{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:22:07Z","timestamp":1791030127396,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,6,12]],"date-time":"2010-06-12T00:00:00Z","timestamp":1276300800000},"content-version":"vor","delay-in-days":346,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.jep.2009.06.003","type":"journal-article","created":{"date-parts":[[2009,6,13]],"date-time":"2009-06-13T04:48:31Z","timestamp":1244868511000},"page":"369-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)"],"prefix":"10.1016","volume":"124","author":[{"given":"C\u00e2ndida Aparecida Leite","family":"Kassuya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Cremoneze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Ferrari Lemos","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Sandro","family":"Simas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"da Rocha Lapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Mello-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria \u00c9lida Alves","family":"Stefanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander Roberto","family":"Zampronio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2009.06.003_bib1","first-page":"376","article-title":"Screening of the biological activity from essential oils of native species from the atlantic rain forest (S\u00e3o Paulo - Brazil)","volume":"3","author":"Apel","year":"2006","journal-title":"Pharmacology on Line"},{"key":"10.1016\/j.jep.2009.06.003_bib2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0076-6879(88)62087-8","article-title":"Sponge implants as models","volume":"162","author":"Bailey","year":"1988","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.jep.2009.06.003_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0166-3542(94)00083-K","article-title":"Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells","volume":"27","author":"Chen","year":"1995","journal-title":"Antiviral Research"},{"key":"10.1016\/j.jep.2009.06.003_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ejphar.2006.10.054","article-title":"Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappaB\/MAP kinases in lipopolysaccharide-treated RAW 264.7 cells","volume":"556","author":"Choi","year":"2007","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2009.06.003_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1590\/S1519-566X2006000100018","article-title":"Insecticidal activity of cerrado plant extracts on Rhodnius milesi Carcavallo, Rocha, Galv\u00e3o & Jurberg (Hemiptera: Reduviidae) under laboratory conditions","volume":"35","author":"Coelho","year":"2006","journal-title":"Neotropical Entomology"},{"key":"10.1016\/j.jep.2009.06.003_bib6","first-page":"R527","article-title":"Multiple mechanisms mediate antipyretic action of glucocorticoids","volume":"269","author":"Coelho","year":"1995","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.jep.2009.06.003_bib7","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.4049\/jimmunol.161.12.6861","article-title":"Lipopolysaccharide-induced leukocyte rolling and adhesion in the rat mesenteric microcirculation: regulation by glucocorticoids and role of cytokines","volume":"161","author":"Davenpeck","year":"1998","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.jep.2009.06.003_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF01967298","article-title":"Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents","volume":"26","author":"De Young","year":"1989","journal-title":"Agents and Actions"},{"key":"10.1016\/j.jep.2009.06.003_bib9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cbi.2008.10.017","article-title":"Normo-glycemic and hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex. Retz.)Sm. in streptozotocin-induced diabetic rats","volume":"179","author":"Eliza","year":"2009","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.jep.2009.06.003_bib10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF01966298","article-title":"Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration \u201cin vivo\u201d by indirect mechanisms","volume":"30","author":"Faccioli","year":"1990","journal-title":"Agents and Actions"},{"key":"10.1016\/j.jep.2009.06.003_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pbb.2004.08.008","article-title":"Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot","volume":"79","author":"Feltenstein","year":"2004","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.jep.2009.06.003_bib12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejphar.2007.04.059","article-title":"Anti-inflammatory effects of compounds alpha-humulene and (\u2212)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea","volume":"569","author":"Fernandes","year":"2007","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2009.06.003_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1476-5381.1990.tb14671.x","article-title":"Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse","volume":"99","author":"Henriques","year":"1990","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2009.06.003_bib14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.exppara.2007.08.015","article-title":"Trypanosoma cruzi: antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.) Schultz Bip. (Asteraceae, Compositae) against epimastigote and amastigote forms","volume":"118","author":"Izumi","year":"2008","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.jep.2009.06.003_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chroma.2005.04.042","article-title":"Preparative isolation and purification of costunolide and dehydrocostuslactone from Aucklandia lappa Decne by high-speed counter-current chromatography","volume":"1076","author":"Li","year":"2005","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/j.jep.2009.06.003_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.lfs.2007.08.014","article-title":"Effects of honokiol and magnolol on acute and inflammatory pain models in mice","volume":"81","author":"Lin","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2009.06.003_bib17","first-page":"R724","article-title":"Roles of interleukin 1 beta and tumor necrosis factor in lipopolysaccharide fever in rats","volume":"259","author":"Long","year":"1990","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.jep.2009.06.003_bib18","first-page":"579","article-title":"Magnoliaceae nativas del Brasil. Revista de la Academia Colombiana de Ciencias Exactas","volume":"17","author":"Lozano-Contreas","year":"1990","journal-title":"F\u00edsicas y Naturales"},{"key":"10.1016\/j.jep.2009.06.003_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1254\/jphs.CRJ06010X","article-title":"Systemic inflammatory response syndrome (SIRS): molecular pathophysiology and gene therapy","volume":"101","author":"Matsuda","year":"2006","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.jep.2009.06.003_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(83)90261-3","article-title":"Effects of several anti-inflammatory drugs on the various parameters involved in the inflammatory response in rat carrageenin-induced pleurisy","volume":"95","author":"Mikami","year":"1983","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2009.06.003_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0378-8741(89)90100-1","article-title":"Chemical and pharmacological studies on Talauma ovata St. Hil. (Magnoliaceae)","volume":"26","author":"Morato","year":"1989","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2009.06.003_bib22","series-title":"Medicinal Plants of Brazil","author":"Mors","year":"2000"},{"key":"10.1016\/j.jep.2009.06.003_bib23","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2174\/138955706777934937","article-title":"Naturally occurring NF-kappaB inhibitors","volume":"6","author":"Nam","year":"2006","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.jep.2009.06.003_bib24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.bjp.0705650","article-title":"Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression","volume":"142","author":"Posadas","year":"2004","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2009.06.003_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-8993(98)00402-8","article-title":"Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide","volume":"802","author":"Quan","year":"1998","journal-title":"Brain Research"},{"key":"10.1016\/j.jep.2009.06.003_bib26","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Antiinflammatory action of glucocorticoids\u2014new mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.jep.2009.06.003_bib27","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1016\/j.bmcl.2008.06.008","article-title":"A new sesquiterpene lactone from the roots of Saussurea lappa: structure\u2013anticancer activity study","volume":"18","author":"Robinson","year":"2008","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.jep.2009.06.003_bib28","first-page":"R1244","article-title":"Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature","volume":"289","author":"Rudaya","year":"2005","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.jep.2009.06.003_bib29","first-page":"475","article-title":"Constituents of Talauma ovata bark","volume":"68","author":"Stefanello","year":"1997","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2009.06.003_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0367-326X(02)00008-4","article-title":"New neolignans from Talauma ovata","volume":"73","author":"Stefanello","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2009.06.003_bib31","first-page":"1","article-title":"Ocorr\u00eancia de quimiotipos em Talauma ovata, uma planta medicinal brasileira","volume":"8","author":"Stefanello","year":"2005","journal-title":"Revista Brasileira de Plantas Medicinais"},{"key":"10.1016\/j.jep.2009.06.003_bib32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/10412905.2008.9700089","article-title":"Chemical composition, seasonal variation and evaluation of antimicrobial activity of essential oils of Talauma ovata A. St. Hil. (Magnoliaceae)","volume":"20","author":"Stefanello","year":"2008","journal-title":"Journal of Essential Oil Research"},{"key":"10.1016\/j.jep.2009.06.003_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejphar.2007.01.095","article-title":"Magnolia ovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB","volume":"565","author":"Tanaka","year":"2007","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2009.06.003_bib34","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1016\/j.molimm.2006.12.004","article-title":"Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation","volume":"44","author":"Tse","year":"2007","journal-title":"Molecular Immunology"},{"key":"10.1016\/j.jep.2009.06.003_bib35","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s000110050619","article-title":"Involvement of CRH in fever induced by a distinct pre-formed pyrogenic factor (PFPF)","volume":"49","author":"Zampronio","year":"2000","journal-title":"Inflammation Research"},{"key":"10.1016\/j.jep.2009.06.003_bib36","first-page":"R1670","article-title":"Interleukin-8 induces fever by a prostaglandin-independent mechanism","volume":"266","author":"Zampronio","year":"1994","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.jep.2009.06.003_bib37","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejphar.2008.02.044","article-title":"Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation","volume":"586","author":"Zhou","year":"2008","journal-title":"European Journal of Pharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874109003493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874109003493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:13:46Z","timestamp":1759940026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874109003493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0378874109003493"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2009.06.003","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2009.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}