{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:24:39Z","timestamp":1780500279738,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.jep.2009.01.019","type":"journal-article","created":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T09:35:01Z","timestamp":1233221701000},"page":"210-215","source":"Crossref","is-referenced-by-count":32,"title":["Sesquiterpene lactones with antinociceptive and antipyretic activity from two Centaurea species"],"prefix":"10.1016","volume":"122","author":[{"given":"Esra K\u00fcpeli","family":"Akkol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhan","family":"Arif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Ergun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Yesilada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2009.01.019_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0378-8741(95)90036-5","article-title":"Effect of various pretreatments on the hypotermic activity of repin in naive rats","volume":"49","author":"Akbar","year":"1995","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2009.01.019_bib2","first-page":"468","article-title":"Flavonoids from Centaurea sinaica","volume":"63","author":"Al-Easa","year":"1992","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2009.01.019_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1055\/s-2006-962790","article-title":"Chemical constituents of Centaurea pallescens","volume":"53","author":"Ali","year":"1987","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2009.01.019_bib4","first-page":"281","article-title":"Cytotoxic activity of flavonoids from Carthamus arborescens. Ononis natrix ssp. ramosissima and Centaurea malacitana","volume":"68","author":"Barrero","year":"1997","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2009.01.019_bib5","first-page":"191","article-title":"Constituents of Centaurea ornata ssp. ornata","volume":"65","author":"Bastos","year":"1994","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2009.01.019_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-2006-962361","article-title":"Centaurea corcubionensis: a study of its hypoglycemic activity in rats","author":"Chucla","year":"1988","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2009.01.019_bib7","first-page":"29","article-title":"Phytochemical investigation of Centaurea araneosa growing in Egypt","volume":"2","author":"Farrag","year":"1993","journal-title":"Zagrep Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2009.01.019_bib8","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/240410a0","article-title":"Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol","volume":"240","author":"Flower","year":"1972","journal-title":"Nature"},{"key":"10.1016\/j.jep.2009.01.019_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0378-8741(99)00112-9","article-title":"Anti-inflammatory and immunological effects of Centaurea cyanus flower-heads","volume":"68","author":"Garbacki","year":"1999","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2009.01.019_bib10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jep.2007.03.009","article-title":"Evaluation of the antiulcerogenic effect of the sesquiterpene lactones from Centaurea solstitialis ssp. solstitialis by using various in vivo and biochemical techniques","volume":"112","author":"G\u00fcrb\u00fcz","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2009.01.019_bib11","first-page":"178","article-title":"Chemical and biological activity of the genus Centaurea","volume":"67","author":"Kaij-A-Kamb","year":"1992","journal-title":"Pharmaceutica Acta Helvetica"},{"key":"10.1016\/j.jep.2009.01.019_bib12","first-page":"47","article-title":"The C-glycosyl flavonoids from flowers of Centaurea malitensis","volume":"17","author":"Kamanzi","year":"1983","journal-title":"Plant\u00e9s Medicinal et Phytotherapi\u00e9"},{"key":"10.1016\/j.jep.2009.01.019_bib13","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/ptr.2097","article-title":"Total phenolic contents, free radical scavenging activities and inhibitory effects of NF-kappa B of eight Centaurea L. species","volume":"21","author":"Karamenderes","year":"2007","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2009.01.019_bib14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0024-3205(02)02200-2","article-title":"A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species","volume":"72","author":"K\u00fcpeli","year":"2002","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2009.01.019_bib15","first-page":"226","article-title":"Dehydrocostus lactone and 8\u03b2-hydroxydehydrocostus lactone in Centaurea chilensis Hook and Arn","volume":"18","author":"Negrete","year":"1984","journal-title":"Plant\u00e9s Medicinal et Phytotherapi\u00e9"},{"key":"10.1016\/j.jep.2009.01.019_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0378-8741(93)90062-A","article-title":"Two new antiinflammatory elemanolides from Centaurea chilensis","volume":"40","author":"Negrete","year":"1993","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2009.01.019_bib17","first-page":"107","article-title":"The effect of aggregation, electric shock and adrenergic blocking drugs on inhibition of the \u201cwrithing syndrome\u201d","volume":"139","author":"Okun","year":"1963","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2009.01.019_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1055\/s-2006-957386","article-title":"Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis","volume":"64","author":"Orallo","year":"1998","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2009.01.019_bib19","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1021\/jm049937r","article-title":"Quantitative structure\u2013activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappa B","volume":"18","author":"Siedle","year":"2004","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.jep.2009.01.019_bib20","first-page":"88","article-title":"Constituents of Centaurea chilensis","volume":"65","author":"Sepulveda","year":"1994","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2009.01.019_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-8741(96)01491-2","article-title":"Medicinal plants used in the Barros Area, Badajoz Province (Spain)","volume":"55","author":"Vazquez","year":"1997","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2009.01.019_bib22","first-page":"465","article-title":"Centaurea L","volume":"vol. V","author":"Wagenitz","year":"1975"},{"key":"10.1016\/j.jep.2009.01.019_bib23","first-page":"245","article-title":"New eudesmane sesquiterpene and thiophene derivatives from the roots of Rhaponticum uniflorum","volume":"52","author":"Wei","year":"1997","journal-title":"Die Pharmazie"},{"key":"10.1016\/j.jep.2009.01.019_bib24","series-title":"Biodiversity: Biomolecular Aspects of Biodiversity and Innovative Utilization","first-page":"119","article-title":"Biodiversity in Turkish Folk Medicine","author":"Yesilada","year":"2002"},{"key":"10.1016\/j.jep.2009.01.019_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jep.2004.07.021","article-title":"Isolation of antiulcerogenic sesquiterpene lactones from Centaurea solstitialis ssp. solstitialis through bioassay-guided fractionation procedures in rats","volume":"95","author":"Yesilada","year":"2004","journal-title":"Journal of Ethnopharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874109000427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874109000427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T05:22:32Z","timestamp":1545456152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874109000427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0378874109000427"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2009.01.019","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}