{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:24:06Z","timestamp":1791224646102,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.jep.2006.07.031","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T14:34:03Z","timestamp":1154529243000},"page":"281-288","source":"Crossref","is-referenced-by-count":97,"title":["Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model"],"prefix":"10.1016","volume":"109","author":[{"given":"Ana Beatriz","family":"Montanher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Maria","family":"Zucolotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloir Paulo","family":"Schenkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia Silvia","family":"Fr\u00f6de","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2006.07.031_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejphar.2004.06.003","article-title":"Tumour necrosis factor-alpha mediates neutrophil migration to the knee synovial cavity during immune inflammation","volume":"496","author":"Bombini","year":"2004","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.07.031_bib2","first-page":"104","article-title":"Anti-inflammatory activity of Passiflora incarnata L. in rats","volume":"10","author":"Borreli","year":"1996","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2006.07.031_bib3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1476-5381.1995.tb13305.x","article-title":"Involvement of B1 or B2 receptors in bradykinin-induced rat paw oedema","volume":"114","author":"Campos","year":"1995","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.07.031_bib4","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/sj.bjp.0704403","article-title":"Tumour necrosis factor-alpha and leukotriene B(4) mediate the neutrophil migration in immune inflammation","volume":"134","author":"Canetti","year":"2001","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.07.031_bib5","series-title":"Maracuj\u00e1. Tecnologia de produ\u00e7\u00e3o, p\u00f3s-colheita, agroind\u00fastria, mercado, Cinco Continente","first-page":"33","article-title":"Morfologia externa e taxonomia","author":"Carvalho-Okano","year":"2001"},{"key":"10.1016\/j.jep.2006.07.031_bib6","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0006-2952(01)00773-0","article-title":"Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases","volume":"62","author":"Chi","year":"2001","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2006.07.031_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0024-3205(01)01387-X","article-title":"Additional evidence of the anti-inflammatory and anti-allergic properties of the sesquiterpene polygodial","volume":"70","author":"Da Cunha","year":"2001","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2006.07.031_bib8","first-page":"5","article-title":"Pharmacochemical study of aqueous extracts of Passiflora alata Dryander and Passiflora edulis Sims","volume":"21","author":"De Paris","year":"2002","journal-title":"Acta Farmaceutica Bonaerense"},{"key":"10.1016\/j.jep.2006.07.031_bib9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0367-326X(01)00306-9","article-title":"Comparative biological activity study on Passiflora incarnata and Passiflora edulis","volume":"72","author":"Dhawan","year":"2001","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2006.07.031_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0952-3278(96)90053-8","article-title":"Interaction between nitric oxide and cyclooxygenase pathway","volume":"54","author":"Di Rosa","year":"1996","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"10.1016\/j.jep.2006.07.031_bib11","unstructured":"Farmacop\u00e9ia Brasileira, 1977. Third ed. Andrei, S\u00e3o Paulo, pp. 839\u2013840."},{"key":"10.1016\/j.jep.2006.07.031_bib12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/09629350123332","article-title":"Myeloperoxidase and adenosine-deaminase levels in the pleural fluid leakage induced by carrageenan in the mouse model of pleurisy","volume":"10","author":"Fr\u00f6de","year":"2001","journal-title":"Mediators Inflammation"},{"key":"10.1016\/j.jep.2006.07.031_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0196-9781(98)00170-3","article-title":"Analysis of the inflammatory response induced by substance P in the mouse pleural cavity","volume":"20","author":"Fr\u00f6de-Saleh","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.jep.2006.07.031_bib14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000045671","article-title":"Hemodialysis-induced degranulation of polymorphonuclear cells: no correlation between membrane markers and degranulation products","volume":"85","author":"Grooteman","year":"2000","journal-title":"Nephron"},{"key":"10.1016\/j.jep.2006.07.031_bib15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0031-9422(02)00378-3","article-title":"Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2","volume":"61","author":"Jang","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2006.07.031_bib16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000085108","article-title":"Histamine in allergic inflammation and immune modulation","volume":"137","author":"Jutel","year":"2005","journal-title":"Journal Investigational Allergology Clinical Immunology"},{"key":"10.1016\/j.jep.2006.07.031_bib17","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1164\/ajrccm.162.5.9911065","article-title":"Lipopolysaccharide enhances substance P-mediated neutrophil adherence to epithelial cells and cytokine release","volume":"162","author":"Kuo","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.jep.2006.07.031_bib18","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1074\/jbc.M411263200","article-title":"Myeloperoxidase potentiates nitric oxide-mediated nitrosation","volume":"280","author":"Lakshmi","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2006.07.031_bib19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/ptr.2650050607","article-title":"Assessment of the hypnotic\/sedative effects and toxicity of Passiflora edulis aqueous extract in rodents and humans","volume":"5","author":"Maluf","year":"1991","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2006.07.031_bib20","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.4049\/jimmunol.166.6.4042","article-title":"Early response cytokines and innate immunity: essential roles for TNF receptor 1 and type 1 IL-1 receptor during Escherichia coli pneumonia in mice","volume":"166","author":"Mizgerd","year":"2001","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.jep.2006.07.031_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00011-004-1256-2","article-title":"Involvement of the neuropeptide substance P in lung inflammation induced by hepatic ischemia\/reperfusion","volume":"53","author":"Okaya","year":"2004","journal-title":"Inflammation Research"},{"key":"10.1016\/j.jep.2006.07.031_bib22","first-page":"259","article-title":"Aproveitamento alternativo da casca do maracuj\u00e1-amarelo (Passiflora edulis f. flavicarpa) para produ\u00e7\u00e3o de doce em calda","volume":"22","author":"Oliveira","year":"2002","journal-title":"Ci\u00eancia e tecnologia e alimentos"},{"key":"10.1016\/j.jep.2006.07.031_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ptr.694","article-title":"Comparative pharmacological study on hydroethanol extracts of Passiflora alata and Passiflora edulis leaves","volume":"15","author":"Petry","year":"2001","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2006.07.031_bib24","series-title":"Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas","author":"Pio Corr\u00eaa","year":"1978"},{"key":"10.1016\/j.jep.2006.07.031_bib25","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/S0002-9440(10)63437-2","article-title":"The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival","volume":"165","author":"Prince","year":"2004","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.jep.2006.07.031_bib26","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF00920477","article-title":"Comparative evaluation of arachidonic acid (aa)- and tetradecanoylphorbol acetate (tpa)-induced dermal inflammation","volume":"17","author":"Rao","year":"1993","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2006.07.031_bib27","unstructured":"Sacco, J.C., 1980. Passifloraceas. In: Reitz, R. (Ed.), Flora Ilustrada Catarinense, Itaja\u0131: Herb\u00e1rio Barbosa Rodrigues, Brazil, pp. 132."},{"key":"10.1016\/j.jep.2006.07.031_bib28","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1096\/fj.03-0835fje","article-title":"Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis","volume":"18","author":"Sainz","year":"2004","journal-title":"FASEB Journal"},{"key":"10.1016\/j.jep.2006.07.031_bib29","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1476-5381.1996.tb15472.x","article-title":"Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy","volume":"118","author":"Saleh","year":"1996","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.07.031_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0014-2999(97)01005-4","article-title":"Pro-inflammatory effects induced by bradykinin in a murine model of pleurisy","volume":"331","author":"Saleh","year":"1997","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.07.031_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","article-title":"Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan","volume":"20","author":"Saleh","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.jep.2006.07.031_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.bjp.0705236","article-title":"Effect of a kinin B2 receptor antagonist on LPS- and cytokine-induced neutrophil migration in rats","volume":"139","author":"Santos","year":"2003","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.07.031_bib33","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1021\/jf00118a028","article-title":"Cyanogenesis of Passiflora edulis","volume":"31","author":"Spencer","year":"1983","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2006.07.031_bib34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1271\/bbb.68.119","article-title":"A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production","volume":"68","author":"Ueda","year":"2004","journal-title":"Bioscience, Biotechnology and Biochemistry"},{"key":"10.1016\/j.jep.2006.07.031_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0014-2999(94)90599-1","article-title":"Differential effects of indomethacin and dexamethasone on cytokine production in carrageenin-induced rat pleurisy","volume":"252","author":"Utsunomiya","year":"1994","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2006.07.031_bib36","series-title":"Florian\u00f3polis (SC): Programa de p\u00f3s-gradua\u00e7\u00e3o em Farm\u00e1cia","article-title":"Avalia\u00e7\u00e3o da atividade antiinflamat\u00f3ria dos extratos aquosos de Passiflora alata Dryander e Passiflora edulis Sims, no modelo da pleurisia induzida por carragenina, em camundongos. [disserta\u00e7\u00e3o]","author":"Vargas","year":"2004"},{"key":"10.1016\/j.jep.2006.07.031_bib37","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbrc.2004.08.062","article-title":"Nitric oxide regulates interactions of PMN with human brain microvessel endothelial cells","volume":"323","author":"Wong","year":"2004","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jep.2006.07.031_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.jep.2006.07.031_bib39","unstructured":"Zucolotto, S.M., 2005. Estudo fitoqu\u00edmico das folhas, frutos e ra\u00edzes de Passiflora edulis forma flavicarpa Degener [disserta\u00e7\u00e3o]. Florian\u00f3polis (SC): Programa de p\u00f3s-gradua\u00e7\u00e3o em Farm\u00e1cia. Universidade Federal de Santa Catarina, Brazil."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874106003680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874106003680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T13:17:31Z","timestamp":1555766251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874106003680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0378874106003680"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2006.07.031","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}