{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:00:55Z","timestamp":1772827255817,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Sciences Council of the Republic of China","award":["NSC 98-2320-B-039-028-MY3"],"award-info":[{"award-number":["NSC 98-2320-B-039-028-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.jep.2011.03.040","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T06:50:33Z","timestamp":1302591033000},"page":"440-449","source":"Crossref","is-referenced-by-count":23,"title":["Kinsenoside, a high yielding constituent from Anoectochilus formosanus, inhibits carbon tetrachloride induced Kupffer cells mediated liver damage"],"prefix":"10.1016","volume":"135","author":[{"given":"Wen-Tsong","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Tzu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Bin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Bo","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Chan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2011.03.040_bib0005","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1086\/314659","volume":"179","author":"Alizian","year":"1999","journal-title":"The Journal of Infectious Diseases"},{"key":"10.1016\/j.jep.2011.03.040_bib0010","doi-asserted-by":"crossref","first-page":"G700","DOI":"10.1152\/ajpgi.00126.2006","article-title":"Proteasome inhibition attenuates hepatic injury in the bile duct-ligated mouse","volume":"291","author":"Anan","year":"2006","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.jep.2011.03.040_bib0015","first-page":"1633","article-title":"Extracellular signal regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures","volume":"18","author":"Bhat","year":"1998","journal-title":"Journal of Neuoscience"},{"key":"10.1016\/j.jep.2011.03.040_bib0020","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.4049\/jimmunol.161.11.6206","article-title":"Antisense oligonucleotides targeting protein kinase C-alpha, -beta I, or -delta but not -eta inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: involvement of a nuclear factor kappa B-dependent mechanism","volume":"161","author":"Chen","year":"1998","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.jep.2011.03.040_bib0025","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidium thiocyanate\u2013phenol\u2013chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.jep.2011.03.040_bib0030","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1248\/cpb.48.1803","article-title":"Glycosidic constituents from in vitro Anoectochilus formosanus","volume":"48","author":"Du","year":"2000","journal-title":"Chemical Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2011.03.040_bib0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1248\/bpb.24.65","article-title":"Higher yielding isolation of kinsenoside in Anoectochilus formosanus and its antihyperliposis effect","volume":"24","author":"Du","year":"2001","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2011.03.040_bib0040","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11418-007-0169-0","article-title":"Pharmacologically active compounds in the Anoectochilus and Goodyera species","volume":"62","author":"Du","year":"2008","journal-title":"Journal of Nature Medicines"},{"key":"10.1016\/j.jep.2011.03.040_bib0045","doi-asserted-by":"crossref","first-page":"4.1","DOI":"10.1002\/0471140856.tx1404s14","article-title":"Isolation of liver Kupffer cells","volume":"14","author":"Froh","year":"2002","journal-title":"Current Protocols in Toxicology"},{"key":"10.1016\/j.jep.2011.03.040_bib0050","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nri2423","article-title":"New regulators of NF-\u03baB in inflammation","volume":"8","author":"Ghosh","year":"2008","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.jep.2011.03.040_bib0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes","volume":"13","author":"Guha","year":"2001","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.jep.2011.03.040_bib0060","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1073\/pnas.93.7.2774","article-title":"Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages","volume":"93","author":"Hambleton","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jep.2011.03.040_bib0065","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/SHK.0b013e3181f0e7a3","article-title":"Kinsenoside isolated from Anoectochilus formosanus suppresses LPS-stimulated inflammatory reactions in macrophages and endotoxin shock in mice","volume":"35","author":"Hsiao","year":"2010","journal-title":"Shock"},{"key":"10.1016\/j.jep.2011.03.040_bib0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3177\/jnsv.51.40","article-title":"Effects of Anoectochilus formosanus on endurance capacity in mice","volume":"51","author":"Ikeuchi","year":"2005","journal-title":"Journal of Nutritional Science and Vitaminlogy"},{"key":"10.1016\/j.jep.2011.03.040_bib0075","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/0031-9422(93)85037-R","article-title":"Aliphatic and aromatic glucosides from Anoectochilus koshunensis","volume":"33","author":"Ito","year":"1993","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2011.03.040_bib0080","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd2289","article-title":"Targeting dual-specificity phosphatases: manipulating MAP kinase signaling and immune responses","volume":"6","author":"Jeffrey","year":"2007","journal-title":"Nature Reviews. Drug Discovery"},{"key":"10.1016\/j.jep.2011.03.040_bib0085","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.3748\/wjg.v12.i46.7413","article-title":"Role of Kupffer cells in the pathogenesis of liver disese","volume":"12","author":"Kolios","year":"2006","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.jep.2011.03.040_bib0090","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/exmp.2001.2399","article-title":"Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats","volume":"71","author":"Luckey","year":"2001","journal-title":"Experimental and Molecular Pathology"},{"key":"10.1016\/j.jep.2011.03.040_bib0095","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/(SICI)1098-1136(199702)19:2<152::AID-GLIA6>3.0.CO;2-2","article-title":"Inducible nitric oxide synthase expression in activated rat microglial cultures is downregulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors","volume":"19","author":"Minghetti","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.jep.2011.03.040_bib0100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jat.892","article-title":"Kupffer cells are responsible for liver cirrhosis induced by carbon tetrachloride","volume":"23","author":"Muriel","year":"2003","journal-title":"Journal of Applied Toxicology"},{"key":"10.1016\/j.jep.2011.03.040_bib0105","first-page":"219","article-title":"Kupffer cells inhibition prevents hepatic lipid peroxidation and damage induced by carbon tetrachloride","volume":"130","author":"Muriel","year":"2001","journal-title":"Comparative Biochemistry and Physiology C"},{"key":"10.1016\/j.jep.2011.03.040_bib0110","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1443-9573.2005.00208.x","article-title":"CD14 expression on Kupffer cells during the course of carbon tetrachloride-mediated liver injury","volume":"6","author":"Qiu","year":"2005","journal-title":"Chinese Journal of Digestive Diseases"},{"key":"10.1016\/j.jep.2011.03.040_bib0115","doi-asserted-by":"crossref","first-page":"G200","DOI":"10.1152\/ajpgi.2001.281.1.G200","article-title":"Attenuation of CCl4-induced hepatic fibrosis by GdCl3 treatment or dietary glyceine","volume":"281","author":"Rivera","year":"2001","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.jep.2011.03.040_bib0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1432-1327.2000.00956.x","article-title":"Important role of membrane-associated CD14 in the induction of IFN-\u03b2 and subsequent nitric oxide production by murine macrophages in response to bacterial lipopolysaccharide","volume":"267","author":"Saito","year":"2000","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.jep.2011.03.040_bib0125","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI10613","article-title":"Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice","volume":"107","author":"Sass","year":"2001","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.jep.2011.03.040_bib0130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0378-8741(01)00302-6","article-title":"Ameliorative effects of Anoectochilus formosanus extract on osteopenia in ovariectomized rats","volume":"77","author":"Shih","year":"2001","journal-title":"Journal of Rthnopharmacology"},{"key":"10.1016\/j.jep.2011.03.040_bib0135","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1046\/j.1440-1681.2002.03717.x","article-title":"Antihyperglycemic and anti-oxidant properties of Anoectochilus formosanus in diabetic rats","volume":"29","author":"Shih","year":"2002","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"10.1016\/j.jep.2011.03.040_bib0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.phymed.2004.02.008","article-title":"Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats","volume":"12","author":"Shih","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2011.03.040_bib0145","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1093\/clinchem\/43.8.1512","article-title":"Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function","volume":"43","author":"Sturgill","year":"1997","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.jep.2011.03.040_bib0150","doi-asserted-by":"crossref","first-page":"G256","DOI":"10.1152\/ajpgi.00550.2001","article-title":"Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation","volume":"283","author":"Su","year":"2002","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.jep.2011.03.040_bib0155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0027-5107(01)00183-X","article-title":"Molecular mechanisms underling chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-\u03baB activation","volume":"480\/481","author":"Surh","year":"2001","journal-title":"Mutation Research"},{"key":"10.1016\/j.jep.2011.03.040_bib0160","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.regpep.2004.03.009","article-title":"Secretion of inflammatory mediators by isolated rat Kupffer cells: the effect of octreotide","volume":"120","author":"Valatas","year":"2004","journal-title":"Regulatory Peptides"},{"key":"10.1016\/j.jep.2011.03.040_bib0165","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/ptr.2025","article-title":"The hepatoprotective activity of kinsenoside from Anoectochilus formosanus","volume":"21","author":"Wu","year":"2007","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.jep.2011.03.040_bib0170","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1271\/bbb.90824","article-title":"A standardized aqueous of Anoectochilus formosanus ameliorated thioacetamide-induced liver fibrosis in mice: the role of Kupffer cells","volume":"74","author":"Wu","year":"2010","journal-title":"Bioscience Biotechnology and Biochemistry"},{"key":"10.1016\/j.jep.2011.03.040_bib0175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.amjsurg.2007.09.045","article-title":"Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells","author":"Xu","year":"2008","journal-title":"American Journal of Surgery"},{"key":"10.1016\/j.jep.2011.03.040_bib0180","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jep.2007.05.022","article-title":"Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats","volume":"114","author":"Zhang","year":"2007","journal-title":"Journal of Ethnopharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111001917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111001917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T07:36:27Z","timestamp":1686036987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874111001917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0378874111001917"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2011.03.040","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}