{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:47:01Z","timestamp":1783482421129,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.jep.2010.04.008","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T08:46:17Z","timestamp":1272271577000},"page":"1-9","source":"Crossref","is-referenced-by-count":38,"title":["Growth inhibitory and apoptosis inducing by effects of total flavonoids from Lysimachia clethroides Duby in human chronic myeloid leukemia K562 cells"],"prefix":"10.1016","volume":"131","author":[{"given":"Yan-li","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hua","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-qin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben-gang","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2010.04.008_bib1","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1128\/JVI.74.11.5024-5031.2000","article-title":"Antiapoptotic herpesvirus Bcl-2 homologs escape caspasemediated conversion to proapoptotic proteins","volume":"74","author":"Bellows","year":"2000","journal-title":"Journal of Virology"},{"key":"10.1016\/j.jep.2010.04.008_bib2","first-page":"294","article-title":"Chemical and pharmacological advances of study on Lysimachia","author":"Chang","year":"2004","journal-title":"China Journal of Chinese Materia Medica"},{"key":"10.1016\/j.jep.2010.04.008_bib3","volume":"vol. 1","author":"Chinese Herb Editor Board","year":"1999"},{"key":"10.1016\/j.jep.2010.04.008_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0320(19970101)27:1<1::AID-CYTO2>3.0.CO;2-L","article-title":"Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis)","volume":"27","author":"Darzynkiewicz","year":"1997","journal-title":"Cytometry"},{"key":"10.1016\/j.jep.2010.04.008_bib5","first-page":"955","article-title":"Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response","volume":"9","author":"Davis","year":"2003","journal-title":"Clinical Cancer Research"},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2010.04.008_bib6","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1038\/sj.cdd.4401437","article-title":"Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs","volume":"11","author":"Ganten","year":"2004","journal-title":"Cell Death Differentiation"},{"key":"10.1016\/j.jep.2010.04.008_bib7","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1182\/blood.V93.7.2353","article-title":"Subcellular distribution and redistribution of BCL-2 family proteins in human leukemia cells undergoing apoptosis","volume":"93","author":"Han","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jep.2010.04.008_bib8","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1182\/blood.V93.7.2353","article-title":"Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis","volume":"93","author":"Jia","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jep.2010.04.008_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.jep.2010.04.008_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0921-8777(95)00063-1","article-title":"The comet assay: mechanisms and technical considerations","volume":"363","author":"Klaude","year":"1996","journal-title":"Mutation Research"},{"key":"10.1016\/j.jep.2010.04.008_bib11","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.275.5303.1132","article-title":"The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis","volume":"275","author":"Kluck","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jep.2010.04.008_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/sj.bjp.0706728","article-title":"Rosmarinic acid as a downstream inhibitor of IKK-beta in TNF-alpha-induced upregulation of CCL11 and CCR3","volume":"148","author":"Lee","year":"2006","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.jep.2010.04.008_bib13","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/emboj\/16.10.2794","article-title":"FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)","volume":"16","author":"Li","year":"1997","journal-title":"EMBO Journal"},{"key":"10.1016\/j.jep.2010.04.008_bib14","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/emboj\/16.10.2794","article-title":"FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)","volume":"16","author":"Medema","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.jep.2010.04.008_bib15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","article-title":"Apoptosis by death factor","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jep.2010.04.008_bib16","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The Fas death factor","volume":"267","author":"Nagata","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jep.2010.04.008_bib17","doi-asserted-by":"crossref","first-page":"26953","DOI":"10.1074\/jbc.272.43.26953","article-title":"FLICE is predominantly expressed as two functionally active isoforms, caspase-8\/a and caspase-8\/b","volume":"272","author":"Scaffidi","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2010.04.008_bib18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.jep.2010.04.008_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/sj.neo.7900203","article-title":"TRAIL\/Apo-2L: mechanisms and clinical applications in cancer","volume":"3","author":"Srivastava","year":"2001","journal-title":"Neoplasia"},{"key":"10.1016\/j.jep.2010.04.008_bib20","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1074\/jbc.274.8.5053","article-title":"Distinct caspase cascades are initiated in receptor mediated and chemical-induced apoptosis","volume":"274","author":"Sun","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2010.04.008_bib21","first-page":"21","article-title":"Effect of flavonoids from Lysimachia clethroides on gene expresion of HL-60 cell","volume":"15","author":"Tang","year":"2007","journal-title":"Pharmaceutical and Clinical Research"},{"key":"10.1016\/j.jep.2010.04.008_bib22","first-page":"112","article-title":"Experiment studies on anti-tumnior of flavonoids from Lysimachia clethroides","volume":"8","author":"The Prevention and Cure of Tumor Group in Hankou Airforce Hospital","year":"1977","journal-title":"New Chinese Medicine"},{"key":"10.1016\/j.jep.2010.04.008_bib23","first-page":"293","article-title":"The anti-tumor effect of the flavonoids from Lysimachia clethroides on L615 cell line","volume":"12","author":"The Prevention and Cure of Tumor Group in Hankou Airforce Hospital","year":"1981","journal-title":"New Chinese Medicine"},{"key":"10.1016\/j.jep.2010.04.008_bib24","series-title":"Apoptosis Gene","author":"Wilson","year":"1998"},{"key":"10.1016\/j.jep.2010.04.008_bib25","first-page":"31","article-title":"The primary studies on the anti-tumor effect of the extracts of Lysmachia clethroides","volume":"22","author":"Xu","year":"2003","journal-title":"Chinese Wild Plant Resources"},{"key":"10.1016\/j.jep.2010.04.008_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0378-8741(02)00082-X","article-title":"Inhibition of proliferation and induction of apoptosis by tetraandrine in HepG2 cells","volume":"81","author":"Yoo","year":"2002","journal-title":"Journal of Ethnopharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874110002394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874110002394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T01:15:02Z","timestamp":1591233302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874110002394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0378874110002394"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2010.04.008","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}