{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:40:50Z","timestamp":1788871250503,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009974","name":"Cardinal Tien Hospital","doi-asserted-by":"crossref","award":["CTH-97-1-2A17"],"award-info":[{"award-number":["CTH-97-1-2A17"]}],"id":[{"id":"10.13039\/501100009974","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009974","name":"Cardinal Tien Hospital","doi-asserted-by":"crossref","award":["CTH-99-1-2A22"],"award-info":[{"award-number":["CTH-99-1-2A22"]}],"id":[{"id":"10.13039\/501100009974","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Research Institute of Chinese Medicine","award":["NRICM98-DBCM-08"],"award-info":[{"award-number":["NRICM98-DBCM-08"]}]},{"name":"the National Science Council, ROC","award":["NSC 98-2323-B-077-001"],"award-info":[{"award-number":["NSC 98-2323-B-077-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.jep.2011.08.075","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T15:39:36Z","timestamp":1315582776000},"page":"162-168","source":"Crossref","is-referenced-by-count":39,"title":["Gastrodia elata prevents huntingtin aggregations through activation of the adenosine A2A receptor and ubiquitin proteasome system"],"prefix":"10.1016","volume":"138","author":[{"given":"Chuen-Lin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Mou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaw-Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Lian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Kuei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2011.08.075_bib0005","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0031-9422(94)00771-K","article-title":"Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia","volume":"38","author":"Andersson","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2011.08.075_bib0010","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.yjmcc.2008.11.001","article-title":"PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts","volume":"46","author":"Asai","year":"2009","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.jep.2011.08.075_bib0015","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1474-4422(03)00411-3","article-title":"Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics","volume":"2","author":"Blum","year":"2003","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.jep.2011.08.075_bib0020","series-title":"New Encyclopedia of Herbs and Their Uses","author":"Bown","year":"2001"},{"key":"10.1016\/j.jep.2011.08.075_bib0025","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/mds.22376","article-title":"Treatment of the symptoms of Huntington's disease: preliminary results comparing aripiprazole and tetrabenazine","volume":"24","author":"Brusa","year":"2009","journal-title":"Movement Disorders"},{"key":"10.1016\/j.jep.2011.08.075_bib0030","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1093\/hmg\/ddp230","article-title":"The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin\u2013proteasome system","volume":"18","author":"Chiang","year":"2009","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.jep.2011.08.075_bib0035","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1074\/jbc.M413279200","article-title":"cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant huntingtin with expanded polyglutamine residues","volume":"280","author":"Chiang","year":"2005","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2011.08.075_bib0040","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1471-4159.2005.03029.x","article-title":"CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model","volume":"93","author":"Chou","year":"2005","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.jep.2011.08.075_bib0045","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0024-3205(91)90043-B","article-title":"Physiological and pharmacological properties of adenosine: therapeutic implications","volume":"49","author":"Daval","year":"1991","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2011.08.075_bib0050","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1100\/tsw.2008.60","article-title":"The ubiquitin\u2013proteasome pathway in Huntington's disease","volume":"8","author":"Finkbeiner","year":"2008","journal-title":"The Scientific World Journal"},{"key":"10.1016\/j.jep.2011.08.075_bib0055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0074-7742(05)63007-3","article-title":"Adenosine and brain function","volume":"63","author":"Fredholm","year":"2005","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/j.jep.2011.08.075_bib0060","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2121-8-32","article-title":"Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation","volume":"8","author":"Howard","year":"2007","journal-title":"BMC Cell Biology"},{"key":"10.1016\/j.jep.2011.08.075_bib0065","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0024-3205(99)00473-7","article-title":"Anticonvulsive and free radical scavenging actions of two herbs. Uncaria rhynchophylla (MIQ) Jack and Gastrodia elata Bl., in kainic acid-treated rats","volume":"65","author":"Hsieh","year":"1999","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2011.08.075_bib0070","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/np0605182","article-title":"Neuroprotective principles from Gastrodia elata","volume":"70","author":"Huang","year":"2007","journal-title":"Journal of Natural Products"},{"key":"10.1016\/j.jep.2011.08.075_bib0075","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.lfs.2004.05.008","article-title":"Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis: the role of the MAPK family","volume":"75","author":"Huang","year":"2004","journal-title":"Life Sciences"},{"key":"10.1016\/j.jep.2011.08.075_bib0080","doi-asserted-by":"crossref","first-page":"13838","DOI":"10.1074\/jbc.M008589200","article-title":"Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells","volume":"276","author":"Huang","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jep.2011.08.075_bib0085","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/jnr.21287","article-title":"Ubiquitin\u2013proteasome system alterations in a striatal cell model of Huntington's disease","volume":"85","author":"Hunter","year":"2007","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.jep.2011.08.075_bib0090","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/00001756-200303240-00007","article-title":"Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation","volume":"14","author":"Igarashi","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.jep.2011.08.075_bib0095","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/BF02979066","article-title":"Inhibitory effects of constituents of Gastrodia elata Bl. on glutamate-induced apoptosis in IMR-32 human neuroblastoma cells","volume":"22","author":"Lee","year":"1999","journal-title":"Archives of Pharmacal Research"},{"key":"10.1016\/j.jep.2011.08.075_bib0100","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1093\/hmg\/ddq127","article-title":"Inhibiting the ubiquitin\u2013proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments","volume":"19","author":"Li","year":"2010","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.jep.2011.08.075_bib0105","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/hmg\/7.9.1355","article-title":"A cellular model that recapitulates major pathogenic steps of Huntington's disease","volume":"7","author":"Lunkes","year":"1998","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.jep.2011.08.075_bib0110","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.nbd.2010.09.021","article-title":"A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease","volume":"41","author":"Mievis","year":"2011","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.jep.2011.08.075_bib0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington's disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.jep.2011.08.075_bib0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington's disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2011.08.075_bib0125","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0076-6879(99)09026-6","article-title":"Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates","volume":"309","author":"Wanker","year":"1999","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.jep.2011.08.075_bib0130","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1750-3639.1997.tb00897.x","article-title":"Toward understanding the molecular pathology of Huntington's disease","volume":"7","author":"Wellington","year":"1997","journal-title":"Brain Pathology"},{"key":"10.1016\/j.jep.2011.08.075_bib0135","first-page":"482","article-title":"The effect of vanillin on the fully amygdala-kindled seizures in the rat","volume":"24","author":"Wu","year":"1989","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.jep.2011.08.075_bib0140","doi-asserted-by":"crossref","first-page":"22460","DOI":"10.1074\/jbc.M702439200","article-title":"Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6","volume":"282","author":"Zhang","year":"2007","journal-title":"Journal of Biological Chemistry"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111006489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874111006489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T20:16:18Z","timestamp":1588796178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874111006489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0378874111006489"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2011.08.075","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}