{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:25:45Z","timestamp":1791073545510,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.jep.2008.09.015","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T08:40:01Z","timestamp":1222332001000},"page":"372-377","source":"Crossref","is-referenced-by-count":149,"title":["Evaluation of antiulcer activity of the main phenolic acids found in Brazilian Green Propolis"],"prefix":"10.1016","volume":"120","author":[{"given":"Muriel Primon de","family":"Barros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marivane","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson Luis","family":"Maistro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus Freire","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo Barreto","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo Kennup","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Faloni de","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2008.09.015_bib1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1515\/znc-2006-5-605","article-title":"Antiulcerogenic activity of crude extract, fractions and populnoic acid isolated from Austroplenckia populnea (Celastraceae)","volume":"61","author":"Andrade","year":"2006","journal-title":"Zeistschrift fur Naturforschung C"},{"key":"10.1016\/j.jep.2008.09.015_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1051\/apido:2000102","article-title":"Propolis: recent advances in chemistry and plant origin","volume":"31","author":"Bankova","year":"2000","journal-title":"Apidologie"},{"key":"10.1016\/j.jep.2008.09.015_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jep.2006.10.022","article-title":"Effect of Brazilian green propolis on experimental gastric ulcers in rats","volume":"110","author":"Barros","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0378-8741(90)90007-G","article-title":"Pharmacological assay of Casearia silvestris. I. Preventive anti-ulcer activity and toxicity of the leaf crude extract","volume":"30","author":"Basile","year":"1990","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib5","first-page":"65","article-title":"Observational survey of NSAID-related upper gastro-intestinal adverse events in Belgium","volume":"65","author":"Belaiche","year":"2002","journal-title":"Acta Gastroenterologic Belgian"},{"key":"10.1016\/j.jep.2008.09.015_bib6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.phymed.2003.09.006","article-title":"Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip","volume":"12","author":"Bighetti","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2008.09.015_bib7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/1099-1573(200012)14:8<581::AID-PTR776>3.0.CO;2-S","article-title":"The plant kingdom as a source of anti-ulcer remedies","volume":"14","author":"Borrelli","year":"2000","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2008.09.015_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0367-326X(02)00185-5","article-title":"Propolis, an old remedy used in modern medicine","volume":"73","author":"Castaldo","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2008.09.015_bib9","first-page":"49","article-title":"Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product","volume":"3","author":"Castro","year":"2001","journal-title":"Annual Review of Biomedical Science"},{"key":"10.1016\/j.jep.2008.09.015_bib10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(02)11030-0","article-title":"Peptic ulcer disease","volume":"360","author":"Chan","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2008.09.015_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0092-8674(95)90408-5","article-title":"Calcium signaling","volume":"80","author":"Clapham","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jep.2008.09.015_bib12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jep.2006.11.032","article-title":"Analysis of propolis from Baccharis dracunculifolia DC. (Compositae) and its effects on mouse fibroblasts","volume":"111","author":"Funari","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0378-8741(02)00243-X","article-title":"Study on the increment of the production of gastric mucus in rats treated with Opuntia ficus indica (L.) Mill. Cladodes","volume":"83","author":"Galati","year":"2002","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2005.12.002","article-title":"Antiulcer and antimicrobial activity of Anogeissus latifolia","volume":"106","author":"Govindarajan","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.foodchem.2007.10.084","article-title":"Antiulcerative properties of crude polyphenols and juice of apple, and Chinese quince extracts","volume":"108","author":"Hamauzu","year":"2008","journal-title":"Food Chemistry"},{"key":"10.1016\/j.jep.2008.09.015_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0140-6736(95)91378-5","article-title":"NSAIDs, Cox-2 inhibitors, and the gut","volume":"346","author":"Hayllar","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2008.09.015_bib17","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.bmc.2004.11.055","article-title":"Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents","volume":"13","author":"Hung","year":"2005","journal-title":"Bioorganical Medicinal Chemistry"},{"key":"10.1016\/j.jep.2008.09.015_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/ecam\/nek005","article-title":"Brazilian green propolis protects against retinal damage in vitro and in vivo","volume":"3","author":"Inokuchi","year":"2006","journal-title":"Evidence Based Complementary Alternative Medicine"},{"key":"10.1016\/j.jep.2008.09.015_bib19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jep.2005.08.064","article-title":"Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: Possible mechanism for the inhibition of acid formation","volume":"104","author":"Jainu","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1248\/bpb.18.223","article-title":"Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric-lesions and gastric-mucosal resistance to ulcerogenic agents in rats","volume":"18","author":"Kinoshita","year":"1995","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2008.09.015_bib21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1211\/jpp.59.4.0017","article-title":"Baccharis dracunculifolia, the main botanical source of Brazilian green propolis, displays antiulcer activity","volume":"59","author":"Lemos","year":"2007","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jep.2005.11.032","article-title":"Can the aqueous decoction of mango flowers be used as antiulcer agent?","volume":"106","author":"Lima","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1515\/znc-1998-1-220","article-title":"Chemical composition of Brazilian propolis from S\u00e3o Paulo state","volume":"53","author":"Marcucci","year":"1998","journal-title":"Zeistschrift fur Naturforschung C"},{"key":"10.1016\/j.jep.2008.09.015_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1254\/jjp.57.495","article-title":"Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of treprenone and cimetidine","volume":"57","author":"Morimoto","year":"1991","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000136758","article-title":"Interrelationships between the gastric secretory responses, prostaglandin E2 inhibition and serum level of immunoreactive gastrin in pylorus-ligated and antrectomized rats","volume":"16","author":"Nagy","year":"1968","journal-title":"Pharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib26","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.lfs.2006.09.017","article-title":"Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions","volume":"80","author":"Nakajima","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2008.09.015_bib27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0378-8741(00)00261-0","article-title":"Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats","volume":"72","author":"Nwafor","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0016-5085(88)90604-X","article-title":"Studies on the mechanism of ethanol-induced gastric damage in rats","volume":"94","author":"Oates","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2008.09.015_bib29","unstructured":"OECD, 2001. Guideline for Testing of Chemicals. Guideance no. 420. Fixed Dose Procedure, Adopted December 17, 2001. Disponible in http:\/\/iccvam.niehs.nih.gov\/SuppDocs\/FedDocs\/OECD\/OECD_GL420.pdf."},{"key":"10.1016\/j.jep.2008.09.015_bib30","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1021\/jf011432b","article-title":"Botanical origin and chemical composition of Brazilian Propolis","volume":"50","author":"Park","year":"2002","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2008.09.015_bib31","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1515\/znc-2003-7-824","article-title":"Distribution of quinic acid derivates and other phenolic compounds in Brazilian propolis","volume":"58","author":"Pereira","year":"2003","journal-title":"Zeistschrift fur Naturforschung C"},{"key":"10.1016\/j.jep.2008.09.015_bib32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0960-894X(00)00630-2","article-title":"Synthesis and evaluation of caffeic acid amides as antioxidants","volume":"11","author":"Rajan","year":"2001","journal-title":"Bioorganical Medical and Chemical Letters"},{"key":"10.1016\/j.jep.2008.09.015_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1590\/S0102-695X2000000100005","article-title":"Atividade Antiinflamat\u00f3ria, Anti\u00falcera G\u00e1strica e Toxicidade Subcr\u00f4ncia do Extrato Etan\u00f3lico de Pr\u00f3polis","volume":"10","author":"Reis","year":"2000","journal-title":"Brazilian Journal of Pharmacognosy"},{"key":"10.1016\/j.jep.2008.09.015_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(02)00041-7","article-title":"Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study","volume":"82","author":"Sairam","year":"2002","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib35","first-page":"463","article-title":"Gastric secretion","volume":"16","author":"Schubert","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2008.09.015_bib36","first-page":"43","article-title":"A simple method for the uniform production of gastric ulceration in the rat","volume":"5","author":"Shay","year":"1945","journal-title":"Gastroenteroogy"},{"key":"10.1016\/j.jep.2008.09.015_bib37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/ecam\/neh078","article-title":"Neuroprotection by Brazilian green propolis against in vitro and in vivo ischemic neuronal damage","volume":"2","author":"Shimazawa","year":"2005","journal-title":"Evidence Based Complementary Alternative Medicine"},{"key":"10.1016\/j.jep.2008.09.015_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-8741(98)00142-1","article-title":"Evaluation of the gastric activity of fixed oil of Ocimum sanctum (Holy Basil)","volume":"65","author":"Singh","year":"1999","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2008.09.015_bib39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00365528709090946","article-title":"Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies","volume":"127","author":"Szabo","year":"1987","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2008.09.015_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/ecam\/neh055","article-title":"Plant origin of green propolis: bee behavior, plant anatomy and chemistry","volume":"2","author":"Teixeira","year":"2005","journal-title":"Evidence Based Complementary Alternative Medicine"},{"key":"10.1016\/j.jep.2008.09.015_bib41","doi-asserted-by":"crossref","first-page":"19S","DOI":"10.1016\/S0002-9343(00)00631-8","article-title":"Mechanisms of protection and healing: current knowledge and future research","volume":"110","author":"Wallace","year":"2001","journal-title":"American Journal of Medicine"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874108004960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874108004960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T05:49:37Z","timestamp":1557812977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874108004960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0378874108004960"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2008.09.015","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}