{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:02:17Z","timestamp":1792000937637,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.jep.2007.11.025","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T10:22:09Z","timestamp":1196072529000},"page":"263-269","source":"Crossref","is-referenced-by-count":79,"title":["Analgesic, anti-inflammatory and antioxidant properties of Buddleja globosa, Buddlejaceae"],"prefix":"10.1016","volume":"116","author":[{"given":"N.","family":"Backhouse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rosales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Apablaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Go\u00efty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Erazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Negrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Theodoluz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Delporte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2007.11.025_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.plefa.2004.11.005","article-title":"Effect of resveratrol and beta-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells","volume":"72","author":"Awad","year":"2005","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"10.1016\/j.jep.2007.11.025_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1076\/phbi.35.1.49.13273","article-title":"Anti-inflammatory and antypiretic metabolites of Acaena splendens","volume":"35","author":"Backhouse","year":"1997","journal-title":"International Journal of Pharmacognosy"},{"key":"10.1016\/j.jep.2007.11.025_bib3","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/ptr.997","article-title":"Bioactive phenolic derivatives from Acaena splendens methanol extract","volume":"16","author":"Backhouse","year":"2002","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2007.11.025_bib4","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.phytochem.2006.11.029","article-title":"Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)","volume":"68","author":"Brinker","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2007.11.025_bib5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1211\/0022357023501","article-title":"Acteoside protects endothelial cells against free radical-induced oxidative stress","volume":"56","author":"Chiou","year":"2004","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib6","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0076-6879(94)33063-8","article-title":"Antioxidant effectiveness in ischemia-reperfusion tissue injury","volume":"233","author":"Das","year":"1994","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.jep.2007.11.025_bib7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1023\/A:1008138807481","article-title":"Biological activities of new antitumoral of indole derivatives in an inclusion complex with cyclodextrin","volume":"37","author":"De Azevedo","year":"2000","journal-title":"Journal of Inclusion Phenomena and Macrocyclic Chemistry"},{"key":"10.1016\/j.jep.2007.11.025_bib8","first-page":"147","article-title":"Effect of minor components of virgin olive oil on topical anti-inflamatory assays","volume":"5","author":"De la Puerta","year":"2002","journal-title":"Zeitschrift f\u00fcr Naturforschung [C]"},{"key":"10.1016\/j.jep.2007.11.025_bib9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1515\/znc-2002-1-218","article-title":"Pharmaco-toxicological study of Kageneckia oblonga, Rosaceae","volume":"57","author":"Delporte","year":"2002","journal-title":"Zeitschrift f\u00fcr Naturforschung [C]"},{"key":"10.1016\/j.jep.2007.11.025_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jep.2005.02.012","article-title":"Analgesic-anti-inflammatory properties of Proustia pyrifolia","volume":"99","author":"Delporte","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib11","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1055\/s-2004-832630","article-title":"Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids","volume":"70","author":"Ende","year":"2004","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2007.11.025_bib12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1211\/0022357021779014","article-title":"Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica","volume":"54","author":"Feresin","year":"2002","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/(SICI)1099-1573(199902)13:1<78::AID-PTR384>3.0.CO;2-F","article-title":"Topical anti-inflammatory activity of phytosterols isolated from Eryngium foetidum on chronic and acute inflammation models","volume":"13","author":"Garc\u00eda","year":"1999","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2007.11.025_bib14","series-title":"The Flavonoids: Advances in Research","author":"Harborne","year":"1982"},{"key":"10.1016\/j.jep.2007.11.025_bib15","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/jn\/136.6.1517","article-title":"Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygene species but similarly inhibit prostaglandin-E2 formation RAW 264.7 cells","volume":"136","author":"Harris","year":"2006","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.jep.2007.11.025_bib16","series-title":"Nonparametric Statistical Methods","author":"Hollander","year":"1999"},{"key":"10.1016\/j.jep.2007.11.025_bib17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jep.2005.07.001","article-title":"In vitro tests and ethnopharmacological investigations: wound healing as an example","volume":"100","author":"Houghton","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib18","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1515\/znc-2003-11-1215","article-title":"In vitro anti-inflammatory effect of Carthamus lanatus L.","volume":"58","author":"Jalil","year":"2003","journal-title":"Zeitschrift f\u00fcr Naturforschung [C]"},{"key":"10.1016\/j.jep.2007.11.025_bib19","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1021\/jo01344a063","article-title":"Terpenoids LVII. Mass spectral and nuclear magnetic resonance studies of pentacyclic triterpene hydrocarbons","volume":"31","author":"Karliner","year":"1966","journal-title":"Journal of Organic Chemistry"},{"key":"10.1016\/j.jep.2007.11.025_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1179\/135100005X83734","article-title":"Antioxidant property of an active component purified from leaves of paraquat-tolerant Rhemannia glutinosa","volume":"10","author":"Kim","year":"2005","journal-title":"Redox Report"},{"key":"10.1016\/j.jep.2007.11.025_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1254\/jphs.CRJ04003X","article-title":"Anti-inflammatory plant flavonoids and cellular mechanisms","volume":"96","author":"Kim","year":"2004","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.jep.2007.11.025_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.bjp.0706972","article-title":"Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells","volume":"150","author":"Kobori","year":"2007","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jep.2005.01.005","article-title":"Inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by acteoside through blocking of AP-1 activation","volume":"97","author":"Lee","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.chroma.2004.11.024","article-title":"Isolation and purification of acteoside and isoacteoside from Plantago psyllium L., by high speed counter-current chromatography","volume":"1063","author":"Li","year":"2005","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/j.jep.2007.11.025_bib25","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1021\/np990092+","article-title":"Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation","volume":"62","author":"Liao","year":"1999","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2007.11.025_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0006-291X(02)00442-4","article-title":"Molecular modelling of flavonoids that inhibits xanthine oxidase","volume":"294","author":"Lin","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jep.2007.11.025_bib27","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0024-3205(03)00354-0","article-title":"The effects of verbascoside on plasma lipid peroxidation level and erythrocyte membrane fluidity during immobilization in rabbits: a time course study","volume":"73","author":"Liu","year":"2003","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2007.11.025_bib28","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-2952(95)00148-S","article-title":"Effects of an anti-inflammatory peptide (antiflammin 2) on cell influx, eicosanoid biosynthesis and oedema formation by arachidonic acid and tetradecanoyl) phorbol dermal application","volume":"50","author":"Lloret","year":"1995","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1055\/s-2006-959360","article-title":"Antioxidant activity of fruit exudate and C-methylated dihydrochalcones from Myrica gale","volume":"61","author":"Mathiesen","year":"1995","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2007.11.025_bib30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1248\/bpb.18.162","article-title":"Active oxygen scavenging activity of plant extracts","volume":"18","author":"Masaki","year":"1995","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2007.11.025_bib31","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1021\/np0001023","article-title":"Known and novel terpenes from Buddleja globosa displaying selective antifungal activity against dermatophytes","volume":"63","author":"Mensah","year":"2000","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2007.11.025_bib32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-8741(01)00297-5","article-title":"Effects of BuddIeja globosa leaf and its constituents relevant to wound healing","volume":"77","author":"Mensah","year":"2001","journal-title":"Journal of\u2018 Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib33","first-page":"673","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Flavonoids as potential therapeutics agents","volume":"52","author":"Middleton","year":"2000","journal-title":"Pharmacological and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2007.11.025_bib34","unstructured":"Mu\u00f1oz, M., Barrera, E., Meza, L., 1981. El Uso Medicinal y Alimenticio de Plantas Nativas y Naturalizadas en Chile, Museo Historia Natural, Public. Ocasional N\u00b0 33, p. 32."},{"key":"10.1016\/j.jep.2007.11.025_bib35","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/ptr.1723","article-title":"Structure\u2013activity relationship for anti-inflammatory effect of luteolin and its derived glycosides","volume":"19","author":"Odontuya","year":"2005","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2007.11.025_bib36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1124\/jpet.104.071779","article-title":"Antinociceptive properties of mixture of \u03b1-amyrin and \u03b2-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways","volume":"313","author":"Otuki","year":"2005","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2007.11.025_bib37","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1021\/jf061769j","article-title":"Table olives from Portugal: phenolic compounds, antioxidant potential, and antimicrobial activity","volume":"54","author":"Pereira","year":"2006","journal-title":"Journal of Agriculture and Food Chemistry"},{"key":"10.1016\/j.jep.2007.11.025_bib38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-2006-958045","article-title":"Structural requirements for the anti-inflammatory activity of natural triterpenoids","volume":"61","author":"Recio","year":"1995","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2007.11.025_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0378-8741(97)00136-0","article-title":"Anti-inflammatory and antinociceptive activities of extracts and isolated compounds from Stachytarpheta cayennensis","volume":"60","author":"Schapova","year":"1998","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/1071576031000090000","article-title":"Free radical scavengers and antioxidants from Peumus boldus Mol. (\u201cBoldo\u201d)","volume":"37","author":"Schmeda-Hirschmann","year":"2003","journal-title":"Free Radical Research"},{"key":"10.1016\/j.jep.2007.11.025_bib41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jep.2004.01.017","article-title":"Evaluation of the bioactivity of triterpene mixture isolated from Carmona retusa (Vahl.) Masam leaves","volume":"92","author":"Villase\u00f1or","year":"2004","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.11.025_bib42","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ptr.910","article-title":"Bioactivity studies on beta-sitosterol and its glucoside","volume":"16","author":"Villase\u00f1or","year":"2002","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2007.11.025_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.17660\/ActaHortic.2002.576.29","article-title":"Domestication studies of matico (Buddleja globosa Hope)","volume":"576","author":"Vogel","year":"2002","journal-title":"Acta Horticulturae"},{"key":"10.1016\/j.jep.2007.11.025_bib44","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/mrc.1393","article-title":"Spectral assignments and reference data. Complete assignments of 1H and 13C NMR data for phenylethanoid glycosides","volume":"42","author":"Wu","year":"2004","journal-title":"Magnetic Resonance in Chemistry"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874107006204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874107006204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,4]],"date-time":"2019-05-04T23:30:37Z","timestamp":1557012637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874107006204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0378874107006204"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2007.11.025","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}