{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:33:56Z","timestamp":1791920036725,"version":"4.3.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.jep.2007.12.018","type":"journal-article","created":{"date-parts":[[2008,1,12]],"date-time":"2008-01-12T07:39:16Z","timestamp":1200123556000},"page":"569-573","source":"Crossref","is-referenced-by-count":38,"title":["Anti-inflammatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae)"],"prefix":"10.1016","volume":"116","author":[{"given":"D.","family":"Rodrigues Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Svidzinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Bersani-Amado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.G.","family":"Cortez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2007.12.018_bib1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0006-291X(79)91280-4","article-title":"Prostaglandin E and F levels in mouse epidermis are increased by tumor-promoting phorbol esters","volume":"90","author":"Ashendel","year":"1979","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jep.2007.12.018_bib2","volume":"vol. 1","author":"Correa","year":"1984"},{"key":"10.1016\/j.jep.2007.12.018_bib3","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0031-9422(81)80027-1","article-title":"Amides from Ottonia corcovadensis","volume":"20","author":"Costa","year":"1981","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2007.12.018_bib4","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1016\/S0040-4039(00)96650-4","article-title":"Synthetic approaches to isobutylamides of insecticidal interest","volume":"28","author":"Crombie","year":"1987","journal-title":"Tetrahedron Letters"},{"key":"10.1016\/j.jep.2007.12.018_bib5","series-title":"Trease and Evans\u2019 Pharmacognosy","author":"Evans","year":"1989"},{"key":"10.1016\/j.jep.2007.12.018_bib6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0006-291X(80)90767-6","article-title":"Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by phorbol ester TPA","volume":"92","author":"Furstenberger","year":"1980","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jep.2007.12.018_bib7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1055\/s-2007-971526","article-title":"(2E,4E)-N-isobutyl-9-piperonyl-nona-2-4-dienoic amide from Ottonia anisum","volume":"43","author":"Giesbrecht","year":"1981","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2007.12.018_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-2006-957597","article-title":"Antithrombotic action of the Kava pyrone (+)-kavain prepared from Piper methysticum on human platelets","volume":"63","author":"Gleitz","year":"1997","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2007.12.018_bib9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1476-5381.1989.tb11801.x","article-title":"Modulation by glycyrrhetenic acid derivatives of TPA-induced mouse ear edema","volume":"96","author":"Inoue","year":"1989","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2007.12.018_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/1523-1747.ep12275349","article-title":"Arachidonic acid metabolism in cultured mouse keratinocytes","volume":"85","author":"Kondoh","year":"1985","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.jep.2007.12.018_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0378-8741(83)90022-3","article-title":"Piperovatine, the tongue numbing principle of Ottonia frutescens","volume":"7","author":"Makapugay","year":"1983","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.12.018_bib12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0006-291X(86)80186-3","article-title":"Modulation by phorbol myristate acetate of arachidonic acid release and leukotriene synthesis by human polymorphonuclear leukocytes stimulated with A23187","volume":"141","author":"McColl","year":"1986","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jep.2007.12.018_bib13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0378-8741(02)00224-6","article-title":"In vitro neuropharmacological evaluation of piperovatine, an isobutylamide from Piper piscatorum (Piperaceae)","volume":"83","author":"McFerren","year":"2002","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.12.018_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-8741(97)00154-2","article-title":"Piscicidal properties of Piper piscicatorum (Piperaceae)","volume":"60","author":"McFerren","year":"1998","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2007.12.018_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3181\/00379727-57-14776","article-title":"Estimation of the ED50 and its error by means of logarithmic-probit graph paper","volume":"57","author":"Miller","year":"1944","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"10.1016\/j.jep.2007.12.018_bib16","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1021\/jo00833a022","article-title":"Chemistry of Ottonia vahlii Kth. II. Constitution of the nonvolatile component","volume":"35","author":"Price","year":"1970","journal-title":"Journal of Organic Chemistry"},{"key":"10.1016\/j.jep.2007.12.018_bib17","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1039\/p19820001493","article-title":"Isolation and identification of amides from Piper callosum: synthesis of pipercallosidine and pipercallosine","volume":"1","author":"Pring","year":"1982","journal-title":"Journal of the Chemical Society Perkin Transactions"},{"key":"10.1016\/j.jep.2007.12.018_bib18","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1001\/archinte.156.19.2181","article-title":"Leukotrienes in asthma: the potential therapeutic role of antileukotriene agents","volume":"156","author":"Smith","year":"1996","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.jep.2007.12.018_bib19","series-title":"Medicinal Plants and Traditional Medicine in Africa","author":"Sofowora","year":"1993"},{"key":"10.1016\/j.jep.2007.12.018_bib20","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/cpt1974165part2900","article-title":"Anti-inflammatory drugs","volume":"16","author":"Van Arman","year":"1974","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.jep.2007.12.018_bib21","first-page":"427","article-title":"Cyclo-oxygenase inhibitors from spices","volume":"34","author":"Venkateshwarlu","year":"1997","journal-title":"Indian Drugs"},{"key":"10.1016\/j.jep.2007.12.018_bib22","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3181\/00379727-143-37397","article-title":"Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat","volume":"143","author":"Vinegar","year":"1973","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"10.1016\/j.jep.2007.12.018_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chroma.2004.03.056","article-title":"Preparative isolation and purification of amides from the fruits of Piper longum L. by upright counter-current chromatography and reversed-phase liquid chromatography","volume":"1040","author":"Wu","year":"2004","journal-title":"Journal of Chromatography A"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874108000111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874108000111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T09:58:09Z","timestamp":1546336689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874108000111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0378874108000111"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2007.12.018","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}