{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:22:19Z","timestamp":1788546139217,"version":"build-2803163510"},"reference-count":58,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.jep.2005.09.007","type":"journal-article","created":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T11:24:09Z","timestamp":1130325849000},"page":"215-224","source":"Crossref","is-referenced-by-count":42,"title":["Antiulcerogenic activity of Alchornea castaneaefolia: Effects on somatostatin, gastrin and prostaglandin"],"prefix":"10.1016","volume":"104","author":[{"given":"Cl\u00e9lia Akiko","family":"Hiruma-Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Roberta","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clenilson Martins","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Donizete Pezzuto","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner","family":"Vilegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba Regina Monteiro Souza","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2005.09.007_bib1","series-title":"Carbon-13 NMR of Flavonoids","author":"Agrawal","year":"1989"},{"key":"10.1016\/j.jep.2005.09.007_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0367-326X(00)00131-3","article-title":"Antibacterial activity of Alchornea cordifolia stem bark","volume":"71","author":"Ajali","year":"2000","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2005.09.007_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0014-2999(03)01909-5","article-title":"Antiulcerogenic effect and cytotoxic activity of semi-synthetic crotonin obtained from Croton cajucara Benth","volume":"472","author":"Almeida","year":"2003","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib4","series-title":"Cerrado: esp\u00e9cies vegetais \u00fateis","author":"Almeida","year":"1998"},{"key":"10.1016\/j.jep.2005.09.007_bib5","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0271-5317(99)00080-9","article-title":"Acute and chronic stress-induced oxidative gastrointestinal injury in rats, and the protective ability of a novel grape seed proanthocyanidin extract","volume":"19","author":"Bagchi","year":"1999","journal-title":"Nutrition Research"},{"key":"10.1016\/j.jep.2005.09.007_bib6","first-page":"55","article-title":"Role of reactive oxygen species in mercaptomethlimidazole-induced gastric acid secretion and stress-induced gastric ulceration","volume":"76","author":"Bandyopadhyay","year":"1999","journal-title":"Current Science"},{"key":"10.1016\/j.jep.2005.09.007_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0378-8741(02)00121-6","article-title":"In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent: ellagic acid","volume":"81","author":"Banzouzi","year":"2002","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib8","first-page":"65","article-title":"Observational survey of NSAID-related upper gastro-intestinal adverse events in Belgium","volume":"65","author":"Belaiche","year":"2002","journal-title":"Acta Gastroenterology"},{"key":"10.1016\/j.jep.2005.09.007_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/1099-1573(200012)14:8<581::AID-PTR776>3.0.CO;2-S","article-title":"The plant kingdom as a source of anti-ulcer remedies","volume":"14","author":"Borrelli","year":"2000","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2005.09.007_bib10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(02)11030-0","article-title":"Peptic-ulcer disease","volume":"360","author":"Chan","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2005.09.007_bib11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1139\/y95-018","article-title":"Intraluminal pH modulates gastric prostaglandin synthesis","volume":"73","author":"Curtis","year":"1995","journal-title":"Canadian Journal Physiology and Pharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib12","series-title":"Amazonian Ethnobotanical Dictionary","author":"Duke","year":"1994"},{"key":"10.1016\/j.jep.2005.09.007_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0367-326X(00)00254-9","article-title":"Antimicrobial activities of Alchornea cordifolia","volume":"72","author":"Ebi","year":"2001","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2005.09.007_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2165\/00002018-200124010-00004","article-title":"Nephrotoxicity and hepatotoxicity of histamine H2 receptor antagonists","volume":"24","author":"Fisher","year":"2001","journal-title":"Drug Safety"},{"key":"10.1016\/j.jep.2005.09.007_bib15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0301-0546(02)79150-7","article-title":"Anaphylaxis to proton pump inhibitors","volume":"30","author":"Gonzalez","year":"2002","journal-title":"Allergie Immunopathology"},{"key":"10.1016\/j.jep.2005.09.007_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1248\/bpb.25.487","article-title":"Effects of tea from Turnera ulmifolia L. on mouse gastric mucosa support the Turneraceae as a new source of antiulcerogenic drugs","volume":"25","author":"Gracioso","year":"2002","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2005.09.007_bib17","series-title":"The Flavonoids. Advances in Research Since 1986","author":"Harborne","year":"1996"},{"key":"10.1016\/j.jep.2005.09.007_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(02)00298-X","article-title":"The biochemistry and medical significance of the flavonoids review","volume":"96","author":"Havsteen","year":"2002","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.jep.2005.09.007_bib19","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1078\/09447110260573155","article-title":"Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa","volume":"9","author":"Hiruma-Lima","year":"2002","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2005.09.007_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0014-2999(94)90720-X","article-title":"Cimetidine and omeprazole accelerate gastric ulcer healing by an increase in gastrin secretion","volume":"263","author":"Ito","year":"1994","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib21","first-page":"2","article-title":"Research applications","volume":"II","author":"Krous","year":"1980"},{"key":"10.1016\/j.jep.2005.09.007_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-8741(99)00174-9","article-title":"Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions","volume":"71","author":"LaCasa","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib23","series-title":"Peptic Ulcer","first-page":"92","article-title":"A method for rapid production of stress ulcers in rats","author":"Levine","year":"1971"},{"key":"10.1016\/j.jep.2005.09.007_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0079-6468(08)70365-5","article-title":"Anti-ulcer drugs of plant origin","volume":"28","author":"Lewis","year":"1991","journal-title":"Progress in Medicinal Chemistry"},{"key":"10.1016\/j.jep.2005.09.007_bib25","first-page":"99","article-title":"A simplified method of evaluation dose-effect experiments","volume":"95","author":"Litchfield","year":"1949","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2005.09.007_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/00365521.1974.12096899","article-title":"Influence of feeding and sham feeding upon serum gastrin and gastric acid secretion in control subjects and duodenal ulcer patients","volume":"9","author":"Mayer","year":"1974","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2005.09.007_bib27","first-page":"13","article-title":"The role of gastrin in ulcer pathogenesis. Bailliere's Best Practice & Research","volume":"14","author":"McColl","year":"2000","journal-title":"Clinical Gastroenterology"},{"key":"10.1016\/j.jep.2005.09.007_bib28","series-title":"Cerrado ambiente e flora","first-page":"286","article-title":"Flora vascular do Cerrado","author":"Mendon\u00e7a","year":"1998"},{"key":"10.1016\/j.jep.2005.09.007_bib29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1254\/jjp.33.939","article-title":"Effect of polyamines on acidified ethanol-induced gastric lesions in rats","volume":"33","author":"Mizui","year":"1983","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib30","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1440-1746.1998.tb00641.x","article-title":"Acute in vivo effect of octreotide acetate, a somatostatin analogue on the cellular function of gastric mucosa in the rat","volume":"13","author":"Motegi","year":"1998","journal-title":"Journal Gastroenterology and Hepatology"},{"key":"10.1016\/j.jep.2005.09.007_bib31","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/35002501","article-title":"Biodiversity hotspots for conservation priorities","volume":"403","author":"Myers","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jep.2005.09.007_bib32","first-page":"421","article-title":"Smooth muscle relaxing flavonoids from Alchornea cordifolia","volume":"2","author":"Ogungbamila","year":"1990","journal-title":"Acta Pharmaceutica Nordica"},{"key":"10.1016\/j.jep.2005.09.007_bib33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF02235252","article-title":"A method for experimental, penetrating gastric and duodenal ulcers in rats. Observations on normal healing","volume":"6","author":"Okabe","year":"1971","journal-title":"American Journal of Digestion Disease"},{"key":"10.1016\/j.jep.2005.09.007_bib34","series-title":"Guide to the Care and Use of Experimental Animals","author":"Olfert","year":"1993"},{"key":"10.1016\/j.jep.2005.09.007_bib35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00002800-200311000-00008","article-title":"Gastric ulcers and GERD: the new \u201cplagues\u201d of the 21st century update for the clinical nurse specialist","volume":"17","author":"O\u2019Malley","year":"2003","journal-title":"Clinical Nurse Specialist"},{"key":"10.1016\/j.jep.2005.09.007_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-8741(03)00195-8","article-title":"Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves","volume":"89","author":"Osadebe","year":"2003","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1023\/A:1026601506677","article-title":"Effect of dehydroelucidine on mucus production. A quantitative study","volume":"44","author":"Penisi","year":"1999","journal-title":"Digestion Disease Sciences"},{"key":"10.1016\/j.jep.2005.09.007_bib38","first-page":"23S","article-title":"Role of prostaglandins in gastroprotection","volume":"43","author":"Peskar","year":"1998","journal-title":"Digestion Disease Sciences"},{"key":"10.1016\/j.jep.2005.09.007_bib39","series-title":"Plantas do Pantanal","author":"Pott","year":"1994"},{"key":"10.1016\/j.jep.2005.09.007_bib40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1345\/aph.1D085","article-title":"Acute interstitial nephritis due to pantoprazole","volume":"38","author":"Ra","year":"2004","journal-title":"Annals of Pharmacotherapy"},{"key":"10.1016\/j.jep.2005.09.007_bib41","first-page":"1281","article-title":"Gastric Ulcerogenicity of non-steroidal anti-inflamatory drugas in mice with mucosa sensitized by cholinomimetic treatment","volume":"27","author":"Rainsford","year":"1978","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib42","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/S0100-879X2002000500003","article-title":"Antioxidant properties of natural compounds used in popular medicine for gastric ulcer","volume":"35","author":"Repetto","year":"2002","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.jep.2005.09.007_bib43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3109\/00365529509107756","article-title":"Gastric blood flow in ulcer diseases","volume":"208","author":"Sato","year":"1995","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2005.09.007_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0367-326X(99)00133-1","article-title":"A phytochemical investigation of Alchornea latifolia","volume":"71","author":"Setzer","year":"2000","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2005.09.007_bib45","first-page":"43","article-title":"A simple method for the uniform production of gastric ulceration in the rat","volume":"5","author":"Shay","year":"1945","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2005.09.007_bib46","series-title":"Symposium of Brazilian Medicinal Plants","first-page":"106","article-title":"Etnobot\u00e2nica no munic\u00edpio de Porto Nacional","author":"Silva","year":"2000"},{"key":"10.1016\/j.jep.2005.09.007_bib47","first-page":"903","article-title":"Effect of indomethacin on blood flow distribution in the stomach of cats with acute gastric ulcer","volume":"14","author":"Skarstein","year":"1979","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2005.09.007_bib48","series-title":"Manual de Ensaios Toxicol\u00f3gicos in vivo","author":"Souza Brito","year":"1995"},{"key":"10.1016\/j.jep.2005.09.007_bib49","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3748\/wjg.v8.i2.375","article-title":"Gastrin, somatostatin, G and D cells of gastric ulcer in rats","volume":"8","author":"Sun","year":"2002","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2005.09.007_bib50","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.2042-7158.1991.tb03461.x","article-title":"Effects of a polysaccharide fraction from the roots of Bupleurum folcatum L. on experimental gastric ulcer models in rats and mice","volume":"43","author":"Sun","year":"1991","journal-title":"Journal Pharmacy and Pharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00351774","article-title":"Distention ulcer as a model for testing of drugs for ulcerogenic side effects","volume":"41","author":"Szelenyi","year":"1978","journal-title":"Archives of Toxicology"},{"key":"10.1016\/j.jep.2005.09.007_bib52","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1254\/jjp.19.418","article-title":"A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing","volume":"19","author":"Takagi","year":"1969","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib53","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1248\/bpb.25.1151","article-title":"Antiulcerogenic activity of four extracts obtained from the bark wood of Quassia amara L. (Simaroubaceae)","volume":"25","author":"Toma","year":"2002","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2005.09.007_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-8741(98)00015-4","article-title":"Antiamoebic and phytochemical screening of some Congolese medicinal plants","volume":"61","author":"Tona","year":"1998","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2005.09.007_bib55","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.lfs.2003.07.021","article-title":"Mucosal damage induced by preferential COX-1 and COX-2 inhibitors: role of prostaglandins and inflammatory response","volume":"74","author":"Villegas","year":"2004","journal-title":"Life Science"},{"key":"10.1016\/j.jep.2005.09.007_bib56","series-title":"Plant Drug Analysis","author":"Wagner","year":"1986"},{"key":"10.1016\/j.jep.2005.09.007_bib57","first-page":"G742","article-title":"Regulation of fundic and antral somatostatin secretion by CCK and gastrin","volume":"274","author":"Zavros","year":"1998","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.jep.2005.09.007_bib58","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1345\/aph.1A303","article-title":"Lansoprazole-induced thrombocytopenia","volume":"36","author":"Zlabek","year":"2002","journal-title":"Annals of Pharmacotherapy"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874105006124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874105006124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:49:51Z","timestamp":1626644991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874105006124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":58,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0378874105006124"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2005.09.007","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}