{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:57:57Z","timestamp":1789156677515,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.jep.2010.05.058","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T08:40:22Z","timestamp":1275554422000},"page":"439-449","source":"Crossref","is-referenced-by-count":24,"title":["Effect of the Plant Matrix on the Uptake of Luteolin Derivatives-containing Artemisia afra Aqueous-extract in Caco-2 cells"],"prefix":"10.1016","volume":"130","author":[{"given":"James T.","family":"Mukinda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Syce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervin","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2010.05.058_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(00)01642-2","article-title":"Absorption and metabolism of genistin in the isolated rat small intestine","volume":"475","author":"Andlauer","year":"2000","journal-title":"FEBS Letters"},{"key":"10.1016\/j.jep.2010.05.058_bib2","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1021\/jf970373s","article-title":"Uses and properties of citrus flavonoids","volume":"45","author":"Benavente-Garcia","year":"1997","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2010.05.058_bib3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1155\/S1110724304403106","article-title":"Bioavailability and biokinetics of anthocyanins from red grape juice and red wine","volume":"5","author":"Bitsch","year":"2004","journal-title":"Journal of Biomedicine and Biotechnology"},{"key":"10.1016\/j.jep.2010.05.058_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0014-5793(00)01211-4","article-title":"Dietary flavonoid and isoflavone glycosides are hydrolyzed by the lactase site of lactase phlorizin hydrolase","volume":"468","author":"Day","year":"2000","journal-title":"FEBS Letters"},{"key":"10.1016\/j.jep.2010.05.058_bib5","first-page":"370","article-title":"Absorption and metabolism of flavonoids in the Caco-2 cell culture model and a perused rat intestinal model","volume":"30","author":"Liu","year":"2002","journal-title":"The American Society for Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.jep.2010.05.058_bib6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.jep.2010.05.058_bib7","unstructured":"Muganga, R., 2004. Luteolin levels in selected folkloric preparations and the bioavailability of luteolin from Artemisia afra aqueous extract in the vervet monkey. Master's Thesis, Discipline of Pharmacology, School of Pharmacy, University of the Western Cape, Bellville."},{"key":"10.1016\/j.jep.2010.05.058_bib8","unstructured":"Mukinda, J.T., 2005. Acute and chronic toxicity of the flavonoid-containing plant, Artemisia afra in rodents. Master's Thesis, University of the Western Cape, Bellville, South Africa."},{"key":"10.1016\/j.jep.2010.05.058_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jep.2007.02.011","article-title":"Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents","volume":"112","author":"Mukinda","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2010.05.058_bib10","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1093\/jn\/132.7.1956","article-title":"Unique uptake and transport of isoflavone aglycones by human intestinal Caco-2 cells: comparison of isoflavonoids and flavonoids","volume":"132","author":"Murota","year":"2002","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.jep.2010.05.058_bib11","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1124\/dmd.31.12.1507","article-title":"Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette review series)","volume":"31","author":"Pang","year":"2003","journal-title":"Journal of Drug Metabolism and Disposition"},{"key":"10.1016\/j.jep.2010.05.058_bib12","first-page":"1","article-title":"Evaluation of the first-pass glucuronidation of selected flavones in gut by Caco-2 monolayer model","volume":"8","author":"Pong","year":"2005","journal-title":"Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2010.05.058_bib13","series-title":"Indigenous Healing Plants","author":"Roberts","year":"1990"},{"key":"10.1016\/j.jep.2010.05.058_bib14","unstructured":"Schutte, M.E., 2007. Effect of (mixtures of) flavonoids on the in vitro and in vivo bioavailability of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). A biologically based modeling approach. Thesis Wageningen University, Wageningen, the Netherlands."},{"key":"10.1016\/j.jep.2010.05.058_bib15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0014-5793(98)01304-0","article-title":"Intestinal absorption of luteolin and luteolin 7-0-\u03b2-glucoside in rats and humans","volume":"438","author":"Shimoi","year":"1998","journal-title":"FEBS Letters"},{"key":"10.1016\/j.jep.2010.05.058_bib16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00394-005-0568-5","article-title":"The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites","volume":"45","author":"Silberberg","year":"2006","journal-title":"European Journal of Nutrition"},{"key":"10.1016\/j.jep.2010.05.058_bib17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0014-5793(99)01160-6","article-title":"The small intestine can both absorb and glucuronidate luminal flavonoids","volume":"458","author":"Spencer","year":"1999","journal-title":"FEBS Letters"},{"key":"10.1016\/j.jep.2010.05.058_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0928-0987(00)00178-0","article-title":"Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine","volume":"12","author":"Suzuki","year":"2000","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2010.05.058_bib19","series-title":"Medicinal plants of South Africa","author":"Van Wyk","year":"2000"},{"key":"10.1016\/j.jep.2010.05.058_bib20","unstructured":"Waithaka, J., 2004. The evaluation of markers for quality control studies of flavonoid-containing medicinal preparations. Master's Thesis, Discipline of Pharmacology, School of Pharmacy, University of Western Cape, Bellville."},{"key":"10.1016\/j.jep.2010.05.058_bib21","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.freeradbiomed.2004.01.002","article-title":"Serial review: absorption and metabolism of flavonoids","volume":"36","author":"Walle","year":"2004","journal-title":"Journal of Free Radical Biology and Medicine"},{"key":"10.1016\/j.jep.2010.05.058_bib22","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/S0006-2952(98)00048-3","article-title":"Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells","volume":"55","author":"Walgren","year":"1998","journal-title":"Journal of Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2010.05.058_bib23","series-title":"The medicinal and poisonous plants of Southern and Eastern Africa","author":"Watt","year":"1962"},{"key":"10.1016\/j.jep.2010.05.058_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.phymed.2003.11.002","article-title":"Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans","volume":"12","author":"Wittemer","year":"2005","journal-title":"Journal of Phytomedicine"},{"key":"10.1016\/j.jep.2010.05.058_bib25","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/jps.10050","article-title":"New and better protocols for a short-term Caco-2 cell culture system","volume":"91","author":"Yamashita","year":"2002","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2010.05.058_bib26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1023\/A:1012102522787","article-title":"In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth","volume":"14","author":"Yee","year":"1997","journal-title":"Journal of Pharmaceutical Research"},{"key":"10.1016\/j.jep.2010.05.058_bib27","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1124\/jpet.105.100701","article-title":"A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza","volume":"317","author":"Zhang","year":"2006","journal-title":"Journal of Pharmacology and Experimental Therapeutics"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874110003788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874110003788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T19:58:10Z","timestamp":1559159890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874110003788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0378874110003788"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2010.05.058","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}