{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:28:59Z","timestamp":1777613339658,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.jep.2006.06.013","type":"journal-article","created":{"date-parts":[[2006,7,9]],"date-time":"2006-07-09T11:06:52Z","timestamp":1152443212000},"page":"35-40","source":"Crossref","is-referenced-by-count":10,"title":["Toxicological and cytotoxic evaluation of standardized extracts of Galphimia glauca"],"prefix":"10.1016","volume":"109","author":[{"given":"Luc\u00eda","family":"Aguilar-Santamar\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Herrera-Arellano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas E.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Alonso-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elva I.","family":"Cort\u00e9s-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nestor","family":"Ledesma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Tortoriello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2006.06.013_bib1","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1016\/0009-8981(76)90437-X","article-title":"Provisional recommendations on OFCC methods for the measurement of catalytic concentrations of enzymes. Part 2. IFCC method aspartate aminotransferase","volume":"70","author":"Bergmeyer","year":"1976","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.jep.2006.06.013_bib2","first-page":"145F","article-title":"IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC. Method for alanine aminotransferase (I-alanine 2-oxoglutarate aminotransferase, ec 2.6.1.2)","volume":"105","author":"Bergmeyer","year":"1980","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.jep.2006.06.013_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1124\/pr.56.1.5","article-title":"Structural effects and neurofunctional sequelae of developmental exposure to psychotherapeutic drugs: experimental and clinical aspects","volume":"56","author":"Costa","year":"2004","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.jep.2006.06.013_bib4","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1021\/np010419i","article-title":"Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor friedelanes","volume":"65","author":"del Rayo-Camacho","year":"2002","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2006.06.013_bib5","unstructured":"Estrada, E., 1985. Jard\u00edn Bot\u00e1nico de Plantas Medicinales Maximino Mart\u00ednez. Universidad Aut\u00f3noma de Chapingo, Departamento de Fitotecnia, M\u00e9xico."},{"key":"10.1016\/j.jep.2006.06.013_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0027-5107(00)00065-8","article-title":"The in vitro micronucleus technique","volume":"455","author":"Fenech","year":"2000","journal-title":"Mutation Research"},{"key":"10.1016\/j.jep.2006.06.013_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jep.2005.06.001","article-title":"Trends in ethnopharmacology","volume":"100","author":"Gilani","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2006.06.013_bib8","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1055\/s-2005-871224","article-title":"Nor-secofriedelanes as spasmolytics, advances of structure-activity relationships","volume":"71","author":"Gonz\u00e1lez-Cortazar","year":"2005","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.06.013_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2005.07.008","article-title":"Medicinal plants: traditions of yesterday and drugs tomorrow","volume":"27","author":"Gurib-Fakim","year":"2006","journal-title":"Molecular Aspects of Medicine"},{"key":"10.1016\/j.jep.2006.06.013_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phymed.2005.03.003","article-title":"Anxiolytic and antidepressant-like activity of a standardized extract from Galphimia glauca","volume":"13","author":"Herrera-Ruiz","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2006.06.013_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1021\/np050305x","article-title":"Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives","volume":"69","author":"Herrera-Ruiz","year":"2006","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2006.06.013_bib12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/01.AOG.0000158858.79134.ea","article-title":"Do no harm: avoidance of herbal medicines during pregnancy","volume":"105","author":"Marcus","year":"2005","journal-title":"Obstetrics and Gynecology"},{"key":"10.1016\/j.jep.2006.06.013_bib13","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton","year":"2000","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.jep.2006.06.013_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0021-9258(18)43072-4","article-title":"A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum","volume":"164","author":"Otto","year":"1946","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2006.06.013_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3181\/00379727-91-22245","article-title":"Measurement of cell grow in tissue culture","volume":"88","author":"Oyama","year":"1956","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"10.1016\/j.jep.2006.06.013_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.7182\/prtr.14.2.k7743w3j64855180","article-title":"Hepatotoxicity of herbal remedies: an emerging dilemma","volume":"14","author":"Pak","year":"2004","journal-title":"Progress in Transplantation"},{"key":"10.1016\/j.jep.2006.06.013_bib17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jep.2005.06.006","article-title":"Ethnopharmacology and drug discovery","volume":"100","author":"Patwardhan","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2006.06.013_bib18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/251156a0","article-title":"New giemsa method for the differential staining of sister chromatids","volume":"251","author":"Perry","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.jep.2006.06.013_bib19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0378-8741(95)01230-B","article-title":"Vasoactive effects of aqueous extracts from five Mexican medicinal plants on isolated rat aorta","volume":"46","author":"Perusquia","year":"1995","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2006.06.013_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-2003-37043","article-title":"Galphimine B modulates synaptic transmission on dopaminergic ventral tegmental area neurons","volume":"69","author":"Prieto-G\u00f3mez","year":"2003","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.06.013_bib21","first-page":"71","article-title":"Assay related to cancer drug discovery","volume":"vol. 6","author":"Suffnes","year":"1991"},{"key":"10.1016\/j.jep.2006.06.013_bib22","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1107\/S0108270192006644","article-title":"Structure of Galphimine B","volume":"49","author":"Toscano","year":"1993","journal-title":"Acta Crystallographica Section C"},{"key":"10.1016\/j.jep.2006.06.013_bib23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1055\/s-2006-961442","article-title":"Effect of Galphimia glauca methanolic extract on neuropharmacological tests","volume":"58","author":"Tortoriello","year":"1992","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.06.013_bib24","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1055\/s-2006-959717","article-title":"Sedative effects of galphimine B, a Nor,seco-triterpenoid from Galphimia glauca","volume":"59","author":"Tortoriello","year":"1993","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.06.013_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1055\/s-2006-957440","article-title":"Galphimine-B modifies electrical activity of ventral tegmental area neurons in rats","volume":"64","author":"Tortoriello","year":"1998","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.06.013_bib26","first-page":"517","article-title":"Cytotoxic activity of some Mexican plants used in traditional medicine","volume":"LXIII","author":"Villarreal","year":"1992","journal-title":"Fitoterapia"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874106003278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874106003278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T21:07:08Z","timestamp":1736456828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874106003278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0378874106003278"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2006.06.013","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}