{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:31:05Z","timestamp":1761708665060},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002994","name":"Ministry of Knowledge Economy (MKE)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002994","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korea Industrial Technology Foundation (KOTEF)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.jep.2011.05.032","type":"journal-article","created":{"date-parts":[[2011,6,5]],"date-time":"2011-06-05T18:53:45Z","timestamp":1307300025000},"page":"312-319","source":"Crossref","is-referenced-by-count":34,"title":["Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. and Dioscorea nipponica Makino, in vitro"],"prefix":"10.1016","volume":"137","author":[{"given":"Namho","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Kyung","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyangshuk","family":"Rhim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungjoo Kim","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Zin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwon","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Yeou","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Jeong","family":"Kuh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2011.05.032_bib0005","first-page":"201","article-title":"Expression and localization of cell growth factors in the salivary gland: a review. Kaibogaku zasshi","volume":"76","author":"Amano","year":"2001","journal-title":"Journal of Anatomy"},{"key":"10.1016\/j.jep.2011.05.032_bib0010","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1001\/jama.284.17.2215","article-title":"Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial","volume":"284","author":"Apfel","year":"2000","journal-title":"The Journal of the American Medical Association"},{"key":"10.1016\/j.jep.2011.05.032_bib0015","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0025-6196(11)61474-2","article-title":"Diabetic peripheral neuropathic pain: clinical and quality-of-life issues","volume":"81","author":"Argoff","year":"2006","journal-title":"Mayo Clinic Proceedings"},{"key":"10.1016\/j.jep.2011.05.032_bib0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neulet.2009.05.010","article-title":"A synthetic analog of verbenachalcone potentiates NGF-induced neurite outgrowth and enhances cell survival in neuronal cell models","volume":"459","author":"Clement","year":"2009","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.jep.2011.05.032_bib0025","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1523\/JNEUROSCI.5201-07.2008","article-title":"A new nerve growth factor-mimetic peptide active on neuropathic pain in rats","volume":"28","author":"Colangelo","year":"2008","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.jep.2011.05.032_bib0030","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1046\/j.1471-4159.1996.66030963.x","article-title":"Suramin induces phosphorylation of the high-affinity nerve growth factor receptor in PC12 cells and dorsal root ganglion neurons","volume":"66","author":"Gill","year":"1996","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.jep.2011.05.032_bib0035","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Greene","year":"1976","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jep.2011.05.032_bib0040","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1002\/jnr.22519","article-title":"Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species","volume":"88","author":"Gundimeda","year":"2010","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.jep.2011.05.032_bib0045","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cbi.2008.08.012","article-title":"Panaxydol treatment enhances the biological properties of Schwann cells in vitro","volume":"177","author":"He","year":"2009","journal-title":"Chemico-biological Interactions"},{"key":"10.1016\/j.jep.2011.05.032_bib0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1242\/jeb.132.1.133","article-title":"Regulation of the synthesis of nerve growth factor","volume":"132","author":"Heumann","year":"1987","journal-title":"The Journal of Experimental Biology"},{"key":"10.1016\/j.jep.2011.05.032_bib0055","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1055\/s-2007-969112","article-title":"Isolation and hypoglycemic activity of dioscorans A, B, C, D, E, and F; glycans of Dioscorea japonica rhizophors","volume":"52","author":"Hikino","year":"1986","journal-title":"Planta Medica"},{"key":"10.1016\/j.jep.2011.05.032_bib0060","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1081\/CNV-120018230","article-title":"The cytotoxicity of Methyl Protodioscin against human cancer cell lines in vitro","volume":"21","author":"Hu","year":"2003","journal-title":"Cancer Investigation"},{"key":"10.1016\/j.jep.2011.05.032_bib0065","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1248\/bpb.27.1257","article-title":"Induction of nerve growth factor by butanol fraction of Liriope platyphylla in C6 and primary astrocyte cells","volume":"27","author":"Hur","year":"2004","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2011.05.032_bib0070","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2337\/diabetes.55.03.06.db05-1091","article-title":"Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals","volume":"55","author":"Kakinoki","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2011.05.032_bib0075","first-page":"425","article-title":"Characteristics of antidiabetic effect of Dioscorea rhizome (1)\u2014Hypoglycemic effect","volume":"21","author":"Kang","year":"2008","journal-title":"The Korean Journal of Food and Nutrition"},{"key":"10.1016\/j.jep.2011.05.032_bib0080","first-page":"430","article-title":"Characteristics of antidiabetic effect of Dioscorea rhizome (2)\u2014Prevention of diabetic neuropathy by NGF induction","volume":"21","author":"Kang","year":"2008","journal-title":"The Korean Journal of Food and Nutrition"},{"key":"10.1016\/j.jep.2011.05.032_bib0085","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/350158a0","article-title":"Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF","volume":"350","author":"Kaplan","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.jep.2011.05.032_bib0090","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.intimp.2004.07.001","article-title":"Methanol extract of Dioscoreae rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis","volume":"4","author":"Kim","year":"2004","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.jep.2011.05.032_bib0095","first-page":"1377","article-title":"Effect of H2O fraction of Dioscorea japonica thunb with Selenium on plasma glucose and lipid metabolism in streptozotocin induced diabetic rats","volume":"31","author":"Kim","year":"1998","journal-title":"The Korean Journal of Nutrition"},{"key":"10.1016\/j.jep.2011.05.032_bib0100","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1126\/science.3306916","article-title":"The nerve growth factor 35 years later","volume":"237","author":"Levi-Montalcini","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.jep.2011.05.032_bib0105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.aca.2007.07.070","article-title":"Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry","volume":"599","author":"Lin","year":"2007","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.jep.2011.05.032_bib0110","first-page":"95","article-title":"Neuropathic pain quality-of-life impact, cost and cost effectiveness of therapy","volume":"27","author":"O\u2019Connor","year":"2009","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.jep.2011.05.032_bib0115","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4062\/biomolther.2009.17.3.256","article-title":"Hypoglycemic effect of Yacon tuber extract and constituent, chlorogenic acid, in streptozotocin-induced diabetic rats","volume":"17","author":"Park","year":"2009","journal-title":"Biomolecules & Therapeutics"},{"key":"10.1016\/j.jep.2011.05.032_bib0120","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1001\/jama.288.20.2579","article-title":"Molecular understanding of hyperglycemia's adverse effects for diabetic complications","volume":"288","author":"Sheetz","year":"2002","journal-title":"The Journal of the American Medical Association"},{"key":"10.1016\/j.jep.2011.05.032_bib0125","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/00019052-200210000-00010","article-title":"Update on diabetic neuropathy","volume":"15","author":"Simmons","year":"2002","journal-title":"Current Opinion in Neurology"},{"key":"10.1016\/j.jep.2011.05.032_bib0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3940(91)90727-B","article-title":"An in vitro model to study diabetic neuropathy","volume":"129","author":"Sotelo","year":"1991","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.jep.2011.05.032_bib0135","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/SPC.0b013e32832b7df5","article-title":"Advances in the management of diabetic peripheral neuropathy","volume":"3","author":"Tesfaye","year":"2009","journal-title":"Current Opinion in Supportive and Palliative Care"},{"key":"10.1016\/j.jep.2011.05.032_bib0140","first-page":"36","article-title":"Glucose neurotoxicity","volume":"9","author":"Tomlinson","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2011.05.032_bib0145","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.expneurol.2008.06.017","article-title":"Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons","volume":"213","author":"Tosaki","year":"2008","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.jep.2011.05.032_bib0150","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s001250051477","article-title":"Diabetic neuropathies","volume":"43","author":"Vinik","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.jep.2011.05.032_bib0155","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2337\/diacare.26.5.1553","article-title":"Diabetic autonomic neuropathy","volume":"26","author":"Vinik","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jep.2011.05.032_bib0160","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jnr.490410215","article-title":"Spontaneously immortalized adult mouse Schwann cells secrete autocrine and paracrine growth-promoting activities","volume":"41","author":"Watabe","year":"1995","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.jep.2011.05.032_bib0165","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1248\/bpb.27.583","article-title":"Antiosteoporotic activity of the water extract of Dioscorea spongiosa","volume":"27","author":"Yin","year":"2004","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.jep.2011.05.032_bib0170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.carbpol.2005.04.020","article-title":"Structural features and immunological activity of a polysaccharide from Dioscorea opposita Thunb roots","volume":"61","author":"Zhao","year":"2005","journal-title":"Carbohydrate Polymers"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111003977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111003977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T17:12:15Z","timestamp":1637773935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874111003977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0378874111003977"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2011.05.032","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}