{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:38:59Z","timestamp":1773203939187,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002993","name":"Consejer\u00eda de Educaci\u00f3n, Universidades y Sostenibilidad, Gobierno de Canarias","doi-asserted-by":"publisher","award":["180234-04-01"],"award-info":[{"award-number":["180234-04-01"]}],"id":[{"id":"10.13039\/501100002993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.jep.2008.03.004","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T11:05:05Z","timestamp":1205579105000},"page":"496-499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Diuretic activity of some Withania aristata Ait. fractions"],"prefix":"10.1016","volume":"117","author":[{"given":"D.","family":"Mart\u00edn-Herrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Abdala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Benjumea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Guti\u00e9rrez-Luis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2008.03.004_bib1","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1248\/cpb.54.1226","article-title":"Trypanocidal constituents in plants 6.1. Minor withanolides from the aerial parts of Physalis angulata","volume":"54","author":"Abe","year":"2006","journal-title":"Chemical & Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2008.03.004_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.fitote.2004.01.002","article-title":"The in vitro antibacterial\/synergistic activities of Withania somnifera extracts","volume":"75","author":"Arora","year":"2004","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2008.03.004_bib3","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0944-7113(00)80030-6","article-title":"Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study","volume":"7","author":"Bhattacharya","year":"2000","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2008.03.004_bib4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/0031-9422(95)00429-B","article-title":"Antifungal steroidal lactones from Withania coagulance","volume":"40","author":"Choudhary","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2008.03.004_bib5","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1021\/np0701374","article-title":"Isolation, structures, and structure-cytotoxic activity relationships of withanolides and physalins from Physalis angulata","volume":"70","author":"Damu","year":"2007","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2008.03.004_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0378-8741(89)90047-0","article-title":"New Contribution to the ethnopharmacological study of the Canary Island","volume":"25","author":"Darias","year":"1989","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.03.004_bib7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1076\/phbi.39.3.170.5937","article-title":"Plants used in urinary pathologies in the Canary Islands","volume":"39","author":"Darias","year":"2001","journal-title":"Pharmaceutical Biology"},{"key":"10.1016\/j.jep.2008.03.004_bib8","first-page":"83","article-title":"Medicinal plants in therapy","volume":"63","author":"Farnsworth","year":"1985","journal-title":"Bulletin of the World Health Organization"},{"key":"10.1016\/j.jep.2008.03.004_bib9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0367-326X(02)00325-8","article-title":"Quantitative HPLC analysis of withanolides in Whitania somnifera","volume":"74","author":"Ganzera","year":"2003","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2008.03.004_bib10","first-page":"107","article-title":"Withanolides of Withania aristata and Withania frutescens","volume":"68","author":"Gonz\u00e1lez","year":"1972","journal-title":"Anales de Qu\u00edmica"},{"key":"10.1016\/j.jep.2008.03.004_bib11","first-page":"64","article-title":"Withania steroids. II. Five steroidal lactones of Withania aristata","volume":"70","author":"Gonz\u00e1lez","year":"1974","journal-title":"Anales de Qu\u00edmica"},{"key":"10.1016\/j.jep.2008.03.004_bib12","unstructured":"Ja\u00e9n, J., 1989. Manual de Medicina Popular Canaria. Secretos de Nuestros Viejos Yerberos, Santa Cruz de Tenerife, Centro de Cultura Popular Canaria, p. 82."},{"key":"10.1016\/j.jep.2008.03.004_bib13","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0040-4020(02)01601-0","article-title":"Cyclooxygenase-2 enzyme inhibitory withanolides from Withania somnifera leaves","volume":"59","author":"Jayaprakasam","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2008.03.004_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0160-5402(84)90054-8","article-title":"A method for screening diuretic agents in the rats","volume":"11","author":"Kau","year":"1984","journal-title":"Journal Pharmacological Methods"},{"key":"10.1016\/j.jep.2008.03.004_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jep.2005.01.045","article-title":"Acute diuretic effect of aqueous extract of Retama raetam in normal rats","volume":"99","author":"Maghrani","year":"2005","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.03.004_bib16","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.lfs.2007.01.029","article-title":"A standardized root extract of Withania somnifera and its major constituent withanolide\u2014a elicit humoral and cell-mediated immune responses by upregulation of Th1-dominant polarization in BALB\/c mice","volume":"80","author":"Malik","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2008.03.004_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jep.2007.07.005","article-title":"Diuretic activity of Withania aristata: an endemic Canary Island species","volume":"113","author":"Mart\u00edn-Herrera","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.03.004_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2006.11.009","article-title":"Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice","volume":"111","author":"Muregi","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.03.004_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.phymed.2003.07.012","article-title":"Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis","volume":"12","author":"Owais","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2008.03.004_bib20","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1021\/np070096b","article-title":"Cytotoxic withanolides from the flowers of Datura metel","volume":"70","author":"Pan","year":"2007","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2008.03.004_bib21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0378-8741(91)90018-9","article-title":"Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs","volume":"31","author":"Pantoja","year":"1991","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.03.004_bib22","series-title":"Plantas Medicinales o \u00datiles en la Flora Canaria","author":"P\u00e9rez-Paz","year":"1999"},{"key":"10.1016\/j.jep.2008.03.004_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1472-8206.2006.00461.x","article-title":"Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats","volume":"21","author":"Rasool","year":"2007","journal-title":"Fundamental & Clinical Pharmacology"},{"key":"10.1016\/j.jep.2008.03.004_bib24","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.plantsci.2006.12.016","article-title":"In vitro flowering of Withania somnifera Dunal\u2014an important antitumor medicinal plant","volume":"172","author":"Saritha","year":"2007","journal-title":"Plant Science"},{"key":"10.1016\/j.jep.2008.03.004_bib25","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1177\/1934578X0700200714","article-title":"A cytotoxic and hepatoprotective agent from Withania somnifera and biological evaluation of its ester derivatives","volume":"2","author":"Saxena","year":"2007","journal-title":"Natural Product Communications"},{"key":"10.1016\/j.jep.2008.03.004_bib26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/ptr.2650070508","article-title":"Diuretic Activity of Satureja montana subsp. montana extracts and oil in rats","volume":"7","author":"Stani\u0107","year":"1993","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2008.03.004_bib27","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1021\/np060147p","article-title":"Ashwagandhanolide, a bioactive dimeric thiowithanolide isolated from the roots of Withania somnifera","volume":"69","author":"Subbaraju","year":"2006","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2008.03.004_bib28","series-title":"Investigaciones Fitoqu\u00edmicas en plantas Canarias","author":"Valera","year":"2002"},{"key":"10.1016\/j.jep.2008.03.004_bib29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.phymed.2006.03.005","article-title":"Hypocholesteremic and antioxidant effects of Withania somnifera (Dunal) in hypercholesteremic rats","volume":"14","author":"Visavadiya","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2008.03.004_bib30","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1158\/1078-0432.CCR-06-0948","article-title":"Selective killing of cancer cells by leaf extract of ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect","volume":"13","author":"Widodo","year":"2007","journal-title":"Clinical Cancer Research"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874108001487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874108001487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:13:04Z","timestamp":1759939984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874108001487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0378874108001487"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2008.03.004","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diuretic activity of some Withania aristata Ait. fractions","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2008.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}