{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:50:18Z","timestamp":1781700618933,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Nature Science Foundation","award":["30400548"],"award-info":[{"award-number":["30400548"]}]},{"name":"Natural Science Basic Research Plan in Shaanxi Province","award":["2006C222"],"award-info":[{"award-number":["2006C222"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.jep.2011.05.034","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T04:34:43Z","timestamp":1307939683000},"page":"12-18","source":"Crossref","is-referenced-by-count":54,"title":["Achyranthes bidentata root extract prevent OVX-induced osteoporosis in rats"],"prefix":"10.1016","volume":"139","author":[{"given":"Rong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Quan","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Bing","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2011.05.034_bib0005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF01622738","article-title":"Bone density and shape as determinants of bone strength in IGF-I and\/or pamidronate-treated ovariectomized rats","volume":"6","author":"Ammann","year":"1996","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jep.2011.05.034_bib0010","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/jn\/126.1.161","article-title":"Dietary soybean prevents bone loss in an ovariectomized rat model of osteoporosis","volume":"126","author":"Arjmandi","year":"1996","journal-title":"J. Nutr."},{"issue":"6 Suppl","key":"10.1016\/j.jep.2011.05.034_bib0015","doi-asserted-by":"crossref","first-page":"1364S","DOI":"10.1093\/ajcn\/68.6.1364S","article-title":"Bone-sparing effect of soy protein in ovarian hormonedeficient rats is related to its isoflavone content","volume":"68","author":"Arjmandi","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"issue":"6 Suppl","key":"10.1016\/j.jep.2011.05.034_bib0020","first-page":"1858S","article-title":"Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian deficiency in rats","volume":"68","author":"Arjmandi","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jep.2011.05.034_bib0025","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1359\/jbmr.2002.17.7.1139","article-title":"Ris edronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by threedimensional microcomputed tomography","volume":"17","author":"Borah","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2011.05.034_bib0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1359\/jbmr.2001.16.1.97","article-title":"Comparison of trabecular bone microarchitecture and remodeling in glucocorticoid-induced and postmenopausal osteoporosis","volume":"16","author":"Dalle Carbonare","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2011.05.034_bib0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-2265.2003.01774.x","article-title":"Hormone replacement therapy: current controversies","volume":"58","author":"Davison","year":"2003","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.jep.2011.05.034_bib0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ncprheum0977","article-title":"Potential new drug targets for osteoporosis","volume":"5","author":"Deal","year":"2009","journal-title":"Nat. Clin. Pract. Theum."},{"key":"10.1016\/j.jep.2011.05.034_bib0045","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bone.2005.10.024","article-title":"Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis","volume":"38","author":"Devareddy","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jep.2011.05.034_bib0050","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1359\/jbmr.2001.16.9.1674","article-title":"Effect of 16 months of treatment with tibolone on bone mass, turnover, and biomechanical quality in mature ovariectomized rats","volume":"16","author":"Ederveen","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2011.05.034_bib0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1024\/0300-9831.72.1.13","article-title":"Calcium bioavailability in relation to bone health","volume":"72","author":"Fairweather-Tait","year":"2002","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.jep.2011.05.034_bib0060","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1161\/STROKEAHA.107.487132","article-title":"Herbal medicine in stroke: does it have a future?","volume":"38","author":"Feigin","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2011.05.034_bib0065","first-page":"868","article-title":"Determination of ecdysterone in Achyranthes bidentata BL. and its activity promoting proliferation of osteoblast-like cells","volume":"35","author":"Gao","year":"2000","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.jep.2011.05.034_bib0070","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1076\/apab.105.5.435.3292","article-title":"Influence of ovariectomy and estradiol treatment on calcium homeostasis during aging in rats","volume":"105","author":"Gaumet","year":"1997","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.jep.2011.05.034_bib0075","unstructured":"Guide for the Care and Use of Laboratory Animals, 1996. National Academy Press, Washington, DC."},{"key":"10.1016\/j.jep.2011.05.034_bib0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s002239900329","article-title":"Preventive effects of traditional Chinese (Kampo) medicines on experimental osteoporosis induced by ovariectomy in rats","volume":"61","author":"Hidaka","year":"1997","journal-title":"Calcified Tissue Int."},{"key":"10.1016\/j.jep.2011.05.034_bib0085","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0169-6009(91)90124-I","article-title":"The ovariectomized rat model of postmenopausal bone loss","volume":"15","author":"Kalu","year":"1991","journal-title":"Bone Miner."},{"key":"10.1016\/j.jep.2011.05.034_bib0090","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.ecl.2005.07.009","article-title":"Pathophysiology of age-related bone loss and osteoporosis","volume":"34","author":"Khosla","year":"2005","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.jep.2011.05.034_bib0095","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1172\/JCI33612","article-title":"Building bone to reverse osteoporosis and repair fractures","volume":"118","author":"Khosla","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2011.05.034_bib0100","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000399407","article-title":"The flavonoids. A class of semi-essential food components: their role in human nutrition","volume":"24","author":"K\u00fchnau","year":"1976","journal-title":"World Rev. Nutr. Diet"},{"key":"10.1016\/j.jep.2011.05.034_bib0105","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s001980170022","article-title":"The temporal changes of trabecular architecture in ovariectomized rats assessed by MicroCT","volume":"12","author":"Laib","year":"2001","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jep.2011.05.034_bib0110","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1055\/s-2005-871275","article-title":"Five new oleanolic acid glycosides from Achyranthes bidentata with inhibitory activity on osteoclast formation","volume":"71","author":"Li","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2011.05.034_bib0115","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jep.2009.02.025","article-title":"The osteoprotective effect of Radix Dipsaci extract in ovariectomized rats","volume":"123","author":"Liu","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2011.05.034_bib0120","first-page":"120","article-title":"The research development in the chemical constituents and pharmacological activities of Achyranthes bidentata Bl","volume":"11","author":"Meng","year":"2001","journal-title":"Chin. J. Med. Chem."},{"key":"10.1016\/j.jep.2011.05.034_bib0125","article-title":"Flavonoids from Achyranthes bidentata BI","volume":"426","author":"Nicolov stefan","year":"1996","journal-title":"Acta Hoctic"},{"key":"10.1016\/j.jep.2011.05.034_bib0130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1359\/jbmr.2003.18.1.140","article-title":"Tower climbing exercise started 3 months after ovariectomy recovers bone strength of the femur and lumbar vertebrae in aged osteopenic rats","volume":"18","author":"Notomi","year":"2003","journal-title":"J. Bone Miner. Res."},{"issue":"6 Suppl","key":"10.1016\/j.jep.2011.05.034_bib0135","doi-asserted-by":"crossref","first-page":"1375S","DOI":"10.1093\/ajcn\/68.6.1375S","article-title":"Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women","volume":"68","author":"Potter","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jep.2011.05.034_bib0140","first-page":"27","article-title":"Hormone replacement therapy in postmenopausal women","volume":"30","author":"Prelevic","year":"2005","journal-title":"Minerva Endocrinol."},{"key":"10.1016\/j.jep.2011.05.034_bib0145","series-title":"Current Topics of Osteoporosis","first-page":"513","article-title":"Prevention and treatment of osteoporosis with traditional herbal medicine","author":"Qin","year":"2005"},{"key":"10.1016\/j.jep.2011.05.034_bib0150","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: concepts, conflicts, and prospects,","volume":"115","author":"Raisz","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"6 Suppl","key":"10.1016\/j.jep.2011.05.034_bib0155","doi-asserted-by":"crossref","first-page":"1333S","DOI":"10.1093\/ajcn\/68.6.1333S","article-title":"Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones","volume":"68","author":"Setchell","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jep.2011.05.034_bib0160","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrc1879","article-title":"Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis","volume":"6","author":"Shang","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jep.2011.05.034_bib0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.maturitas.2005.01.012","article-title":"Justification for the use of HRT in the long-term prevention of Osteoporosis","volume":"51","author":"Stevenson","year":"2005","journal-title":"Maturitas"},{"key":"10.1016\/j.jep.2011.05.034_bib0170","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bone.2010.05.001","article-title":"Effects of soy isoflavone supplements on bone turnover markers in menopausal women: systematic review and meta-analysis of randomized controlled trials","volume":"47","author":"Taku","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.jep.2011.05.034_bib0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S8756-3282(99)00098-8","article-title":"The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone","volume":"25","author":"Ulrich","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.jep.2011.05.034_bib0180","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0959-437X(00)00228-8","article-title":"Genetic control of skeletal development","volume":"11","author":"Wagner","year":"2001","journal-title":"Curr. Opin. Genet."},{"key":"10.1016\/j.jep.2011.05.034_bib0185","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jcb.20071","article-title":"Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1","volume":"15","author":"Wattel","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2011.05.034_bib0190","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1142\/S0192415X05002916","article-title":"The use of preventive strategies for bone loss","volume":"33","author":"Xu","year":"2005","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2011.05.034_bib0195","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.bone.2005.11.019","article-title":"Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption","volume":"38","author":"Zhang","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jep.2011.05.034_bib0200","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bone.2008.08.127","article-title":"Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats","volume":"45","author":"Zhang","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.jep.2011.05.034_bib0205","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/jssc.200700468","article-title":"Supercritical fluid extraction of ecdysterone from the roots of Achyranthes bidentata BL","volume":"31","author":"Zheng","year":"2008","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jep.2011.05.034_bib0210","series-title":"Pharmacopoeia of the People's Republic of China","author":"Zhonghua Renmin Gongheguo wei sheng bu yao dian wei yuan hui","year":"2000"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111003990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111003990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T17:48:32Z","timestamp":1560275312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874111003990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0378874111003990"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2011.05.034","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}