{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:30:31Z","timestamp":1771921831697,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.jep.2011.04.060","type":"journal-article","created":{"date-parts":[[2011,4,30]],"date-time":"2011-04-30T21:57:48Z","timestamp":1304200668000},"page":"197-203","source":"Crossref","is-referenced-by-count":62,"title":["Aqueous extract of Tribulus terrestris Linn induces cell growth arrest and apoptosis by down-regulating NF-\u03baB signaling in liver cancer cells"],"prefix":"10.1016","volume":"136","author":[{"given":"Hye Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Sun","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-jee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Ae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Ho","family":"Kor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa Seung","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Keun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2011.04.060_bib0005","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1515\/znc-2007-5-602","article-title":"Cytotoxic cholestane and pregnane glycosides from Tribulus macropterus","volume":"62","author":"Abdel-Hameed el","year":"2007","journal-title":"Zeitschrift f\u00fcr Naturforschung C"},{"key":"10.1016\/j.jep.2011.04.060_bib0010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0968-0004(00)01740-0","article-title":"Life-or-death decisions by the Bcl-2 protein family","volume":"26","author":"Adams","year":"2001","journal-title":"Trends in Biochemical Sciences"},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2011.04.060_bib0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1365-2605.2000.00020.x","article-title":"Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions","volume":"23","author":"Adimoelja","year":"2000","journal-title":"International Journal of Andrology"},{"key":"10.1016\/j.jep.2011.04.060_bib0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ccr.2004.09.003","article-title":"Nuclear factor-kappaB: the enemy within","volume":"6","author":"Aggarwal","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jep.2011.04.060_bib0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1196\/annals.1372.005","article-title":"The protective effect of Tribulus terrestris in diabetes","volume":"1084","author":"Amin","year":"2006","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.jep.2011.04.060_bib0030","first-page":"341","article-title":"Effect of saponin from Tribulus terrestris on hyperlipidemia","volume":"26","author":"Chu","year":"2003","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"10.1016\/j.jep.2011.04.060_bib0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/j.jep.2011.04.060_bib0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cellimm.2005.01.006","article-title":"NF-kappaB inducible genes BCL-X and cyclin E promote immature B-cell proliferation and survival","volume":"232","author":"Feng","year":"2004","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.jep.2011.04.060_bib0045","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nature Protocols"},{"key":"10.1016\/j.jep.2011.04.060_bib0050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4615-0629-4_24","article-title":"Aflatoxin, hepatitis and worldwide liver cancer risks","volume":"504","author":"Henry","year":"2002","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.jep.2011.04.060_bib0055","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2005.09.040","article-title":"Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens","volume":"337","author":"Hsieh","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.jep.2011.04.060_bib0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1359-6101(00)00018-6","article-title":"NF-kappaB and cell-cycle regulation: the cyclin connection","volume":"12","author":"Joyce","year":"2001","journal-title":"Cytokine & Growth Factor Reviews"},{"key":"10.1016\/j.jep.2011.04.060_bib0065","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/cr.2008.30","article-title":"The IkappaB kinase\u2014a bridge between inflammation and cancer","volume":"18","author":"Karin","year":"2008","journal-title":"Cell Research"},{"key":"10.1016\/j.jep.2011.04.060_bib0070","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jep.2009.04.046","article-title":"Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication","volume":"124","author":"Kim","year":"2009","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.04.060_bib0075","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/15216540500239697","article-title":"Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression","volume":"57","author":"Kim","year":"2005","journal-title":"Journal of the International Union of Biochemistry and Molecular Biology Life"},{"key":"10.1016\/j.jep.2011.04.060_bib0080","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1084\/jem.20052136","article-title":"Enhancement of clonogenicity of human multiple myeloma by dendritic cells","volume":"203","author":"Kukreja","year":"2006","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.jep.2011.04.060_bib0085","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1084\/jem.189.11.1839","article-title":"The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis","volume":"189","author":"Li","year":"1999","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.jep.2011.04.060_bib0090","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1101\/gad.7.11.2063","article-title":"Proposed NF-kappa B\/I kappa B family nomenclature","volume":"7","author":"Nabel","year":"1993","journal-title":"Genes & Development"},{"key":"10.1016\/j.jep.2011.04.060_bib0095","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/138161207780162944","article-title":"NF-kappa B signaling and carcinogenesis","volume":"13","author":"Okamoto","year":"2007","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.jep.2011.04.060_bib0100","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/ijc.22534","article-title":"A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines","volume":"120","author":"Okudaira","year":"2007","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.jep.2011.04.060_bib0105","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jep.2005.09.027","article-title":"Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats","volume":"104","author":"Phillips","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.04.060_bib0110","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1248\/bpb.28.2211","article-title":"In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. with potent activity against fluconazole-resistant fungal","volume":"28","author":"Zhang","year":"2005","journal-title":"Biological & Pharmaceutical Bulletin"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111003126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111003126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T22:53:31Z","timestamp":1543791211000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874111003126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0378874111003126"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2011.04.060","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}