{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:17:20Z","timestamp":1789885040160,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.jep.2011.06.040","type":"journal-article","created":{"date-parts":[[2011,7,7]],"date-time":"2011-07-07T22:39:34Z","timestamp":1310078374000},"page":"956-962","source":"Crossref","is-referenced-by-count":28,"title":["A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice"],"prefix":"10.1016","volume":"137","author":[{"given":"Jittima","family":"Weerachayaphorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aporn","family":"Chuncharunee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitrawina","family":"Mahagita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buarong","family":"Lewchalermwongse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apichart","family":"Suksamrarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawinee","family":"Piyachaturawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2011.06.040_bib0005","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1470-2045(02)00777-5","article-title":"Phyto-oestrogens and cancer","volume":"3","author":"Adlercreutz","year":"2002","journal-title":"Lancet Oncology"},{"key":"10.1016\/j.jep.2011.06.040_bib0010","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(92)91174-7","article-title":"Dietary phyto-oestrogens and the menopause in Japan","volume":"339","author":"Adlercreutz","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2011.06.040_bib0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/jn\/126.1.161","article-title":"Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis","volume":"126","author":"Arjmandi","year":"1996","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.jep.2011.06.040_bib0020","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/clinchem\/12.8.482","article-title":"Phenolphthalein monophosphate as a substrate for serum alkaline phosphatase","volume":"12","author":"Babson","year":"1966","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.jep.2011.06.040_bib0025","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1079\/PNS2003309","article-title":"Dietary phyto-oestrogens and bone health","volume":"62","author":"Branca","year":"2003","journal-title":"Proceedings of the Nutrition Society"},{"key":"10.1016\/j.jep.2011.06.040_bib0030","doi-asserted-by":"crossref","first-page":"E443","DOI":"10.1152\/ajpendo.00333.2006","article-title":"High-calcium diet modulates effects of long-term prolactin exposure on the cortical bone calcium content in ovariectomized rats","volume":"292","author":"Charoenphandhu","year":"2007","journal-title":"American Journal of Physiology\u2013Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2011.06.040_bib0035","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1359\/jbmr.2000.15.12.2362","article-title":"A dominant negative cadherin inhibits osteoblast differentiation","volume":"15","author":"Cheng","year":"2000","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jep.2011.06.040_bib0040","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1056\/NEJM199506153322401","article-title":"The use of estrogens and progestins and the risk of breast cancer in postmenopausal women","volume":"332","author":"Colditz","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.jep.2011.06.040_bib0045","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1126\/science.3810166","article-title":"Osteoporosis reexamined: complexity of bone biology is a challenge","volume":"235","author":"Culliton","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.jep.2011.06.040_bib0050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.tem.2005.05.001","article-title":"Dose-dependent effects of phytoestrogens on bone","volume":"16","author":"Dang","year":"2005","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2011.06.040_bib0055","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1074\/jbc.M109.043471","article-title":"Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements","volume":"285","author":"Hewitt","year":"2010","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2011.06.040_bib0060","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm1096-1132","article-title":"Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta","volume":"2","author":"Hughes","year":"1996","journal-title":"Nature Medicine"},{"key":"10.1016\/j.jep.2011.06.040_bib0065","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S0140-6736(97)01339-1","article-title":"Case\u2013control study of phyto-oestrogens and breast cancer","volume":"350","author":"Ingram","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2011.06.040_bib0070","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1621100","article-title":"Increased osteoclast development after estrogen loss: mediation by interleukin-6","volume":"257","author":"Jilka","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jep.2011.06.040_bib0075","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0169-6009(08)80230-9","article-title":"Prostaglandin E2 increased rat cortical bone mass when administered immediately following ovariectomy","volume":"21","author":"Ke","year":"1993","journal-title":"Bone and Mineral"},{"key":"10.1016\/j.jep.2011.06.040_bib0080","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1210\/jc.86.1.289","article-title":"Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: histomorphometric evidence in a longitudinal study","volume":"86","author":"Khastgir","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2011.06.040_bib0085","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1210\/jc.2010-0856","article-title":"Update on estrogens and the skeleton","volume":"95","author":"Khosla","year":"2010","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2011.06.040_bib0090","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001395.pub3","article-title":"Phytoestrogens for vasomotor menopausal symptoms","author":"Lethaby","year":"2007","journal-title":"Cochrane Database of Systematic Review"},{"key":"10.1016\/j.jep.2011.06.040_bib0095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/8756-3282(90)90056-5","article-title":"Decreasing rates of bone resorption in growing rats in vivo: comparison of different types of bones","volume":"11","author":"Li","year":"1990","journal-title":"Bone"},{"key":"10.1016\/j.jep.2011.06.040_bib0100","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/en.2003-0900","article-title":"Mining the complexities of the estrogen signaling pathways for novel therapeutics","volume":"144","author":"McDonnell","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jep.2011.06.040_bib0105","doi-asserted-by":"crossref","first-page":"E817","DOI":"10.1152\/ajpendo.00071.2002","article-title":"Estrogen-induced osteogenesis in intact female mice lacking ERbeta","volume":"283","author":"McDougall","year":"2002","journal-title":"American Journal of Physiology\u2013Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2011.06.040_bib0110","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1210\/en.2002-0074","article-title":"Estrogen receptor-alpha dependency of estrogen's stimulatory action on cancellous bone formation in male mice","volume":"144","author":"McDougall","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jep.2011.06.040_bib0115","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3177\/jnsv.40.201","article-title":"Evaluation of the effect of soybean milk and soybean milk peptide on bone metabolism in the rat model with ovariectomized osteoporosis","volume":"40","author":"Omi","year":"1994","journal-title":"Journal of Nutritional Science and Vitaminology"},{"key":"10.1016\/j.jep.2011.06.040_bib0120","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1016\/8756-3282(95)00329-C","article-title":"The effect of ovariectomy on bone metabolism in rats","volume":"17","author":"Omi","year":"1995","journal-title":"Bone"},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2011.06.040_bib0125","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.maturitas.2005.06.013","article-title":"The importance of preventive health care in post-menopausal women","volume":"52","author":"Palacios","year":"2005","journal-title":"Maturitas"},{"key":"10.1016\/j.jep.2011.06.040_bib0130","first-page":"121","article-title":"Estrogenic activity of Curcuma comosa in rats","volume":"10","author":"Piyachaturawat","year":"1995","journal-title":"Asia Pacific Journal of Pharmacology"},{"key":"10.1016\/j.jep.2011.06.040_bib0135","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF02556619","article-title":"Regional variations in histomorphometric bone dynamics from the skeleton of an osteoporotic woman","volume":"40","author":"Podenphant","year":"1987","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jep.2011.06.040_bib0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S8756-3282(97)00276-7","article-title":"Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture","volume":"22","author":"Qu","year":"1998","journal-title":"Bone"},{"issue":"Suppl. 3","key":"10.1016\/j.jep.2011.06.040_bib0145","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF02210682","article-title":"Osteoporosis prevention and treatment with sex hormone replacement therapy","volume":"14","author":"Rozenberg","year":"1995","journal-title":"Clinical Rheumatology"},{"key":"10.1016\/j.jep.2011.06.040_bib0150","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1210\/jc.2002-020656","article-title":"IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo","volume":"87","author":"Rubin","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2011.06.040_bib0155","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s11418-010-0414-9","article-title":"Chromosome number variation of phytoestrogen-producing Curcuma (Zingiberaceae) from Thailand","volume":"64","author":"Soontornchainaksaeng","year":"2010","journal-title":"Journal of Natural Medicines"},{"key":"10.1016\/j.jep.2011.06.040_bib0160","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.1016\/j.bmc.2008.05.051","article-title":"Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: isolation, chemical modification and estrogenic activity evaluation","volume":"16","author":"Suksamrarn","year":"2008","journal-title":"Bioorganic and Medicinal Chemistry"},{"key":"10.1016\/j.jep.2011.06.040_bib0165","doi-asserted-by":"crossref","first-page":"E426","DOI":"10.1152\/ajpendo.00134.2010","article-title":"Bone modeling in bromocriptine-treated pregnant and lactating rats: possible osteoregulatory role of prolactin in lactation","volume":"299","author":"Suntornsaratoon","year":"2010","journal-title":"American Journal of Physiology\u2013Endocrinology and Metabolism"},{"key":"10.1016\/j.jep.2011.06.040_bib0170","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1073\/pnas.87.6.2172","article-title":"Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats","volume":"87","author":"Takano-Yamamoto","year":"1990","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jep.2011.06.040_bib0175","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1210\/endo-128-1-408","article-title":"High concentrations of 17 beta-estradiol stimulate trabecular bone formation in adult female rats","volume":"128","author":"Tobias","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.jep.2011.06.040_bib0180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jbmr.5650020206","article-title":"The effects of ovariectomy and 17 beta-estradiol on cortical bone histomorphometry in growing rats","volume":"2","author":"Turner","year":"1987","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.jep.2011.06.040_bib0185","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.maturitas.2008.01.001","article-title":"Preventive effects of Pueraria mirifica on bone loss in ovariectomized rats","volume":"59","author":"Urasopon","year":"2008","journal-title":"Maturitas"},{"key":"10.1016\/j.jep.2011.06.040_bib0190","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jep.2010.03.026","article-title":"Protection of centrilobular necrosis by Curcuma comosa Roxb. in carbon tetrachloride-induced mice liver injury","volume":"129","author":"Weerachayaphorn","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.jep.2011.06.040_bib0195","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/jf802702c","article-title":"Estrogenic activity of diarylheptanoids from Curcuma comosa Roxb. Requires metabolic activation","volume":"57","author":"Winuthayanon","year":"2009","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.jep.2011.06.040_bib0200","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1289\/ehp.0900613","article-title":"Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms","volume":"117","author":"Winuthayanon","year":"2009","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.jep.2011.06.040_bib0205","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/endo-123-2-681","article-title":"Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats","volume":"123","author":"Wronski","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.jep.2011.06.040_bib0210","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/BF02556007","article-title":"Long-term effects of ovariectomy and aging on the rat skeleton","volume":"45","author":"Wronski","year":"1989","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jep.2011.06.040_bib0215","first-page":"136","article-title":"Hormone replacement therapy in postmenopausal women","volume":"50","author":"Yasui","year":"2003","journal-title":"Journal of Medical Investigation"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111004697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111004697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T05:59:01Z","timestamp":1592719141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874111004697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0378874111004697"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2011.06.040","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}