{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:47:14Z","timestamp":1774280834153,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.jep.2007.04.002","type":"journal-article","created":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T11:10:15Z","timestamp":1177499415000},"page":"490-497","source":"Crossref","is-referenced-by-count":60,"title":["Neutralization of snake venom phospholipase A2 toxins by aqueous extract of Casearia sylvestris (Flacourtiaceae) in mouse neuromuscular preparation"],"prefix":"10.1016","volume":"112","author":[{"given":"Walter L.G.","family":"Cavalcante","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayn\u00e1 O.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeli","family":"Dal Pai-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo S.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clayton Z.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreimar M.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia","family":"Gallacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2007.04.002_bib1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0300-9084(00)01150-0","article-title":"Myotoxic phospholipases A2 in Bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu","volume":"82","author":"Andri\u00e3o-Escarso","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.jep.2007.04.002_bib2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0300-9084(03)00138-X","article-title":"Inhibition of enzymatic and pharmacological activities of some snake venoms and toxins by Mandevilla velutina (Apocynaceae) aqueous extract","volume":"85","author":"Biondo","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.jep.2007.04.002_bib3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00299-003-0722-6","article-title":"Direct organogenesis of Mandevilla illustris (Vell) Woodson and effects of its aqueous extract on the enzymatic and toxic activities of Crotalus durissus terrificus snake venom","volume":"22","author":"Biondo","year":"2004","journal-title":"Plant Cell Reports"},{"key":"10.1016\/j.jep.2007.04.002_bib4","series-title":"Venom Phospholipase A2 Enzymes: Structure, Function and Mechanism","first-page":"269","article-title":"Multicomponent neurotoxic phospholipases A2","author":"Bon","year":"1997"},{"key":"10.1016\/j.jep.2007.04.002_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0305-0491(00)00237-6","article-title":"Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A2","volume":"127","author":"Borges","year":"2000","journal-title":"Comparative Biochemistry and Physiology"},{"key":"10.1016\/j.jep.2007.04.002_bib6","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/S0041-0101(01)00169-6","article-title":"Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae)","volume":"39","author":"Borges","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1432-1033.1974.tb03838.x","article-title":"Biochemistry and pharmacology of the crotoxin complex. Biochemical analysis of crotapotin and the basic Crotalus phospholipase A","volume":"49","author":"Breithaupt","year":"1974","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.jep.2007.04.002_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/abbi.1998.0853","article-title":"Immunochemical characterization and role in toxic activities of region 115\u2013129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom","volume":"358","author":"Calderon","year":"1998","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.jep.2007.04.002_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00508469","article-title":"Crotoxin, the neurotoxin of South American rattlesnake venom, is a presynaptic toxin acting like beta-bungarotoxin","volume":"296","author":"Chang","year":"1977","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"10.1016\/j.jep.2007.04.002_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jep.2005.01.063","article-title":"Antihemorrhagic, antinucleolytic and other antiophidian properties of the aqueous extract from Pentaclethra macroloba","volume":"100","author":"da Silva","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.04.002_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.etp.2005.09.004","article-title":"Paralyzing and myotoxic effects of a recombinant bothropstoxin-I (BthTX-I) on mouse neuromuscular preparations","volume":"57","author":"Gallacci","year":"2006","journal-title":"Experimental and Toxicologic Pathology"},{"key":"10.1016\/j.jep.2007.04.002_bib12","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.toxicon.2003.11.005","article-title":"Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity","volume":"42","author":"Guti\u00e9rrez","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cbi.2004.09.016","article-title":"Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): anti-proteolytic and anti-hemorrhagic properties","volume":"150","author":"Janu\u00e1rio","year":"2004","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.jep.2007.04.002_bib14","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.toxicon.2003.11.002","article-title":"Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes","volume":"42","author":"Kini","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib15","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.toxicon.2003.11.008","article-title":"An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action","volume":"42","author":"Lomonte","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib16","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jep.2005.06.039","article-title":"Antiophidian properties of the aqueous extract of Mikania glomerata","volume":"102","author":"Maiorano","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.04.002_bib17","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0041-0101(92)90429-9","article-title":"Plant with a reputation against snakebite","volume":"30","author":"Martz","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib18","series-title":"Staining Methods: Histologic and Biochemical Medical Division","author":"Mc Manus","year":"1960"},{"key":"10.1016\/j.jep.2007.04.002_bib19","series-title":"Handbook of Clinical Toxicology of Animal Venoms and Poisons","first-page":"367","article-title":"Biology and distribution of venomous snakes of medical importance and the composition of snake venoms","author":"Meier","year":"1995"},{"key":"10.1016\/j.jep.2007.04.002_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0031-9422(00)00229-6","article-title":"Plant natural products active against snake bite\u2014the molecular approach","volume":"55","author":"Mors","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2007.04.002_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jep.2004.12.028","article-title":"Anticoagulant and antifibrinogenolytic properties of the aqueous extract from Bauhinia forficata against snake venoms","volume":"98","author":"Oliveira","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.04.002_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0041-0101(03)00166-1","article-title":"Antagonism of myotoxic and paralyzing activities of bothropstoxin-I by suramin","volume":"42","author":"Oliveira","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0378-8741(00)00243-9","article-title":"Snakebites and ethnobotany in the northwest region of Colombia. Part I. Traditional use of plants","volume":"71","author":"Otero","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.04.002_bib24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0041-0101(98)00188-3","article-title":"Lysine 49 phospholipase A2 proteins","volume":"37","author":"Ownby","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib25","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/0041-0101(90)90161-Y","article-title":"Properties of the early phases of crotoxin poisoning at frog neuromuscular junctions","volume":"28","author":"Rodrigues-Simioni","year":"1990","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib26","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/0041-0101(95)00089-5","article-title":"No role for enzymatic activity or dantrolene-sensitive Ca2+ stores in the muscular effects of bothropstoxin, a Lys49 phospholipase A2 myotoxin","volume":"33","author":"Rodrigues-Simioni","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF00997027","article-title":"Biochemistry and pharmacology of the crotoxin complex. I. Subfractionation and recombination of the crotoxin complex","volume":"270","author":"Rubsamen","year":"1971","journal-title":"Naunyn-Schmiedebergs Archiv f\u00fcr Pharmakologie"},{"key":"10.1016\/j.jep.2007.04.002_bib28","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/cber.19380710527","article-title":"Schlangengiffe, III: Mitteilung Reiningung und Krystallization des Klappershclangengiffes","volume":"71","author":"Slotta","year":"1938","journal-title":"Berichte der Deutschen Chemischen Gesellschaft"},{"key":"10.1016\/j.jep.2007.04.002_bib29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0041-0101(97)00133-5","article-title":"A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogenic activity","volume":"36","author":"Soares","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/abbi.1999.1492","article-title":"Structural and functional characterization of a myotoxin I from Bothrops moojeni (caissaca) snake venom","volume":"373","author":"Soares","year":"2000","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.jep.2007.04.002_bib31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/abbi.2000.2244","article-title":"Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom","volume":"387","author":"Soares","year":"2001","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.jep.2007.04.002_bib32","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1358\/dof.2004.029.11.851973","article-title":"Neutralizing effects of Brazilian plants against snake venoms","volume":"29","author":"Soares","year":"2004","journal-title":"Drugs Future"},{"key":"10.1016\/j.jep.2007.04.002_bib33","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.2174\/1385272043369610","article-title":"Phospholipases A2 myotoxins from Bothrops snake venoms: structure\u2013function relationship","volume":"8","author":"Soares","year":"2004","journal-title":"Current Organic Chemistry"},{"key":"10.1016\/j.jep.2007.04.002_bib34","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.2174\/092986705774370655","article-title":"Medicinal plants with inhibitory properties against snake venoms","volume":"12","author":"Soares","year":"2005","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.jep.2007.04.002_bib35","first-page":"371","article-title":"Bothrops moojeni myotoxin-II, a Lys49-phospholipase A2 homologue: an example of function versatility of snake venom proteins","volume":"142","author":"St\u00e1beli","year":"2006","journal-title":"Comparative Biochemistry and Physiology C"},{"key":"10.1016\/j.jep.2007.04.002_bib36","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0041-0101(02)00393-8","article-title":"Report of a WHO workshop on the standartization and control of antivenoms","volume":"41","author":"Theakston","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2007.04.002_bib37","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.toxicon.2005.04.023","article-title":"Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction","volume":"46","author":"Ticli","year":"2005","journal-title":"Toxicon"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874107001973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874107001973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T01:22:34Z","timestamp":1546910554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874107001973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0378874107001973"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2007.04.002","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}