{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:46:34Z","timestamp":1774262794423,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009381","name":"International Medical University","doi-asserted-by":"crossref","award":["IMU 091-05"],"award-info":[{"award-number":["IMU 091-05"]}],"id":[{"id":"10.13039\/501100009381","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Malaysian Ministry of Science, Technology and Innovation","award":["02-02-09-SF0005"],"award-info":[{"award-number":["02-02-09-SF0005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.jep.2010.11.026","type":"journal-article","created":{"date-parts":[[2010,11,20]],"date-time":"2010-11-20T09:35:50Z","timestamp":1290245750000},"page":"881-887","source":"Crossref","is-referenced-by-count":42,"title":["In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19)"],"prefix":"10.1016","volume":"133","author":[{"given":"Yan","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badrul Amini","family":"Abd-Rashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakiah","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rusli","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Wah","family":"Mak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.K.","family":"Pook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Meng","family":"Er","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Eng","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2010.11.026_bib0005","first-page":"69","article-title":"Hydroxy betulinic acid from the leaves of Orthosiphon stamineus","volume":"16","author":"Amzad","year":"2003","journal-title":"Asian Coordinating Group for Chemistry"},{"key":"10.1016\/j.jep.2010.11.026_bib0010","first-page":"9","article-title":"The effect of Mandookaparni (Centella asiatica) on the general mental ability (medhya) of mentally retarded children","volume":"8","author":"Appa Rao","year":"1973","journal-title":"Indian Journal of Medical Research"},{"key":"10.1016\/j.jep.2010.11.026_bib0015","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1021\/np000607t","article-title":"Five novel highly oxygenated diterpenes of Orthosiphon stamineus from Myanmar","volume":"64","author":"Awale","year":"2001","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2010.11.026_bib0020","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/1389200023337054","article-title":"The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans","volume":"3","author":"Danielson","year":"2002","journal-title":"Current Drug Metabolism"},{"key":"10.1016\/j.jep.2010.11.026_bib0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/abbi.1994.1280","article-title":"Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic prosperities","volume":"312","author":"Gillam","year":"1994","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.jep.2010.11.026_bib0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/13880209009082833","article-title":"Antidiarrheal activity of diterpenes of Andrographis paniculata (Kalmegh) against Escherichia coli enterotoxin in in vivo models","volume":"28","author":"Gupta","year":"1990","journal-title":"International Journal of Crude Drug Research"},{"key":"10.1016\/j.jep.2010.11.026_bib0035","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0031-6997(25)00021-3","article-title":"The molecular biology of cytochrome P450s","volume":"40","author":"Gonzalez","year":"1988","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.jep.2010.11.026_bib0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/tx700079z","article-title":"Cytochrome P450 and chemical toxicology","volume":"21","author":"Guengerich","year":"2008","journal-title":"Chemical Research in Toxicology"},{"key":"10.1016\/j.jep.2010.11.026_bib0045","doi-asserted-by":"crossref","first-page":"PL209","DOI":"10.1016\/S0024-3205(99)00407-5","article-title":"Effects of ginseng components on cDNA-expressed cytochrome P450 enzyme catalytic activity","volume":"65","author":"Henderson","year":"1999","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2010.11.026_bib0050","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0278-6915(99)00079-4","article-title":"Dietary flavonoids: intake, health effects and bioavailability","volume":"37","author":"Hollman","year":"1999","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.jep.2010.11.026_bib0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0021-9673(96)00237-3","article-title":"Determination of biologically active constituents in Centella asiatica","volume":"742","author":"Inamdar","year":"1996","journal-title":"Journal of Chromatography A"},{"key":"10.1016\/j.jep.2010.11.026_bib0060","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jep.2005.11.024","article-title":"Impact of Andrographis paniculata crude extract on mouse hepatic cytochrome P450 enzymes","volume":"105","author":"Jarukamjorn","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2010.11.026_bib0065","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/BF00541938","article-title":"Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man","volume":"26","author":"Kupfer","year":"1984","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.jep.2010.11.026_bib0070","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1124\/dmd.30.11.1153","article-title":"Inhibition of human cytochrome P450 activities by kava extract and kavalactones","volume":"30","author":"Mathews","year":"2002","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/j.jep.2010.11.026_bib0075","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1248\/bpb.28.173","article-title":"Antiproliferative constituents from umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica","volume":"28","author":"Miyako","year":"2005","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2010.11.026_bib0080","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/clpt.1985.194","article-title":"Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations","volume":"38","author":"Nakamura","year":"1985","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.jep.2010.11.026_bib0085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jep.2010.05.002","article-title":"In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica","volume":"130","author":"Pan","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2010.11.026_bib0090","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jep.2007.10.013","article-title":"Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide","volume":"115","author":"Pekthong","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2010.11.026_bib0095","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cbi.2008.10.054","article-title":"Effects of Andrographis paniculata extract and andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures","volume":"179","author":"Pekthong","year":"2009","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.jep.2010.11.026_bib0100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/pca.2800030308","article-title":"Standardization of the Indian crude drug Kalmegh by high pressure liquid chromatographic determination of andrographolide","volume":"3","author":"Sharma","year":"1992","journal-title":"Phytochemical Analysis"},{"key":"10.1016\/j.jep.2010.11.026_bib0105","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1248\/cpb.48.1711","article-title":"Constituents of the Vietnamese medicinal plant Orthosiphon stamineus","volume":"48","author":"Tezuka","year":"2000","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2010.11.026_bib0110","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1248\/bpb.28.1021","article-title":"Cytochrome P450 2D6 (CYP2D6) inhibitory constituents of Catharanthus roseus","volume":"28","author":"Usia","year":"2005","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2010.11.026_bib0115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.clpt.2003.09.014","article-title":"St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole","volume":"75","author":"Wang","year":"2004","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.jep.2010.11.026_bib0120","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/clpt.1984.256","article-title":"Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism","volume":"36","author":"Wedlund","year":"1984","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.jep.2010.11.026_bib0125","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000028398","article-title":"The CYP2C19 enzyme polymorphism","volume":"61","author":"Wedlund","year":"2000","journal-title":"Pharmacology"},{"key":"10.1016\/j.jep.2010.11.026_bib0130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0163-7258(89)90047-8","article-title":"Genetic polymorphism of S-mephenytoin hydroxylation","volume":"43","author":"Wilkinson","year":"1989","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.jep.2010.11.026_bib0135","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/abbi.1993.1506","article-title":"Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4\u2032-hydroxylation","volume":"306","author":"Wrighton","year":"1993","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.jep.2010.11.026_bib0140","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0024-3205(02)01913-6","article-title":"Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity","volume":"71","author":"Zou","year":"2002","journal-title":"Life Sciences"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874110008111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874110008111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T03:10:16Z","timestamp":1740712216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874110008111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0378874110008111"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2010.11.026","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}