{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:39:26Z","timestamp":1790077166289,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.jep.2008.06.001","type":"journal-article","created":{"date-parts":[[2008,6,7]],"date-time":"2008-06-07T09:13:27Z","timestamp":1212830007000},"page":"94-98","source":"Crossref","is-referenced-by-count":36,"title":["Evaluation of the antiulcerogenic and analgesic activities of Cordia verbenacea DC. (Boraginaceae)"],"prefix":"10.1016","volume":"119","author":[{"given":"Erika de Freitas","family":"Rold\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Witaicenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Noboru","family":"Seito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9lia Akiko","family":"Hiruma-Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Claudio","family":"Di Stasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2008.06.001_bib1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1055\/s-2003-45098","article-title":"Purification of gastroprotective triterpenoids from the stem bark of Amphipterygium adstringens, role of prostaglandins, sulfhydryls, nitric oxide and capsaicin-sensitive neurons","volume":"69","author":"Arrieta","year":"2003","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2008.06.001_bib2","first-page":"260","article-title":"Topical anti-inflammatory activity and toxicity of Cordia verbenacea","volume":"60","author":"Basile","year":"1989","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2008.06.001_bib3","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1590\/S0100-879X2002001000017","article-title":"Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC","volume":"35","author":"Bayeux","year":"2002","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/j.jep.2008.06.001_bib4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jep.2006.09.032","article-title":"Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea","volume":"110","author":"Calixto","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.06.001_bib5","unstructured":"Correa, M.P., 1984. Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas, vol. 2. IBDF (Minist\u00e9rio da Agricultura), Bras\u00edlia, p. 142."},{"key":"10.1016\/j.jep.2008.06.001_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0024-3205(99)00120-4","article-title":"Flavonoids: old and new aspects of a class of natural therapeutic drugs","volume":"65","author":"Di Carlo","year":"1999","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2008.06.001_bib7","series-title":"Plantas medicinais na Amaz\u00f4nia e na Mata Atl\u00e2ntica","first-page":"406","article-title":"Lamiales medicinais","author":"Di Stasi","year":"2002"},{"key":"10.1016\/j.jep.2008.06.001_bib8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0022-3565(25)05180-8","article-title":"Synthetic analgesics. II. Dithienylbutenyl and dithienylbutylamines","volume":"107","author":"Eddy","year":"1953","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2008.06.001_bib9","series-title":"Plantas medicinais: Arte e Ci\u00eancia \u2013 Um guia de estudo interdisciplinar","first-page":"129","article-title":"Qu\u00edmica de produtos naturais: m\u00e9todos gerais.","author":"Ferri","year":"1996"},{"key":"10.1016\/j.jep.2008.06.001_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000139325","article-title":"Flavonoid Inhibition of enzymic and nonenzymic lipid peroxidation in rat liver differs from its influence on the glutathione-related enzymes","volume":"51","author":"G\u00e1lvez","year":"1995","journal-title":"Pharmacology"},{"key":"10.1016\/j.jep.2008.06.001_bib11","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0016-5085(84)80068-2","article-title":"Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection","volume":"87","author":"Guth","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2008.06.001_bib12","first-page":"502","article-title":"The inhibitory effect of fentanyl and other morphine-like analgesics on the worm induced tail withdraw reflex in rats","volume":"13","author":"Jansen","year":"1963","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.jep.2008.06.001_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1248\/bpb.28.101","article-title":"19\u03b1-Hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa","volume":"28","author":"Jung","year":"2005","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2008.06.001_bib14","series-title":"Federation Proceedings, vol. 18","first-page":"412","article-title":"Acetic acid analgesic screening","author":"Koster","year":"1959"},{"key":"10.1016\/j.jep.2008.06.001_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-8741(99)00174-9","article-title":"Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions","volume":"71","author":"La Casa","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.06.001_bib16","first-page":"2001","article-title":"Anti-ulcer drugs of plant origin","volume":"vol. 28","author":"Lewis","year":"1991"},{"key":"10.1016\/j.jep.2008.06.001_bib17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF02836508","article-title":"Study of total alkaloids from rhizoma Coptis chinensis on experimental gastric ulcers","volume":"11","author":"Li","year":"2005","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"10.1016\/j.jep.2008.06.001_bib18","first-page":"51","article-title":"Protective effects of total alkaloids from rhizoma Coptis chinensis on alcohol-induced gastric lesion in rats","volume":"31","author":"Li","year":"2006","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jep.2008.06.001_bib19","first-page":"54","article-title":"New xanthone derivatives as potent anti-inflammatory agents","volume":"41","author":"Librowski","year":"2005","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.jep.2008.06.001_bib20","first-page":"320","article-title":"A hippocratic screen for pure or crude drug materials","volume":"25","author":"Malone","year":"1962","journal-title":"Lloydia"},{"key":"10.1016\/j.jep.2008.06.001_bib21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1159\/000007703","article-title":"Ethanol related gastric mucosal damage: evidence of a free radical-mediated mechanism and beneficial effect of oral supplementation with bionormalizer, a novel natural antioxidant","volume":"60","author":"Marotta","year":"1999","journal-title":"Digestion"},{"key":"10.1016\/j.jep.2008.06.001_bib22","series-title":"Introdu\u00e7\u00e3o a fitoqu\u00edmica experimental","author":"Matos","year":"1988"},{"key":"10.1016\/j.jep.2008.06.001_bib23","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/S0968-0896(03)00067-1","article-title":"Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action","volume":"11","author":"Matsuda","year":"2003","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10.1016\/j.jep.2008.06.001_bib24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1254\/jjp.33.939","article-title":"Effect of polyamines on acidified ethanol induced gastric lesions in rats","volume":"33","author":"Mizui","year":"1983","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1016\/j.jep.2008.06.001_bib25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/np058097w","article-title":"Triterpene saponins with gastroprotective effects from tea seed (the seeds of Camellia sinensis)","volume":"69","author":"Morikawa","year":"2006","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2008.06.001_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1254\/jjp.57.495","article-title":"Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of terpenone and cimetidine","volume":"57","author":"Morimoto","year":"1991","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1016\/j.jep.2008.06.001_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9422(00)00303-4","article-title":"Tetraoxygenated naturally occurring xanthones","volume":"55","author":"Peres","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2008.06.001_bib28","first-page":"568","article-title":"Comparative study of the safety and efficacy of ebrotidine versus ranitidine and placebo in the prevention of piroxican-induced gastroduodenal lesions","volume":"47","author":"Puscas","year":"1997","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.jep.2008.06.001_bib29","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1248\/cpb.25.1017","article-title":"Pharmacological studies of Panacis japonici Rhizoma","volume":"25","author":"Saito","year":"1977","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2008.06.001_bib30","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1043661802002293","article-title":"Evidences for involvement of nitric oxide in the gastroprotective effect of bromocriptine and cyclosporin on water immersion stress-induced gastric lesions","volume":"46","author":"Samini","year":"2002","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.jep.2008.06.001_bib31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0378-8741(91)90008-2","article-title":"Pharmacological assay of Cordia verbenacea III: oral and topical antiinflammatory activity and gastrotoxicity of a crude leaf extract","volume":"31","author":"Serti\u00e9","year":"1991","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.06.001_bib32","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.phymed.2003.09.013","article-title":"Pharmacological assay of Cordia verbenacea V: oral and topical anti-inflammatory activity, analgesic effects and fetus toxicity of a crude leaf extract","volume":"12","author":"Serti\u00e9","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2008.06.001_bib33","first-page":"43","article-title":"A simple method for the uniform production of gastric ulceration in the rat","volume":"5","author":"Shay","year":"1945","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2008.06.001_bib34","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.2042-7158.1991.tb03461.x","article-title":"Effects of polysaccharide fraction from the roots of Bupleurum falcatum L. on experimental gastric ulcer models in rats and mice","volume":"43","author":"Sun","year":"1991","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.jep.2008.06.001_bib35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0889-8553(21)00457-X","article-title":"Experimental gastric and duodenal ulcers","volume":"19","author":"Szabo","year":"1990","journal-title":"Gastroenterology Clinical North America"},{"key":"10.1016\/j.jep.2008.06.001_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1248\/bpb.24.1","article-title":"Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing","volume":"24","author":"Tsukimi","year":"2001","journal-title":"Biological Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2008.06.001_bib37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0378-8741(87)90141-3","article-title":"Anti-ulcer action of Panax japonicus rhizome","volume":"19","author":"Yamahara","year":"1987","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.06.001_bib38","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0031-9422(99)00198-3","article-title":"A saponin with anti-ulcerogenic effect from the flowers of Spartium junceum","volume":"51","author":"Yesilada","year":"1999","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2008.06.001_bib39","first-page":"219","article-title":"Gastroprotective effects of flavonoids in plant extracts","volume":"56","author":"Zayachkivska","year":"2005","journal-title":"Journal of Physiology and Pharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874108003000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874108003000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T17:01:27Z","timestamp":1738256487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874108003000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0378874108003000"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2008.06.001","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}