{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:05:42Z","timestamp":1790795142477,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.jep.2006.09.046","type":"journal-article","created":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T15:46:46Z","timestamp":1163519206000},"page":"1-7","source":"Crossref","is-referenced-by-count":21,"title":["Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews"],"prefix":"10.1016","volume":"111","author":[{"given":"Carla","family":"Schultz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myllene P.","family":"Bossolani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luce M.B.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa R.","family":"Lima-Landman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Lapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caden","family":"Souccar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2006.09.046_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/70200271","article-title":"Chemistry of the genus Plectranthus","author":"Abdel-Mogib","year":"2002","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2006.09.046_bib2","doi-asserted-by":"crossref","first-page":"22167","DOI":"10.1016\/S0021-9258(18)45685-2","article-title":"Reversible inhibitions of gastric H+,K+-ATPase by scopadulcic acid B and diacetyl scopadol. New biochemical tools of H+,K+-ATPase","volume":"265","author":"Asano","year":"1990","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2006.09.046_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1590\/S0102-86502005000300007","article-title":"Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosis: an experimental study in young rats","volume":"20","author":"Battochio","year":"2005","journal-title":"Acta Cirurgica Brasileira"},{"key":"10.1016\/j.jep.2006.09.046_bib4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1748-1716.1976.tb10184.x","article-title":"A method for preparing isolated glands from the rabbit gastric mucosa","volume":"96","author":"Berglindh","year":"1976","journal-title":"Acta Physiologica Scandinavica"},{"key":"10.1016\/j.jep.2006.09.046_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2006.09.046_bib6","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1055\/s-2003-45186","article-title":"Antispasmodic effect of the essential oil of Plectranthus barbatus and some major constituents on the guinea-pig ileum","volume":"69","author":"C\u00e2mara","year":"2003","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.09.046_bib7","first-page":"155","article-title":"Atividade citot\u00f3xica de Plectranthus barbatus Andr. (Lamiaceae)","volume":"22","author":"Costa","year":"2003","journal-title":"Acta Farmac\u00eautica Bonaerense"},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2006.09.046_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1590\/S0074-02761991000600032","article-title":"The water extract of Coleus barbatus Benth decreases gastric secretion in rats","volume":"86","author":"Fischman","year":"1991","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.jep.2006.09.046_bib9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)84756-1","article-title":"The colorimetric determination of phosphorus","volume":"66","author":"Fiske","year":"1925","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2006.09.046_bib10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.ph.42.030180.000551","article-title":"Mechanisms of gastric H+ and Cl\u2212 transport","volume":"42","author":"Forte","year":"1980","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.jep.2006.09.046_bib11","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1021\/np50075a008","article-title":"Scopadulciol, an inhibitor of gastric H+, K+-ATPase from Scoparia dulcis, and its structure-activity relationships","volume":"54","author":"Hayashi","year":"1991","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2006.09.046_bib12","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1016\/S0040-4020(01)88671-3","article-title":"Isolation, structure determination, and absolute configuration of barbatusol, a new bioactive diterpene with rearranged abietane skeleton from the Labiate Coleus barbatus","volume":"39","author":"Kelecom","year":"1983","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2006.09.046_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/10412905.2002.9699783","article-title":"Essential oils from leaves, stems, and roots of Plectranthus barbatus Andr. (Labiatae) grown in Brazil","volume":"14","author":"Kerntopf","year":"2002","journal-title":"Journal of Essential Oil Research"},{"key":"10.1016\/j.jep.2006.09.046_bib14","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3109\/00365529509096336","article-title":"Effects of ranitidine on gastric vesicles containing H+,K+-adenosine triphosphatase in rats","volume":"30","author":"Kubo","year":"1995","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2006.09.046_bib15","series-title":"Natural Drugs and the Digestive Tract","first-page":"63","article-title":"Inhibitors of gastric secretion from Brazilian folk medicinal plants","author":"Lapa","year":"1992"},{"key":"10.1016\/j.jep.2006.09.046_bib16","series-title":"2000 Years of Natural Products Research \u2014 Past, Present and Future","first-page":"119","article-title":"Medicinal plant research in Latin America A report on the mechanism of the anti-acid\/antiulcer activity of Stachytarpheta cayennensis Vahl","author":"Lapa","year":"2000"},{"key":"10.1016\/j.jep.2006.09.046_bib17","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1021\/jm00158a001","article-title":"The mechanism of action of the gastric acid secretion inhibitor omeprazole","volume":"29","author":"Lindberg","year":"1986","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.jep.2006.09.046_bib18","series-title":"Plantas Medicinais no Brasil: Nativas e Ex\u00f3ticas Cultivadas","first-page":"259","article-title":"Plectranthus barbatus Andrews","author":"Lorenzi","year":"2002"},{"key":"10.1016\/j.jep.2006.09.046_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2005.09.011","article-title":"Plectranthus: a review of ethnobotanical uses","volume":"103","author":"Lukhoba","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2006.09.046_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0378-8741(03)00107-7","article-title":"Antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in Kenya","volume":"87","author":"Matu","year":"2003","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2006.09.046_bib21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/s-2006-960103","article-title":"Inhibition of gastric H+, K+-ATPase and acid secretion by ellagic acid","volume":"57","author":"Murakami","year":"1991","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.09.046_bib22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1055\/s-2006-960982","article-title":"Effect of salvianolic acid A, a depside from roots of Salvia miltiorrhiza, on gastric H+,K+-ATPase","volume":"56","author":"Murakami","year":"1990","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.09.046_bib23","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.2042-7158.1992.tb03238.x","article-title":"Gastric H+, K+-ATPase inhibition by catechins","volume":"44","author":"Murakami","year":"1992","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.jep.2006.09.046_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3109\/14756369909036551","article-title":"Inhibition of gastric H+, K+-ATPase by flavonoids: a structure-activity study","volume":"14","author":"Murakami","year":"1999","journal-title":"Journal of Enzyme Inhibition"},{"key":"10.1016\/j.jep.2006.09.046_bib25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0254-6299(15)30834-6","article-title":"Screening Plectranthus species for antibacterial activity","volume":"64","author":"Rabe","year":"1998","journal-title":"South African Journal of Botany"},{"key":"10.1016\/j.jep.2006.09.046_bib26","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/hlca.19860690504","article-title":"Neue Diterpene aus Blattdr\u00fcsen von Plectranthus barbatus (Labiatae). Die absolute Konfiguration der 2-Hydroxypropyl-Seitenkette in Coleon E","volume":"69","author":"R\u00fcedi","year":"1986","journal-title":"Helvetica Chimica Acta"},{"key":"10.1016\/j.jep.2006.09.046_bib27","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/hlca.19720550619","article-title":"Struktur von Coleon E, einem neuen diterpenoiden Methylenchino aus der Coleus barbatus-Gruppe (Labiatae)","volume":"55","author":"R\u00fcedi","year":"1972","journal-title":"Helvetica Chimica Acta"},{"key":"10.1016\/j.jep.2006.09.046_bib28","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1016\/S0021-9258(17)32907-1","article-title":"Nonelectrogenic H+ pump in plasma membranes of hog stomach","volume":"251","author":"Sachs","year":"1976","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2006.09.046_bib29","series-title":"Constituintes Qu\u00edmicos Ativos e Propriedades Biol\u00f3gicas de Plantas Medicinais Brasileiras","first-page":"330","article-title":"Malva-santa","author":"Sousa","year":"2004"},{"key":"10.1016\/j.jep.2006.09.046_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/1043-6618(94)80093-6","article-title":"Boldo and boldine: an emerging case of natural drug development","volume":"29","author":"Speisky","year":"1994","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.jep.2006.09.046_bib31","first-page":"15","article-title":"In vitro antioxidant activity of Coleus barbatus (Andr.) Benth (false boldo) and Peumus boldo (Molina) (Boldo do Chile): a comparative study","volume":"vol. 34","author":"Tamasiro","year":"1998"},{"key":"10.1016\/j.jep.2006.09.046_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002329900274","article-title":"Signal transduction and activation of acid secretion in the parietal cell","volume":"159","author":"Urushidani","year":"1997","journal-title":"The Journal of Membrane Biology"},{"key":"10.1016\/j.jep.2006.09.046_bib33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-2006-957599","article-title":"Inhibition of gastric acid secretion by the aqueous extract and purified fractions of Stachytarpheta cayennensis Schau","volume":"63","author":"Vela","year":"1997","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2006.09.046_bib34","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/S0021-9258(18)61620-5","article-title":"Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080 a substituted pyridyl(1,2a)imidazole","volume":"262","author":"Wallmark","year":"1987","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2006.09.046_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.physiol.65.072302.114200","article-title":"Cell biology of acid secretion by the parietal cell","volume":"65","author":"Yao","year":"2003","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.jep.2006.09.046_bib36","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/0040-4020(77)88005-8","article-title":"Barbatusin and cyclobutatusin, two novel diterpenoids from Coleus barbatus Bentham","volume":"33","author":"Zelnik","year":"1977","journal-title":"Tetrahedron"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874106005873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874106005873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T18:51:16Z","timestamp":1628103076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874106005873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0378874106005873"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2006.09.046","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}