{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:06:22Z","timestamp":1791252382337,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.jep.2010.11.015","type":"journal-article","created":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T11:09:32Z","timestamp":1289560172000},"page":"834-842","source":"Crossref","is-referenced-by-count":107,"title":["Taraxacum officinale Weber extracts inhibit LPS-induced oxidative stress and nitric oxide production via the NF-\u03baB modulation in RAW 264.7 cells"],"prefix":"10.1016","volume":"133","author":[{"given":"Chung Mu","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hee","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hyuk","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2010.11.015_bib0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.jep.2010.11.015_bib0010","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0891-5849(99)00242-7","article-title":"Oxidative stress and gene regulation","volume":"28","author":"Allen","year":"2000","journal-title":"Free Radical and Biological Medicine"},{"key":"10.1016\/j.jep.2010.11.015_bib0015","series-title":"Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis","author":"Bisset","year":"1994"},{"key":"10.1016\/j.jep.2010.11.015_bib0020","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/9780470110171.ch2","article-title":"Analysis of phenolic compounds of interest in metabolism","volume":"1","author":"Bray","year":"1954","journal-title":"Methods of Biochemical Analysis"},{"key":"10.1016\/j.jep.2010.11.015_bib0030","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.lfs.2007.09.028","article-title":"Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages","volume":"81","author":"Chen","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2010.11.015_bib0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0009-8981(01)00762-8","article-title":"Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract","volume":"317","author":"Cho","year":"2002","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.jep.2010.11.015_bib0040","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s11373-005-9028-8","article-title":"Chrysoeriol potently inhibits the induction of nitric oxide synthase by blocking AP-1 activation","volume":"12","author":"Choi","year":"2005","journal-title":"Journal of Biomedical Science"},{"key":"10.1016\/j.jep.2010.11.015_bib0045","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S1567-5769(01)00100-X","article-title":"Anti-inflammatory effects of chemically modified tetracyclines by the inhibition of nitric oxide and interleukin-12 synthesis in J774 cell line","volume":"1","author":"D\u2019Agostino","year":"2001","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.jep.2010.11.015_bib0050","doi-asserted-by":"crossref","first-page":"9413","DOI":"10.1021\/jf0502395","article-title":"Synergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteins","volume":"53","author":"Dalby-Brown","year":"2005","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0055","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.jep.2010.11.015_bib0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-1161(91)90130-Z","article-title":"Application of the neutral red assay (NR assay) to monolayer cultures of primary hepatocytes: rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS)","volume":"253","author":"Fautz","year":"1991","journal-title":"Mutation Research"},{"key":"10.1016\/j.jep.2010.11.015_bib0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0891-5849(88)90023-8","article-title":"Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes","volume":"4","author":"Fraga","year":"1988","journal-title":"Free Radical and Biological Medicine"},{"key":"10.1016\/j.jep.2010.11.015_bib0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-4274(99)00024-7","article-title":"Intracellular oxidation\/reduction status in the regulation of transcription factors NF-kappaB and AP-1","volume":"106","author":"Gius","year":"1999","journal-title":"Toxicology Letter"},{"key":"10.1016\/j.jep.2010.11.015_bib0075","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0092-8674(02)01201-1","article-title":"Pattern recognition receptors: doubling up for the innate immune response","volume":"111","author":"Gordon","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jep.2010.11.015_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1556\/AAlim.29.2000.1.1","article-title":"In vitro antioxidant evaluation of dandelion (Taraxacum officinale WEB.) water extracts","volume":"29","author":"Hagymasi","year":"2000","journal-title":"Acta Alimentaria"},{"key":"10.1016\/j.jep.2010.11.015_bib0085","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/jn\/136.6.1517","article-title":"Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells","volume":"136","author":"Harris","year":"2006","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.jep.2010.11.015_bib0090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/jf0258858","article-title":"Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro","volume":"51","author":"Hu","year":"2003","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0095","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.phymed.2003.12.012","article-title":"Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro","volume":"12","author":"Hu","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2010.11.015_bib0100","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1021\/jf803255p","article-title":"Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) Testa and its phenolic components on Cu2+-treated low-density lipoprotein (LDL) oxidation and lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages","volume":"57","author":"Huang","year":"2009","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0105","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jep.2007.09.006","article-title":"Anti-inflammatory activity of Taraxacum officinale","volume":"115","author":"Jeon","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2010.11.015_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1026581301366","article-title":"Nitric oxide up-regulates DNA-binding activity of nuclear factor-kappaB in macrophages stimulated with silica and inflammatory stimulants","volume":"215","author":"Kang","year":"2000","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejphar.2004.07.030","article-title":"Regulation of the expression of inducible nitric oxide synthase","volume":"500","author":"Kleinert","year":"2004","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.jep.2010.11.015_bib0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mrrev.2008.03.002","article-title":"Inflammation: gearing the journey to cancer","volume":"659","author":"Kundu","year":"2008","journal-title":"Mutation Research"},{"key":"10.1016\/j.jep.2010.11.015_bib0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02980103","article-title":"Antioxidants and inhibitor of matrix metalloproteinase-1 expression from leaves of Zostera marina L","volume":"27","author":"Kim","year":"2004","journal-title":"Archives of Pharmaceutical Research"},{"key":"10.1016\/j.jep.2010.11.015_bib0130","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1089\/jmf.2009.1249","article-title":"Anti-inflammatory effect of Taraxacum officinale leaves on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells","volume":"13","author":"Koh","year":"2010","journal-title":"Journal of Medicinal Food"},{"key":"10.1016\/j.jep.2010.11.015_bib0135","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","article-title":"Glutathione peroxidase activity in selenium-deficient rat liver","volume":"71","author":"Lawrence","year":"1976","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jep.2010.11.015_bib0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cbi.2007.01.020","article-title":"Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage","volume":"167","author":"Lima","year":"2007","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.jep.2010.11.015_bib0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jep.2010.05.029","article-title":"Taraxacum officinale protects against lipopolysaccharide-induced acute lung injury in mice","volume":"130","author":"Liu","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2010.11.015_bib0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0155","series-title":"Herbal Medicines: A Guide for Health-care Professionals","author":"Newall","year":"1996"},{"key":"10.1016\/j.jep.2010.11.015_bib0160","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/ptr.3121","article-title":"Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in Sprague\u2013Dawley rats","volume":"24","author":"Park","year":"2010","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2010.11.015_bib0165","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3746\/jfn.2010.15.2.092","article-title":"Luteolin and chicoric acid, two major constituents of dandelion leaf, inhibited nitric oxide and lipid peroxide formation in lipopolysaccharide-stimulated RAW 264.7 cells","volume":"15","author":"Park","year":"2010","journal-title":"Journal of Food Science and Nutrition"},{"key":"10.1016\/j.jep.2010.11.015_bib0170","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.fct.2010.02.019","article-title":"TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators","volume":"48","author":"Park","year":"2010","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.jep.2010.11.015_bib0175","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1055\/s-0028-1099379","article-title":"The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals","volume":"26","author":"Racz-Kotilla","year":"1974","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2010.11.015_bib0180","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ptr.1180","article-title":"Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages","volume":"17","author":"Ryu","year":"2003","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2010.11.015_bib0185","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/rcm.1767","article-title":"Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography\/electrospray ionization mass spectrometry","volume":"19","author":"Schutz","year":"2005","journal-title":"Rapid Communications in Mass Spectrometry"},{"key":"10.1016\/j.jep.2010.11.015_bib0190","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3748\/wjg.v11.i4.597","article-title":"Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats","volume":"11","author":"Seo","year":"2005","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2010.11.015_bib0195","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.intimp.2009.04.011","article-title":"Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK\/AP-1 activation","volume":"9","author":"Shan","year":"2009","journal-title":"International Immunopharmacology"},{"issue":"Suppl.","key":"10.1016\/j.jep.2010.11.015_bib0200","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/0006-2952(91)90386-J","article-title":"Effect of ethanol on cadmium-induced lipid peroxidation and antioxidant enzymes in rat liver","volume":"42","author":"Sharma","year":"1991","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.jep.2010.11.015_bib0205","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0027-5107(01)00183-X","article-title":"Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation","volume":"480-481","author":"Surh","year":"2001","journal-title":"Mutation Research"},{"key":"10.1016\/j.jep.2010.11.015_bib0210","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0215","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1021\/jf9801973","article-title":"Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products","volume":"46","author":"Velioglu","year":"1998","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0220","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0031-9422(95)00865-9","article-title":"Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale","volume":"42","author":"Williams","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2010.11.015_bib0225","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0741-8329(03)00100-9","article-title":"Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease","volume":"30","author":"Xiong","year":"2003","journal-title":"Alcohol"},{"key":"10.1016\/j.jep.2010.11.015_bib0230","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1097\/01.ASN.0000024253.59665.F1","article-title":"Histone deacetylases augment cytokine induction of the iNOS gene","volume":"13","author":"Yu","year":"2002","journal-title":"Journal of American Society of Nephrology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874110008007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874110008007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T07:22:33Z","timestamp":1559805753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874110008007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0378874110008007"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2010.11.015","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}