{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:13:50Z","timestamp":1771013630520,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.jep.2005.01.063","type":"journal-article","created":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T07:41:18Z","timestamp":1114069278000},"page":"145-152","source":"Crossref","is-referenced-by-count":47,"title":["Antihemorrhagic, antinucleolytic and other antiophidian properties of the aqueous extract from Pentaclethra macroloba"],"prefix":"10.1016","volume":"100","author":[{"given":"Jociv\u00e2nia O.","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana S.","family":"Coppede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa C.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina D.","family":"Sant\u2019Ana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio K.","family":"Ticli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio V.","family":"Mazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 R.","family":"Giglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo S.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreimar M.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suely V.","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2005.01.063_bib1","first-page":"19","article-title":"Anticrotalic and antitumoral activities of gel filtration fractions of aqueous extract from Tabernaemontana catharinensis (Apocynaceae)","volume":"137C","author":"de Almeida","year":"2004","journal-title":"Comparative Biochemistry and Physiology"},{"key":"10.1016\/j.jep.2005.01.063_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0300-9084(00)01150-0","article-title":"Myotoxic phospholipases A2 in Bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxin from Bothrops jararacussu","volume":"82","author":"Andri\u00e3o-Escarso","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.jep.2005.01.063_bib3","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/0041-0101(87)90134-6","article-title":"Evidence that Crotalus durissus terrificus (South American rattlesnake) envenomation in humans causes myolysis rather than hemolysis","volume":"25","author":"Azevedo-Marques","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib4","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1055\/s-2000-8577","article-title":"Inhibition of the lethal and myotoxic activities of Crotalus durissus terrificus venom by Tabernaemontana catharinensis: identification of one of the active components","volume":"66","author":"Batina","year":"2000","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2005.01.063_bib5","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0300-9084(03)00138-X","article-title":"Inhibition of enzymatic and pharmacological activities of some snake venoms and toxins by Mandevilla velutina (Apocynaceae) aqueous extract","volume":"85","author":"Biondo","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.jep.2005.01.063_bib6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00299-003-0722-6","article-title":"Direct organogenesis of Mandevilla illustris (Vell) Woodson and effects of its aqueous extract on the enzymatic and toxic activities of Crotalus durissus terrificus snake venom","volume":"22","author":"Biondo","year":"2004","journal-title":"Plant Cell Report"},{"key":"10.1016\/j.jep.2005.01.063_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0305-0491(00)00237-6","article-title":"Effects of aqueous extract of Casearia silvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A2","volume":"127","author":"Borges","year":"2000","journal-title":"Comparative Biochemistry and Physiology"},{"key":"10.1016\/j.jep.2005.01.063_bib8","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/S0041-0101(01)00169-6","article-title":"Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae)","volume":"39","author":"Borges","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib9","doi-asserted-by":"crossref","unstructured":"Esmeraldino, L.E., Souza, A.M., Sampaio, S.V., 2005. Evaluation of the effect of aqueous extract extract of Croton urucurana Baillon (Euphorbiaceae) on the hemorrhagic activity induced by the venom of B. jararaca using new techniques to quantify hemorrhagic activity in rat skin. Phytomedicine, in press.","DOI":"10.1016\/j.phymed.2004.01.012"},{"key":"10.1016\/j.jep.2005.01.063_bib10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/10575630290033169","article-title":"Quinovic acid glycosides from Mitragyna stipulosa\u2014first examples of natural inhibitors of snake venom phosphodiesterase I","volume":"16","author":"Fatima","year":"2002","journal-title":"Natural Product Letters"},{"key":"10.1016\/j.jep.2005.01.063_bib11","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/0041-0101(92)90437-A","article-title":"Antivenom and biological effects of ar-tumerone isolated from Curcuma longa (Zingiberiaceae)","volume":"30","author":"Ferreira","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0041-0101(89)90096-2","article-title":"Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rica crotaline snake venoms and their neutralization by a polyvalent antivenom","volume":"27","author":"Gen\u00e9","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib13","series-title":"Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism","first-page":"205","article-title":"Interaction of snake venom phospholipases A2 with plant isolates","author":"Gowda","year":"1997"},{"key":"10.1016\/j.jep.2005.01.063_bib14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0041-0101(88)90010-4","article-title":"An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica","volume":"26","author":"Guti\u00e9rrez","year":"1988","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib15","series-title":"Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism","first-page":"321","article-title":"Phospholipases A2 myotoxins from Bothrops snake venoms","author":"Guti\u00e9rrez","year":"1997"},{"key":"10.1016\/j.jep.2005.01.063_bib16","first-page":"377","article-title":"Comprendiendo los venenos de serpientes: 50 a\u00f1os de investigaciones en Am\u00e9rica Latina","volume":"50","author":"Guti\u00e9rrez","year":"2002","journal-title":"Revista de Biologia Tropical"},{"key":"10.1016\/j.jep.2005.01.063_bib17","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0300-9084(03)00126-3","article-title":"Neutralization of some hematological and hemostatic alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi pauloensis snake venom, by the aqueous extract from Casearia mariquitensis (Flacourtiaceae)","volume":"85","author":"Izidoro","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.jep.2005.01.063_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cbi.2004.09.016","article-title":"Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): anti-proteolytic and anti-hemorrhagic properties","volume":"150","author":"Janu\u00e1rio","year":"2004","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.jep.2005.01.063_bib19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.toxicon.2003.11.007","article-title":"Natural phospholipase A2 myotoxin inhibitor proteins from snakes, mammals and plants","volume":"42","author":"Lizano","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib20","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0041-0101(98)00126-3","article-title":"Snake venoms and the hemostatic system","volume":"36","author":"Markland","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib21","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0041-0101(92)90429-9","article-title":"Plant with a reputation against snakebite","volume":"30","author":"Martz","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.toxicon.2004.06.002","article-title":"A new hemorrhagic metalloprotease from Bothrops jararacussu snake venom: isolation and biochemical characterization","volume":"44","author":"Mazzi","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0031-9422(00)00229-6","article-title":"Plant natural products active against snake-bite the molecular approach","volume":"55","author":"Mors","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2005.01.063_bib24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/jcp.2003.014472","article-title":"Membrane associated proteases and their inhibitors in tumor angiogenisis","volume":"57","author":"Noe","year":"2004","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.jep.2005.01.063_bib25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.patbio.2004.02.002","article-title":"Involvement of matrix metalloproteinases (MMPs) in cutaneousmelanoma progression","volume":"52","author":"Ntayi","year":"2004","journal-title":"Pathologie Biologie"},{"key":"10.1016\/j.jep.2005.01.063_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/15569549809009250","article-title":"Structure, function and biophysical aspects of the myotoxins from snake venoms","volume":"17","author":"Ownby","year":"1998","journal-title":"Journal of Toxicology-Toxin Reviews"},{"key":"10.1016\/j.jep.2005.01.063_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/B:HREV.0000011395.11179.af","article-title":"Matrix metalloproteinase inhibitor development and remodeling of drug discovery","volume":"9","author":"Peterson","year":"2004","journal-title":"Heart Failure Reviews"},{"key":"10.1016\/j.jep.2005.01.063_bib28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/abbi.2000.1958","article-title":"Structural and functional characterization of neuwiedase, a non-hemorrhagic fibrin(ogen)olytic metalloprotease from Bothrops neuwiedi snake venom","volume":"381","author":"Rodrigues","year":"2000","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.jep.2005.01.063_bib29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1532-0456(03)00169-8","article-title":"Hydrolysis of DNA by 17 snake venoms","volume":"135","author":"de Roodt","year":"2003","journal-title":"Comparative Biochemistry and Physiology C: Toxicology and Pharmacology"},{"key":"10.1016\/j.jep.2005.01.063_bib30","series-title":"Handbook of Toxinology","article-title":"Phospholipases","author":"Rosenberg","year":"1990"},{"key":"10.1016\/j.jep.2005.01.063_bib31","first-page":"1091","article-title":"Inhibition of proteases, myotoxins and phospholipases A2 from Bothrops venoms by the heteromeric protein complex of Didelphis albiventris opossum serum","volume":"43","author":"Soares","year":"1997","journal-title":"Biochemistry and Molecular Biology International"},{"key":"10.1016\/j.jep.2005.01.063_bib32","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.toxicon.2003.11.004","article-title":"Chemical modifications on phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties","volume":"42","author":"Soares","year":"2003","journal-title":"Review Toxicon"},{"key":"10.1016\/j.jep.2005.01.063_bib33","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.2174\/1385272043369610","article-title":"Phospholipase A2 myotoxins from Bothrops snake venoms: structure\u2013function relationship","volume":"8","author":"Soares","year":"2004","journal-title":"Current Organic Chemistry"},{"key":"10.1016\/j.jep.2005.01.063_bib34","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1358\/dof.2004.029.11.851973","article-title":"Neutralizing effects of snake venoms exhibited by Brazilian plants","volume":"29","author":"Soares","year":"2004","journal-title":"Drugs Future"},{"key":"10.1016\/j.jep.2005.01.063_bib35","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/pro.5560040502","article-title":"The metzincins\u2014topological and sequential relation between theastacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases","volume":"4","author":"St\u00f6cker","year":"1995","journal-title":"Protein Science"},{"key":"10.1016\/j.jep.2005.01.063_bib36","doi-asserted-by":"crossref","unstructured":"Ticli, F.K., Cambraia, R.S., Hage, L.I., Pereira, P.S., Magro, A., Fontes, M.R., Fran\u00e7a, S.C., Giglio, J.R., Soares, A.M., Sampaio, S.V., 2005. Rosmarinic acid, a new phospholipase A2 snake venom inhibitor from Cordia verbenacea (Boraginaceae): anti-inflammatory and anti-myotoxic properties. Toxicon, in press.","DOI":"10.1016\/j.toxicon.2005.04.023"},{"key":"10.1016\/j.jep.2005.01.063_bib37","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0006-2952(01)00800-0","article-title":"Inhibitory properties of the anti-bothropic complex from Didelphis albiventris serum on toxic and pharmacological actions of metalloproteases and myotoxins from Bothrops asper venom","volume":"62","author":"Trento","year":"2001","journal-title":"Biochemistry and Pharmacology"},{"key":"10.1016\/j.jep.2005.01.063_bib38","doi-asserted-by":"crossref","unstructured":"Veronese, E.L.G., Esmeraldino, L.E., Trombone, A.P.F., Santana, A.E., Bechara, G.H., Ketelhut, I., Cintra, A.C.O., Giglio, J.R., Sampaio, S.V., 2005. Inhibition of the myotoxic activity of Bothrops jararacussu venom and its two major myotoxins BthTX-I and BthTX-II, by the aqueous extract from Tabernaemontana catharinensis A.DC. (Apocynaceae). Phytomedicine 11, in press.","DOI":"10.1016\/j.phymed.2003.07.010"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874105002126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874105002126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T23:36:40Z","timestamp":1550187400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874105002126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0378874105002126"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2005.01.063","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}