.2003.12.005_BIB28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jlb.49.3.277","article-title":"Stimulation of human peripheral blood polymorphonuclear cell iodination by lignin-related substances","volume":"49","author":"Sakagami","year":"1991","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.jep.2003.12.005_BIB29","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1248\/cpb.39.950","article-title":"Lignified material as a potential medicinal resource. IV. Dehydrogenation polymers of some phenylpropenoids and their capacity of stimulate polymorphonuclear cell iodination","volume":"39","author":"Sakagami","year":"1991","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2003.12.005_BIB30","first-page":"293","article-title":"Induction of endogenous TNF production by biological response modifiers and bacterial preparations (review)","volume":"1","author":"Sakagami","year":"1992","journal-title":"International Journal of Oncology"},{"key":"10.1016\/j.jep.2003.12.005_BIB31","first-page":"155","article-title":"Prevention of oral diseases by polyphenols (review)","volume":"13","author":"Sakagami","year":"1999","journal-title":"In vivo"},{"key":"10.1016\/j.jep.2003.12.005_BIB32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/jmicro\/51.2.87","article-title":"Study of NADPH oxidase-activated sites in human neutrophils","volume":"51","author":"Segushi","year":"2002","journal-title":"Journal of Electron Microscopy"},{"key":"10.1016\/j.jep.2003.12.005_BIB33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0306-3623(96)00413-2","article-title":"The antiplatelet aggregatory activity of Acacia nilotica is due to blockade of calcium influx through membrane calcium channels","volume":"29","author":"Shah","year":"1997","journal-title":"General Pharmacology"},{"key":"10.1016\/j.jep.2003.12.005_BIB34","first-page":"432","article-title":"Effect of tannin-rich plant (Acacia nilotica) on some nutritional and bacteriological parameters ingoats","volume":"104","author":"Sotohy","year":"1997","journal-title":"Deutsche Tierarztliche Wochenschrift"},{"key":"10.1016\/j.jep.2003.12.005_BIB35","first-page":"237","article-title":"Comparison of neutrophil chemotactic factor release by human and rabbit alveolar macrophages in response to tannin exposure","volume":"125","author":"Specks","year":"1995","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"10.1016\/j.jep.2003.12.005_BIB36","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1021\/np000347f","article-title":"Kinmonosides A\u2013C, three new cytotoxic saponins from the fruits of Acacia concinna, a medicinal plant collected in myanmar","volume":"63","author":"Tezuka","year":"2000","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2003.12.005_BIB37","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0006-2952(90)90556-Z","article-title":"Effects of non-steroidal anti-inflammatory drugs on human neutrophil NADPH oxidase in both whole cell and cell-free systems","volume":"40","author":"Umeki","year":"1990","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2003.12.005_BIB38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1165\/ajrcmb\/3.3.235","article-title":"Modulation of inflammatory cell function by cotton bract tannin: changes in the capacity of alveolar macrophages and neutrophils to produce hydrogen peroxide","volume":"3","author":"Vuk-Pavlovic","year":"1990","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.jep.2003.12.005_BIB39","first-page":"208","article-title":"Effects of Acacia arabica and Caralluma edulis on blood glucose levels of normal and alloxan diabectic rabbits","volume":"39","author":"Wadood","year":"1989","journal-title":"Journal of the Pakistan Medical Association"},{"key":"10.1016\/j.jep.2003.12.005_BIB40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02027156","article-title":"Calcium pyrophosphate induced pleurisy in rat: a new model of acute inflammation","volume":"5","author":"Willoughby","year":"1975","journal-title":"Agents and Actions"},{"key":"10.1016\/j.jep.2003.12.005_BIB41","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1248\/cpb.39.1075","article-title":"Inhibitory effects of non-steroidal anti-inflammatory drugs on superoxide generation","volume":"39","author":"Yuda","year":"1991","journal-title":"Chemical and Pharmaceutical Bulletin Tokyo"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887410300446X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887410300446X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T19:22:50Z","timestamp":1682623370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887410300446X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S037887410300446X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2003.12.005","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}