{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:59:13Z","timestamp":1792292353127,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.jep.2010.02.024","type":"journal-article","created":{"date-parts":[[2010,2,27]],"date-time":"2010-02-27T04:31:04Z","timestamp":1267245064000},"page":"46-52","source":"Crossref","is-referenced-by-count":48,"title":["Hepatoprotective and in vivo antioxidant effects of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae)"],"prefix":"10.1016","volume":"129","author":[{"given":"Abidemi J.","family":"Akindele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth O.","family":"Ezenwanebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidozie C.","family":"Anunobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunmilayo O.","family":"Adeyemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2010.02.024_bib1","first-page":"311","article-title":"Hepatoprotective activity of Panchgavya gritha in CCl4 induced hepatotoxicity in rats","volume":"35","author":"Achyilla","year":"2003","journal-title":"Indian Journal of Pharmacology"},{"issue":"2","key":"10.1016\/j.jep.2010.02.024_bib2","first-page":"1","article-title":"Acute and subchronic toxicological assessment of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae) aqueous leaf extract","volume":"3","author":"Adeyemi","year":"2010","journal-title":"International Journal of Applied Research in Natural Products"},{"key":"10.1016\/j.jep.2010.02.024_bib3","unstructured":"Adjanohoun, E.J., Ahyi, A.M.R., Ake Assi, L., Akpagana, K., Chibon, P., El-Hadji, A., Eyme, J., Garba, M., Gassita, J.N., Gbeassor, M., Goudote, E., Guinko, S., Houdoto, K.K., Houngnon, P., Keita, A., Keoula, A., KlugoOcloo, W.P., Lo, I., Siamevi, K.M., Taffame, K.K., 1986. Contribution aux \u00e9tudes ethnobotaniques et floristiques au Togo. Agence de Coop\u00e9ration Culturelle et Technique, Paris."},{"key":"10.1016\/j.jep.2010.02.024_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jep.2006.03.038","article-title":"Evaluation of the antidiarrhoeal activity of Byrsocarpus coccineus","volume":"108","author":"Akindele","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"issue":"1","key":"10.1016\/j.jep.2010.02.024_bib5","first-page":"28","article-title":"Anxiolytic and sedative effects of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae) extract","volume":"3","author":"Akindele","year":"2010","journal-title":"International Journal of Applied Research in Natural Products"},{"key":"10.1016\/j.jep.2010.02.024_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jep.2007.03.033","article-title":"Toxicological assessment of the aqueous root extract of Sanseviera liberica Gerome and Labroy (Agavaceae)","volume":"113","author":"Amida","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2010.02.024_bib7","unstructured":"Burkill, H.M., 1985. Useful Plants of West Tropical Africa, vol. 1, 2nd ed. Families A\u2013D. Royal Botanic Gardens, Kew, pp. 446\u2013447."},{"key":"10.1016\/j.jep.2010.02.024_bib8","first-page":"2859","article-title":"Lipid peroxidation and irreversible damage in the rat hepatocytes model: protection by the silybin-phospholipid complex","volume":"38","author":"Carini","year":"1992","journal-title":"Biochemistry and Pharmacology"},{"key":"10.1016\/j.jep.2010.02.024_bib9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.5897\/AJB2005.000-3127","article-title":"Phytochemical constituents of some Nigerian medicinal plants","volume":"4","author":"Edeoga","year":"2005","journal-title":"African Journal of Biotechnology"},{"key":"10.1016\/j.jep.2010.02.024_bib10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/taap.1993.1072","article-title":"Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species","volume":"119","author":"elSisi","year":"1993","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.jep.2010.02.024_bib11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0006-2952(87)90724-6","article-title":"Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminiscence","volume":"36","author":"Fraga","year":"1987","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2010.02.024_bib12","series-title":"Essentials of Practical Microtechniques","author":"Galigher","year":"1971"},{"key":"10.1016\/j.jep.2010.02.024_bib13","first-page":"158","article-title":"Hepatoprotective and antioxidant effects of Argyreia speciosa in rats","volume":"5","author":"Habbu","year":"2008","journal-title":"African Journal of Traditional, Complementary and Alternative Medicine"},{"key":"10.1016\/j.jep.2010.02.024_bib14","unstructured":"Hayes, A.W., 1989. Guidelines for acute oral toxicity testings. Principles and Methods of Toxicity, 2nd ed. Raven Press Ltd., New York, p. 185 (Table 4)."},{"key":"10.1016\/j.jep.2010.02.024_bib15","series-title":"Casarett & Doull's Toxicology: The Basic Science of Poisons","first-page":"557","article-title":"Toxic responses of the liver","author":"Jaeschke","year":"2008"},{"key":"10.1016\/j.jep.2010.02.024_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2165\/00002018-200124070-00001","article-title":"Drug-induced liver disorders: implications for drug development and regulation","volume":"24","author":"Kaplowitz","year":"2001","journal-title":"Drug Safety"},{"key":"10.1016\/j.jep.2010.02.024_bib17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1055\/s-2006-960043","article-title":"Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus","volume":"57","author":"Lanhers","year":"1991","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2010.02.024_bib18","unstructured":"Lee, W.M., 2006. Drug-induced acute liver failure in the United States 2005: results from the U.S. Acute Liver Failure Study Group. FDA-PhRMA-AASLD Hepatotoxicity Steering Committee meeting 28 January 2005 (accessed January 20, 2006, at http:\/\/www.fda.gov\/cder\/livertox\/presentations2005\/William_Lee.ppt)."},{"key":"10.1016\/j.jep.2010.02.024_bib19","series-title":"Zakim and Boyer's Hepatology","first-page":"37","article-title":"Anatomy of the liver","author":"McCuskey","year":"2006"},{"key":"10.1016\/j.jep.2010.02.024_bib20","series-title":"Enzymology and Medicine","author":"Moss","year":"1974"},{"key":"10.1016\/j.jep.2010.02.024_bib21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/ptr.1498","article-title":"Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats","volume":"18","author":"Mroueh","year":"2004","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2010.02.024_bib22","series-title":"Quality Control of Herbal Drugs","author":"Mukherjee","year":"2002"},{"key":"10.1016\/j.jep.2010.02.024_bib23","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMra052270","article-title":"Drug-related hepatotoxicity","volume":"354","author":"Navarro","year":"2006","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.jep.2010.02.024_bib24","first-page":"311","article-title":"A spectrophotometric assay for iodide oxidation by thyroid peroxidase","volume":"4","author":"Nicholas","year":"1962","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2010.02.024_bib25","first-page":"77","article-title":"Screening of some Nigerian medicinal plants for antioxidant activity using 2,2-diphenyl picryl-hydrazyl radical","volume":"5","author":"Oke","year":"2002","journal-title":"African Journal of Biomedical Research"},{"key":"10.1016\/j.jep.2010.02.024_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.jep.2010.02.024_bib27","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/190821a0","article-title":"Reversible nature of liver cell damage due to carbon tetrachloride as demonstrated by the use of phenergan","volume":"190","author":"Ree","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.jep.2010.02.024_bib28","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3923\/ijp.2005.226.233","article-title":"Antioxidants: their role in health and disease","volume":"1","author":"Saeed","year":"2005","journal-title":"International Journal of Pharmacology"},{"key":"10.1016\/j.jep.2010.02.024_bib29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3109\/00498259409043270","article-title":"Influence of a series of natural flavonoids on free radical generating systems and oxidative stress","volume":"24","author":"Sanz","year":"1994","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jep.2010.02.024_bib30","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0002-9440(10)65594-0","article-title":"Evidence of hepatocyte apoptosis in rat liver after administration of carbon tetrachloride","volume":"153","author":"Shi","year":"1998","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.jep.2010.02.024_bib31","first-page":"077","article-title":"Evaluation of the hypoglycemic and antioxidant activities of Morinda officinalis in streptozocin-induced diabetic rats","volume":"43","author":"Soon","year":"2002","journal-title":"Singapore Medical Journal"},{"key":"10.1016\/j.jep.2010.02.024_bib32","unstructured":"Trease, G.E., Evans, W.C., 1989. Pharmacognosy. Brailliar Tiridel Can, 13th ed. Macmillian Publishers."},{"key":"10.1016\/j.jep.2010.02.024_bib33","unstructured":"United States National Institutes for Health publication, 1985. No. 85-23."},{"key":"10.1016\/j.jep.2010.02.024_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2007.08.031","article-title":"Hepatoprotective effect of Hypericum japonicum extract and its fractions","volume":"116","author":"Wang","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2010.02.024_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Critical Reviews in Toxicology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411000139X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887411000139X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T18:25:44Z","timestamp":1544639144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887411000139X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S037887411000139X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2010.02.024","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}