{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T22:47:12Z","timestamp":1777070832878,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.jep.2008.01.012","type":"journal-article","created":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T12:19:07Z","timestamp":1200917947000},"page":"51-57","source":"Crossref","is-referenced-by-count":49,"title":["Antidepressant activity of standardised extract of Marsilea minuta Linn."],"prefix":"10.1016","volume":"117","author":[{"given":"Subrat Kumar","family":"Bhattamisra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay Kumar","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok Kumar","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paras Nath","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2008.01.012_bib1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1176\/ajp.146.6.730","article-title":"Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects","volume":"146","author":"Arora","year":"1989","journal-title":"The American Journal of Psychiatry"},{"key":"10.1016\/j.jep.2008.01.012_bib2","first-page":"75","article-title":"The antifertility effect of an Australian species of the aquatic fern Marsilea L.","volume":"1","author":"Bhardwaja","year":"1984","journal-title":"Indian Fern Journal"},{"key":"10.1016\/j.jep.2008.01.012_bib3","first-page":"117","article-title":"Experimental methods for evaluation of psychotropic agents in rodents: II\u2014antidepressants","volume":"37","author":"Bhattacharya","year":"1999","journal-title":"Indian Journal of Experimental Biology"},{"key":"10.1016\/j.jep.2008.01.012_bib4","first-page":"S38","article-title":"Effect of Marsilea minuta Linn. on learning and memory performance in rats","volume":"37","author":"Bhattamisra","year":"2005","journal-title":"Indian Journal of Pharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib5","first-page":"3","article-title":"Behavioural characterization of Marsilea minuta in rodents","volume":"22","author":"Bhattamisra","year":"2006","journal-title":"Indian Journal of Natural Product"},{"key":"10.1016\/j.jep.2008.01.012_bib6","first-page":"15","article-title":"Anxiolytic activity of Marsilea minuta Linn.","volume":"1","author":"Bhattamisra","year":"2007","journal-title":"Journal of Herbal Medicine and Toxicology"},{"key":"10.1016\/j.jep.2008.01.012_bib7","series-title":"Mechanisms of Actions of Neurotoxic Substances","first-page":"21","article-title":"Neurotransmitter binding interaction as a screen for neurotoxicity","author":"Bondy","year":"1981"},{"key":"10.1016\/j.jep.2008.01.012_bib8","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.lfs.2006.06.003","article-title":"The comparison of immobility time in experimental rat swimming models","volume":"79","author":"Calil","year":"2006","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2008.01.012_bib9","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/0040-4020(75)85102-7","article-title":"Structure of Marsileagen: a new hexahydroxy triterpine from Marsilea minuta Linn.","volume":"31","author":"Chakravarti","year":"1975","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2008.01.012_bib10","first-page":"53","article-title":"The chemistry and pharmacology of Marsiline: a sedative and anticonvulsant principle isolated from Marsilea minuta Linn. and Marsilea Rajastanensis gupta","volume":"VII","author":"Chatterjee","year":"1963","journal-title":"Journal of Experimental Medical Sciences"},{"key":"10.1016\/j.jep.2008.01.012_bib11","first-page":"348","article-title":"Adaptation of the tail suspension test to the rat","volume":"17","author":"Chermat","year":"1986","journal-title":"Journal de Pharmacologie"},{"key":"10.1016\/j.jep.2008.01.012_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000127099","article-title":"Thyroxine replacement increases central 5-HT activity and reduces depressive symptoms in hypothyroidism","volume":"64","author":"Cleare","year":"1996","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jep.2008.01.012_bib13","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1365-2265.1995.tb00540.x","article-title":"Neuroendocrine evidence for an association between hypothyroidism reduced central 5-HT activity and depression","volume":"43","author":"Cleare","year":"1995","journal-title":"Clinical Endocrinology"},{"key":"10.1016\/j.jep.2008.01.012_bib14","first-page":"25","article-title":"Psychopharmacological studies on Marsilea minuta Linn.","volume":"5","author":"Dash","year":"2003","journal-title":"Drug Lines"},{"key":"10.1016\/j.jep.2008.01.012_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0166-4328(96)00067-8","article-title":"Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth","volume":"73","author":"Detke","year":"1996","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.jep.2008.01.012_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviours in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1471-4159.1966.tb09873.x","article-title":"Regional studies of catecholamines in the rat brain\u2014I","volume":"13","author":"Glowinski","year":"1966","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.jep.2008.01.012_bib18","series-title":"Neuropharmacology of Serotonin","first-page":"326","article-title":"The effects of drugs on serotonin-mediated behavioural models","author":"Green","year":"1985"},{"key":"10.1016\/j.jep.2008.01.012_bib19","first-page":"176","article-title":"Studies of antifertility activity of Marsilea minuta Linn.","volume":"64","author":"Gupta","year":"2002","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2008.01.012_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0367-326X(99)00140-9","article-title":"Hypocholesterolemic activity of Marsilea minuta Linn. in gerbils","volume":"71","author":"Gupta","year":"2000","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2008.01.012_bib21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0006-8993(93)91015-K","article-title":"5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims\/depressives: increase in 5-HT2 sites in cortex and amygdala","volume":"614","author":"Hrdina","year":"1993","journal-title":"Brain Research"},{"key":"10.1016\/j.jep.2008.01.012_bib22","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1476-5381.1994.tb14808.x","article-title":"In vivo properties of SB 200646A, a 5-HT 2C\/2B receptor antagonist","volume":"111","author":"Kennett","year":"1994","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib23","first-page":"209","article-title":"Regulation of serotonin type 2 (5-HT2) and adrenergic receptors in rat cerebral cortex following novel classical antidepressant treatment","volume":"16","author":"Lafaille","year":"1991","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"10.1016\/j.jep.2008.01.012_bib24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2008.01.012_bib25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioural effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behavioural Pharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF02805977","article-title":"The effects of paroxetine given repeatedly on the 5-HT receptor subpopulations in the rat brain","volume":"127","author":"Maj","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jep.2005.12.004","article-title":"The hydroalcoholic extract of Salvia elegans induces anxiolytic- and antidepressant-like effects in rats","volume":"106","author":"Mora","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/1099-1077(200008)15:6<397::AID-HUP212>3.0.CO;2-L","article-title":"A review of the role of serotonin receptors in psychiatric disorders","volume":"15","author":"Naughton","year":"2000","journal-title":"Human Psychopharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pbb.2003.09.015","article-title":"Antidepressant-like effects of NMDA-receptor antagonist injected into the dorsal hippocampus of rats","volume":"77","author":"Padovan","year":"2004","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"10.1016\/j.jep.2008.01.012_bib30","first-page":"35","article-title":"Antifungal efficacy of various pteridophytes plant parts extracts: a study in vitro","volume":"15","author":"Parihar","year":"2002","journal-title":"Advances in Plant Sciences"},{"key":"10.1016\/j.jep.2008.01.012_bib31","first-page":"48","article-title":"Toxic effect of plant extracts of Marsilea minuta L. on the growth of Staphylococcus aureus","volume":"20","author":"Parihar","year":"2003","journal-title":"Indian Fern Journal"},{"key":"10.1016\/j.jep.2008.01.012_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/1097-4547(20000701)61:1<101::AID-JNR12>3.0.CO;2-S","article-title":"Increased septal 5-HIAA efflux in rats that do not develop learned helplessness after inescapable stress","volume":"61","author":"Patrick","year":"2000","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.jep.2008.01.012_bib33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib34","first-page":"327","article-title":"Behavioural despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"key":"10.1016\/j.jep.2008.01.012_bib35","first-page":"101","article-title":"1-(2,5-Dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A\/2C antagonists, D 1 antagonists and 5-HT 1A agonists","volume":"273","author":"Schreiber","year":"1995","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2008.01.012_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0041-008X(81)90197-6","article-title":"Biochemical changes in the brain consequent to dietary exposure of developing and mature rats to chlordecone (Kepone)","volume":"59","author":"Seth","year":"1981","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib37","first-page":"13","article-title":"Alterations of high affinity binding sites of neurotransmitter receptors in rats after neonatal exposure to streptomycin","volume":"3","author":"Seth","year":"1982","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jep.2008.01.012_bib38","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0028-3908(79)90087-X","article-title":"A neuropharmacologically relevant animal model of depression","volume":"18","author":"Sherman","year":"1979","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib39","series-title":"Ayurvedic Drugs and their Plant Sources","author":"Sivarajan","year":"1994"},{"key":"10.1016\/j.jep.2008.01.012_bib40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF00181261","article-title":"The tail suspension test: ethical considerations","volume":"90","author":"Thierry","year":"1986","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib42","series-title":"Plant Drug Analysis: A Thin Layer Chromatography Atlas","author":"Wagner","year":"1984"},{"key":"10.1016\/j.jep.2008.01.012_bib43","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2307\/2443362","article-title":"Polyphenolics of the Marsileaceae and their possible phylogenetic utility","volume":"71","author":"Wallace","year":"1984","journal-title":"American Journal of Botany"},{"key":"10.1016\/j.jep.2008.01.012_bib44","series-title":"Textbook of Psychopharmacology","first-page":"88","article-title":"Animal models of depression and schizophrenia","author":"Weiss","year":"1998"},{"key":"10.1016\/j.jep.2008.01.012_bib45","unstructured":"WHO, 1999. WHO Director-General unveils new global strategies for mental health. Press Release WHO\/99-67. http:\/\/www.who.int\/inf-pr-1999\/en\/pr99-67.html."},{"key":"10.1016\/j.jep.2008.01.012_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00427414","article-title":"The validity of animal models of depression","volume":"83","author":"Willner","year":"1984","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jep.2008.01.012_bib47","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1056\/NEJM200012283432607","article-title":"Managing depression in medical outpatients","volume":"343","author":"Whooley","year":"2000","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.jep.2008.01.012_bib48","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.lfs.2004.04.014","article-title":"Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders","volume":"75","author":"Zhang","year":"2004","journal-title":"Life Sciences"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887410800038X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887410800038X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T03:43:07Z","timestamp":1630554187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887410800038X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S037887410800038X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2008.01.012","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}