{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:04:26Z","timestamp":1787061866151,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.jep.2006.05.017","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T16:38:31Z","timestamp":1149179911000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Effect of total phenolics from Laggera alata on acute and chronic inflammation models"],"prefix":"10.1016","volume":"108","author":[{"given":"Yihang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxia","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2006.05.017_bib1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.87.4.1620","article-title":"Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide","volume":"87","author":"Beckman","year":"1990","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jep.2006.05.017_bib2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0031-9422(00)80757-8","article-title":"Cuauthemone sesquiterpenoids from Blumea alata","volume":"24","author":"Bohlmann","year":"1985","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2006.05.017_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-079X.1997.tb00342.x","article-title":"Protective effect of melatonin in carrageenin-induced models of local inflammation","volume":"23","author":"Cuzzocrea","year":"1997","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.jep.2006.05.017_bib4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0891-5849(97)00280-3","article-title":"Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation","volume":"24","author":"Cuzzocrea","year":"1998","journal-title":"Free Radical Biology Medicine"},{"key":"10.1016\/j.jep.2006.05.017_bib5","first-page":"171","article-title":"A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in mouse","volume":"13","author":"Dawson","year":"1991","journal-title":"International Journal of Tissue Reactions"},{"key":"10.1016\/j.jep.2006.05.017_bib6","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/S0024-3205(02)02167-7","article-title":"Effects of caffeoyl conjugates of isoprenyl-hydroquinone glucoside and quinic acid on leukocyte function","volume":"71","author":"Gongora","year":"2002","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2006.05.017_bib7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1055\/s-2003-39715","article-title":"Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid","volume":"69","author":"Gongora","year":"2003","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.05.017_bib8","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0090-6980(82)90131-9","article-title":"Changes in the levels of prostaglandins and thromboxane and their roles in the accumulation of exudate in rat carrageenin-induced pleurisy\u2014a profile analysis using gas chromatography\u2013mass spectrometry","volume":"23","author":"Harada","year":"1982","journal-title":"Prostaglandins"},{"key":"10.1016\/j.jep.2006.05.017_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ddr.430170207","article-title":"Local anti-inflammatory activity of steroid-21-oate esters in the carrageenan pleurisy model of acute inflammation","volume":"17","author":"Heiman","year":"1989","journal-title":"Drug Development Research"},{"key":"10.1016\/j.jep.2006.05.017_bib10","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1021\/np50051a009","article-title":"Studies on the activities of tannins and related compounds. X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes","volume":"50","author":"Kimura","year":"1987","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2006.05.017_bib11","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/S0031-9422(98)00401-4","article-title":"Sesquiterpenoid glucosides from Laggera pterodonta","volume":"49","author":"Li","year":"1998","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2006.05.017_bib12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1254\/fpj.99.363","article-title":"Suppressive effect of sialic acid on the prostaglandin E2-mediated oedema in carrageenin-induced inflammation of rat hind paws","volume":"99","author":"Matsuda","year":"1992","journal-title":"Nippon Yakurigaku Zassshi"},{"key":"10.1016\/j.jep.2006.05.017_bib13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1128\/AAC.42.1.140","article-title":"Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase","volume":"42","author":"McDougall","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.jep.2006.05.017_bib14","first-page":"967","article-title":"Inhibition of neutrophil elastase activity by phenolic compounds from plants","volume":"56","author":"Melzig","year":"2001","journal-title":"Pharmazie"},{"key":"10.1016\/j.jep.2006.05.017_bib15","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/0031-9422(92)80373-M","article-title":"Caffeoylquinic acids from flowers of Arnica montana and Arnica chamissonis","volume":"31","author":"Merfort","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2006.05.017_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(83)90261-3","article-title":"Effect of several anti-inflammatory drugs on the various parameters involved in the inflammation response in rat carrageenan-induced pleurisy","volume":"95","author":"Mikami","year":"1983","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.05.017_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.jep.2006.05.017_bib18","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1096\/fasebj.6.12.1381691","article-title":"Nitric oxide as a secretory product of mammalian cells","volume":"6","author":"Nanthan","year":"1996","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.jep.2006.05.017_bib19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000248453","article-title":"Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: rat pleurisy induced by carrageenin and phorbol myristate acetate","volume":"179","author":"Oh-ishi","year":"1989","journal-title":"Dermatologica"},{"key":"10.1016\/j.jep.2006.05.017_bib20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF01986569","article-title":"Release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenan-induced inflammation: effect of non-steroidal anti-inflammatory drugs","volume":"33","author":"Peskar","year":"1991","journal-title":"Agent Actions"},{"key":"10.1016\/j.jep.2006.05.017_bib21","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0031-9422(98)80077-0","article-title":"Eudesmane sesquiterpenes from Laggera alata","volume":"47","author":"Raharivelomanana","year":"1998","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2006.05.017_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1063-4584(98)80006-X","article-title":"Anti-inflammatory activity of chondroitin sulfate","volume":"6","author":"Ronca","year":"1998","journal-title":"Osteoarthritis and Cartilage"},{"key":"10.1016\/j.jep.2006.05.017_bib23","doi-asserted-by":"crossref","first-page":"26066","DOI":"10.1016\/S0021-9258(18)47160-8","article-title":"Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation","volume":"269","author":"Rubbo","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2006.05.017_bib24","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1001\/jama.1953.63690130001006","article-title":"On the mechanism through which hydrocorticosterone affects the resistance of tissues to injury. An experimental study with granuloma pouch techniques","volume":"152","author":"Selye","year":"1953","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.jep.2006.05.017_bib25","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1021\/jf00097a031","article-title":"Influence of processing and storage on the phenolic compositon of apple juice","volume":"38","author":"Spanos","year":"1990","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2006.05.017_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3181\/00379727-216-44170","article-title":"Inhibition of cyclooxygenase. A novel approach to cancer prevention","volume":"216","author":"Subbaramaiah","year":"1997","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"10.1016\/j.jep.2006.05.017_bib27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0367-326X(02)00181-8","article-title":"A new dicaffeoylquinic acid butyl ester from Isertia pittieri","volume":"73","author":"Um","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2006.05.017_bib28","first-page":"2588","article-title":"Pathway of onset development and decay of carrageenan pleurisy in the rat","volume":"41","author":"Vinegar","year":"1982","journal-title":"Federation Proceedings"},{"key":"10.1016\/j.jep.2006.05.017_bib29","series-title":"Drug Discovery and Evaluation. Pharmacological Assays","author":"Vogel","year":"1997"},{"key":"10.1016\/j.jep.2006.05.017_bib30","first-page":"246","article-title":"The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics","volume":"22","author":"Whittle","year":"1964","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.05.017_bib31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/jps.3030460902","article-title":"Effects of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocort isone esters","volume":"46","author":"Winter","year":"1957","journal-title":"Journal of the American Pharmaceutical Association Science Ecology"},{"key":"10.1016\/j.jep.2006.05.017_bib32","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carrageenan-induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs","volume":"111","author":"Winter","year":"1962","journal-title":"Proceedings of the Society for Experimental Biology Medicine"},{"key":"10.1016\/j.jep.2006.05.017_bib33","first-page":"46","article-title":"Anti-inflammatory mechanism of sodium glycyrrhetinate","volume":"7","author":"Wu","year":"1991","journal-title":"Chinese Pharmacological Bulletin"},{"key":"10.1016\/j.jep.2006.05.017_bib34","series-title":"Chemistry of Natural Medicinal Products","author":"Yao","year":"2001"},{"key":"10.1016\/j.jep.2006.05.017_bib35","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0031-9422(03)00370-4","article-title":"Eudesmane and megastigmane glucosides from Laggera alata","volume":"23","author":"Zheng","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2006.05.017_bib36","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1021\/np0205856","article-title":"Eudesmane derivatives and other sesquiterpenes from Laggera alata","volume":"66","author":"Zheng","year":"2003","journal-title":"Journal of Natural Products"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874106002753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874106002753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:11:57Z","timestamp":1759939917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874106002753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0378874106002753"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2006.05.017","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of total phenolics from Laggera alata on acute and chronic inflammation models","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2006.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}